Abstract: A medicament delivery device (100) for delivery of medicament through a cannula (132) from a cartridge (10), the device comprising a first container (11) for storage of a first substance, a second container (12), and valve means for closing a distal end of the second chamber (12), the second container (12) being arranged coaxially with respect to the first container (11), a mixing element (304) being provided for causing displacement of the second substance into the first container (11) through the valve means in a mixing stroke, a release element being provided for holding the mixing element (304) in an initial position and being operable to release the mixing element (304) to initiate the mixing stroke, there being a needle shroud (400) for shrouding the cannula, and removal of the needle shroud (400) from the cannula (132) causing operation of the release element.

Abstract: A sanitary washing device is on a toilet including a bowl. The sanitary washing device includes a casing, a nozzle, a shielding plate, and a controller. The nozzle washes a human body private part. The nozzle is advanceable and retractable between a storage position and an advanced position. The shielding plate is rotatable with respect to the casing and positioned frontward of the nozzle when the nozzle is at the storage position. The controller controls an operation of the nozzle. The nozzle has a first spout hole squirting water. The shielding plate is at a first position when the nozzle is at the advanced position. The controller performs a frontward washing operation of squirting water after using the sanitary washing device. A part of the shielding plate is positioned frontward of a front end part of the nozzle in the frontward washing operation.

Abstract: The invention provides, in some aspects, a container system for medical solutions such as peritoneal dialysis (PD) solutions. The invention particularly features a system which includes a first compartment that contains a first medical solution, e.g., a PD osmotic agent, and a second compartment that contains a second medical solution, e.g., a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. To that end, a container system can include a diffuser that is disposed in a fluid pathway between the first and second compartments, e.g., to facilitate homogeneous mixing of the first and second PD agents.

Abstract: A penis erection stimulation system comprises an infusion device (11) adapted for implantation inside the patient's body, at least one reservoir (R1, R2) adapted for implantation inside the patient's body in fluid connection with the infusion device to supply to the infusion device a substance to be injected into the patient's body, and a cooling device implantable along with the reservoir for keeping the content within at least one compartment of the reservoir at a temperature below 37° C. The reservoir preferably comprises at least one first compartment accommodating or adapted to accommodate a first substance and at least one second compartment accommodating or adapted to accommodate as a second substance a drug for stimulating penis erection, wherein the at least one second compartment is cooled by means of the cooling device.

Abstract: The invention relates to a device (1) for monitoring sample-collection carried out using a piston pump (3, 8) such as a syringe, characterized in that said device includes a pressure sensor (11) close to the suction and/or delivery opening (6). Said device is in particular suited for use in an analysis automaton, in particular for analyzing a blood sample. Such a sensor guarantees that the liquid to be analyzed is properly sucked up, in particular that no air is sucked up and that neither the suction or delivery sides are blocked.

Abstract: A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle.

Abstract: A valve assembly is provided which includes a housing having an inlet end and an outlet end and defining a fluid channel and a central chamber. A dissolvable valve member is positioned to obstruct flow through the channel within the chamber. The dissolvable valve member is formed of a material which is dissolvable at a predetermined rate upon contact with a preselected fluid. The preselected fluid is selected from the group consisting of blood, urine, saline and antimicrobial solutions. The dissolvable valve member can be formed from a fluid soluble glass or a starch based material.

Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.

Abstract: A container for medical products has at least one chamber. At least two lyophilized active substances and/or auxiliary substances are jointly present in the at least one chamber.

Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.

Abstract: This pharmaceutical injection device comprises a main body case (2) having an injection needle extension/retraction opening (1); a pharmaceutical syringe mounting portion (3) provided inside the main body case (2); a piston (5) capable of moving relative to the pharmaceutical syringe mounting portion (3); a drive mechanism (6) for the piston (5); a controller (7) that is electrically connected to the drive mechanism (6); and an orientation sensor (8) that is electrically connected to the controller (7). The controller (7) controls the speed of the piston (5) in order to reduce liquid leakage during pharmaceutical mixing.

Abstract: A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, is also sufficiently viscous to rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing.

Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.

Abstract: A device and a method are proposed for actuating a carpule, in which a piston is displaced in the carpule by means of a ram that is telescopically extensible by rotation, and in this way a liquid medicament formulation is expelled. For carrying out different processes, different operating movements are provided, particularly the operation of an operating element in different directions and/or the operation of different operating elements. This promotes simple, intuitive and safe operation.

Abstract: The invention provides a device and methods suitable for producing a cellular spray of cells. The sprayed cells are of interest for covering and growing on a surface, including a skin wound. In applying the method and/or using the device, cells for grafting onto a patient are dispersed in a solution and sprayed with the device for distribution over the recipient's graft site.

Abstract: A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.

Abstract: A drug reconstitution device, method of manufacturing the drug reconstitution device and method of producing a reconstituted drug solution using the drug reconstitution device utilizes a forward osmosis membrane element positioned within a housing of the device between an input chamber and an output chamber to draw liquid from the input chamber to the output chamber via an osmotic process. The output chamber contains draw solutes and a drug to be reconstituted to produce the reconstituted drug solution in the output chamber.

Abstract: A plunger-driven delivery device for use with a feeding tube for delivering an ingestible material to a user is provided. The delivery device includes a device body having a first chamber, a second chamber and an exit orifice through which the ingestible material is delivered to the feeding tube. A first plunger is disposed in the first chamber, and a second plunger is disposed in the second chamber. The delivery device can be provided with the ingestible material disposed in the first chamber and a flushing liquid disposed in the second chamber. The delivery device is operable to provide sequential delivery first of the ingestible material and then the flushing liquid into the feeding tube. In some embodiments, a mechanical interlock is disposed between the first and second plungers to prevent use of the second plunger until the first plunger has been depressed.

Abstract: The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: An administering device for administering an active substance from a multi-chamber container comprising a first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance, wherein the administering device comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device, the container being moveable relative to the housing, and the administering device further comprising a first indicator for indicating a position of the container relative to the housing upon completion of a mixing step, and a second indicator for indicating a position of the container relative to the housing upon completion of a venting step.

Abstract: The invention provides exemplary aerosolization apparatus and methods for aerosolizing a substance. According to one exemplary method, a liquid is transferred from a first chamber into a second chamber having a substance that is in a dry state to form a solution. The solution is then transferred from the second chamber and onto an atomization member. The atomization member is operated to aerosolize the solution.

Abstract: A method of storing and delivery a drug, such as by lyophilizing and reconstituting, comprises performing both storing and delivering with the same container closure assembly. The container closure is assembled in a preparation configuration during which lyophilization occurs. After lyophilizing, the powdered drug is forced into a spiral channel in the container closure assembly by a plunger. The plunger leaves substantially no head space for the powdered drug, and the assembly is sealed thereby now being in the storage configuration. For delivery of the stored powdered drug, a syringe of diluent is introduced to the container assembly thereby changing the assembly to the delivery configuration. The spiral channel is continuous between an input end and a delivery end with the delivery end being in fluid communication with a delivery outlet of the assembly. The assembly includes a diluent flow path that forces the diluent into a spiral channel at only the input end.

Abstract: A transfer system (100, 100?, 100?) adapted to allow first contents of a first container (20) and second contents of a second container (30) to mix to form a material. The mixed material is retrieved to a syringe (40). The transfer system (100, 100?, 100?) comprises first (17) and second (18) flow control members for controlling fluid flow between the containers (20, 30) and the syringe (40). The invention further relates to a drug mixing kit comprising a container unit containing first and second containers, and a transfer unit comprising ports for receiving the containers and a syringe and a number of flow channels. The container unit and the transfer unit are adapted to be coupled together to form a drug mixing kit.

Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.

Abstract: A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.

Abstract: A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.

Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.

Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.

Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.

Abstract: The present disclosure relates to an apparatus and method for combining a solid particulate with a solvent prior to an injection protocol within an injector device. The solid particulate may be a pharmaceutical compound and the microcapsules contain a solvent for such particulate. Upon application of pressure, the microcapsules may be configured to burst and release the solvent, thereby dispersing and/or partially dissolving the particulate. The injector therefore allows for the use of relatively unstable pharmaceutically active compounds in a device that requires relatively long storage times and the use of pharmaceutical compounds that are relatively stable in the dry state.

Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.

Abstract: A system for extracting and processing adipose tissue to generate a therapeutically effective amount of adipose-derived stem cells, comprising an adipose tissue extraction device and a modified centrifuge tube comprising a plurality of lipoaspirate inlet fittings, a plurality of processing fluid inlet fittings, and a plurality of pellet extraction tubes. The adipose tissue extraction device is used to extract a quantity of adipose tissue from a human being, the lipoaspirate is moved into the first modified centrifuge tube via a sterile transfer, a plurality of processing steps are performed to clean and dissociate the lipoaspirate, and a pellet containing an enhanced fraction of stem cells is obtained by centrifuging the modified centrifugal tube. The pellet is resuspended in a fluid and administered to a human patient for a therapeutic or cosmetic purpose.

Abstract: A drug mixing and expelling device (1) for mixing a drug with a liquid, thereby forming a reconstituted liquid drug. The device comprises a reservoir (2) containing a liquid, a vial (4) containing a drug, a vial, means (5) for establishing a fluid connection between the reservoir and a vial positioned in the vial adapter (3), means (7, 8) for forcing the liquid from the reservoir to a vial, and means (9) for activating said forcing means during establishment of the fluid connection between the reservoir and the vial. The forcing of liquid into the vial provides a pressure therein, which can be used for infusion of the reconstituted drug directly from the vial. The device also comprises a suction unit (13) for aspiration.

Abstract: A gonadotropin is administered within a surprisingly effective narrow range for the purpose of treating chronic pain or other central sensitization sequelae. In one aspect, a recipient is provided with at least one of human chorionic gonadotropin (uHCG and/or rHCG), a pharmaceutically active HCG analogue, and a pharmaceutically active metabolite of the HCG or analogue at a dosage selected to provide, or be equivalent to, a human subcutaneous dosage of between 120 IU/day and 170 IU/day of HCG, and more preferably between 140 IU/day and 160 IU/day of HCG. A kit is also described, which includes a supply of the HCG-related drug, a delivery device, and a label that identifies chronic pain or central sensitization as an indication of the drug.

Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.

Abstract: A kit is described including at least one container including a predetermined quantity of sterilized biodegradable carriers in a powder form having a treatment agent disposed therein. The kit further includes a delivery device for delivering the predetermined quantity of sterilized biodegradable carriers with the treatment agent disposed therein to a treatment site. In other embodiments, methods are described for producing the sterilized treatment agent loaded biodegradable carriers and delivering the sterilized carriers to a treatment site.

Abstract: The present invention relates to a carrier linked pramipexole prodrug or a pharmaceutical acceptable salt thereof, wherein pramipexole is bound via a linker to a polymeric carrier. The invention also relates to pharmaceutical compositions comprising said polymeric pramipexole prodrug and their use as medicaments.

Abstract: Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.

Abstract: Dispensing unit for mixers of biphasic compounds, for dispensing a quantity of mixed biphasic compound through a channel of at least a mixing unit by means of at least a piston sliding inside at least a mixing chamber, wherein it includes at least a drive element for said piston which can be remotely controlled.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: An apparatus includes a housing, a medicament container disposed within the housing, a first energy storage member and second energy storage member. The medicament container includes a first plunger disposed within a proximal end portion of the medicament container and a second plunger disposed within the medicament container spaced apart from the first plunger. The first energy storage member is configured to produce a force when actuated to move at least the second plunger within the medicament container. The second energy storage member is configured to produce a force when actuated to move the first plunger and the second plunger within the medicament container. The second energy storage member is different than the first energy storage member.

Abstract: An implantable cardiac therapeutic device having at least one implantable sensor arranged to sense at least one physiologic characteristic of a patient, an implantable therapeutic agent delivery assembly wherein the delivery assembly and a therapeutic agent to be delivered are configured for placement in a patient's pericardial space, and a controller in communication with the at least one implantable sensor and with the therapeutic agent delivery assembly wherein the controller evaluates the at least one physiologic characteristic for indications of a condition indicating administration of the therapeutic agent and wherein, upon detection of such indications, induces the therapeutic agent delivery assembly to deliver the agent.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: A device for automatically mixing powder for injection, includes an injector body, a solvent bottle, a needle, a first impelling unit and a second impelling unit. The injector body has a solute bottle and its mouth is opposite the mouth of the solvent bottle. The first impelling unit is disposed upon the solvent bottle. The second impelling unit is sleeved with a needle and located between the mouth of solute bottle and mouth of solvent bottle. A first and a second impelling sleeve-are driven by the solvent bottle to slide along the solute bottle, so the first end of the needle is fixed and extend through the solute bottle. The solvent bottle drives the first impelling sleeve and second impelling sleeve to turn with each other. The second impelling sleeve slides opposite the first impelling sleeve to make the second end of the needle extend through the solvent bottle.

Abstract: In an apparatus for storing and administering active substances, at least one transfer mechanism is provided, and a first reservoir that contains an active substance in dissolved form is also provided, the active substance being administered by way of the transfer mechanism. A second reservoir having the active substance in solid form is additionally provided in the apparatus.

Abstract: A drug delivery system includes an automatic injector that can deliver a small, precise amount of a therapeutic agent. The automatic injector includes a chamber for containing a liquid component and a thin porous member that carries thereon and/or therein the small, precise amount of therapeutic agent. Upon activation of the automatic injector, a flow path opens from the chamber through the porous member, enabling the liquid component to rapidly mix with the therapeutic agent before being injected.

Abstract: Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.

Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.

Abstract: A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.