Abstract: A method for determining a shear elasticity and shear viscosity of a material based on resonance characteristics. A focused ultrasound wave is directed at the material to induce oscillations in the material, and a velocity of the material is measured. A spectrum of frequency of oscillation versus velocity is developed, and the resonance characteristics exhibited by the spectrum are used to estimate the shear elasticity and viscosity of the material.

Abstract: A balloon catheter is provided which may be used to dilate hardened regions of stenosis. The balloon catheter is provided with dilation wires that may be extended so that the dilation wires are disposed adjacent an outer surface of the balloon during dilation. Thus, as the balloon is expanded, the dilation wires are squeezed between the balloon and the stenosed region to crack or breakup the stenosis. The dilation wires may also be retracted away from the balloon. Thus, the stenosed region may be dilated with the balloon without using the dilation wires if desired.

Abstract: A medical retrieval device is used to retrieve and/or fragment stones (and/or other objects) from the body of a patient. The device has a retrieval basket with a releasable tip. The tip release is designed to release in a controlled pre-determined manner and under a predetermined force before any other component of the device fails due to a force exerted on the basket.

Abstract: The invention relates to a device for generating shock waves for medical therapy comprising two electrodes of a spark discharge section, wherein the device is filled with a liquid medium, and wherein the liquid medium comprises a colloidal suspension of a conducting, semiconducting, or polarizable substance in water.

Abstract: An ultrasonic lithotripter comprising a first transmission probe which has a hollow portion in the form of a through hole and transmits ultrasonic vibration and a superfine second transmission probe which can be passed through the hollow portion of the first transmission probe. An object of manipulation is held by means of the second transmission probe as it is manipulated by means of the first transmission probe.

Abstract: An embodiment of a medical retrieval device includes a sheath having a proximal end and a distal end, a handle at the proximal end of the sheath, and a basket. The basket has a collapsed position when the basket is within the sheath and collapsed and an expanded position when the basket is positioned beyond the distal end of the sheath and expanded. The basket includes a plurality of legs, at least one leg having a frangible portion wherein the at least one leg breaks upon application of a predetermined force to the basket. A distal portion of the plurality of legs may be formed from a single piece of material.

Abstract: Disclosed is a micro-emulsifier comprising a stack of piezoelectric materials, a horn at a proximal end of the stack of piezoelectric materials, and a transmission wire receivable in the horn for transmission of ultrasound waves able to be produced by the stack of piezoelectric materials. The ultrasound waves are able to be produced in a direction parallel to a longitudinal axis of the stack of piezoelectric materials and the horn. The transmission wire comprises a first end receivable in the horn and a second end remote from the first end, the second end having a bulb thereon.

Abstract: Ultrasound catheter devices and methods of the present invention generally provide for ablation and/or disruption of vascular occlusions. An ultrasound transmission member, such as a wire, transmits vibrational energy from an ultrasound transducer to a distal head of the catheter to disrupt vascular occlusions. An absorber member is disposed on or around the ultrasound transmission wire at a location adjacent the sonic connector of the catheter. The absorber member absorbs heat, vibrations, and/or the like from the ultrasound transmission wire at or near the area where the transmission wire is coupled with the sonic connector. The absorptive function typically slows the process of wear and tear on the transmission wire, thus extending the useful life of the ultrasound catheter.

Abstract: Invasive side-firing electrohydraulic lithotripsy probes that creates a substantially annular shockwave to break up concretions are disclosed. Generally, the side-firing electrohydraulic lithotripsy probe includes a lithotripter tip including a first electrode and a second electrode. The first electrode is positioned at a distal end of the lithotripter tip and the second electrode is positioned in the lithotripter tip such that an end of the second electrode is coaxially aligned with an end of the first electrode. An electric arc between the first and second electrodes causes a shockwave to radiate radially from the lithotripter tip.

Abstract: A system comprises a guide wire, an embolic protection basket carried on the guide wire, and a catheter carried on the guide wire adjacent the embolic protection basket. The catheter includes an elongated carrier and a balloon about the carrier in sealed relation thereto. The balloon is arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon forms a mechanical shock wave within the balloon.

Abstract: A system for breaking obstructions in body lumens includes a catheter including an elongated carrier, a balloon about the carrier in sealed relation thereto, the balloon being arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon that forms a mechanical shock wave within the balloon. The system further includes a power source that provides electrical energy to the arc generator.

Abstract: The method of stimulation for a genital tissue or reproductive organ of an infertility or impotence diagnosed patient is disclosed. The stimulation has the steps of activating an acoustic shock wave generator or source to emit acoustic shock waves; and subjecting the genital tissue, reproductive organ or the entire reproductive region of the body to the acoustic shock waves stimulating said tissue, organ or body wherein the tissue, organ or body is positioned within a path of the emitted shock waves. The emitted shock waves can be convergent, divergent, planar or near planar.

Abstract: A method of diagnosing and treating a patient having benign prostatic hyperplasia caused by insufficient blood flow to the prostate due to atherosclerosis of a pelvic artery is disclosed. A method of diagnosing the patient's condition includes determining if a stenosis exists within a pelvic vessel. A method of treating the patient's condition may include placing a stent within the stenosed pelvic artery.

Abstract: Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Generally, an ultrasound catheter device includes an elongate flexible catheter body with one or more lumens, an ultrasound transmission member extending longitudinally through the catheter body lumen and a distal head coupled with the transmission member and positioned adjacent the distal end of the catheter body for disrupting occlusions. A proximal housing of the catheter device may include one or more features for dissipating heat from the ultrasound transmission wire, such as a fluid inlet aperture for passage of fluid, use of heat conductive materials in the proximal housing, surface features to increase the housing's surface area, heat conductive members disposed adjacent the transmission member and the like. Various irrigation fluids may be used, such as cooled, oxygen supersaturated or lubricious fluids.

Abstract: The method of stimulating an aquatic life form is disclosed. The method has the steps of activating a pressure pulse or an acoustic shock wave generator or source to emit pressure pulse or acoustic shock waves; and subjecting the aquatic life form to the pressure pulse or acoustic shock waves stimulating said aquatic life form wherein the aquatic life form is positioned within a path of the emitted shock waves. The aquatic life form is a tissue having cells. The tissue can be an egg, zygotic embryo or larvae or an immature or a mature specimen. The aquatic life form may be a fish, shellfish, any crustacean, mussel, slam, oyster, abalone, scallop, shrimp, lobster, crab, crawfish, eel, octopus or any other aquatic life form. The method of stimulating includes activating the cells within the treated tissue thereby releasing growth factor proteins or other chemical compositions promoting growth and accelerating maturization.

Abstract: A medical device is provided. The medical device includes a sheath with an extended distal end portion, a proximal end portion, and a lumen defined therethrough. A handle is fixedly connected to the proximal end portion of the sheath, the handle includes an operator that is translatable between a first position and a second position. A flow path is defined within the handle in fluid communication with the proximal end portion of the sheath, wherein the operator is configured to substantially block the flow path in a second position and allow flow therethrough in a first position. The flow path includes a portion that is configured to communicate with a remote source of suction. The handle additionally includes a second inlet portion configured to receive a tool therethrough and allow the tool to extend through the lumen of the sheath.

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.

Abstract: A system and method for facilitating the fixation of bone fractures is disclosed. The system includes a flexible wire attached to a tip. The tip may comprise a substantially planar surface and a pointed cutting edge and cutting threads. The system may further comprise a sleeve that is insertable over the flexible wire to provide additional stability and strength. The sleeve may be smooth or may comprise a gripping means to increase the holding strength of the system. The system and method may be used to deliver treatment to a bone to facilitate fixation. The treatment may comprise medications, adhesives, implants, fasteners, suturing materials, and/or other means of fixation.

Abstract: A single-blow mechanical shockwave generation device used in urological surgery for disintegration of urinary duct stones comprises a striking device which strikes a shock wave generation device at high speed. The shock waves are transmitted by a shock wave transfer device to an object for destruction with which the shock wave transfer device is in direct or indirect contact. The striking device is displaced by way of the expansion of a high-pressure gas introduced prior to each shock wave generation into an accumulation device. The accumulation device is supplied with high pressure gas from independent gas stores and with supply and sealing devices. The stored gas is released by the manual manipulation of a control device which connects the accumulation device to the striking device.

Abstract: An intravascular filter assembly is disclosed for fragmenting a thrombotic or atherosclerotic occlusion and capturing thrombotic or atherosclerotic debris within a blood vessel. The intravascular filter assembly includes an elongate shaft and an expandable filter coupled to the distal region of the elongate shaft. One or more piezoelectric elements are secured to the elongate shaft at a location proximal of the expandable filter. A conducting wire is attached to the one or more piezoelectric elements and extends toward the proximal end of the elongate shaft. The one or more piezoelectric elements are configured to generate ultrasonic waves when subjected to an electrical voltage to fragment a thrombotic or atherosclerotic occlusion within a blood vessel.

Abstract: An apparatus comprising an implantable acoustic transducer, an acoustic transducer interface circuit communicatively coupled to the acoustic transducer, and a controller circuit communicatively coupled to the acoustic transducer interface circuit. The controller is configured to, in response to receiving an indication of a patient condition associated with a development of a blood vessel obstruction, initiate delivery of acoustic energy that mitigates the blood vessel obstruction. Other systems and methods are described.

Abstract: The invention relates to a single-blow mechanical shockwave generation device used in urological surgery for disintegration of urinary duct stones, comprising a striking device which strikes a shock wave generation device at high speed. The shock waves are transmitted by a shock wave transfer device to an object for destruction with which the shock wave transfer device is in direct or indirect contact. The striking device is displaced by way of the expansion of a high-pressure gas introduced prior to each shock wave generation into an accumulation device. The accumulation device is supplied with high pressure gas from independent gas stores and with supply and sealing devices. The stored gas is released by the manual manipulation of a control device which connects the accumulation device to the striking device.

Abstract: Systems and methods are described providing for the use of ultrasound energy to effect the dislodging of one or more blood clots inside blood vessels. Such clots can include those inside retinal vessels, especially in patients with central retinal vein occlusion. Embodiments of the present disclosure may be used for any retinal arterial or venous occlusion. In exemplary embodiments, a small probe can be inserted into the eye of a patient and placed over the retinal vessels. Acoustic streaming created by the probe can be directed to an area or region including targeted blood vessels, resulting in increased flow in one or more retinal veins and facilitating or effecting mechanical dislodging of one or more blood clots in the targets blood vessels. Exemplary embodiments can utilize ultrasonic energy produced at a frequency of approximately 44 MHz to 46 MHz with pulse repetition frequencies of approximately 100 Hz to 100 kHz.

Abstract: A lithotriptor device embodiment is provided including a lithotriptor that has a proximal handle, an elongate shaft extending distally from the handle with a lumen extending through a major length of the elongate shaft, and a wire basket distally attached to a drive wire. The drive wire extends through the lumen of the elongate shaft and is operatively connected to the handle. The device includes a drill mechanism assembly with a drill bit disposed near the distal end of the elongate shaft.

Abstract: Occluding structures may be created within a body lumen by advancing a length of material distally through the body lumen. By drawing a distal location on the advanced length of material in a proximal direction, the material may be compacted into a structure which at least partially occludes the lumen. The occluding structure may be used to remove kidney stones from the ureter in conjunction with lithotripsy and irrigation.

Abstract: A sinus bone-breaking instrument comprising a longitudinally extending handle and a relatively small laterally extending distal head designed to fit upward into a bone channel and having a laterally inward and upward inclined lower surface shaped to hook bone fragments in the bone channel and with a downward pulling on the handle to break off the bone fragments leaving the bone channel free of bone fragments.

Abstract: Ultrasound medical systems and related methods are described.

Abstract: A surgical instrument for fragmenting and extracting stones includes an outer sheath having a proximal end and a distal end and an inner core longitudinally extending through the core and longitudinally movable relative to the core. The outer sheath has a basket sized for entrapping the stones and located near the distal end of the outer sheath. The distal end of the inner core is longitudinally moveable from a retracted position within the basket to an extended position past the distal end of the outer sheath. The distal end of the inner core is also adapted to engage and fragment the stones. Longitudinal movement of the inner core relative to the outer sheath transforms the basket from an expanded condition to a collapsed condition to entrap stones within the basket and provide a small profile for insertion and withdrawal.

Abstract: A method of fat cavitation including infiltrating adipose tissue with a liquid, creating a puncture in a patient's skin, providing a wire, the wire being generally uniform in diameter and having a first end and a second end and introducing the second end of the wire through the puncture in the patient's skin. The method further includes placing at least a portion of the second end of the wire in contact the adipose tissue, generating an ultrasonic wave, transmitting the ultrasonic wave to the second end of the wire, creating cavitation bubbles in at least a portion of the targeted adipose tissue and liquefying at least a portion of the targeted adipose tissue. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: The present invention is a device for the destruction of adipose tissue comprising two or more ultrasound generators positioned on opposing sides of the treatment area each generating a non-focused wave that converge forming a interferential clash zone with the treatment area therein. Ultrasound generators are contained within a handpiece housing. Furthermore the present invention provides an optional housing having a source of vacuum for encompassing a treatment area whereby the treatment area is drawn bell-shaped into the housing whereupon a pair of shock wave generators are energized to produce cavitational areas within the treatment area and a third interferential energized area between the cavitational areas.

Abstract: A medical retrieval instrument of the present invention includes a plurality of filaments for holding an object and a hollow section through which a first end of each of said plurality of filaments passes. The hollow section comprises a plurality of fixing sections for fixing a second end of each of said plurality of filaments, for example. The hollow section is arranged in a distal end portion of a sheath. The hollow section is inserted into the body cavity by the sheath and then holds an object such as renal calculus or ureteral calculus in the body cavity and retrieves them to outside the body.

Abstract: An ultrasonic calculus treatment apparatus includes a longitudinal-vibration piezoelectric oscillator for vibrating in the axial direction of an ultrasonic transmitting member and a torsional-vibration piezoelectric oscillator for vibrating about the axial direction, and further includes driving circuits for driving the piezoelectric oscillators at respective resonance frequencies and a mode selection switch for permitting the oscillators to vibrate independently or in combination, so that lithotripsy can be performed effectively in accordance with the size of a calculus or a function of an operating tool.

Abstract: Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.

Abstract: Output optical energy pulses including relatively high energy magnitudes at the beginning of each pulse are disclosed. As a result of the relatively high energy magnitudes which lead each pulse, the leading edge of each pulse includes a relatively large slope. This slope is preferably greater than or equal to 5. Additionally, the full-width half-max value of the output optical energy distributions are between 0.025 and 250 microseconds and, more preferably, are about 70 microseconds. A flashlamp is used to drive the laser system, and a current is used to drive the flashlamp. A flashlamp current generating circuit includes a solid core inductor which has an inductance of 50 microhenries and a capacitor which has a capacitance of 50 microfarads.

Abstract: An expansible and retractable mechanism of the type disclosed in U.S. Pat. No. 5,924,175 and/or a medical grasper of the type disclosed in U.S. Pat. No. 5,906,622 in which (1) the fixed flexure elements are self-biased to move into the expanded condition thereof. A handpiece for the medical grasper is constructed and arranged so that after a stone has been grasped, a further digital pull on the movable handpiece structure effects the application of a limiting resiliently yielding force to the gripping action.

Abstract: Apparatus and method for the removal of lens tissue includes a first handpiece having a laser emitting probe sized for insertion into a lens capsule and radiating a lens therein. The laser emitting probe includes a lumen for introducing irrigation fluid into the lens capsule. A second handpiece includes a pulsed controlled vibrated needle for insertion into the lens capsule and emulsifying laser eradiated lens tissue. The vibrated needle includes a lumen therethrough for aspiration of emulsified lens tissue and irrigation fluid.

Abstract: Thrombectomy and other treatments are achieved using a catheter having a positioning cage and a macerator within the positioning cage. The catheter is introduced to a target body lumen, typically a blood vessel, and a positioning cage deployed at a treatment site. The macerator is then operated to disrupt thrombus, clot, or other occlusive materials at the treatment site, and the catheter is used to collect and remove the disruptive materials from the body lumen. In particular examples, the macerator may be radially expansible and optionally rotated and/or axially translated within the positioning cage to effect disruption of the occlusive material.

Abstract: A medical device includes a handle, a sheath, and an object-engaging unit. The distal end portion of the sheath is strong enough to resist being deformed by the object-engaging unit, yet another portion of the sheath is flexible enough to bend sufficiently.

Abstract: A method and apparatus for removing plaque, fatty deposits, and other occlusions from blood vessels using ultrasonic energy. The method and apparatus has particular application in removing plaque from the carotid artery in a non-thermal manner. The apparatus is designed to have as small a cross-sectional profile as possible, therefore allowing the apparatus to be used in a minimally-invasive manner. As a result, the apparatus can be used in both surgical and outpatient treatment with minimal post-operative complications and minimal damage to areas other than the area of treatment. An ultrasonic probe may include aspiration channels on its outer surface. An aspiration sheath may surround the ultrasonic probe, such that the location of an aspiration port may be varied axially relative to the ultrasonic tip.

Abstract: A medical retrieval device for retrieving foreign objects from a patient and the method of constructing the device are disclosed. The device incorporates a wire cable composed of a precursor alloy to a superelastic material to improve durability of the device. Because precursor alloys exhibit a linear stress-strain relationship and a yield point associated with a relatively high stress level, the device transfers greater stresses before experiencing deformation. Thus, greater crushing forces can be achieved using a device of this type. These crushing forces may be needed when the foreign object is too large to remove intact. This property also facilitates the device in dilating ducts to retrieve foreign objects. Using the precursor alloy additionally eliminates the need for heat treatment of the cables used in constructing the device. A retrieval device made of precursor alloy cable also is less susceptible to permanent deformation and unwinding during use.

Abstract: This invention relates to an improved method and apparatus for generating profiled pulses of ultrasonic frequency vibratory energy at a distal surface of an ultrasonic applicator of an ultrasonic surgical instrument for application to tissues of a patient, including the providing of a profiled pulse signal with a first profile and a maximum magnitude during a first time portion and a second profile and a minimum magnitude during a second time portion, the second time portion being greater than or equal to the duration of the first time portion, the first time portion being between one millisecond and fifty milliseconds in duration, and the maximum magnitude in the range between two and twenty times the minimum magnitude.

Abstract: A probe assembly and method for ablating tissue is provided. The probe assembly comprises an elongated shaft having a rigid section and a flexible section distally extending from the rigid section. The probe assembly further comprises a tissue penetrating element associated with the flexible section. For example, it can be mounted to the flexible section or can be located on a separate element, such as a trocar that can be disposed within the elongated shaft. The probe assembly further comprises one or more ablative elements, such as electrodes, that is associated with the flexible section. Like the tissue penetrating element, the ablative element(s) can be mounted to the flexible section or can be located on a separate element. Thus, the flexible section of the shaft can be flexed to deflect the tissue penetrating element, so that it can be steered through tissue. In this manner, sensitive anatomical structures can be avoided, e.g.

Abstract: An ultrasonic surgery apparatus enabling smooth surgery. The ultrasonic apparatus is provided with an ultrasonic chip, a vibration inducing unit which induces ultrasonic vibration to the ultrasonic chip, an aspiration unit which aspirates tissue emulsified by vibration of the ultrasonic chip, a detection unit which detects a clogging condition of the ultrasonic chip, a footswitch, having a pedal, for emitting an output signal which is based on a depression amount or a depression position of the pedal, and a control unit which controls at least one of ultrasonic power and a pulse-duty ratio of the ultrasonic vibration based on the output signal from the footswitch and a detection result obtained by the detection unit.

Abstract: A delivery apparatus for a self-expanding stent is disclosed. The apparatus has an outer sheath forming an elongated tubular member having distal and proximal ends and an inside and outside diameter. The apparatus also includes an inner shaft located coaxially within the outer sheath. The inner shaft has a distal end, a proximal end and longitudinal axis extending therebetween. At least a portion of the inner shaft is made from a flexible coiled member. The shaft preferably includes a stop attached thereto, the stop being proximal to the distal end of the sheath. Lastly, the apparatus includes a self-expanding stent located within the outer sheath, wherein the stent makes frictional contact with the outer sheath and the shaft is disposed coaxially within a lumen of the stent. During deployment of the stent, the stent makes contact with the stop.

Abstract: A method and system for providing control that include providing a workpiece that includes a target shape, providing a cutting tool, providing a 3-D image associated with the workpiece, identifying the target shape within the workpiece image, providing a 3-D image associated with the cutting tool, registering the workpiece with the workpiece image, registering the cutting tool with the cutting tool image, tracking at least one of the workpiece and the cutting tool, transforming the tracking data based on image coordinates to determine a relationship between the workpiece and the cutting tool, and, based on the relationship, providing a control to the cutting tool. In one embodiment, the workpiece image can be represented as volume pixels (voxels) that can be classified and/or reclassified based on target shape, waste, and/or workpiece.

Abstract: A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.

Abstract: A cardiac constraint jacket is formed of flexible material defining a volume between an open upper end and a lower end. The jacket is dimensioned for an apex of a patient's heart to be inserted into the volume through the open upper end and for the jacket to be slipped over the heart. The jacket includes a receiving member along its upper end for engagement to a delivery apparatus, the apparatus used in positioning the jacket on the heart. The delivery apparatus includes a handle and a band. The band is generally hoop shaped having a first end and a second end attached to the handle, the first end fixedly attached to the handle and the second end releasably attached to the handle. Alternatively, the first end can be attached to a releasable end cap of the handle. In use, the second end of the band is released from the handle and inserted into the jacket receiving member. The jacket is threaded onto the band and the band end re-attached to the handle.

Abstract: A metal probe for intracorporeal calculi crushing has a point at its distal end with one or several lateral notches next to the probe end. These notches secure a calculus laterally against an adjacent duct wall and thus prevent it from drawing aside when it is crushed by the notch.

Abstract: A medical retrieval device is used to retrieve and/or fragment stones (and/or other objects) from the body of a patient. The device has a retrieval basket with a releasable tip. The tip release is designed to release in a controlled pre-determined manner and under a pre-determined force before any other component of the device fails due to a force exerted on the basket.

Abstract: A medical instrument for treating biological tissue comprises a housing (2), a pressure wave generation means (4) and a transmission means (8) for coupling the unfocused pressure waves into the body of living beings. The transmission means (8) comprises a pressure chamber (12) having an inlet and an outlet end, the pressure chamber (12) containing a liquid (14) into which pressure waves from the pressure wave generation means (4) can be coupled, which pressure waves can be transmitted to a membrane (16) arranged at the outlet end of the pressure chamber (12) which membrane (16) couples the pressure waves transmitted from the liquid unfocusedly into the biological tissue.