Organic Material Containing Patents (Class 606/231)
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Patent number: 6977231Abstract: A suturable adhesion-preventing membrane has high suture strength, good biocompatibility, decomposition and absorption in a living body, sufficient adhesion-preventing effect, and desirable guided tissue regeneration. The membrane is composed of at least one non-woven fabric layer made of collagen fibers, or a laminated membranous substance consisting of at least one non-woven fabric layer made of collagen fibers and at least one sponge layer made of collagen, and a coating layer of gelatin or hyaluronic acid on the surface or surfaces of the above membrane. Preferably, the membrane comprises one to six compressed cross-linked collagen non-woven fabric layers wherein a layer has a fibers having a fiber diameter of 0.05 mm to 1.0 mm, a bulk density of 5.0×10?4 to 5 g/cm3 and a thickness of 0.1 mm to 50 mm, and a coating layer containing gelatin or hyaluronic acid and having a thickness of 0.05 mm to 20 mm, wherein the coating layer covers one or both sides or a part or whole of the surface of the membrane.Type: GrantFiled: January 21, 2000Date of Patent: December 20, 2005Assignee: Nipro CorporationInventor: Kazuhisa Matsuda
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Patent number: 6881766Abstract: Sutures fabricated from and/or coated with compositions including water-soluble glass are described herein. Pledgets containing water-soluble glass within the interstices of the pledget and/or coated with compositions including water-soluble glass are also described herein. The water-soluble glass optionally includes a therapeutic agent, e.g., silver to promote wound repair.Type: GrantFiled: February 7, 2003Date of Patent: April 19, 2005Assignee: Tyco Healthcare Group LPInventor: Matthew Hain
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Patent number: 6878757Abstract: Compositions with antimicrobial properties contain a fatty acid ester salt mixed with a bioabsorbable copolymer. These compositions are useful in forming coatings for surgical articles, including multifilament sutures.Type: GrantFiled: December 5, 2003Date of Patent: April 12, 2005Assignee: Tyco Healthcare Group LPInventor: Mark Roby
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Publication number: 20040267316Abstract: A high strength suture is made from a LCP/polyester composite of braided filaments having a high coefficient of friction. Knots tied in a suture made from such braided filaments have a tendency to stay in place better than the prior art UHMWPE/polyester composite knots. The inventive suture may include a multifilament cover of fibers of LCP and/or LCP composite fibers. Where a core is employed, the core may be made up of twisted fibers of LCP and liquid crystal composite fibers. If desired, the composite fibers can be a combination of LCP and other polymers such as polyester, nylon, fluoropolymers such as FEP or PTFE or olefins such as polypropylene, polyethylene or UHMWPE. A low friction coating, such as silicone, may be applied over the outside surfaces of the suture.Type: ApplicationFiled: June 24, 2004Publication date: December 30, 2004Applicant: LINVATEC CORPORATIONInventors: Amber Powell, Drew Amery
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Patent number: 6794484Abstract: The present invention is directed to absorbable polylactone copolymers prepared in part from about 2 to about 80 mole percent glycolide, utilizing a combination of a monofunctional polymerization initiator and a di-functional polymerization initiator, to achieve rates of crystallization of the copolymer of at least about 2 times faster than the rate of crystallization of a copolymer made by a similar process utilizing either the mono-functional or the di-functional polymerization initiator alone. Medical devices containing such copolymers are also disclosed.Type: GrantFiled: June 28, 2002Date of Patent: September 21, 2004Assignee: Ethicon, Inc.Inventors: Hugh D. Newman, Jr., Sasa Andjelic, Brian M. Kelly, Dennis D. Jamiolkowski, Rao S. Bezwada
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Patent number: 6794485Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.Type: GrantFiled: October 31, 2002Date of Patent: September 21, 2004Assignee: Poly-Med, Inc.Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
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Patent number: 6747121Abstract: The present invention relates in general to implantable, resorbable copolymers containing L-lactide and glycolide repeat units, and in particular to terpolymers containing L-lactide, glycolide, and one other type of repeat unit selected from the group consisting of D-lactide, D,L-lactide, and &egr;-caprolactone. Medical devices for in vivo implantation applications containing such implantable, resorbable copolymers are also described, as well as methods for making such copolymers and devices.Type: GrantFiled: September 5, 2001Date of Patent: June 8, 2004Assignee: Synthes (USA)Inventor: Sylwester Gogolewski
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Patent number: 6743505Abstract: The present invention relates to a process of forming bioabsorbable, multifilament yarn from Lactide-rich copolymers, including the steps of extruding and spinning a Lactide-rich copolymer to form a spun multifilament yarn, pre-tensioning the spun multifilament yarn to form a pre-tensioned yarn, heating the pre-tensioned yarn to form a pre-tensioned, preheated yarn, annealing and drawing the pre-tensioned, preheated yarn for a first time, annealing and drawing the yarn for a second time, cooling the twice-drawn yarn to a lower temperature, and taking-up the cooled multifilament yarn, to yarns prepared by the process and to medical devices prepared from such yarns.Type: GrantFiled: July 26, 2002Date of Patent: June 1, 2004Assignee: Ethicon, Inc.Inventors: Attila Antal, Gaoyuan Chen, Dominick Egidio, Anthony Tiano, Edward Walker
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Patent number: 6703035Abstract: This invention deals with crystalline, nitrogen copolyester lubricant coating devices comprising sutures, wherein said lubricant comprises a triaxial copolyester chain with a central nitrogenous base or a copolyester with more than one carboxylic group ionically linked to a basic amino acid.Type: GrantFiled: March 1, 2002Date of Patent: March 9, 2004Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby
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Patent number: 6689153Abstract: A coated/impregnated anchoring device and/or suture to prevent infection, deliver site specific drugs, and deliver human growth factors to the surgical site. The coatings can include anti-microbial agents to prevent or fight infection en route to and at the surgical site. The coatings can also include site specific drugs and/or human growth factors to fight infection, anesthetize tissue and/or bone en route and at the site, promote tissue regeneration, promote bone regeneration, and/or other desired medical processes.Type: GrantFiled: April 14, 2000Date of Patent: February 10, 2004Assignee: Orthopaedic Biosystems Ltd, Inc.Inventor: Jeffry B. Skiba
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Patent number: 6656922Abstract: Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong hydrophilicity and high negative charge. Amphiphilic heparin derivatives were synthesized by conjugation to bile acids, sterols, and alkanoic acids, respectively. These heparin derivatives were slightly hydrophobic, exhibited good solubility in water, and have high anticoagulation activity. These slightly hydrophobic heparin derivatives are efficiently absorbed in the gastrointestinal tract and can be used in oral dosage forms. Methods of using these amphiphilic heparin derivatives and similarly modified macromolecules for oral administration are also disclosed.Type: GrantFiled: April 30, 2001Date of Patent: December 2, 2003Assignee: Mediplex Corporation, KoreaInventors: Youngro Byun, Yong-Kyu Lee
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Patent number: 6624097Abstract: An implantable medical article as well as an implantable fiber which is particularly useful for medical implants is disclosed. The fiber includes comprises a first component formed from a substantially resorbable material and a second component formed from a fiber-forming polymer.Type: GrantFiled: December 5, 2000Date of Patent: September 23, 2003Assignee: Solutia Inc.Inventors: Donald H. Martin, John H. Southern
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Patent number: 6607548Abstract: A novel polymer composition is provided which includes a base material including a biodegradable polymer or copolymer, and a copolymer additive including one or more monomers imparting a tensile strength to the polymer composition at room temperature that is lower than a tensile strength at room temperature for the base material.Type: GrantFiled: May 17, 2001Date of Patent: August 19, 2003Assignee: Inion Ltd.Inventors: Timo Pohjonen, Harri Happonen, Pertti Helevirta, Auvo Kaikkonen, Jan Nieuwenhuis, Piet E. Haers, Hermann Sailer
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Patent number: 6596818Abstract: Disclosed is a radiation-crosslinkable thermoplastic polymer composition, a process for the preparation thereof, an angioplasty balloon made using such a composition, and a method of using the angioplasty balloon. The composition contains a reactive monomer cross-linker, that facilitates cross-linking of the reaction product upon contact of the cross-linker-containing composition with a particle beam from a radiation source.Type: GrantFiled: October 8, 1997Date of Patent: July 22, 2003Inventor: Alan M. Zamore
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Publication number: 20030135238Abstract: A biocompatible tissue-bonding adhesive composition comprising a polyol of functionality N. The polyol being terminated has at least one polyisocyanate in solution with at least (N-1)% of the solution comprising free polyisocyanate. N may be in the range 1.5-8. The polyol may be a branched polypropylene/polyethylene oxide copolymer.Type: ApplicationFiled: December 12, 2001Publication date: July 17, 2003Inventor: Michael T. Milbocker
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Patent number: 6589943Abstract: Formulations for enhanced mucosal absorption of heparin are disclosed. In one embodiment, a powdered heparin composition is made by dissolving an amphiphilic heparin derivative including heparin covalently bonded to a hydrophobic agent in a water phase, dispersing the water phase in an organic phase such that an emulsion is formed, and drying the emulsion. In another embodiment, an amorphiphilic heparin derivative dispersed in an oil phase is made by dissolving the amphiphilic heparin derivative in water or a water/organic co-solvent, dispersing the water or co-solvent in the oil phase, and evaporating the water or co-solvent. In another embodiment, heparin-containing nanoparticles having surfactant molecules associated with a hydrophobic agent on the outside of the nanoparticles are made by dissolving the amphiphilic heparin derivative in an aqueous solvent, mixing the surfactant with the aqueous solvent, and disrupting nanoparticles of the amphiphilic heparin derivative.Type: GrantFiled: May 9, 2001Date of Patent: July 8, 2003Assignee: Mediplex Corporation, KoreaInventors: Youngro Byun, Yong-Kyu Lee
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Publication number: 20030023209Abstract: A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide include bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatable surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF-&bgr; activity is also provided.Type: ApplicationFiled: January 25, 2002Publication date: January 30, 2003Applicant: United States Surgical CorporationInventors: Elliott A. Gruskin, Christofer T. Chistoforou
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Patent number: 6494898Abstract: A synthetic absorbable monofilament comprising glycolide and epsilon caprolactone is provided. The monofilament exhibits physical characteristics equivalent to or superior than gut sutures. The monofilaments can be fabricated into a wide variety of surgical devices such as sutures, meshes, and the like.Type: GrantFiled: September 26, 1998Date of Patent: December 17, 2002Assignee: United States Surgical CorporationInventors: Mark S. Roby, Ying Jiang, Lyudmila K. Kokish
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Publication number: 20020055759Abstract: The application concerns surgical suture coated with one or more biologically active compounds. The application discloses methods of making coated suture, placing the coated suture in an organism, and methods of using the coated suture in the treatment of diseases such as cancer.Type: ApplicationFiled: November 6, 2001Publication date: May 9, 2002Inventor: Terry Y. Shibuya
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Patent number: 6342065Abstract: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably &egr;-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 25%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.4 dl/g. A variety of surgical constructs may be formed from the present copolymers. Surgical sutures made of mono- or multifilament yarns of the present copolymers will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.Type: GrantFiled: March 13, 2000Date of Patent: January 29, 2002Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby
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Patent number: 6335383Abstract: The present invention provides surgical article and suture coated with bioabsorbable microdispersions which contains a fluid carrier that is a liquid polymer and a particular material.Type: GrantFiled: March 7, 1996Date of Patent: January 1, 2002Assignee: Ethicon, Inc.Inventors: Angelo G. Scopelianos, Steven C. Arnold, Rao S. Bezwada, Mark B. Roller, Shawn T. Huxel, Robert J. Tannhauser
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Patent number: 6264674Abstract: The present invention provides an apparatus and process for improving the properties of braided ligature by hot stretching the braid.Type: GrantFiled: November 9, 1998Date of Patent: July 24, 2001Inventors: Robert L. Washington, Richard T. Entrekin
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Patent number: 6245753Abstract: Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong hydrophilicity and high negative charge. Amphiphilic heparin derivatives were synthesized by conjugate to bile acids, sterols, and alkanoic acids, respectively. The hydrophobicity of the heparin derivatives depended on the feed mole ratio of heparin to hydrophobic agent. The heparin derivatives were slightly hydrophobic and exhibited good solubility in a water-acetone solvent, as well as water. The heparin derivatives have a high anticoagulant activity. These slightly hydrophobic heparin derivatives can be absorbed in gastric intestinal tract and can be used as oral dosage form. Also, the heparin derivatives can be used for the surface modification to prevent anticoagulation for medical devices such as extracorporeal devices and implanted devices.Type: GrantFiled: April 27, 1999Date of Patent: June 12, 2001Assignee: Mediplex Corporation, KoreaInventors: Youngro Byun, Yong-Kyu Lee
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Patent number: 6235869Abstract: Synthetic absorbable medical devices made totally or in part from a random polymer comprising glycolide, lactide, trimethylene carbonate, and caprolactone are provided. The polymer can be fabricated into a monofilament which exhibits physical characteristics equivalent to or superior than gut sutures.Type: GrantFiled: October 9, 1999Date of Patent: May 22, 2001Assignee: United States Surgical CorporationInventors: Mark S. Roby, Lydmilla K. Kokish, Rooma M. Mehta, Jerry Y. Jonn
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Patent number: 6197320Abstract: Crystalline, low melting -Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell microporous template or constucts for tissue regeneration; the polymers bearing basic functionalities can be linked ionically or covalently to the ester chain which induces autocatalyzed hydrolysis.Type: GrantFiled: June 29, 1998Date of Patent: March 6, 2001Inventor: Shalaby W. Shalaby
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Patent number: 6162537Abstract: An implantable medical article as well as an implantable fiber which is particularly useful for medical implants is disclosed. The fiber includes comprises a first component formed from a substantially resorbable material and a second component formed from a fiber-forming polymer.Type: GrantFiled: October 31, 1997Date of Patent: December 19, 2000Assignee: Solutia Inc.Inventors: Donald H. Martin, John H. Southern
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Patent number: 6130271Abstract: A deformable surgical repair device is manufactured from a block or graft copolymer. The copolymer comprises a plurality of first linkages selected from the group consisting of glycolic acid ester and lactic acid ester linkages, and mixtures thereof, and a plurality of second linkages selected from the group consisting of 1,3-dioxan-2-one; 1,4-dioxan-2-one and .epsilon.-caprolactone linkages. The plurality of first linkages comprises at least about 50 up to about 90 mole percent of the copolymer. In an alternative Claim, the deformable surgical repair device is manufactured from a blend of a first and a second absorbable polymer. The first absorbable polymer comprises a plurality of linkages selected from the group consisting of glycolic acid ester and lactic acid ester linkages, and mixtures thereof. The second absorbable polymer comprises a plurality of linkages selected from the group consisting of 1,3-dioxan-2-one; 1,4-dioxan-2-one and .epsilon.-caprolactone linkages.Type: GrantFiled: January 9, 1998Date of Patent: October 10, 2000Assignee: Tyco Group S.a.r.l.Inventors: Peter Kendrick Jarrett, Donald James Casey, Steven L. Peake
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Patent number: 6113624Abstract: Medical devices or components for medical devices formed from bioabsorbable elastomers comprising a segmented copolymer are disclosed. The segmented copolymer is a copolymer of from about 30 to about 40 mole percent of lactide and the balance being substantially p-dioxanone. The segmented copolymers surprisingly exhibit elastomeric properties, and the copolymers are bioabsorbable. The combination of physical and biological properties of these elastomeric copolymers are particularly well suited for numerous medical and surgical applications.Type: GrantFiled: January 26, 1999Date of Patent: September 5, 2000Assignee: Ethicon, Inc.Inventors: Rao S. Bezwada, Kevin L. Cooper
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Patent number: 6093200Abstract: Composite materials have a core portion formed from a biocompatible material and at least one shell portion of a biocompatible material joined to the core portion. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The composite materials may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.Type: GrantFiled: September 10, 1997Date of Patent: July 25, 2000Assignee: United States SurgicalInventors: Cheng-Kung Liu, Ying Jiang, Mark S. Roby, Steven L. Bennett, Richard P. Stevenson, Jeffrey P. Pietrangeli
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Patent number: 6031018Abstract: The present claims are directed to a tipped surgical suture and a solventless method for making a tipped suture comprising a suture coated with 6-30 weight percent, based on the total weight of the tipped region of the suture, of a bioresorbable aliphatic polyester copolymer which itself comprises from 70-100 mole % of e-caprolactone repeating units or from 80-100 mole % of trimethylene carbonate repeating units, the remainder of repeating units in the copolymer comprising a plurality of lactide, 1,4-dioxan-2-one, 1,4-dioxepan-2-one units.Type: GrantFiled: December 1, 1997Date of Patent: February 29, 2000Assignee: Ethicon, Inc.Inventors: Angelo G. Scopelianos, Rao S. Bezwada
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Patent number: 5972366Abstract: A surgical implant or external wound dressing which functions as both a hemostat and a device to safely and effectively deliver any of a number of pharmaceuticals to targeted tissue at a controlled rate is disclosed. The device generally comprises a carrier in the form of fibers, sutures, fabrics, cross-linked solid foams or bandages, a pharmaceutical in solid micoparticulate form releasably bound to the carrier fibers, and a lipid adjuvant which aids the binding of the microparticles to the fibers as well as their function in the body.Type: GrantFiled: September 17, 1996Date of Patent: October 26, 1999Assignee: The Unites States of America as represented by the Secretary of the ArmyInventors: Duncan H. Haynes, Ben H. Bodeker, Mark D. Kline
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Patent number: 5939191Abstract: A gut suture is coated with a bioabsorbable copolymer obtained by polymerizing a major amount of .epsilon.-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of polyhydric alcohol as initiator. The coated gut suture can be packaged in the absence of conventional tubing fluid, i.e., in the dry state, while at the same time retaining flexibility, pliability and resistance to fray. In an alternative embodiment, a gut suture is coated with a pre-coating composition prior to being coated with the bioabsorbable copolymer.Type: GrantFiled: June 23, 1997Date of Patent: August 17, 1999Assignee: United States Surgical CorporationInventors: Steven L. Bennett, Ying Jiang, Mark S. Roby, Nagabhushanam Totakura
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Patent number: 5925065Abstract: A coated gut suture is prepared by applying a moisture-retaining substance to the gut suture, followed by coating the suture with a synthetic bioabsorbable polymer. A particularly useful moisture-retaining substance is glycerol. The synthetic bioabsorbable polymer contains a epsilon-caprolactone as the major constituent. The gut suture can be packed in the absence of conventional tubing fluid while retaining flexibility, pliability, and resistance to fray.Type: GrantFiled: November 5, 1996Date of Patent: July 20, 1999Assignee: United States Surgical CorporationInventors: Nagabhushanam Totakura, Mark S. Roby
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Patent number: 5895413Abstract: The invention relates to a surgical suture which can be used for stitching together extensive skin deformations or skin areas desired to be surgically removed or in view of preventing the expansion of the scar of conventional surgical wounds. Therefore, the suture of the invention is made of silicone elastomer having a visco-elastic elongation of more than 50%, preferably more than 100% and an elongating force of only 1-20N when the elongation is 100%.Type: GrantFiled: February 11, 1997Date of Patent: April 20, 1999Inventor: Rolf E. A. Nordstrom
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Patent number: 5891167Abstract: A catgut suture includes a dehydrothermal cross-linked collagen coating which is insoluble in tubing solution. The collagen coating is formed by immersing the gut suture in a solution of collagen in acidified water. Optionally, a plasticizer may be included in the coating solution. The suture is then heated in a vacuum to effect cross-linking of the collagen.Type: GrantFiled: June 19, 1996Date of Patent: April 6, 1999Assignee: United States Surgical CorporationInventor: Nagabhushanam Totakura
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Patent number: 5891166Abstract: An apparatus and method for ultrasonically forming a surgical suture tip from a length of unfinished surgical suture material. The apparatus includes a first tipping die having a first face for contacting a portion of the length of unfinished surgical suture material. A second tipping die having a second face is also provided. At least one mechanical actuator is provided for moving the first face of the first tipping die toward the second face of the second tipping die. A second actuator vibrates at least one of the first and second tipping dies at an ultrasonic frequency of about 15 KHz to 70 KHz. The method of ultrasonically forming a suture tip comprises the positioning a surgical suture between the first face of the tipping die and the second face of the tipping die then vibrating the dies at an appropriate frequency.Type: GrantFiled: October 30, 1996Date of Patent: April 6, 1999Assignee: Ethicon, Inc.Inventor: Semyon Schervinsky
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Patent number: 5889075Abstract: A surgical suture fabricated from a copolymer containing dioxanone, trimethylene carbonate and glycolide is treated with gamma radiation to enhance bioabsorbability without adversely effecting handling properties.Type: GrantFiled: October 10, 1997Date of Patent: March 30, 1999Assignee: United States Surgical CorporationInventors: Mark Roby, Anthony Arena
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Patent number: 5876421Abstract: A method for removing residual xylene from sutures includes contacting the suture with water either subjecting the suture to an atmosphere containing water vapor or be immersing the suture in liquid water, followed by drying the suture.Type: GrantFiled: March 25, 1997Date of Patent: March 2, 1999Inventors: Robert D. Torgerson, Ross R. Muth
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Patent number: 5871502Abstract: The present invention provides an improved process for manufacturing a polypropylene monofilament suture comprising aging a polypropylene filament that has been drawn in two separate drawing steps in the range of from about 4.times.to about 8.5.times.for less than two days then annealing the polypropylene filament to provide a polypropylene suture.Type: GrantFiled: April 8, 1996Date of Patent: February 16, 1999Assignee: Ethicon, Inc.Inventor: Jogendra Suryadevara
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Patent number: 5868788Abstract: Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers lactide, and p-dioxanone are described. The segmented copolymers exhibit a broad range of properties, especially high strength and long elongations. This unique elastomeric behavior makes the copolymers of the present invention useful in a varity of medical device applications, especially adhesion prevention barriers and hemostatic devices.Type: GrantFiled: October 20, 1997Date of Patent: February 9, 1999Assignee: Ethicon, Inc.Inventors: Rao S. Bezwada, Kevin Cooper
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Patent number: 5817129Abstract: The present invention provides a process and apparatus for coating sutures.Type: GrantFiled: October 31, 1996Date of Patent: October 6, 1998Assignee: Ethicon, Inc.Inventors: Samsel K. Labrecque, Vishvaroop Agarwal, Henry Pokropinski, Jr.
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Patent number: 5792181Abstract: A surgical suture comprised of a first thermally formed tip portion having a first length which is adjacent to a body portion having a second length. The first thermally formed tip portion has a generally uniform cross-section perpendicular to the first length, while the body portion has a varying cross-section which corresponds to a distribution of different cross-sectional sizes along the second length. The generally uniform cross-section of the first thermally formed tip portion has an average cross-sectional size that is less than the average of the different cross-sectional sizes along the second length.Type: GrantFiled: May 10, 1996Date of Patent: August 11, 1998Assignee: Ethicon, Inc.Inventors: Bernd Haase, John J. Price, Kenneth J. Smith, Hal B. Woodrow
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Patent number: 5786022Abstract: The present invention provides a coating mixture composed of a solvent selected from the group consisting of ethyl acetate, ethyl acetate/ethanol, n-propyl acetate/acetone, isopropyl acetate/ethanol, ethyl acetate/acetone and blends thereof; a biocompatable polymer and optionally a fatty acid salt. The present invention also provides a process for coating surgical articles comprising forming a coating mixture, contacting a surgical article with the coating mixture; and drying the coated surgical article to substantially remove the solvent.Type: GrantFiled: October 31, 1996Date of Patent: July 28, 1998Assignee: Ethicon, Inc.Inventors: Vishvaroop Agarwal, Alastair W. Hunter
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Patent number: 5713920Abstract: Medical devices or components for medical devices formed from bioabsorbable elastomers comprising a random copolymer are disclosed. The random copolymer is a copolymer of from about 30 to about 70 weight percent of: a) .epsilon.-caprolactone, trimethylene carbonate, an ether lactone, or a mixture of these, and b) the balance being substantially glycolide, para-dioxanone, or a mixture of these. The random copolymers surprisingly exhibit elastomeric properties, and the copolymers are bioabsorbable. The combination of physical and biological properties of these elastomeric copolymers are particularly well-suited for numerous medical and surgical applications.Type: GrantFiled: August 7, 1995Date of Patent: February 3, 1998Assignee: Ethicon, Inc.Inventors: Rao S. Bezwada, Angelo G. Scopelianos
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Patent number: 5695879Abstract: A surgical suture material of absorbable, synthetic polymer is formed from glycolide-trimethylene carbonate copolymer with a glycolide content higher than 76 wt. % and with a statistical distribution of the monomers. Within 9 to 21 days, the suture material has a complete breaking strength loss and is completely absorbed in vivo after 35 to 91 days.Type: GrantFiled: November 9, 1995Date of Patent: December 9, 1997Assignee: B. Braun Surgical GmbHInventors: Helmut Goldmann, Helmut Hierlemann, Erhard Mueller, Heinrich Planck
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Patent number: 5660854Abstract: A surgical implant or external wound dressing which functions as both a hemostat and a device to safely and effectively deliver any of a number of pharmaceuticals to targeted tissue at a controlled rate is disclosed. The device generally comprises a carrier in the form of fibers, sutures, fabrics, cross-linked solid foams or bandages, a pharmaceutical in solid micoparticulate form releasably bound to the carrier fibers, and a lipid adjuvant which aids the binding of the microparticles to the fibers as well as their function in the body.Type: GrantFiled: November 28, 1994Date of Patent: August 26, 1997Inventors: Duncan H Haynes, Ben H. Bodeker, Mark D. Kline
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Patent number: 5633343Abstract: Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers glycolide, and p-dioxanone are described. The segmented copolymers exhibit a broad range of properties, especially high strength and stiffness, and fast absorption rates and breaking strength retention (BSR) profiles, useful in a variety of medical devices. Most importantly, for suture applications where Vicryl.RTM.-like polyglcolide-polylactide sutures with excellent tensile properties, but shorter BSR profiles than Vicryl.RTM. are needed. The copolymers of the present invention have such properties, making them useful in plastic surgery where faster absorption times would lead to less tissue scarring.Type: GrantFiled: June 30, 1995Date of Patent: May 27, 1997Assignee: Ethicon, Inc.Inventors: Rao S. Bezwada, Kevin Cooper, Dennis D. Jamiolkowski, Hugh D. Newman, Jr.
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Patent number: 5621050Abstract: This invention relates to materials for medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk properties, but inappropriate frictional properties. This invention also relates to a hydrophilic coating material that provides improved frictional properties.Type: GrantFiled: June 7, 1995Date of Patent: April 15, 1997Assignee: American Cyanamid CompanyInventors: Peter K. Jarrett, George Jessup, Louis Rosati, Chris Martin, John W. Maney
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Patent number: 5609609Abstract: The invention provides a surgical suture comprising a suture body and a coating layer comprising ingredients A, B and C:<ingredient A> at least one higher fatty acid salt;<ingredient B> at least one film-forming polymer selected from the group consisting of polycaprolactone, caprolactone-lactic acid copolymer, caprolactone-glycolic acid copolymer, polylactic acid and lactic acid-glycolic acid copolymer; and<ingredient C> at least one sucrose fatty acid ester; and method for preparation thereof.Type: GrantFiled: December 21, 1995Date of Patent: March 11, 1997Assignee: Gunze LimitedInventors: Hiroshi Ohshima, Satoshi Hashimoto
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Patent number: 5584858Abstract: A coating and tubing fluid for sutures, especially gut sutures, is provided. The coating composition includes linseed oil, an organic solvent and a catalyst. The tubing fluid includes water, a softening agent, a C.sub.2 -C.sub.4 alcohol and a lubricant of fatty acids, fatty acid alcohols and/or triglycerides of fatty acids. Gut sutures coated with the coating composition may be stored or packaged in the tubing fluid to provide sutures with improved flexibility, pliability, run-down performance and superior resistance to fraying and breaking.Type: GrantFiled: November 14, 1994Date of Patent: December 17, 1996Assignee: United States Surgical CorporationInventor: Nagabhushanam Totakura