Cataracts Or Glaucoma Patents (Class 606/6)
  • Patent number: 11961622
    Abstract: A computer-implemented method and system are applied to a first instance of a first disease-specific semantic model. The method and system: receive a first request; process the first instance of the first disease-specific semantic model based on the first request to generate a first processed instance of the first disease-specific semantic model; and provide the first processed instance of the first disease-specific semantic model as output.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: April 16, 2024
    Assignee: Realyze Intelligence, Inc.
    Inventors: Gilan El Saadawi, Aaron Brauser, Gary Wallace
  • Patent number: 11918516
    Abstract: An illustrative method of treating a patient having an eye condition includes determining that the patient has a closed-angle or narrow-angle glaucoma. The method further includes treating the closed-angle or narrow-angle glaucoma during a surgical procedure performed on the patient. The method further includes, during the surgical procedure, treating the patient with an excimer laser to create a plurality of perforations in the trabecular meshwork by applying a plurality of shots to the trabecular meshwork from the excimer laser.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: March 5, 2024
    Assignee: Elios Vision, Inc.
    Inventors: Johannes Junger, Markus Enders
  • Patent number: 11903876
    Abstract: A method of treating a patient having an eye condition includes determining, during a pre-operative analysis of the patient, that the patient has a risk of developing glaucoma. The method further includes treating the patient with an excimer laser to prophylactically treat glaucoma based on the pre-operative analysis determination that the patient has the risk of developing glaucoma.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: February 20, 2024
    Assignee: Elios Vision, Inc.
    Inventors: Johannes Junger, Markus Enders
  • Patent number: 11896525
    Abstract: Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: February 13, 2024
    Assignees: OREGON HEALTH & SCIENCE UNIVERSITY, BAYLOR COLLEGE OF MEDICINE
    Inventors: David Huang, Gangjun Liu, Jianlong Yang, Stephen Pflugfelder
  • Patent number: 11890184
    Abstract: Aspects of the present invention may include systems and methods for intraocular lens selection using a formula and a deep learning machine to estimate the error of the formula. In an aspect, the disclosure provides a method for intraocular lens selection. The method may include obtaining at least two ocular measurement parameters and a lens selection parameter for an eye. The method may include determining an intraocular lens power based on a formula using the at least two ocular measurement parameters. The method may include determining an estimated error of the formula using a deep learning machine trained on verified post-operative results using intraocular lenses selected by the formula. The method may include adjusting the lens selection parameter based on the estimated. The method may include redetermining the intraocular lens power based on the formula and the adjusted lens selection parameter.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: February 6, 2024
    Inventor: John Gregory Ladas
  • Patent number: 11877951
    Abstract: An illustrative method of delivering laser energy to a surface of a trabecular meshwork of an eye includes inserting a probe into the eye and delivering, at multiple locations along the trabecular meshwork, shots of the laser energy via the probe to create a plurality of perforations in the trabecular meshwork. The plurality of perforations form a line or curve that is transverse to a Schlemm's canal in the eye.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: January 23, 2024
    Assignee: Elios Vision, Inc.
    Inventors: Johannes Junger, Markus Enders
  • Patent number: 11730627
    Abstract: In certain embodiments, a system for aligning an eye with a patient interface of a laser device includes a camera, a display screen, and a computer. The camera records images of the eye through the patient interface of the laser device. A liquid is disposed between and is in contact with the patient interface and the outer surface of the eye. The images include an outline of the liquid. The display screen displays the images of the eye. The computer aligns the eye with the patient interface by: identifying the outline of the liquid in an image received from the camera; determining a misalignment of the eye according to the outline; and instructing the display screen to display a description of the misalignment.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: August 22, 2023
    Assignee: Alcon Inc.
    Inventors: Mario Abraham, Michael Wittnebel
  • Patent number: 11679272
    Abstract: A process for safely providing retinal phototherapy includes generating an interferometric signal or pattern by applying a near infrared light beam to a retinal pigment epithelium of a retina of an eye. A level or concentration of melanin within the retinal pigment epithelium of the retina is compared to a normal level or concentration using the detected interferometric signal or pattern. One or more treatment parameters of the retinal phototherapy is adjusted if the level or concentration of melanin in the retinal pigment epithelium of the eye exceeds the normal level or concentration by a predetermined amount.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: June 20, 2023
    Assignee: Ojai Retinal Technology, LLC
    Inventors: David B. Chang, Jeffrey K. Luttrull
  • Patent number: 11583445
    Abstract: Intraocular pressure in an eye is reduced by delivering a high resolution optical coherence tomography (OCT) beam and a high resolution laser beam through the cornea, and the anterior chamber into the irido-corneal angle along an angled beam path. The OCT beam provides OCT imaging for surgery planning and monitoring, while the laser beam is configured to modify tissue or affect ocular fluid by photo-disruptive interaction. In one implementation, a volume of ocular tissue within an outflow pathway in the irido-corneal angle is modified to create a channel opening in one or more layers of the trabecular meshwork. In another implementation, a volume of fluid in the Schlemm's canal is affected by the laser to bring about a pneumatic expansion of the canal. In either implementation, resistance to aqueous flow through the eye is reduced.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: February 21, 2023
    Assignee: ViaLase, Inc.
    Inventor: Ferenc Raksi
  • Patent number: 11564836
    Abstract: An apparatus includes a laser source and a scanner. The laser source is configured to generate electromagnetic radiation. The scanner scans at least part of a limbal area of an eye with the electromagnetic radiation generated by the laser source, thereby directing the electromagnetic radiation through an entire thickness of the limbal area of the eye without any contact with the eye and irradiating one or more regions of a trabecular meshwork of the eye with the electromagnetic radiation.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: January 31, 2023
    Assignees: RAMOT AT TEL AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Michael Belkin, Mordechai Goldenfeld
  • Patent number: 11471326
    Abstract: A device for irradiating ocular tissue, including a source of electromagnetic radiation; a beacon scattering the electromagnetic radiation transmitted through an opacity in ocular tissue so as to form scattered electromagnetic radiation; a modulator transmitting output electromagnetic radiation having a field determined from a recording of the scattered electromagnetic radiation transmitted through the opacity, so that the output electromagnetic radiation is transmitted through the opacity to the beacon. The device can be used to treat amblyopia or correct optical aberrations in corneal or lens tissue.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: October 18, 2022
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lihong Wang, Frank L. Brodie, Yuecheng Shen, Yan Liu, Haowen Ruan
  • Patent number: 11369266
    Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: June 28, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Stephan Wyder, Philip M. Buscemi, Matthias Pfister, Alexander Holzer
  • Patent number: 11353714
    Abstract: A laser system includes a laser source generating a laser beam having ultra-short pulses; a laser delivery assembly optically receiving the laser beam and comprising: a beam splitter configured to split the laser beam between a first beam delivery path and a second beam delivery path; and at least one focusing lens optically coupled to the beam splitter and configured to focus the laser beam from each of the first beam delivery path and the second beam delivery path to a focal point on a predefined plane; wherein the first beam delivery path intersects the predefined plane at a first angle, the second beam delivery path intersects the predefined plane at a second angle, and a first pulse from the first beam delivery path and a second pulse from the second beam delivery path are coincident at the focal point.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: June 7, 2022
    Inventor: Matthew David Treiser
  • Patent number: 11278451
    Abstract: A computer program product for controlling a laser-assisted eye treatment, configured to encode a system controller with a routine for planning the eye treatment, invention further relates to a laser-assisted eye treatment system including a laser treatment unit and a system controller, to a method for generating control data for a laser-assisted eye treatment system, to a planning method for a laser-assisted eye treatment and to an eye treatment method using a laser beam for treating a patient's eye. The invention provides systems and methods for a fast laser-assisted eye treatment of a patient's eye which improve the security and minimize the risk of a non-optimal eye treatment and enable sale eye treatment planning and a shortening of the critical phase of the eye treatment. Encoding a system controller by a routine for planning the eye treatment is strictly based on an anatomy of a patient's eye.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: March 22, 2022
    Assignee: Carl Zeiss Meditec AG
    Inventors: Delbert Peter Andrews, Michael Stefan Rill, Stefan Gräber, Julia Werth, Rupert Menapace
  • Patent number: 11215814
    Abstract: An ophthalmic laser system uses a non-confocal configuration to determine a laser beam focus position relative to the patient interface (PI) surface. The system includes a light intensity detector with no confocal lens or pinhole between the detector and the objective lens. When the objective focuses the light to a target focus point inside the PI lens at a particular offset from its distal surface, the light signal at the detector peaks. The offset value is determined by fixed system parameters, and can also be empirically determined by directly measuring the PI lens surface by observing the effect of plasma formation at the glass surface. During ophthalmic procedures, the laser focus is first scanned insider the PI lens, and the target focus point location is determined from the peak of the detector signal. The known offset value is then added to obtain the location of the PI lens surface.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: January 4, 2022
    Assignee: AMO Development, LLC
    Inventors: Mohammad Saidur Rahaman, Hong Fu, Roger W. Accurso, Zenon Witowski
  • Patent number: 11000413
    Abstract: In an ophthalmic laser surgical system, a real-time optical coherence tomography (OCT) measurement method acquires OCT data during laser treatment. The treatment laser beam and OCT sample beam are generated simultaneously, and the optical delivery system scans them simultaneously in the eye tissue, where the focus of the treatment laser beam and the focus of the OCT beam coincide with each other in space. While both beams simultaneously scanned in the eye tissue, the OCT device detects returned OCT light from the sample during a data acquisition period, and generates an OCT A-scan based on the detected OCT light. Based on the A-scan, a controller determines a structure of the eye in a depth direction relative to the focus of the OCT beam, and controls the operations ophthalmic laser surgical system accordingly. One exemplary application is the formation of an arcuate corneal incision in cataract surgery.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: May 11, 2021
    Assignee: AMO Development, LLC
    Inventors: Michael J. Simoneau, David A. Dewey, Javier G. Gonzalez
  • Patent number: 10959613
    Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: March 30, 2021
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Stephan Wyder, Philip M. Buscemi, Matthias Pfister, Alexander Holzer
  • Patent number: 10932810
    Abstract: A thrombectomy catheter system is disclosed which includes a catheter having an exhaust lumen, an infusion lumen and a high pressure tube. The high pressure tube includes a nozzle orifice for forming a high pressure jet of fluid for cutting occlusive material from within a body lumen. The nozzle orifice is positioned to direct the high pressure jet of fluid into the distal end of the exhaust lumen which creates a suctioning effect. The infusion lumen replaces fluid that is removed from the body lumen through the exhaust lumen by a suctioning effect created by the fluid jet.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: March 2, 2021
    Assignee: Covidien LP
    Inventors: Arnaz S. Malhi, Daniel Hutton, Manish Deshpande, Phillip Shaltis
  • Patent number: 10835420
    Abstract: The present disclosure relates to systems and methods for marking an undeformed cornea with a mark to allow later detection of a selected location on the cornea after deformation and to systems of methods for performing vision correction surgery based on the mark.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: November 17, 2020
    Assignee: Alcon Inc.
    Inventors: Sissimos Lemonis, Joerg Klenke
  • Patent number: 10828149
    Abstract: A method of treating a lens of a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form a treatment pattern of the light beam, delivering the treatment pattern to the lens of a patient's eye to create a plurality of cuts in the lens in the form of the treatment pattern to break the lens up into a plurality of pieces, and removing the lens pieces from the patient's eye. The lens pieces can then be mechanically removed. The light beam can be used to create larger segmenting cuts into the lens, as well as smaller softening cuts that soften the lens for easier removal.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: November 10, 2020
    Assignee: AMO Development, LLC
    Inventors: William Culbertson, Barry Seibel, Neil Friedman, Georg Schuele, Phillip Gooding
  • Patent number: 10786388
    Abstract: An ophthalmological device for treating eye tissue with laser pulses comprises a projection optical unit for focused projection of the laser pulses, a scanner system for dynamically deflecting the laser pulses and a zoom system, which is arranged between the projection optical unit and the scanner system and which is configured to adjust the focused projection of the laser pulses in the projection direction in different zoom settings. The ophthalmological device moreover comprises a displacement device, which is configured to displace the scanner system depending on the zoom setting of the zoom system. What the displacement of the scanner system coupled to the zoom setting of the zoom system renders possible is the adaptation of the position of the scanner system in a dynamic and synchronized fashion to the setting of the zoom system and hence to the current position of the virtual entry pupil of the zoom system.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: September 29, 2020
    Assignee: Ziemer Ophthalmic Systems AG
    Inventor: Christian Rathjen
  • Patent number: 10639140
    Abstract: A method of treating a cataractous lens of a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form a treatment pattern, delivering the treatment pattern to the lens of the patient's eye to create a plurality of cuts in the form two or more different incisions patterns within the lens to segment the lens tissue into a plurality of patterned pieces, and mechanically breaking the lens into a plurality of pieces along the cuts. A first incision pattern includes two or more crossing cut incision planes. A second incision pattern includes a plurality of laser incision each extending along a first length between a posterior and an anterior surface of the lens capsule.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: May 5, 2020
    Assignee: AMO DEVELOPMENT, LLC
    Inventors: William Culbertson, Barry Seibel, Neil Friedman, Georg Schuele, Phillip Gooding
  • Patent number: 10580699
    Abstract: The present invention relates to a method for the production of layers of solid material, in particular for use as wafers. The method may include the following steps: providing a workpiece for the separation of the layers of solid material with the workpiece optionally having at least one exposed surface, producing and/or providing a carrier unit for receiving at least one layer of solid material having the carrier unit optionally having a receiving layer for holding the layer of solid material, attaching the receiving layer to the exposed surface of the workpiece forming a composite structure, producing a break initiation point by means of pre-defined local stress induction in the peripheral region, including at the edge, of the workpiece, and separating the layer of solid material from the workpiece starting from the break initiation point.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: March 3, 2020
    Assignee: Siltectra GmbH
    Inventors: Lukas Lichtensteiger, Wolfram Drescher
  • Patent number: 10383768
    Abstract: A method of treating a human eye, generally to correct vision, and preferably in one embodiment to increase the amplitude of accommodation of the lens. The method utilizes a laser to create a desired pattern within the lens. Various patterns for treating the eye lens are also disclosed.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: August 20, 2019
    Assignee: NUSITE TECHNOLOGY, LLC
    Inventor: Andrew A. Esposito
  • Patent number: 10363169
    Abstract: A system and method are presented for use in delivering electromagnetic radiation to a limbal area of an eye, for example for treatment of glaucoma. The system includes an illumination unit, a beam shaping device and a control unit. The illumination unit includes a first source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having first optical properties to be delivered to the limbal area of a patient's eye to interact therewith and produce a desired effect, and a second source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having second optical properties. The beam shaping device when accommodated in an optical path of said first and second beams defines one or more regions along a path substantially aligned with a limbus of the patient's eye.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: July 30, 2019
    Assignees: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Michael Belkin, Mordechai Goldenfeld
  • Patent number: 10363433
    Abstract: A drusen treatment method includes confirming a location of drusen in a fundus of a patient; determining a treatment area by including a location on which the drusen exists; and removing the drusen by transferring energy to the treatment area.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: July 30, 2019
    Assignee: LUTRONIC VISION INC
    Inventor: Hae Lyung Hwang
  • Patent number: 10335316
    Abstract: This apparatus treats the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may be located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: July 2, 2019
    Assignee: Johnson & Johnson Surgical Vision, Inc.
    Inventors: Zsolt Bor, Daniel G. Brady, Edward P. Geraghty, Carina R. Reisin, Douglas S. Cali
  • Patent number: 10269643
    Abstract: The present invention relates to a method for the production of layers of solid material, in particular for use as wafers. The method may include the following steps: providing a workpiece for the separation of the layers of solid material with the workpiece optionally having at least one exposed surface, producing and/or providing a carrier unit for receiving at least one layer of solid material having the carrier unit optionally having a receiving layer for holding the layer of solid material, attaching the receiving layer to the exposed surface of the workpiece forming a composite structure, producing a break initiation point by means of pre-defined local stress induction in the peripheral region, including at the edge, of the workpiece, and separating the layer of solid material from the workpiece starting from the break initiation point.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: April 23, 2019
    Assignee: Siltectra, GmbH
    Inventors: Lukas Lichtensteiger, Wolfram Drescher
  • Patent number: 10226838
    Abstract: An embodiment is to provide a laser light irradiation apparatus and a laser peening treatment method, by which even a member to be processed, existing in a narrow portion, can be easily processed by laser peening. The laser light irradiation apparatus 1 according to the embodiment includes: an optical fiber 2 through which laser light is guided; a condensing lens 3 that is placed on one end of the optical fiber, the condensing lens and the optical fiber defining the light path of the laser light; a guide 4 that retains the optical fiber; and a movement mechanism 5 for changing the position of the optical fiber, wherein the light path of the laser light guided through the optical fiber is emitted at an angle changed to more than 0° and less than 90° with respect to the central axis of the optical fiber by the condensing lens.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: March 12, 2019
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Kota Nomura, Itaru Chida, Katsunori Shiihara, Hiroya Ichikawa
  • Patent number: 10219944
    Abstract: An ophthalmic phototherapy device and associated treatment methods to expose an eye to selected multi-wavelengths of light to promote the healing of damaged or diseased eye tissue. The device includes a housing having an interior; an eyepiece disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyepiece; a first light source producing a first light beam having a first therapeutic wavelength and disposed within the housing; a second light source producing a second light beam having a second therapeutic wavelength and disposed within the housing, where the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 5, 2019
    Assignee: LumiThera, Inc.
    Inventors: Clark E Tedford, Scott DeLapp, Scott Bradley
  • Patent number: 10195081
    Abstract: A method of preventing capsular opacification and fibrosis after cataract extraction and and/or preventing fibrosis around a shunt or stent after glaucoma surgery is disclosed herein. In the cataract procedure, after the cortex and nucleus of the natural lens with the cataract has been removed, a photosensitizer is applied inside the lens capsule, a posterior portion of the lens capsule is irradiated so as to activate cross-linkers and prevent capsular opacification and fibrosis, and an intraocular lens is inserted into the lens capsule. In the glaucoma procedure, a fluid drainage opening is formed and/or a stent is inserted into the eye, a photosensitizer is applied inside an anterior chamber of the eye so that a diffused stream of the photosensitizer travels through the fluid drainage opening or the stent, and the tissue surrounding the fluid drainage opening or the stent is irradiated so as to activate cross-linkers and prevent fibrosis.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 5, 2019
    Inventor: Gholam A. Peyman
  • Patent number: 10105261
    Abstract: A laser system calibration method and system are provided. In some methods, a calibration plate may be used to calibrate a video camera of the laser system. The video camera pixel locations may be mapped to the physical space. A xy-scan device of the laser system may be calibrated by defining control parameters for actuating components of the xy-scan device to scan a beam to a series of locations. Optionally, the beam may be scanned to a series of locations on a fluorescent plate. The video camera may be used to capture reflected light from the fluorescent plate. The xy-scan device may then be calibrated by mapping the xy-scan device control parameters to physical locations. A desired z-depth focus may be determined by defining control parameters for focusing a beam to different depths. The video camera or a confocal detector may be used to detect the scanned depths.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: October 23, 2018
    Assignee: Optimedica Corporation
    Inventors: Michael Simoneau, John Scot Hart, Georg Schuele
  • Patent number: 10022543
    Abstract: The present invention provides methods for stimulating cells using quantum dots. In addition, the present invention provides methods for treating a variety of clinical conditions using stimulation of quantum dots to induce cell stimulation and/or function.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: July 17, 2018
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Jefferey Olson
  • Patent number: 9918873
    Abstract: A laser system is calibrated with a tomography system capable of measuring locations of structure within an optically transmissive material such as a tissue of an eye. Alternatively or in combination, the tomography system can be used to track the location of the eye and adjust the treatment in response to one or more of the location or an orientation of the eye. In many embodiments, in situ calibration and tracking of an optically transmissive tissue structure such as an eye can be provided. The optically transmissive material may comprise one or more optically transmissive structures of the eye, or a non-ocular optically transmissive material such as a calibration gel in a container or an optically transmissive material of a machined part.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: March 20, 2018
    Assignee: OptiMedica Corporation
    Inventors: Bruce Woodley, Javier Gonzalez
  • Patent number: 9833136
    Abstract: The present application discloses methods and systems to track the anterior segment while establishing a position of the delay which will permit good control of the placement of anterior segment structures. This allows accurate dewarping by maximizing the amount of corneal surface that is imaged as well as reducing or eliminating overlap between real and complex conjugate images present in frequency-domain optical coherence tomography. A method to dewarp surfaces given partial corneal surface information is also disclosed.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: December 5, 2017
    Assignee: Carl Zeiss Meditec, Inc.
    Inventor: Homayoun Bagherinia
  • Patent number: 9820883
    Abstract: A method and delivery system are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Pulsed laser radiation is delivered from the distal end of a fiber-optic probe sufficient to cause photoablation of selected portions of the trabecular meshwork, the juxtacanalicular trabecular meshwork and an inner wall of Schlemm's canal in the target site. The fiber-optic probe may be advanced so as to create an aperture in the inner wall of Schlemm's canal in which fluid from the anterior chamber of the eye flows. The method and delivery system may further be used on any tissue types in the body.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: November 21, 2017
    Inventor: Michael S. Berlin
  • Patent number: 9795452
    Abstract: A treatment apparatus for a subretinal injection into an eye includes a 3D imaging device configured to generate a 3D image of a retina and a choroid of the eye. The apparatus has a planning device for inputting at least one set position for an injection instrument to be used for the injection. The set position is a location indication in the 3D image. The apparatus includes a 2D imaging device to generate a surface image of the retina and supplement the image to form a supplemented image, via the 2D imaging device ascertaining in the surface image at least one location which, in the surface image, corresponds to the at least one set position indicated in the 3D image, and inserting into the surface image at least one mark that corresponds to the ascertained at least one location. A display device displays the supplemented image.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: October 24, 2017
    Assignee: Carl Zeiss Meditec AG
    Inventors: Thomas Hartkens, Abouzar Eslami
  • Patent number: 9782253
    Abstract: A method of treating a cataractous lens of a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form a treatment pattern, delivering the treatment pattern to the lens of the patient's eye to create a plurality of cuts in the form two or more different incisions patterns within the lens to segment the lens tissue into a plurality of patterned pieces, and mechanically breaking the lens into a plurality of pieces along the cuts. A first incision pattern includes two or more crossing cut incision planes. A second incision pattern includes a plurality of laser incision each extending along a first length between a posterior and an anterior surface of the lens capsule.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: October 10, 2017
    Assignee: Optimedica Corporation
    Inventors: William Culbertson, Barry Seibel, Neil Friedman, Georg Schuele, Phillip Gooding
  • Patent number: 9750640
    Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: September 5, 2017
    Assignee: Optimedica Corporation
    Inventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
  • Patent number: 9724237
    Abstract: A cataract surgical system includes a laser source to generate a first set of laser pulses; a guiding optic to guide the first set of laser pulses to a target region in an eye; a laser controller to generate an electronic representation of a target scan pattern, and to control the guiding optic to scan the first set of laser pulses according to a portion of the target scan pattern to create a first photo-disrupted region in the target region; and an Optical Coherence Tomographic (OCT) imaging system to generate an image of a portion of the first photo-disrupted region. The laser controller can generate an electronic representation of a modified scan pattern in relation to the image generated by the OCT imaging system, and control the guiding optic to scan a second set of laser pulses according the modified scan pattern.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: August 8, 2017
    Assignee: ALCON LENSX, INC.
    Inventors: Ilya Goldshleger, Guy Holland, Adam Juhasz, Ronald M. Kurtz, Kostadin Vardin
  • Patent number: 9700461
    Abstract: Systems, devices, and methods for treating a glaucomatous eye are provided. Embodiments may provide a treatment probe for treating an eye of a patient. The treatment probe may have an elongate body with a contact surface at a distal end of the elongate body. A treatment fiber or light source may be housed in the treatment probe and may be configured to direct treatment energy from the contact surface. The contact surface may be configured to couple to a surface of the eye to deliver the energy into the target area. In many embodiments the contact surface may have a convex configuration with a rounded outer shape and edge that facilitates the sweeping of the probe surface across the eye during treatment delivery. In some embodiments the probe may be swept in arc motions while delivering treatment energy to the eye.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: July 11, 2017
    Assignees: IRIDEX Corporation, National University Hospital (Singapore) PTE Ltd, National University of Singapore
    Inventors: David Buzawa, Paul T. K. Chew
  • Patent number: 9554702
    Abstract: A surgical imaging system can comprise a light source, configured to generate an imaging light beam; a beam guidance system, configured to guide the imaging light beam from the light source; a beam scanner, configured to receive the imaging light from the beam guidance system, and to generate a scanned imaging light beam; a beam coupler, configured to redirect the scanned imaging light beam; and a wide field of view (WFOV) lens, configured to guide the redirected scanned imaging light beam into a target region of a procedure eye.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 31, 2017
    Assignee: Novartis AG
    Inventors: Michael Papac, Lingfeng Yu, Tammo Heeren
  • Patent number: 9495743
    Abstract: Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: November 15, 2016
    Assignee: Optimedica Corporation
    Inventors: David G. Angeley, Philip Gooding, Bruce Woodley, George Marcellino
  • Patent number: 9393155
    Abstract: In accordance with the present invention, a system and method are provided for controlling postoperative shrinkage of the capsular bag, after the lens has been removed from the capsular bag. The purpose is to establish a proper optical alignment for a prosthetic Intraocular Lens (IOL). Included in the system are a laser unit for generating a laser beam, a detector for creating an image of the prosthetic IOL in the capsular bag, and a computer for evaluating the image to determine an alignment difference between the IOL axis and a defined axis of the eye. The computer is also used for guiding the laser beam to alter selected tissue in the eye, to thereby influence postoperative shrinkage of the capsular bag and minimize any potential alignment difference between the IOL axis and the defined axis of the eye during capsular bag shrinkage.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: July 19, 2016
    Assignee: TECHNOLAS PERFECT VISION GMBH
    Inventor: Gerhard Youssefi
  • Patent number: 9393156
    Abstract: Some embodiments disclosed here provide for a method fragmenting a cataractous lens of a patient's eye using an ultra-short pulsed laser. The method can include determining, within a lens of a patient's eye, a high NA zone where a cone angle of a laser beam with a high numerical aperture is not shadowed by the iris, and a low NA zone radially closer to the iris where the cone angle of the laser beam with a low numerical aperture is not shadowed by the iris. Laser lens fragmentation is accomplished by delivering the laser beam with the high numerical aperture to the high NA zone, and the laser beam with the low numerical aperture to the low NA zone. This can result in a more effective fragmentation of a nucleus of the lens without exposing the retina to radiation above safety standards.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: July 19, 2016
    Assignee: AMO Development, LLC
    Inventors: Anthony Dennison, Michael A. Campos, Hong Fu
  • Patent number: 9339336
    Abstract: In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: May 17, 2016
    Assignee: Visualase, Inc.
    Inventors: Ashok Gowda, Roger J. McNichols, Marc Gelnett, Matthew Fox
  • Patent number: 9321990
    Abstract: This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous nucleus in a cell.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: April 26, 2016
    Assignees: The Regents of the University of California, University of Massachusetts
    Inventors: Michael W. Berns, Thoru Pederson, Elliot Botvinick, Linda Zhixia Shi
  • Patent number: 9304722
    Abstract: An image processing apparatus that is capable of performing report printing in a language desired by a user in either manual report printing or autonomic report printing. A storage unit stores information on the image processing apparatus. A touch panel receives input from a log-in user A control unit controls execution of the automatic report printing in which the information is printed by the printing unit as a report when predetermined conditions are satisfied, and execution of the manual report printing in which the information is printed by the printing unit as a report based on an instruction from the log-in user. The control unit performs the automatic report printing in a predetermined language and performs the manual report printing in a language for the log-in user.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: April 5, 2016
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Daiki Tachi
  • Patent number: 9241755
    Abstract: Various embodiments of a capsule polishing device include a resistive-heating element including an electrically resistive, superelastic wire forming a loop between first and second ends of the superelastic wire. The first and second ends of the loop may at least partially extend from a planar face defined by the loop, to an insulating portion. In some embodiments, the capsule polishing device may be configured to perform active capsule polishing through a combination of hyperthermia of LECs and mechanical abrasion of the capsule surface. In some embodiments, at least a side and end portion of the loop of the capsule polishing device may be shaped to follow a contour of the capsule bag. The loop may be heated to approximately 40 to 47 degrees Celsius to destroy LECs (other temperatures are also possible). In some embodiments, the loop may include a roughened surface to increase mechanical abrasion.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: January 26, 2016
    Assignee: Alcon Research, Ltd.
    Inventors: Guangyao Jia, Glenn R. Sussman
  • Patent number: 9226850
    Abstract: Apparatuses and methods for the treatment of glaucoma are provided. The instrument uses either cauterization, a laser to ablate, sonic or ultrasonic energy to emulsify, or mechanical cutting of a portion of the trabecular meshwork. The instrument may also be provided with irrigation, aspiration, and a footplate. The footplate is used to enter Schlemm's canal, serves as a guide, and also protects Schlemm's canal.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: January 5, 2016
    Assignee: The Regents of the University of California
    Inventors: George Baerveldt, Roy Chuck