Abstract: A medical implant assembly having at least two bone attachment structures cooperating with a dynamic longitudinal connecting member, the improvement wherein the connecting member includes: a first end, a transition portion, and a second end; a substantially rod portion extending longitudinally from the first end to the transition portion, and including a longitudinal axis and a substantially rigid core running substantially parallel with the longitudinal axis; a substantially cord portion joined with the rod portion and extending from the transition portion to the second end; and a substantially flexible jacket portion covering the rod and cord portions.

Abstract: A system, medical devices, and methods for use in surgical procedures, such as spinal surgeries. The system, medical devices, and methods are designed to provide a surgeon the ability to add a screw connector, or screw head such as a tulip, to pre-existing implanted bone, such as pedicle, facet, lateral mass, etc., screw system without having to remove the previously implanted screws and/or rods already existing in a patient.

Abstract: Prostheses are described for stabilizing dysfunctional sacroiliac (SI) joints. The prostheses are sized and configured to be press-fit into surgically created pilot SI joint openings in dysfunctional SI joint structures. The prostheses have an integral structure with opposed elongated sections connected by a bridge section. The elongated sections, in some instances, have an unequal length.

Abstract: An orthopedic implant which generally includes a frame structure and a porous structure. Both the frame and porous structure at least partially define at least six surfaces which make a three-dimensional profile of the implant. The porous structure is positioned at least partially within the three-dimensional profile.

Abstract: An implantable medical device is disclosed comprising a thermoplastic composite body having anterior, first lateral, second lateral, posterior, superior, and inferior surfaces, and at least one dense portion and at least one porous portion which are integrally formed. The at least one dense portion is formed of a first thermoplastic polymer matrix that is essentially non-porous, and which is continuous through a thickness dimension from the superior surface to the inferior surface. The at least one porous portion is formed of a porous thermoplastic polymer scaffold having a second thermoplastic polymer matrix which is continuous through the thickness dimension. A method for forming the thermoplastic composite body is disclosed comprising disposing a first powder mixture in a first portion of a mold, disposing a second powder mixture in a second portion of the mold, simultaneously molding the first powder mixture and the second powder mixture, and leaching porogen.

Abstract: An embodiment includes a sacroiliac joint bone anchor system comprising: a bone anchor including an outer surface and an inner surface; wherein (a)(i) the outer surface includes a proximal third, a middle third, and a distal third, (a)(ii) the middle third of the outer surface includes at least one aperture that couples the outer surface to the inner surface; (a)(iii) the proximal third of the outer surface includes proximal threads, and (a)(iv) the distal third of the outer surface includes distal threads; wherein (b)(i) the bone anchor is cannulated, (b)(ii) a channel is located on the inner surface, (b)(iii) the channel extends from a proximal third of the inner surface to a distal third of the inner surface, and (b)(iv) the channel provides at least one half a rotation about a long axis of the bone anchor.

Abstract: An implant for fusing a joint between first and second bone portions. The implant includes a screw member, and a washer polyaxially rotatable relative to the screw member. The screw member includes a head, a lag zone, and a threaded engagement zone. The implant includes a fusion zone for joint compression, extending from the washer to the proximal end of the engagement zone. Fenestrations may be present in the fusion zone. The length of the fusion zone ranges from about 10 mm to about 37 mm. Different surface finishes including roughened and non-roughened may be applied selectively to selected portions of the implant. In an embodiment, the joint is a sacro-iliac joint, and upon implantation the implant extends from the exterior of the ilium, across the joint and into the sacral vertebral body. Instrumentation and methods for preparing the joint and implanting the implant are disclosed.

Abstract: A method of treating scoliosis in a subject includes securing a scoliosis treatment device to first and second locations on the subject's skeletal system, the scoliosis treatment device including a first portion, a second portion moveably mounted relative to the first portion, and an adjustment device disposed on the device and configured to change a distraction force between the first location and the second location, the adjustment device including a rotationally mounted magnetic element configured to move the second portion relative to the first portion in response to rotation of the magnetic element. An external adjustment device is provided external to the subject and is able to adjust the distraction force between the first location and second location.

Abstract: An implant stabilizes two adjacent bones of a joint, while enabling a natural kinematic relative movement of the bones. Support components are connected to each bone of the joint, and a flexible core is interposed between them. The core and at least one of the support components are provided with a smooth sliding surface upon which the core and support component may slide relative to each other, enabling a corresponding movement of the bones. The surfaces may have a mating curvature, to mimic a natural movement of the joint. The core is resilient, and may bend or compress, enabling the bones to move towards each other, and or to bend relative to each other.

Abstract: A gut bioreactor includes a fold region and a flow region. The fold regions include members that cooperate to form crypts. The members may have protuberances extending from a surface of the members into the crypts. The gut bioreactors may include multimaterial fibers that are configured to detect aspects of the crypts or may mechanically move portions of the gut bioreactor.

Abstract: A drill guide to facilitate drilling a hole into a bone and inserting an anchor. The drill guide includes a handle extending to a proximal end and a guide shaft extending from the handle to a distal end. A recess extends into the handle at the proximal end. The drill guide also includes a channel extending through the recess and into the guide shaft and a contact surface extending from the recess. The contact surface may be a proximal surface on a ring extending circumferentially within the recess. The contact surface may alternatively be a proximal surface on a protrusion extending from and within the recess. For example, the protrusion is a triangular protrusion extending along the recess toward the channel. The contact surface allows for the use of inserters of varying sizes within the channel of the drill guide.

Abstract: Methods of joint repair employing sutures and attached fixation devices are discussed. For example, a bone block graft procedure (e.g., Latarjet) is discussed which employs fixation devices to secure contact between graft surfaces of two bones. A suture construct, including a continuous suture loop routed through a first fastener, is secured to a first bone. Looped ends of the suture loop are passed through passageways formed in the two bones. The looped suture ends are further routed through a second fastener. The second fastener is mounted to the second bone and a sliding knot, formed in the looped suture ends, is advanced into contact with the second fastener. The suture is further tensioned using a tensioner device to secure the two bones together.

Abstract: A prosthesis for attachment to an external surface of a trachea and support a membranous portion of the trachea is disclosed. The prosthesis includes a first member, a second member and a biasing member engaged with the first member and the second member. The first member has at least one first tooth adapted to be inserted inside the membranous portion. The second member is movably coupled to the first member and includes at least one second tooth disposed substantially opposite to the at least one first tooth. The at least second tooth is configured to be inserted inside the membranous portion. The biasing member biases the first member relative to the second member to a first position. The first member and the second member are disposed away from the first position when engaged with the trachea applying a tension force on the membranous portion.

Abstract: Systems, devices, and methods for treating the spine are disclosed herein. Medical devices can be positioned along a subject's spine to treat various conditions and diseases. The medical device can include an actuator assembly and a clamp assembly. The actuator assembly can be positioned at an interspinous space between a superior spinous process and an inferior spinous process. The actuator assembly can be used to reconfigure the clamp assembly such that the clamp assembly clamps onto the superior and inferior spinous processes.

Abstract: The present invention relates to a bone plate internal fixator device (101; 501; 701) for epiphysiodesis, comprising a pair of holding elements (102, 103; 502, 503; 702, 703), each one of the holding elements (102, 103; 502,503; 702, 703) respectively comprising a through hole (104, 105; 504, 505; 704, 705) configured for receiving a respective fixing screw (301) to a bone; the bone plate internal fixator device (101; 501; 701) further comprises a central portion (106; 506; 706) which structurally connects and constrains the holding elements (102, 103; 502, 503; 702, 703) with each other; the central portion (106; 506; 706) is flexible so as to allow flexing of the bone plate (101; 501; 701); each said through hole (104, 105; 504, 505; 704, 705) comprises a threaded surface (108, 109; 508, 509; 708, 709) adapted to couple with a corresponding surface (304) of the respective fixing screw (301); the holding elements (102, 103; 502, 503; 702, 703) and the central portion (106; 506; 706) are provided as a composi

Abstract: The present invention relates generally to prosthetic spinal implants. Specifically, the present invention relates to a compliant implant for spinal intervertebral disc replacement.

Abstract: A self-drilling bone screw, comprising a head, a threaded body, and a tip region. The threaded body extends vertically below the head and has a helical male threading. The tip region extends vertically below the treaded body. The tip region is fluted and has a pointed bottom tip, such that the tip region is configured to drill a hole into a bone and generate bone chips. The tip region further has a slot disposed horizontally through a portion of the tip region above the pointed bottom tip, the slot being configured to trap at least some of the bone chips, thereby enabling fusion between the bone and the bone chips. A diameter of threaded body is larger than a maximal diameter of the tip region.

Abstract: A spinal implant includes a first member having a wall that defines an axial cavity. A second member extends between a first end and a second end and defines a longitudinal axis. The second member is configured for disposal with the axial cavity and translation relative to the first member. A third member has an outer surface engageable with tissue and an inner surface disposed to dynamically engage the first end in response to the engagement of the outer surface with the tissue. Systems and methods are disclosed.

Abstract: A spinal fusion implant includes a leading end, an opposite trailing end, an upper portion extending between the leading and trailing ends, a lower portion extending between the leading and trailing ends, and opposed first and second side portions extending between the leading and trailing ends. The upper portion includes at least two rails extending between the leading and trailing ends, the at least two rails including a first rail and a second rail spaced apart from one another, the first rail of the upper portion including a bone-contacting surface being at least partially smoothened. The lower portion includes at least two rails extending between the leading and trailing ends, the at least two rails including a first rail and a second rail spaced apart from one another, the first rail of the lower portion including a bone-contacting surface being at least partially smoothened.

Abstract: A spinal implant is provided and includes a body portion defining a longitudinal axis. The body portion includes a distal end portion, a proximal end portion, opposed side surfaces that extend between the distal and proximal end portions, and top and bottom surfaces configured and adapted to engage vertebral bodies. The top and bottom surfaces have a surface roughness between 3-4 ?m. A cavity extends through the top and bottom surfaces defining a surface area that is at least 25% of a surface area of the top surface or the bottom surface. First orifices are defined through the top surface and second orifices are defined through the bottom surface. The second orifices are connected to the first orifices by a plurality of channel.

Abstract: A fusion device assembly for fusion of a joint, including a first screw portion, including a first distal end, a first proximal end, a first radially outward facing surface, and a first hole, a second screw portion, including a second distal end, a second proximal end, and a second radially outward facing surface, and a section, including a first end slidably engaged with the first hole, a second end non-rotatably secured to the second distal end, and a third radially outward facing surface.

Abstract: An orthopedic implant which generally includes a frame structure and a porous structure. Both the frame and porous structure at least partially define at least six surfaces which make a three-dimensional profile of the implant. The porous structure is positioned at least partially within the three-dimensional profile.

Abstract: A neutralization plate includes a main body, a pair of upper arms extending upwards from the main body, and a pair of lower arms extending downward from the main body to form a generally X-shape with the pair of upper arms. In addition, the neutralization plate includes a horizontal channel formed across a rear side of a midsection of the main body, an aperture formed in the main body between the pair of lower arms and contiguous to a bottom edge of the horizontal channel, and a lower chute formed between the aperture and a lower edge of the horizontal channel. The lower chute is configured for ends of a suture looped through a fractured bone to be passed through the aperture and down the lower chute to a front side of the main body to be anchored separately from the fractured bone.

Abstract: An implant in the form of a bone screw that meets device tracking requirements set for the in the FDA regulations is provided. The bone screw includes a screw body and a tag body formed as an integral extension of the screw body and is connected to the screw body via a frangible interface bone screw. The screw body has a head portion and a threaded shaft portion that extends along a longitudinal axis from the head portion to a screw tip of the screw body. The tag body defines at least one surface configured to display traceability information for the bone screw. The frangible interface is disposed between the tag body and the screw tip of the screw body. The frangible interface is configured to fracture upon application of a predefined mechanical force so that the tag body is removable from the bone screw.

Abstract: The present invention relates generally to implants used in medical procedures such as bone fixation or fusion. More specifically, this application relates to fenestrated implants used in bone fixation or fusion.

Abstract: Embodiments herein are generally directed to extendable rods for use in orthopedic assemblies. In some embodiments, these implants may be used in conjunction with procedures to treat spinal deformities, including, but not limited to, early onset scoliosis.

Abstract: An improved posterior acetabular wall fracture buttress plate has a main plate and a plate extension. The buttress plate has a pair of arms extending from the main plate and an arm extending from the plate extension. The main plate and the plate extension are pre-contoured with a concavity contoured and bent lengthwise off horizontal relative to the main plate to mimic a hip socket contour posteriorly along an undersurface at about 38 degrees plus or minus 8 degrees to mimic a curvature of the hip to yield an angle on the undersurface of 142 degrees plus or minus 8 degrees. The arms are 1.0 cm or less wide. The plate extension extends from the main plate and has at least one transverse groove defining a breakaway section allowing the plate extension to be removed from the main plate.

Abstract: A tether assembly may be attached to a bone to correct a rotational deformity. The bone may have a growth plate that separates a first section of the bone from a second section of the bone. The tether assembly may have a tether member with a first end, a second end, and a central portion extending between the first end and the second end. The first end may have a closed outer wall that defines and fully bounds a first aperture. The second end may have an open outer wall that defines and partially bounds a second aperture. The open outer wall may define a slot in communication with the second aperture. The first and second ends may be securable to the first and second sections of the bone via coupling members inserted through the first and second apertures and anchored in the first and second sections, respectively.

Abstract: A vertebral insert may include a first linkage, a second linkage, and a third linkage. The first, second, and third linkages may at least partially defining a cavity. The insert may be movable between a collapsed configuration and an expanded configuration, and the movement of the first and second linkages with respect to one another may be configured to reciprocally move the insert between the collapsed and expanded configurations.

Abstract: Various embodiments of a pedicle screw assembly disclosed herein include a pedicle screw configured for engaging with bone tissue. The pedicle screw includes a body defining a plurality of channels through the body of the screw and in communication with a plurality of respective distal openings defined along the screw body. The pedicle screw assembly further includes an anchor defining a plurality of anchor members which are configured to be received at least partially through the plurality of channels and the plurality of respective distal openings to further engage the pedicle screw to the bone tissue.

Abstract: An implant stabilizes two adjacent bones of a joint, while enabling a natural kinematic relative movement of the bones. Support components are connected to each bone of the joint, and a flexible core is interposed between them. The core and at least one of the support components are provided with a smooth sliding surface upon which the core and support component may slide relative to each other, enabling a corresponding movement of the bones. The surfaces may have a mating curvature, to mimic a natural movement of the joint. The core is resilient, and may bend or compress, enabling the bones to move towards each other, and or to bend relative to each other.

Abstract: A prosthesis replaces all or a portion of a natural facet joint on a vertebral body. The prosthesis has a prosthesis body accommodating fixation to the vertebral body at or near a pedicle and without support by a lamina. The prosthesis body has a fastening element installed within the vertebral body at or near a pedicle. The prosthesis further has an artificial facet joint structure carried by the prosthesis body at a location spaced from the fastening element. The artificial facet joint structure is adapted and configured to replace all or a portion of a natural facet joint.

Abstract: An apparatus and method is provided for interbody fusion including distracting, in a given direction, and supporting opposing vertebral bodies. A plurality of wafers are consecutively inserted between the vertebral bodies to create a column of wafers. The column of wafers is oriented between the vertebral bodies so as to expand in the given direction as the wafers are consecutively added to the column.

Abstract: To change a spatial relationship between two or more bones in a patient's body, a wedge member is moved into a joint between the bones. The wedge member may have a cam-shaped configuration and be rotated through less than a revolution to apply force against the bones. The wedge member may have a porous construction which enables bone to grow through the wedge member and immobilize the joint. The wedge member may be coated with and/or contain bone growth promoting material. The wedge member may be connected to only one of the bones or may be connected to two adjacent bones. If the wedge member is connected to only one bone, the joint may be capable of being flexed after the wedge member is inserted into the joint.

Abstract: An interbody spinal fusion implant made of a material other than bone adapted for placement across an intervertebral space formed across the height of a disc space between two adjacent vertebral bodies. The implant has a leading end that is curved to form a portion of a circle from side to side, sides that are at least in part straight, and a trailing end with a bone screw receiving hole for receiving at least one bone screw to engage the vertebral bodies.

Abstract: A handle and a method of fabricating a handle, or another article of manufacture, that minimizes or avoids the likelihood of accumulating contamination before, during, or after use. The article includes a core element, for example, a plastic core element, having an outer surface and raised indicia, such as, letters or logos, extending beyond the outer surface; and a light-transferring material completely covering the raised indicia of the core element wherein the raised indicia are visible through the light-transferring material. The complete covering of the indicia avoids separation between the cover and the indicia. The cover material may be a translucent thermoplastic elastomer. Though particularly applicable to the medical device industry, aspects of the invention may be applied to a broad range of industries.

Abstract: A flanged interbody spinal fusion implant for insertion at least in part between adjacent vertebral bodies has opposed upper and lower surfaces adapted to contact each of the adjacent vertebral bodies from within the disc space, a leading end for insertion between the adjacent vertebral bodies, and a trailing end opposite the leading end. The trailing end has a height greater than the maximum height of the disc space forming a flanged portion adapted to overlie a part of the anterior aspects of the vertebral bodies adjacent and proximate the disc space to be fused. The flanged portion has at least two bone screw receiving holes, at least one each adapted to overlie each of the adjacent vertebral bodies at least in part. The implant has at least one locking element to lock one or more of the bone screws inserted in the bone screw receiving holes. Instrumentation for inserting the implant, forming screw holes in the vertebral body, and for locking the locking elements are disclosed.

Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. Kits comprising the same are also provided.

Abstract: The present application is directed to interbody spinal fusion implants having a structural configuration that provides for the maintaining and creating of the normal anatomic angular relationship of two adjacent vertebrae of the spine to maintain and create spinal lordosis. The spinal fusion implants are sized to fit within the disc space created by the removal of disc material between two adjacent vertebrae and conform wholly or in part to the disc space created. The spinal fusion implants of the present invention have upper and lower surfaces that form a support structure for bearing against the end plates of the adjacent vertebrae. The upper and lower surfaces are disposed in a converging angular relationship to each other such that the implants have an overall “wedged-shape” in an elevational side view.

Abstract: A prosthesis replaces all or a portion of a natural facet joint on a vertebral body. The prosthesis has a prosthesis body accommodating fixation to the vertebral body at or near a pedicle and without support by a lamina. The prosthesis body has a fastening element installed within the vertebral body at or near a pedicle. The prosthesis further has an artificial facet joint structure carried by the prosthesis body at a location spaced from the fastening element. The artificial facet joint structure is adapted and configured to replace all or a portion of a natural facet joint.

Abstract: An anchor connected with a suture is moved through a passage between opposite sides of a bone. The anchor is then pivoted to change its orientation. A second anchor is connected with the suture. While tension is maintained in the suture, the suture is secured against movement relative to the anchors. This may be done by tying the suture or by using a suture retainer to hold the suture. A suture retainer may be used in place of the second anchor. The passage may extend across a fracture in the bone. The passage may have either a nonlinear or linear configuration. The passage may be formed by first moving a thin elongated member through the bone. The thin elongated member is then used as a guide for a drill. The thin elongated member is withdrawn from the drill and the suture anchor is moved through a passage in the drill.

Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.

Abstract: Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller.

Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

Abstract: A spinal fixation system including a selectively applied bone growth promoting agent is disclosed. The types of spinal fixation systems which may include a selectively applied bone growth promoting agent include systems comprised of rods, plates, screws, and hooks as well as other types of prostheses.

Abstract: The present invention relates to a bone implant device, particularly for dental and orthopedic prosthesis on the vertebral column, having a quicker osteo-integration compared to the prior art devices. Particularly, the present invention relates to an implant device, of metal or polymer nature, a layer of hyaluronic acid being chemically bound on the surface thereof, for use in applications in contact with the bone, with activity of stimulating the bone tissue growth, as well as a process for preparing the same.

Abstract: Implants, such as interbody spacers, fusion devices and bone grafts, are provided having improved mechanical properties and/or degradation profiles. Such implants include a three-dimensional scaffold formed from particles, such as microspheres, which may in some embodiments be resorbable or biodegradable and which may have at least two different degradation rates. In some embodiments, the scaffold may be elastomeric. The three-dimensional scaffold may be for example, porous or semi-porous. Also provided are kits including such implants, and methods of producing and using the same.

Abstract: An implantable plate for providing support to a bone of a subject when affixed thereto includes a polymeric body of a biocompatible polymer having a desired amount of polymer molecule orientation in a first direction so that the plate can be bent to conform with a contour of the bone of the subject. The polymeric body includes a top surface, a bottom surface, and at least one fastener portion. The fastener portion includes a recess and a fastener hold that is configured for receiving a fastener when affixed to the bone of the subject. A method of manufacturing the implantable plate includes: (1) injection molding a biocompatible polymeric composition into a polymeric body within an injection mold; (2) removing the polymeric body from the injection mold; and (3) forming at least one fastener hole within polymeric body.

Abstract: An implant for the correction and stabilization of the spinal column, comprising pedicle screws that can be screwed into the vertebrae of a spine, and of at least one connection element that connects the pedicle screws at the screw heads. This connection element is formed by a spiral whose spiral windings are arranged offset in the axial direction, following a screw line.

Abstract: A system for securing a graft within a bone includes a tubular cross pin having an interior surface bounding a passageway extending between a proximal end and an opposing distal end, the distal end terminating at a distal end face. A guide pin has an exterior surface extending between a proximal end and an opposing distal end, the exterior surface including an outwardly projecting shoulder. The guide pin is removably received within the passageway of the cross pin such that the distal end face of the cross pin biases against the shoulder and a proximal portion of the guide pin freely projects beyond the proximal end of the cross pin.