Abstract: In one aspect, devices for light treatment of skin are described herein. A device described herein, in some embodiments, comprises an interior compartment having a proximal end and a distal end, and an optical aperture disposed at the distal end. The device also comprises a laser or BBL source that produces a laser or BBL beam. The laser or BBL beam has a first optical path within the interior compartment, between the proximal end and the distal end. Additionally, the first optical path exits the interior compartment through the optical aperture. The device further comprises an imaging system that receives a return signal from the aperture. The return signal received from the aperture has a second path within the interior compartment. Further, a selectively reflective optical element is disposed in the first and second optical paths. The selectively reflective optical element generally transmits the laser or BBL beam.

Abstract: A system for capturing, storing and comparing dermatological images includes two components, namely, a handheld exam control and a patient interface. The handheld exam control includes a camera, display screen, illuminator and a position sensor. The patient interface includes a patient position template and a position sensor interface. The system captures an image sequence and the precise location of each image. Images may be compared to previous images by a clinician.

Abstract: An apparatus is provided for irradiating at least a portion of a patient's brain with electromagnetic radiation to treat stroke, Parkinson's Disease, Alzheimer's Disease, or depression. The apparatus includes a source of the electromagnetic radiation. The apparatus further includes an output optical element including a rigid and substantially thermally conductive material and a surface configured to be in thermal communication with the patient's body. The apparatus further includes a cooler thermally coupled to the output optical element to remove heat from the output optical element. The apparatus further includes a heat sink thermally coupled to the cooler, wherein the heat sink is positioned so that the electromagnetic radiation from the source propagates through the heat sink and through the output optical element.

Abstract: An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

Abstract: A control method for a light therapy device, including steps of: set a light dose range (1-4J/cm2) required by an illuminated portion under a skin surface; calculate an appropriate intensity range outputted by a light source based on the set light dose, an illuminated time, and a proportion of light beam shape variation between the light source and the skin surface; build a corresponding relation between the appropriate intensity range and an ideal illumination range for the skin surface; measure an illumination of the skin surface, and monitor an output light intensity of the light source based on the illumination, ensuring that a light intensity outputted by the light source is a set ideal light intensity whereby, a light dose transmitted from the light therapy device to the illuminated portion could be kept in the set light dose by simply controlling the illumination to be within the set illumination range.

Abstract: The invention resides in a pattern laser comprising a plurality of laser devices each emitting a treatment laser beam into an optical fibre of an optical fibre bundle. An optical coupling module is associated with each laser device and each optical fibre for coupling a treatment laser beam into the associated optical fibre. A controller controls the operation of the laser devices by selectively turning on or off one or more of the laser devices so as to form a laser treatment pattern at an end of the fibre bundle away from the laser devices. A delivery system images the output from the fibre bundle to a treatment zone.

Abstract: A method for providing localized heating of the dermal layers of skin of a patient, using energy in the form of a group of pulses having defined parameters in a controlled manner. This method preferably uses an optical delivery system to deliver pulsed energy to a specific spot of skin so that targeted layers of the affected skin are heated to a desired temperature range. The temperature range is optimally selected to maximize treatment efficacy while minimizing pain to the patient. Example applications include reducing wrinkles, acne, hair, scar tissue, warts, and promoting wound healing. In this method, the temperature of the selected locus rises quickly to the desired temperature range, then is maintained within a controlled range with a relatively flat temperature profile. The method maintains the temperature by controlling one or more of a pulse energy intensity, pulse width, and pulse frequency or time delay between pulses.

Abstract: A method for treating an eye, including the step of applying an electromagnetic wave of distorted sinusoidal current with a resonance frequency and having related harmonics on an eye, an eye orbit, a temple, eyelid areas or a part thereof.

Abstract: A personal care system having a treatment device for applying a treatment to the skin or hair of a user is provided. The treatment device has a camera for taking an image of the skin. The system may include or be in communication with an application programming interface (API) that can process the image. The system or an associated API can recommend the use of treatment regimens or topical products according to information determined from the digital image of the skin.

Abstract: The present invention relates to a light treatment apparatus and a method of controlling the same, and provides to a light treatment apparatus and a method of controlling the same, including: a treatment light irradiating unit for irradiating a treatment region with treatment light a plurality of times while moving on the treatment region; a sensing unit for detecting movement information of the treatment light irradiating unit; and a control unit for controlling an irradiation pattern of the treatment light based on the detected movement information such that an irradiation area of the treatment light to be irradiated from the treatment light irradiating unit overlaps at least in part with an irradiation area of the treatment light which is previously irradiated.

Abstract: A method of producing an array of sharp tips including a biocompatible coating, wherein the biocompatible coating is thicker at a sharp end of the sharp tips than at a broader section of the sharp tips, the method including providing an array of sharp tips, and coating the sharp end of the sharp tips differentially from coating the broader section of the sharp tips. A method of treating skin including producing a hollow in the skin by heating and mechanically compressing epidermis while retaining a covering of stratum corneum. A method of treating tissue including heating a tip to a temperature suitable for producing a crater in the tissue, advancing the tip toward the tissue, detecting when the tip comes into contact with the tissue by detecting a change in mechanical resistance to the advancing, and measuring the mechanical resistance to the advancing. Related apparatus and methods are also described.

Abstract: A process for heat treating biological tissue includes providing a plurality of energy emitters formed into an array. Treatment energy is generated from the plurality of emitters and applied to target tissue. The treatment energy has energy and application parameters selected so as to raise the target tissue temperature sufficiently to create a therapeutic effect while maintaining an average temperature of the target tissue over several minutes at or below a predetermined temperature so as not to destroy or permanently damage the target tissue.

Abstract: Exemplary methods and devices can be provided for improving the appearance of dermal melasma. This can be done, e.g., focusing electromagnetic radiation having a wavelength between about 600 nm and 850 nm into a region of the pigmented dermal tissue at a depth between about 150 and 400 microns, using a lens arrangement having a large numerical aperture between about 0.5 and 0.9. The exemplary local dwell time of the focused radiation can be less than a few milliseconds, and a local fluence provided in the focal region can be between about 50 and 500 J/cm2. The focal region can be scanned through the dermal tissue at speeds on the order of a few cm/s. Such parameters can provide sufficient energy absorption by pigmented cells in the dermis to disrupt them while avoiding damage to the overlying tissue and unpigmented dermal tissue.

Abstract: A mouth guard comprising a plurality of light sources is presented that provide for the emission of light in wavelength ranges that provide antiseptic benefits to a user, wherein the light outputted by the plurality of light sources are activated by a sensor configured to determine a proximity of the mouth guard to an object and generate a signal that is used to control the application of a voltage to the plurality of light sources, for a predetermined time period.

Abstract: A pulsed laser skin treatment device is for laser induced optical breakdown of hair or skin tissue. A feedback system is used for detecting a feedback system based on light and/or sound/and/or contact force or pressure. The feedback signal is used to determine whether a pulse was in the tissue or outside the tissue. With these data an effectiveness of the treatment can be determined which can be provided to a user.

Abstract: Exemplary methods and devices can be provided for improving the appearance of dermal melasma. This can be done, e.g., focusing electromagnetic radiation having a wavelength between about 600 nm and 850 nm into a region of the pigmented dermal tissue at a depth between about 150 and 400 microns, using a lens arrangement having a large numerical aperture between about 0.5 and 0.9. The exemplary local dwell time of the focused radiation can be less than a few milliseconds, and a local fluence provided in the focal region can be between about 50 and 500 J/cm2. The focal region can be scanned through the dermal tissue at speeds on the order of a few cm/s. Such parameters can provide sufficient energy absorption by pigmented cells in the dermis to disrupt them while avoiding damage to the overlying tissue and unpigmented dermal tissue.

Abstract: Provided herein is a multifunctional aesthetic system including a housing, an electromagnetic array situated in the housing and having a plurality of electromagnetic radiation (EMR) sources, each EMR source configured to generate an EMR beam having a wavelength different than that of an EMR beam generated by another of the EMR sources, a controller in electronic communication with the array to operate two or more of the EMR sources to direct the EMR beam to a treatment area, and a sensor in electronic communication with the controller for providing feedback to the controller based on defined parameters to allow the controller to adjust at least one operating condition of the multifunctional system in response to the feedback.

Abstract: The present invention is directed to a system and method for photoeradication of microorganisms from a target. The target is irradiated with pulsed purple or blue light in which (a) the light pulses have a peak irradiance and a pulse duration sufficient to optically excite a photoactive molecule capable of photoeradication of the microorganisms and (b) the light pulses are separated by an off time sufficient to allow the photoactive molecule to return to a ground state creating an oxidation reaction that produces free radicals which destroy a cellular structure of the microorganisms and thereby photoeradicate all or a portion of the microorganisms. The photoactive molecule may comprise either an endogenous molecule present in the microorganisms or an exogenous molecule applied to the target.

Abstract: Systems, methods, and devices for promoting eyelash hair growth includes an energy transducer, positionable proximate the eyelid, configured to provide light energy to a user's eyelids at an output wavelength suitable for stimulating eyelash hair growth, and a scleral shield, positionable inside of the eyelid, to protect the eye from the light energy. The device may be powered by an internal power source, such as a rechargeable battery or disposable batteries, or by an external power source, such as a plug used in connection with an AC outlet. In use, the eyelid is positioned between the energy transducer and the scleral shield, and the light energy from the energy transducer is applied to the eyelash region of the eyelid to promote eyelash hair growth.

Abstract: A device configured to cut hair using laser light includes a handle portion and a shaving portion. The handle portion includes a battery and a laser light source. The laser light source is coupled to and configured to receive power from the battery. The laser light source is also configured to generate laser light having a wavelength selected to target a predetermined chromophore to effectively cut a hair shaft. The shaving portion includes a support and a single fiber optic supported by the support. The fiber optic has a proximal end, a distal end, an outer wall, and a cutting region positioned towards the distal end and extending along a portion of the side wall. The fiber optic is positioned to receive the laser light from the laser light source at the proximal end, conduct the laser light from the proximal end toward the distal end, and emit the light out of the cutting region and toward hair when the cutting region is brought in contact with the hair.

Abstract: A laser device for the selective treatment of acne comprising: a laser source (1) terminating in an optical collimator (2), which supplies a laser beam; said laser source (1) comprises a switch (13) which allows impulses of said laser beam with pre-defined duration to be transmitted; an opto-mechanical interface (3) comprising a lens (4) focusing the laser beam received from the optical collimator (2); an optical fibre (5) connected to said opto-mechanical interface (3); characterized in that said optical fibre (5) has a length greater than 15 m; and said device comprises a handpiece (10) connected to said optical fibre (5) where said handpiece (10) comprises an optical zoom system (11) which allows the diameter of the laser beam emerging from said handpiece (10) to be varied from 0.5 mm to 5 mm.

Abstract: In accordance with various aspects of the present teachings, systems and methods for applying treatment energy, e.g., electromagnetic radiation such as laser radiation in the visible and near infrared wavelengths, to body areas having bulges and fat deposits, loose skin, pain, acne and/or wounds. In some aspects, the systems and methods can enable relatively lengthy treatments to be performed by having the practitioner set-up and/or start the treatment, thereafter allowing the treatment to proceed safely and effectively without the continued presence of the practitioner.

Abstract: A lipolysis radiation paddle (2) comprises a plurality of lipolysis radiation transducers (14) mounted in a base (20). The base (20) has a lower portion (21), and a pair of side portions (26) extending upwardly from respective sides of the lower portion (21). The lower portion (21) is shaped to fit under the jaw (51) of a user (50) of the paddle (2), and has a front end (22) shaped to receive the chin (52) of the user (50). The side portions (26) are each shaped to extend to and along respective sides of the jawline (53) of the user (50). The transducers (14) are directed inwardly towards the skin in proximity to the paddle (2).

Abstract: Various embodiments provide a method for an extended field of view treatment. The method can include the steps of imaging a region; targeting a region with directed ultrasound energy; monitoring the region; moving the imaging, treatment, and monitoring region while spatially correlating to one or more prior regions via imaging and/or position sensing; continuing the extended field of view treatment; and, achieving an ultrasound induced biological effect in the extended field of view treatment region.

Abstract: A therapy apparatus for treating a patient's brain is provided. The therapy apparatus includes a light source having an output emission area positioned to irradiate a portion of the brain with an efficacious power density and wavelength of light. The therapy apparatus further includes an element interposed between the light source and the patient's scalp. The element is adapted to inhibit temperature increases at the scalp caused by the light.

Abstract: Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, and/or fractional scar revision. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

Abstract: The present disclosure relates to a method and a device for controlling a laser output. According to an embodiment, there are provided a method for controlling a laser output of a laser device, provided with a laser generator and a handpiece for radiating a laser generated at the laser generator onto a target, and a device performing the method. The method includes the steps of: measuring, by a plurality of distance sensors arranged along a circumference of one end of the handpiece from which the laser is outputted, distances between the plurality of distance sensors and the target; based on the distances between the distance sensors and the target, calculating an effective area which is a region of the target onto which the laser is really radiated; and increasing or reducing the laser output to radiate the laser onto the effective area with a predetermined energy density.

Abstract: Provided are a morbidity diagnosis support system, a morbidity diagnosis data-generating system, and a morbidity diagnosis support method that are capable of supporting a highly reliable morbidity diagnosis. A morbidity diagnosis support system includes an extension device for extending a tissue section of cells, an image-photographing device for acquiring image data by image-photographing the tissue section, an image analysis device for analyzing the image data to calculate an index of morbidity based on a mode of cracks generated in the tissue section by the extension, and an output device for outputting the calculated index.

Abstract: Devices and methods for dermatology and more particularly to fluid enhanced skin treatment system for skin rejuvenation that can use an abrasive probe for removing epidermal layers while contemporaneously providing for the infusion of therapeutic fluids into the skin.

Abstract: A light based skin treatment device (10, 20) is provided, comprising a light source (18) for providing an incident light beam (21) for treating a skin (30) by laser induced optical breakdown (LIOB) of hair or skin tissue, a transparent exit window (14) for allowing the incident light beam (21) to exit the device (10, 20), and an optical system for focusing the incident light beam (21) into a focal spot (221, 222) in the hair or skin tissue outside the skin treatment device (10, 20).

Abstract: A multichannel stimulation system for regenerating damaged corneal nerves, includes: electrically contacting a contactor of the multichannel unit with the stimulation signal module; providing an electric pulse signal, by the stimulation signal module; transferring an electric pulse signal of a first duration time and an electric pulse signal of a seventh duration time to the first channel, and transferring an electric pulse signal; maintaining an adjusted magnitude of the absolute value of an electric pulse signal when the magnitude of the absolute value of the electric pulse signal desired by a user is adjusted; and confirming whether impedance measured between the first channel and an area where the first channel is attached and impedance measured between the second channel and an area where the second channel is attached exceed a reference impedance.

Abstract: An adapter for attachment to a medical application device includes an energy generating device and a distal tip for applying the energy generated to skin tissue. The adapter includes a substantially hollow body with a distal end portion and a proximal end portion. The proximal end portion is sized to mount on the distal tip of the energy generating device; the distal end portion is substantially open. The adapter further includes at least one through port extending from the proximal end portion to the open distal end portion of the adapter.

Abstract: An electro-mechanical-type handpiece is specially designed to be used with a laser Generator, particularly those that use a CO2 laser and provide a laser beam in fractional mode. The fractional mode laser beam is provided in a pattern of homogeneous points aligned in rows, columns or diagonally, and such a pattern allows internal tissue along an entire length of a vagina of a patient to be treated and a pelvic floor of the patient to be retracted, such that a urinary bladder of the patient is elevated and, owing to the change in angle thereof, slight or moderate losses of urine are resolved or improved. In addition, the device can be used to treat the inner surface of the vagina of the patient, reducing vaginal laxity caused by childbirth and age.

Abstract: The present disclosure relates to a flash generator for providing power supply to a flash tube so that the flash tube rapidly provides a light output adapted to FP-sync, Flat Peak. The flash generator comprises a capacitor bank, an output and a switch configured to switch a current flow from the capacitor bank via the output to provide a variable power via the output. The flash generator further comprises a controller for controlling the switch, whereby by controlling the on time of the switch, the generator is operative to provide, during a time period of 100 to 2000 ?s during a peak time period within the time period, an average power at least 4 times higher than the average power provided during the other time period within the time period, whereby the flash tube during the peak time period becomes fully ignited.

Abstract: There is provided a skin beauty device having a multi-filter type housing, wherein even if a fluid remaining on a skin is sucked from the skin beauty device, the sucked fluid is stored in an inner space of the housing and blocked from being transmitted to a suction motor side, and even if some fluid is transmitted to the suction motor side, the housing includes a plurality of filters to prevent the suction motor from being damaged by the suction of the fluid.

Abstract: An apparatus for destroying pathogens includes a platform and an LED matrix panel. The platform has a portion configured to permit passage of ultraviolet light therethrough. The LED matrix panel is disposed below the portion of the platform and includes a grid and a plurality of discreetly-controlled, ultraviolet light LEDs (UV LEDs). The grid defines a plurality of cells. Each UV LED is associated with one cell such that the cells direct the ultraviolet light emitted by the UV LEDs upwardly through the portion of the platform to sanitize an object supported on the portion of the platform.

Abstract: In accordance with various aspects of the present teachings, systems and methods for applying treatment energy, e.g., electromagnetic radiation such as laser radiation in the visible and near infrared wavelengths, to body areas having bulges and fat deposits, loose skin, pain, acne and/or wounds. In some aspects, the systems and methods can enable relatively lengthy treatments to be performed by having the practitioner set-up and/or start the treatment, thereafter allowing the treatment to proceed safely and effectively without the continued presence of the practitioner.

Abstract: Methods for providing and/or determining therapeutic treatment of at least a portion of a patient's brain are provided. The method includes applying light to at least a portion of a patient's brain and monitoring at least one physiological parameter of the patient. The method further includes receiving real-time feedback information regarding the at least one monitored physiological parameter and adjusting a treatment parameter of the applied light based on the real-time feedback information.

Abstract: The present invention relates to an apparatus for treating skin by means of intense pulsed light (IPL). Such apparatus may be used for the treatment of, for example, cosmetic purposes such as hair depilation or dermatological treatment of skin conditions such as acne or rosacea. The present invention provides an improved apparatus that can be used by a non-medical practitioner and comprises a light source comprising a light emitting element for transmitting light energy to the skin and a charge storage device for discharging an energy dose to the light emitting element. There is further provided at least one sensor for measuring a parameter of the skin and a control system configured to determine the treatment energy dose to be delivered. This treatment energy dose is derived using the sensor measurement and means of reduction in unwanted time delay associated with charging or discharging of the charge storage device in sole dependence on the current or most recently measured skin parameter.

Abstract: The invention provides a method and apparatus for stimulating cellulite reduction using a femtosecond diode laser irradiation system. The system comprises a femtosecond diode laser capable of generating laser light that has a wavelength of 1000 nm-10,000 nm, a power level of 300 mw-5 W, and a pulse duration of less than 1 picosecond. A light-emitting device is coupled to the diode laser by means of flexible waveguide and is held over the skin. The device may be a handheld wand or an area pad comprising a plurality of light-emitting lenses on a surface of the pad. Laser setting controls are set to achieve a depth of photon absorption into the skin to reach subcutaneous adipose tissue.

Abstract: The present invention relates to a method of fatigue testing an elongate specimen, such as a wind turbine blade, comprising: calculating a service life damage sum at one or more locations on at least one respective first section of an elongate specimen, responsive to at least one strain time history associated with the specimen; determining a predicted test damage sum at the one or more locations for each of a plurality of predetermined test blocks separately applicable to the specimen; and selecting at least one test block associated with the plurality of predetermined test blocks based on a comparison of the predicted test damage sum with the service life damage sum for each of the one or more locations, wherein the selected at least one test block is applicable to the specimen to cause a test damage sum at each of the one or more locations that at least substantially matches the service life damage sum at each of the one or more locations.

Abstract: A contact lens, according to the present invention, comprises: a housing having a light-incident part on which a therapeutic beam oscillated from a beam generation part is incident, and a light-emitting part for guiding the therapeutic beam incident from the light-incident part to an eyeball; a first sensing part arranged between the light-incident part and the light-emitting part so as to sense the reaction occurring in a healing site of the eyeball on which the therapeutic beam is irradiated; and a second sensing part arranged in a region of the light-emitting part spaced from the first sensing part so as to sense whether contact has been made with the eyeball.

Abstract: The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the ?-amyloid protein (A?) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of A? in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered.

Abstract: An apparatus for treatment of fungal infections and/or other foot skin disorders, comprises a shoe-type housing having a substantially hollow interior forming a treatment chamber, a supporting platform disposed within the hollow chamber; so that a foot of a patient positioned within the treatment chamber is supported by the platform, so that nails are disposed at the lower level of the front part of the chamber, whereas the heel of the foot is being elevated a rear part thereof. A delivery and control assembly for the aqueous solution is provided. At least one light delivery arrangement is disposed within or in the vicinity of the treatment chamber.

Abstract: The present invention relates to a light therapy device article of manufacture, system and method for providing light is delivered to the skin by means of one or more optical fibers in therapeutic dosages from light source in wavelengths of 614-624 nm, 668-684 nm, 751-772 nm, and 813-846 nm. The light source may be comprised from one or more light emitting diodes LED disposed on a flexible printed circuit board (PCB) and ferrule adapter assembly configured to deliver light to the skin directly of the patient from the light source disposed on the PCB adjacent a scalp surface. A control circuit operably connected to the PCB is adapted to provide energy to one or more zones of LEDs to address hair loss treatment regimen including splotchy balding, receding hairline balding, crown balding and total scalp surface therapy.

Abstract: A cosmetic method of directionally tightening human skin tissue includes providing an ablative laser source and a non-ablative laser source, then using the ablative laser source to form one or more overlapping circular shaped microchannels in the skin tissue; the overlapping microchannels formed have a longitudinal dimension larger than their cross dimension; then, using the non-ablative laser source to weld the microchannels, whereby the welding causes the skin tissue to tighten.

Abstract: A collection optics system for a spectrometer and a Raman spectral system including the collection optics system is provided. The collection optics system is configured to selectively collect a Raman signal from scattered light output from a target object, the collection optics system includes a non-imaging collection unit configured to collect the Raman signal and output the Raman signal, the non-imaging collection unit including an entrance surface on which the scattered light is incident and an exit surface through which the Raman signal is output, and a Raman filter provided on a portion of the entrance surface of the non-imaging collection unit and configured to block the scattered light including a fluorescence signal. Therefore, the collection optics system may suppress reception of the fluorescence signal of the scattered light and selectively collect the Raman signal.

Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.

Abstract: A new and novel method for determining post procedural treatment is disclosed herein. In one embodiment, the method includes the steps of: determining a depth at which a surgical procedure on at least one eye of a patient is to be performed or was performed; providing a first set of instructions for administering a first medication for a first length of time to said at least one eye of said patient, said first length of time based at least in part upon said depth; providing a second set of instructions for administering a second different pressure lowering medication for a second length of time to said at least one eye of said patient, and physically administering the first medication and second different pressure lowering medication based upon the instructions.

Abstract: The invention relates to devices and compositions useful for and methods of female genital skin reduction, improvement of skin tone and treatment of female urinary incontinence, as well as the treatment or improvement of other clinical conditions, including but not limited to those involving the female genitalia.