Abstract: Disclosed herein are systems and methods for nerve conduction block. The systems and methods can utilize at least one renewable electrode. The methods can include delivering a first direct current with a first polarity to an electrode proximate nervous tissue sufficient to block conduction in the nervous tissue. Delivering the first direct current can place the nervous tissue in a hypersuppressed state at least partially preventing conduction of the nervous tissue after cessation of delivering of the first direct current. The nervous tissue can be maintained in the hypersuppressed state for a desired period, such as at least about 1 minute.

Abstract: Described herein are techniques to ensure a user using an external device is authorized to connect and connecting to a correct implantable medical device using a wireless communication protocol. A request for authorization is sent to the external device from the implantable medical device, and the authorization can be provided by an authorization pulse sent using the implantable medical device charger over the inductive link between the charging device and the implanted device. The authorization pulse can be trusted because the inductive link is short range, ensuring the patient is aware of the connection to the implanted device. Once the implanted device receives the authorization pulse, it may finalize the pairing over the first connection.

Abstract: Methods are provided for treating diseases by altering body mass composition in a human subject through application of galvanic vestibular stimulation (GVS) using electrodes placed in electrical contact with the subject's scalp at a location corresponding to each of the subject's left and right vestibular systems. The methods may be used to treat obesity-related diseases such as diabetes, hypertension, type 2 diabetes mellitus and osteoporosis. GVS may be applied for a predetermined period of time at regular intervals.

Abstract: A neuromodulation system for use with electrodes to modulate a volume of neural tissue may include a waveform generator and a controller. The waveform generator may be configured to be electrically connected to the electrodes and provide an electrical waveform through at least some of the electrodes to provide a neuromodulation therapy. The controller may be configured to use a program to control the waveform generator to deliver a neuromodulation therapy by delivering both a fast-acting sub-perception neuromodulation and a slow-acting sub-perception neuromodulation. The fast-acting neuromodulation has a wash-in transition period less than a first time duration, and the slow-acting sub-perception neuromodulation has a wash-in transition period more than a second time duration, the second time duration being longer than the first time duration.

Abstract: Apparatus and methods for imposing electric fields through a target region in a body of a patient are described. The apparatus includes a sensor array having a plurality of temperature sensors with a plurality of first temperature sensors of the sensor array connected to a first conductor, and a plurality of second temperature sensors connected to a second conductor. A circuit is configured to provide a known amount of electricity via the first conductor and the second conductor to a third temperature sensor, the third temperature sensor within the plurality of first temperature sensors, and within the plurality of second temperature sensors.

Abstract: The present disclosure discusses system and methods for improving the efficiency of a remote computing device. The system and methods include generate a profile and delivery schedule for the remote computing device. The system can dynamically update the delivery schedule of future requests the system transmits to the remote computing device based on responses to current request.

Abstract: A system for remotely managing a medical device includes a selective shielding component, configured to (a) shield with an electronic key any portion of device information that identifies the medical device individually while maintaining unshielded with the electronic key an association between such any portion and a rest of the device information and/or (b) shield with an electronic key any portion of device information that identifies the patient individually while maintaining unshielded with the electronic key an association between such any portion and a rest of the device information, and record the selectively shielded device information; a first communication component configured to facilitate transmitting the selectively shielded device information through a network; and a server device communicatively coupled to the network and configured to use the selectively shielded device information to generate reports about the device information, and the clinical event information, but wherein the server devi

Abstract: A medical device, such as a neurostimulator, is provided that includes a housing, a power supply, a signal generator and one or more electrodes coupled to the housing. The signal generator is configured to apply one or more electrical impulses to the one or more electrodes for a period of time, the period of time being defined as a single dose. A memory is coupled to the housing and stores a first content corresponding to a time period that has elapsed and a second content corresponding to a number of single doses that have been emitted by the signal generator. The device is configured to switch from an activated mode and a deactivated mode upon a first occurrence of either a specific number of single doses have been emitted by the signal generator or a specific time period has elapsed.

Abstract: A method programs an implantable medical device to configure the implantable medical device for stimulating neural tissue by at least one electrode. The method includes: performing, by the implantable medical device, an evoked compound action potential (eCAP) threshold search by stimulating the neural tissue with test stimulation pulses; determining, based on the eCAP threshold search, an eCAP threshold amplitude and a coupling factor that is indicative of a coupling between the at least one electrode and the neural tissue; and generating a first set of stimulation parameters containing at least a stimulation amplitude that is determined in dependence on the eCAP threshold amplitude and the coupling factor.

Abstract: Systems, devices and methods are provided for transcutaneously delivering energy impulses to bodily tissues for therapeutic purposes, such as for enhancing the body's bone healing process in spinal fusion patients. A therapeutic stimulator system comprises a housing for an energy source and a signal generator. The system further includes one or more electrodes coupled to the signal generator. A processor is coupled to the housing and configured to determine usage levels of the signal generator and/or motion data of the housing. The system may include a mobile device that allows the patient to input user status data, such as pain levels, and compare the user status data with the usage levels and/or the motion data, thereby improving patient compliance with a prescribed therapy regimen.

Abstract: Techniques for remote monitoring of a patient and corresponding medical device(s) are described. The remote monitoring comprises providing an interactive session configured to allow a user to navigate a plurality of sub sessions, determining a first set of data items in accordance with a first subsession, the first set of data items including the image data, determining a second set of data items in accordance with a second subsession of the interactive session, determining, based at least in part on the first set of data items and the second set of data items, an abnormality, and outputting a post-implant report of the interactive session.

Abstract: In some examples, a method including determining a chronaxie of evoked threshold motor responses from electrical stimulation delivered to a sacral nerve of a patient; and delivering, based on the determined chronaxie, electrical stimulation therapy, configured to treat a patient condition, to the sacral nerve having a pulse width at or near the identified chronaxie, wherein the delivered electrical stimulation is configured to inhibit contraction of at least one a bladder or bowel of the patient.

Abstract: Methods, systems, and devices for homomorphic encryption. In one implementation, the methods include inputting first data into a recurrent artificial neural network, identifying patterns of activity in the recurrent artificial neural network that are responsive to the input of the secure data, storing second data representing whether the identified patterns of activity comports with topological patterns, and statistically analyzing the second data to draw conclusions about the first data.

Abstract: This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient while automatically rescheduling stimulation programs based on detected patient activity.

Abstract: Systems and methods for the efficient use of an implantable pulse generator (IPG) battery are disclosed. A representative system for adjusting an electrical signal of an IPG associated with delivering therapy to a patient comprises a computer readable medium having instructions that cause the IPG to deliver a supply voltage at a first value, adjust the supply voltage from the first value until a threshold break occurs, and, based at least in part of the threshold break, increase the supply voltage from the second value to a third value. As therapy is delivered to the patient, the system iteratively adjusts the supply voltage to approach and reflect a variable minimum voltage needed to provide the requested current to the IPG.

Abstract: A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.

Abstract: A method for aesthetic soft tissue treatment includes placing at least one applicator in contact with the patient's body. The applicator has at least one electrode. Electrotherapy and radio frequency therapy are provided to the soft tissue, optionally with overlay or sequentially. A handheld applicator may be used, with the applicator moving during the therapy, which may provide muscle stimulation in the patient, or provide an analgesic effect during the treatment. A spacing object may be positioned between the skin of the patient and the applicator.

Abstract: An aerosol-generating device may include a housing having flexible portion along its length. The flexible portion is configured to transition between a relaxed or unloaded configuration and a flexed or deflected configuration. A flexible heating element and mouthpiece may also be disposed in the housing. When the housing is in a relaxed or unloaded configuration, the flexible heating element and the mouthpiece are at least partially longitudinally aligned with the flexible portion of the housing.

Abstract: A conditional direct memory access (DMA) channel activation system for executing a complex data transfer in a system-on-chip, comprising: a look-up table constructed and arranged to store elements of an activation profile; and a trigger circuit that controls a DMA transaction according to the activation profile of the look-up table.

Abstract: Methods and systems can facilitate visualizing cathodic and anodic stimulation separately via displaying and modifying graphical representations of anodic and cathodic volumes of activation. Alternately, the methods and systems may separately visualize stimulation of different neural elements, such as nerve fibers and neural cells. These methods and systems can further facilitate programming an electrical stimulation system for stimulating patient tissue.

Abstract: The system and method disclosed utilizes a wearable device to collect data generated pursuant to user's kinesthetic movement. The instant innovation filters and cleans the data, then slices the data into subsets. The subsets are analyzed with a Machine Learning algorithm to identify signal patterns indicative of statistically significant behavioral metrics, and the instant innovation returns insights based in part on relationships between said behavioral metrics. These insights are returned to an observer in the form of a report.

Abstract: A system includes: a processor; a memory coupled to the processor, wherein the memory stores a first content; a medical device coupled to the processor; and a reader coupled to the processor, wherein the reader is configured to read a second content from a storage medium other than the memory such that the processor switches the medical device from a first mode to a second mode based on the first content corresponding to the second content.

Abstract: The present disclosure discusses system and methods for improving the efficiency of a remote computing device. The system and methods include generate a profile and delivery schedule for the remote computing device. The system can dynamically update the delivery schedule of future requests the system transmits to the remote computing device based on responses to current request.

Abstract: This disclosure relates to devices, systems, and methods for autotitrating stimulation parameters.

Abstract: Improved stimulation circuitry for controlling the stimulation delivered by an implantable stimulator is disclosed. The stimulation circuitry includes memory circuitry that stores pulse programs that define pulse shapes, steering programs that define electrode configurations, and aggregate programs that link a selected pulse program with a selected steering program. The aggregate programs also include an amplitude modulation factor that modulates the amplitude defined by the pulse program. The inclusion of an amplitude modulation factor in the aggregate program allows complex amplitude-modulated waveforms to be produced. Pulse definition circuits in the stimulation circuitry execute aggregate programs to generate stimulation waveforms, which stimulation waveforms can be generated simultaneously by the different pulse definition circuits.

Abstract: A lead body is operable to be implanted proximate a target nerve tissue of a patient. A sensing electrode is configured to sense biopotentials over a first partial circumference of the lead body. A stimulation electrode is configured to deliver stimulation energy over a second partial circumference of the lead body. A signal generator is electrically coupled to the stimulation electrode and a sensing circuit is coupled to the sensing electrode. A processor is operable to apply a stimulation signal to the stimulation electrode via the signal generator and, via the sensing circuit, sense an evoked response to the stimulation signal that propagates along a neural pathway.

Abstract: A bridge device includes a housing, a plurality of electrodes exposed outside of the housing such that at least two of the plurality of electrodes can be concurrently placed in contact with a patient's skin. A controller is disposed within the housing. A first communications module is operably coupled to the controller and to the at least two of the plurality of electrodes. The first communications module is configured to allow the controller to communicate with an implantable medical device via at least two of the plurality of electrodes using conducted communication. A second communications module is operably coupled to the controller and is configured to allow the controller to communicate with a remote device external to the patient.

Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: An example of a system for delivering neurostimulation may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration. The stimulation control circuit may be configured to specify the stimulation configuration, and may include volume definition circuitry and stimulation configuration circuitry. The volume definition circuitry may be configured to determine one or more test volumes, determine a clinical effect resulting from the one or more test volumes each being activated by the neurostimulation, and determine a target volume using the determined clinical effect. The stimulation configuration circuitry may be configured to generate the specified stimulation configuration for activating the target volume.

Abstract: A method of stimulating nerve tissue, a tissue stimulation system, and an external control device are provided. The method, system, and control device causes an electrical stimulus to be applied to at least one electrode adjacent the nerve tissue of a patient. The applied electrical stimulus comprises a plurality of pulses defined by a pulse width value and an amplitude value. The pulse amplitude value is increased (e.g., manually), and the pulse width value is automatically decreased in response to increasing the pulse amplitude value in a manner that increases the intensity of the applied electrical stimulus. Alternatively, the pulse width value may be decreased (e.g., manually), and the pulse amplitude value automatically increased in response to decreasing the pulse width value in a manner that increases the intensity of the applied electrical stimulus.

Abstract: Systems and techniques are disclosed to generate programming parameters and modifications during closed-loop adjustment of an implantable neurostimulation device treatment programming, through the identification and application of weights determined from user input indications and rankings of therapy objectives.

Abstract: Systems and techniques are disclosed to generate programming parameters and modifications during closed-loop adjustment of an implantable neurostimulation device treatment programming, through the identification and application of weights determined from user input indications and rankings of therapy objectives.

Abstract: Techniques for therapy delivery are described. A processing circuit may adjust a first therapy parameter from a first level to a second level, and responsive to the adjustment of the first therapy parameter, compare a level of an evoked compound action potential (ECAP) generated from therapy delivery based on the adjusted first therapy parameter to an ECAP threshold. The processing circuit may adjust a second therapy parameter from a third level to a fourth level based on the comparison. The second therapy parameter is different than the first therapy parameter. The processing circuit may cause therapy delivery with the first therapy parameter at the second level and the second therapy parameter at the fourth level.

Abstract: Methods and systems are provided for multi-channel and/or variable neurostimulation. In one example, overlapping of stimulation events between a plurality of pulse train provided by the neurostimulation system is determined, and one or more parameters of one or more of the plurality of pulse trains are adjusted so as to reduce or avoid overlapping of stimulation events of the plurality of pulse train. The one or more parameters may include a start time, a frequency, and a pulse shape.

Abstract: Systems and methods for providing a trial neurostimulation to a patient for assesssing suitability of a permanently implanted neurostimulation are provided herein. In one aspect, a trial neurostimulation system includes an EPG patch adhered to a skin surface of a patient and connected to a lead extending through a percutaneous incision to a target tissue location. The EPG may be a modified version of the IPG used in the permanent system, the EPG may be smaller and/or lighter than the corresponding IPG device. The EPG and a lead extension may be sealed to allow improved patient mobility and reduced risk of infection. The EPG may be compatible with wireless systems used to control and monitor the IPG such that operation and control of the EPG is substantially the same in each system to allow seemless conversion to the permanently implanted system.

Abstract: A system may include electrodes on at least one lead configured to be operationally positioned for use in modulating a volume of neural tissue, a neural modulation generator configured to deliver energy using at least some electrodes to modulate the volume of neural tissue, a programming system configured to program the programmed modulation parameter set, including determine electrode fractionalizations for the electrodes based on a target multipole. The programmed parameter set may include the determined electrode fractionalizations. The target multipole may be used to determine electrode fractionalizations having at least three target poles that directionally and progressively stack fractionalizations of target poles to provide a linear electric field over the volume of tissue. The neural modulation generator may be configured to use the programmed modulation parameter set to provide the linear electric field over the volume of tissue.

Abstract: Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.

Abstract: A method programs an implantable medical device to configure the implantable medical device for stimulating neural tissue by at least one electrode. The method includes: performing, by the implantable medical device, an evoked compound action potential (eCAP) threshold search by stimulating the neural tissue with test stimulation pulses; determining, based on the eCAP threshold search, an eCAP threshold amplitude and a coupling factor that is indicative of a coupling between the at least one electrode and the neural tissue; and generating a first set of stimulation parameters containing at least a stimulation amplitude that is determined in dependence on the eCAP threshold amplitude and the coupling factor.

Abstract: A system for use with a neurostimulator coupled to one or more electrodes implanted adjacent neural tissue of a patient. The system comprises a user input device configured for allowing a user to select different nerve fiber diameters and to select a set of stimulation parameters. The system further comprises processing circuitry configured estimating regions of activation within the neural tissue of the patient based on the selected nerve fiber diameters and the selected stimulation parameter set. The system further comprises a display device configured for displaying the estimated regions of tissue activation. The user input device may further be configured for allowing the user to select different tissue regions of therapy, in which case, the display device may display the different tissue region on a human body map, and different indicia associating the displayed tissue regions for therapy to displayed estimated regions of tissue activation.

Abstract: A field measurement algorithm and measuring circuitry in an implantable stimulator, and an field modelling algorithm operable in an external device, are used to determine an electric field in a patient's tissue. The field measuring algorithm provides at least one test current between two electrodes, and a plurality of voltage differentials are measured at different combinations of the electrodes. The voltage differential data is telemetered to the field modelling algorithm which determines directional resistance at different locations in the patient's tissue. The field modelling algorithm can then use a stimulation program selected for the patient and the determined directional resistances to determine voltages in the patient's tissue at various locations, which in turn can be used to model a more-accurate electric field in the tissue, and preferably to render an electric field image for display in a graphical user interface of the external device.

Abstract: An example of a system for delivering neurostimulation using a stimulation device and controlling the delivery of the neurostimulation may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to program the stimulation device for delivering the neurostimulation according to a pattern of neurostimulation pulses defined by one or more stimulation waveforms. The stimulation control circuit may be configured to determine the pattern of neurostimulation pulses with the one or more stimulation waveforms constrained by one or more thresholds, and may include threshold circuitry that may be configured to receive one or more known values of the one or more thresholds and to determine needed values of the one or more thresholds by executing an algorithm allowing for prediction of the needed values of the one or more thresholds based on the one or more known values.

Abstract: In a method, computer and medical imaging apparatus for the provision of confidence information, an automatic diagnosis system is provided to the computer. Medical image data acquired from a patient are received by or accessed by the computer. A measure of confidence is determined by the computer, which describes the reliability of a correct diagnosis of the medical image data by the diagnosis system. The confidence information concerning the reliability of the correct diagnosis of the medical image data by the diagnosis system is provided as an output from the computer, wherein the confidence information is based on the determined measure of confidence.

Abstract: The present disclosure discusses system and methods for improving the efficiency of a remote computing device. The system and methods include generate a profile and delivery schedule for the remote computing device. The system can dynamically update the delivery schedule of future requests the system transmits to the remote computing device based on responses to current request.

Abstract: Feedback regarding electrical stimulation is provided to a patient. Electrical stimulation is applied to the patient. The electrical stimulation is applied by varying an electrical stimulation parameter. A signal is communicated to the patient via an electronic device. The signal is correlated with the electrical stimulation parameter such that the signal varies in association with the varying of the electrical stimulation parameter. The communicating is performed while the electrical stimulation is applied. Feedback is received from the patient in response to the electrical stimulation. Based on the received feedback from the patient, the electrical stimulation is adjusted.

Abstract: A method of stimulating a patient's brain comprising delivering an electrical stimulation to at least one electrode causing stimulation of a person's anterior cingulum bundle, or especially causing stimulation of a person's dorsal portion of an anterior cingulum bundle resulting in emotional change(s) in a patient comprising one or more of the following: anxiolysis, mirth, analgesia, improved affective tone, enhanced cognitive focus, increased well-being, engagement, or optimism. Further embodiments contemplate an apparatus. Further embodiments contemplate two implanted electrodes within the dorsal portion of the anterior cingulum bundle spaced between about 5 mm and 8 mm apart, having electrical stimulation parameters of between about 1.0 mA and about 3.5 mA, between about 100 Hz to about 150 Hz, and having a pulse width of between about 100 microseconds to about 200 microseconds.

Abstract: Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: a stimulation unit for electrically stimulating at least one nerve using electrical pulses; an electrode assembly connectable to the stimulation unit, the electrode assembly comprising a sensing unit, a storage unit, and a communications unit; and a control unit connected to the stimulation unit and the communications unit, the control unit being configured for controlling operation of the stimulation unit based on information from the electrode assembly.

Abstract: Programming a stimulator device to deliver a stimulation therapy at high-density parameter settings using a cathode-minimized electrode configuration determined to induce paresthesia over a patient pain pattern at low-density parameter settings.

Abstract: The system and method disclosed collects user reported, self-monitored On-task/Off-task Behavior, Fidgeting Behaviors and Walking/Running behaviors as quantified by motion sensors and an intelligent scheduling system. The collected data tells the reminder device what environment a user is scheduled to be in at any point in time in order to appropriately collect behavioral information and use said information to encourage users to be mindful of their own actions and behaviors in order to increase time spent on-task.

Abstract: Techniques for determining the trajectory of a one or more dorsal roots and utilizing the trajectories to improve a spinal cord stimulation model are disclosed. A first improvement constructs a target stimulation field along a path that is parallel with the determined trajectory that is nearest to a specified desired location of stimulation. An allocation of stimulation among the electrodes to mimic the target field is computed. A second improvement models a response of neural elements at evaluation positions that are parallel with the trajectories based on the electric field that is generated for the computed allocation of stimulation among the electrodes. The stimulation amplitude is adjusted based on the neural element modeling to maintain stimulation intensity, and the stimulation amplitude and allocation of stimulation among the electrodes are compiled into an electrode configuration that is communicated to a neurostimulator.

Abstract: Techniques for configuring electrical stimulation therapy parameters is described. Based on user input, processing circuitry may keep a first therapy parameter substantially constant and increase a value of a second therapy parameter until increasing the second therapy parameter further causes the second therapy parameter to be bigger than threshold value. The processing circuitry may adjust the second therapy parameter value and adjust the first therapy parameter value. Prior to adjustment, the first and second therapy parameters set a first intensity, and after adjustment, the first and second therapy parameters set a second intensity that is greater than or equal to the first intensity. The processing circuitry causes delivery of therapy at the second intensity.