Abstract: The present invention provides a pulsed electric signal having an operating positive amplitude of from 10 to 15 .mu.A for the use in the provision of a regime of transcranial electrotherapy (TCET) for the prophylaxis and treatment of allergies.

Abstract: An apparatus and method for applying an electric current to surface layers of a body is described to relieve stress and increase muscle relaxation. The invention provides muscle relaxation and stress reduction by applying an alternating positive and negative d.c. low voltage of substantially equal duration and substantially equal voltage to the skin surface layers. The voltage may be applied at a rate of about 0.2 cycles per second to about 500 cycles per second, with a voltage with a range of about 7.5 volts to about 24 volts, and an amplitude from about 50 microamps to about 1 milliamp.

Abstract: A device for controlling the discharge of a battery supplying an intermittent load, such as a nerve stimulation device. The device includes a controller which operates a switched inductor to feed a capacitor with numerous small pulses from the battery, thereby building up the charge and voltage on the capacitor, and occasionally discharging the capacitor to a load. The capacitor discharge is at a higher current than the small pulses from the battery, so the battery is drained at small instantaneous discharge rates compared to the high instantaneous discharge current from the capacitor.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: An implantable defibrillator/cardioverter which generates a biphasic defibrillation/cardioversion waveform including a pulse generator comprising two capacitors and a pair of switches for connecting the capacitors in parallel during a first phase and in series during a second phase. The first phase has a small "tilt" between the leading edge voltage and the trailing edge voltage. The second phase has a leading edge voltage which is approximately twice the trailing edge voltage of the first phase.

Abstract: The invention is a method of attracting lymphocytes to at least one desired location in the body of a patient for a therapeutic purpose (e.g., treating infection or inflammation, killing tumor cells, etc.), the method comprising contacting the desired location with one or more electrodes and stimulating the tissue with current at an intesity below that which will physically damage the cells, yet sufficient to attract lymphocytes.

Abstract: An improved compact transcutaneous electrical nerve stimulator (TENS) is provided. The compact TENS of the present invention may be used as a therapeutic device for the reduction of the symptoms of chronic and acute pain. The TENS device includes a power supply and electronics which are packaged to provide a compact, light-weight device which may be worn for an extended period of time by a patient requiring pain relief. Electronic circuitry in the TENS generates an output signal in the form of a positive spike waveform followed by a negative longer duration, lower voltage, waveform. The TENS output signal includes a broad range of frequency components, extending into the gigahertz range. Signal conditioning potentiometers are provided for adjustment of the maximum TENS output signal amplitude. Multiple output channel operation may be provided.

Abstract: A method for determining an optimal transchest external defibrillation waveform which, when applied through a plurality of electrodes positioned on a patient's torso will produce a desired response in the patient's cardiac cell membranes. The method includes the steps of providing a quantitative model of a defibrillator circuit for producing external defibrillation waveforms, the quantitative model of a patient includes a chest component, a heart component, a cell membrane component and a quantitative description of the desired cardiac membrane response function. Finally, a quantitative description of a transchest external defibrillation waveform that will produce the desired cardiac membrane response function is computed. The computation is made as a function of the desired cardiac membrane response function, the patient model and the defibrillator circuit model.

Abstract: An apparatus for generating a waveform for use in externally defibrillating the heart of a patient includes a plurality of capacitors chargeable to respective charge potentials. A control apparatus is operatively coupled with the capacitors to sequentially interconnect the capacitors in a circuit with one another to generate the waveform. Structure including e.g. electrodes is operatively coupled with the capacitors and the control apparatus to apply the waveform to the chest of the patient. The waveform preferably includes an emulated first-phase substantially sinusoidally shaped pulse component having a first polarity. According to biphasic embodiments, the waveform also includes an emulated second-phase substantially sinusoidally shaped pulse component having a second polarity. The control apparatus preferably is constructed to truncate the emulated first-phase pulse component at a predetermined time, preferably based on a design rule used to calculate pulse duration.

Abstract: Apparatus and method for selecting from a pair of capacitor banks for delivery of positive and negative polarity portions of a biphasic defibrillator pulse with a selector switch circuit for each capacitor bank, the circuit including a solid state phase selector switch preferably made up of a series connected plurality of IGBT's and each phase selector switch having a phase selector driver and select phase control for turning the phase selector switch ON and OFF when desired to start and truncate selected portions of the biphasic defibrillation pulse.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: A method and apparatus for generating biphasic waveforms uses an implantable cardioverter defibrillator having two capacitor systems and a switching network. A first phase of the biphasic waveform is produced by configuring the two capacitor systems to selectively discharge first in a parallel combination, and then in a series combination. The second phase of the biphasic waveform is produced by reconfiguring the two capacitor systems in a parallel combination. By reverting to a parallel configuration for the second phase of the biphasic waveform, the output characteristics of the second phase of a biphasic waveform of the present invention more closely match a new model for understanding the effectiveness of the biphasic.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: The invention provides a method for delivering electrotherapy to a patient through electrodes connected to a plurality of capacitors, including the steps of discharging at least one of the capacitors across the electrodes to deliver electrical energy to the patient, monitoring a patient-dependent electrical parameter (such as voltage, current or charge) during the discharging step, and adjusting energy delivered to the patient based on a value of the electrical parameter. The adjusting step may include selecting a serial or parallel arrangement for the capacitors based on a value of the electrical parameter.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: Electrical stimulation for the treatment of neuro-muscular disorders, in particular incontinence. A portable electrical stimulation apparatus for treatment of incontinence, comprising one or more electrodes (302) for applying one or more electrical stimulation signals to a patient's body, a signal generator for generating the electrical stimulation signal(s), one or more conductive leads for connecting the signal generator to the electrode(s), to deliver the electrical stimulation signal to the electrode(s); and a power supply, characterized in that the apparatus includes an instruction storage or a programming device for imparting a set of instructions to the signal generator, the signal generator being responsive to the instruction storage or programming device so that the generated signal adopts signal waveform characteristics selected in accordance with said set of instructions.

Abstract: A method and apparatus for inducing fibrillation in a patient, for example to verify the efficacy of a defibrillator system. In the disclosed embodiment, an implantable cardioverter-defibrillator has an output stage coupled via a plurality of leads to the patient's heart. When it is desired to induce fibrillation in the patient, the device's control circuitry initiates an output capacitor charging cycle and subsequent delivery of a multi-phase fibrillation inducing stimulus to the heart. The multiple phases of the stimulus reflect an incremental discharging of the output capacitor. In one embodiment, the stimulus has three phases, with the first two separated by a time interval equal to or slightly less than the patient's "vulnerability window," which is defined as the time period following a paced cardiac event during which repolarization of the cardiac muscle is occurring, rendering the heart susceptible to induced fibrillation.

Abstract: An implantable defibrillator/cardioverter which generates a biphasic waveform having a duration of at least 15-80 msec and a small "tilt" between the leading edge and trailing edge voltages of each phase. In one embodiment, two capacitors are connected in parallel to create an effectively large capacitance to generate a slowly decaying waveform. In another embodiment, a high capacitance bipolar capacitor is used, which capacitance is at least 200 microFarads.

Abstract: A nerve stimulation apparatus includes a waveform generator capable of generating a waveform comprising a sequence of pulses, and a controller. The pulses 20 have parameters as follows, a repetition rate of 150 to 200 Hz, a pulse width of 0,8 to 1,2 ms, a pulse decay which is exponential, an amplitude of between 40 to 60 volts with a negative DC off-set, and an output current of 0,01 to 10 mA. The controller controllably varies the parameters of the pulse generator. A method of controlling pain in a human subject includes applying the waveform to the human subject.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: A method and apparatus for inducing fibrillation in a patient's heart by delivering an alternating current stimulus to the heart from a DC-to DC converter. The hardware of a conventional implantable cardioverter/defibrillator (ICD) is utilized with a modification to the control algorithms. Particularly, when it is desired to induce fibrillation in a patient's heart, typically during ICD implant defibrillation threshold (DFT) testing, a command is delivered from an external instrument to the ICD to deliver the fibrillation shock. The DC-to-DC converter which is normally used to charge the ICD high voltage capacitors is activated and immediately thereafter a first pair the high voltage output switches of the output stage are closed for about 4 milliseconds. This delivers an initial pulse of one polarity. Following an interval of about 4 milliseconds, a second pair of the high voltage output switches are closed for 4 milliseconds delivering an opposite polarity pulse.

Abstract: An electrotherapy method and apparatus for delivering a multiphasic waveform from an energy source to a patient. The preferred embodiment of the method comprises the steps of charging the energy source to an initial level; discharging the energy source across the electrodes to deliver electrical energy to the patient in a multiphasic waveform; monitoring a patient-dependent electrical parameter during the discharging step; shaping the waveform of the delivered electrical energy based on a value of the monitored electrical parameter, wherein the relative duration of the phases of the multiphasic waveform is dependent on the value of the monitored electrical parameter.

Abstract: Methods and apparatus are provided for generating multiphasic charge-balanced cardioversion and defibrillation shocks to apply to a patient's heart to terminate episodes of arrhythmia such as tachycardia and fibrillation. The time-integrated positive shock phase current equals the time-integrated negative shock phase current. The use of charge-balanced shocks has been determined to significantly reduce the effects of post shock block that result when conventional shocks are applied to the heart.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient.

Abstract: An implantable cardioverter defibrillator for generating biphasic waveforms to treat cardiac dysrhythmias creates the second phase of the biphasic waveform from an active low energy source, rather than from a capacitive charge storage system. A high voltage first phase of the biphasic waveform is generated from the charge stored in a typical capacitive charge storage system. A low voltage second phase is generated from the continuous discharge of an active low voltage power source. By using an active low voltage power source system to directly produce the second phase of the biphasic waveform, the overall size and power requirements of the implantable device can be reduced.

Abstract: Electrical stimulation for the treatment of neuro-muscular disorders, in particular incontinence. A portable electrical stimulation apparatus for treatment of incontinence, comprising one or more electrodes (302) for applying one or more electrical stimulation signals to a patient's body, a signal generator for generating the electrical stimulation signal(s), one or more conductive leads for connecting the signal generator to the electrode(s), to deliver the electrical stimulation signal to the electrode(s); and a power supply, characterized in that the apparatus includes an instruction storage or a programming device for imparting a set of instructions to the signal generator, the signal generator being responsive to the instruction storage or programming device so that the generated signal adopts signal waveform characteristics selected in accordance with said set of instructions.

Abstract: A dual-channel RF power delivery system for applying RF energy to dual electrodes of an RF ablation device with independent control of the power level, frequency, phase, and time duration of the RF energy applied to each electrode to more accurately control the ablation of a target tissue. The power delivery system supplies a first controlled RF signal having a first power level, frequency, phase, and time duration to the electrode of a first flexible stylet and a second controlled RF signal having a second power level frequency, phase, and time duration to the electrode of a second flexible stylet. The difference between the first and second power levels and the temperature of the tissue between the first and second stylers are monitored to control the ablation of the target tissue.

Abstract: The present invention uses the chronaxie, a characteristic time that enters into heart defibrillation. The present invention defines a figure of merit for physiologically effective current for characterizing and evaluating a defibrillation pulse. Using this figure of merit then, the present invention compares defibrillation-pulse options and to determine optima for capacitance, tilt, and pulse duration. The combined abilities of optima determination and quantitative comparison of options provides for shorter pulses and lower capacitance values than have been in common use in the prior art. The overall result of the present invention is the specifying of smaller, more efficient implantable defibrillator designs.

Abstract: An implantable defibrillator system for generating biphasic waveforms comprises a self-contained human implantable housing containing a capacitor system for storing an electrical charge, a power supply for charging the capacitor system, and a controller for selectively discharging the electrical charge as a biphasic countershock to be delivered through at least two electrodes in response to a sensing of a cardiac dysrhythmia in the human patient. The controller includes a system for controlling a first duration of a first phase of the biphasic countershock such that the discharge of the electrical charge is of a first polarity and the first duration is variable and a system for controlling a second duration of a second phase of the biphasic countershock such that the discharge of the electrical charge is of a second polarity that is opposite from the first polarity and the second duration is fixed.

Abstract: A galvanic current is applied to acupuncture points of a human face by electrodes that are mounted in a predetermined array on a mask-like device that overlies the face. Each electrode is movable along its longitudinal axis so that its leading end is positionable into abutting relation to the face of the wearer of the mask. A low voltage is applied to each electrode and facial tissue is stimulated by a galvanic current that flows between the electrode and a remote ground. An electronic circuit controls activation of each electrode in accordance with a predetermined pattern to provide an optimal, systematic treatment, but the circuit may be overridden in favor of a manual activation of the electrodes so that the treatment may be provided in accordance with any pattern. A rubber sheath overlies the leading end of each electrode and has an enlarged, disc-shaped leading end to ensure treatment of all areas of the face that require stimulation.

Abstract: The present invention uses switches to set the topology and polarity of a circuit that includes capacitors to deliver an electric pulse to a heart during a defibrillation procedure. The waveform of the electric pulse is biphasic, in that it is a positive portion of the pulse followed by a negative portion of the pulse. The topology and polarity of the circuit are utilized to produce a waveform that approximates the ideal waveform for the specific situation. The circuit provides for combinations of capacitors variously in series and in parallel and changing the topology and polarity of the circuit during discharge of the capacitors.

Abstract: An electrical nerve and an electrical muscle stimulation device used in association with a support unit. The stimulation device is adaptable to be selectively engageable with a plurality of different body braces such that output connectors associated with the stimulation device electrically contact keyed connectors associated with a mounting carrier secured to the particular support unit. The support means includes at least two electrode pads which are selectively positionable at different locations on the support means. The connection between the output connectors of the stimulation device and the keyed connectors applies a stimulation signal to the electrode pads the size of which determines the carrier frequency of the stimulation signal which is impedance matched to the electrode size.

Abstract: A method for the therapeutic stimulation of bone growth of a bone site is disclosed comprising the steps of implanting first and second electrodes into the tissue near the base site. The electrodes are coupled to a bone growth stimulator which generates an alternating current.

Abstract: An implantable defibrillator/cardioverter which generates a biphasic defibrillation/cardioversion waveform including a pulse generator comprising two capacitors and a pair of switches for connecting the capacitors in parallel during a first phase and in series during a second phase. The first phase has a small "tilt" between the leading edge voltage and the trailing edge voltage. The second phase has a leading edge voltage which is approximately twice the trailing edge voltage of the first phase.

Abstract: An electrode for providing TCET, especially via the earlobes of the patient, comprises an electrical conductor for application to the skin, connected to a lead for supplying the TCET signal from a signal generating device, characterized in that the conductor comprises a generally conical needle point capable of penetrating the epidermis so as to provide good electrical contact over a very small area. The electrode can be used in the impedance of less than 100 k.OMEGA.; and with apparatus for generating an electrical signal for use in TCET, adapted to provide a signal at a current of less than 200 .mu.A (0.2 mA), especially when adapted to provide an AC signal in which each positive pulse is relatively short and high without being spiked and the following negative pulse is relatively wide and low, the total amount of positive and negative charge being balanced. Methods of providing TCET treatment to patients using the electrode and apparatus are also provided.