Abstract: An intraluminal device and method of fixation of an intraluminal device at a recipient having an esophagus, a stomach with a cardiac portion and a GE junction between the esophagus and the cardiac portion of the stomach includes deploying the intraluminal device to the recipient. The intraluminal device has a wall defining a cardiac member that is configured to the size and shape of the cardiac portion of the stomach and deployed to the cardiac portion of the stomach and an esophageal member that is configured to the size and shape of a portion of the esophagus and deployed to the esophagus. The intraluminal device having a connector connected with the esophageal portion and cardiac portion and deployed to the GE junction. The wall is fixed to the recipient to resist distal migration of the wall. The fixing includes the wall having a wall characteristic that is configured to facilitate tissue ingrowth.

Abstract: A device for capturing and removing an obstruction in a bodily duct of a patient. The device includes a cylindrical body having a circumference and a longitudinal axis. According to some implementations the cylindrical body is comprised of a plurality of closed cell structures arranged in diagonal rows around the longitudinal axis. At least some of closed cell structures have substantially the same shape and size. According to some implementations at least some of the closed cell structures of substantially the same shape and size occupy a same circumferential location in the cylindrical body and are longitudinally separated from one another by no less than two, three, four or more diagonal rows of closed cell structures. According to other implementations the closed cell structures include diagonally extending struts having at least a curve portion and a straight portion.

Abstract: A multiple stent structure including a plurality of stent bodies arranged end to end in which adjacent stent bodies of the structure are connected by a severable connecting portion disposed between the adjacent stent bodies is disclosed. A method of coating a plurality of stents including depositing a coating on the multiple stent structure and severing the severable connecting portions to disconnect the plurality of stent bodies is disclosed.

Abstract: A venous valve prosthesis includes a frame and a prosthetic valve coupled to the frame. With the venous valve prosthesis implanted in a vein, the prosthetic valve includes a closed configuration wherein an outer surface of the prosthetic valve is in contact with a wall of the vein around a circumference of the prosthetic valve to prevent blood from flowing past the prosthetic valve between the wall of the vein and the outer surface of the prosthetic valve. The prosthetic valve is configured to move to an open configuration such that at least a portion of an outer wall of the prosthetic valve partially collapses away from the wall of the vein in response to antegrade blood flow through the vein to enable blood flow between the outer surface of the prosthetic valve and the wall of the vein.

Abstract: The present invention relates to an endoluminal device for implantation in a body lumen, such as a pancreatic duct. The device is provided with a distal end region having greater flexibility than that of a medial region of the device.

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

Abstract: Prosthetic devices and frames for implantation at a cardiac valve annulus are provided that include an annular frame (having an inflow end and an outflow end) and a plurality of axial frame members that bridge two circumferentially extending rows of angled struts. The axial frame members can include a plurality of axially extending leaflet attachment members and a plurality of axial struts in a 1:1 ratio. Along each of the two rows, the frame can have at least three angled struts between adjacent axial frame members.

Abstract: A system for delivering a surgical staple can include various components. The system may include an elongate body with a proximal end, a distal end, and a plurality of delivery platforms disposed adjacent the distal end. A sheath can move relative to the elongate body from a first position in which the distal end of the sheath is disposed distally of a distal-most distal delivery platform to a second position in which the distal end of the sheath is disposed proximally of at least one delivery platform. A plurality of intravascular tacks can be within the system with each disposed about a corresponding delivery platform.

Abstract: The present invention relates to a thoracic aortic covered stent (100), comprising a bare stent segment (110) and a covered stent segment (120). The bare stent segment (110) comprises a bare wave-shaped ring (111); the covered stent segment (120) has a lesser curvature side region (100c), a greater curvature side region (100a), and two opposite intermediate regions (100b) located between the lesser curvature side region (100c) and the greater curvature side region (100a) respectively; and the covered stent segment (120) comprises a first proximal wave-shaped ring (121).

Abstract: A stent delivery system is provided that includes a self-expanding stent with a longitudinal length and a plurality of individual suture loops spaced along the longitudinal length of the stent, wherein the stent is compressed by the plurality of individual suture loops. The stent delivery system also includes a longitudinal pull member that secures the plurality of individual suture loops about the stent, wherein the plurality of individual suture loops are configured to separate from about the stent when the longitudinal pull wire is removed.

Abstract: An implantable stent includes a plurality of rings. At least a distal end ring has an eased corner feature formed in the polymer substrate at a radially outward, distal-facing corner of the ring while relatively sharp corners of the polymer substrate are maintained in radially inward corners of the ring.

Abstract: Systems and methods for addressing the percutaneous intervention related trauma to the vessels that arise from type-III hostile aortic arches, from uncontrolled prolapse of sheaths, embolic protection devices and stent delivery systems, by stabilizing the systems while stenting of the left and right carotid arteries. Guide wires to stabilize catheters used to access the left or right carotid arteries (CA) for carotid percutaneous intervention of the vessels originating from a tortuous aortic arch are disclosed. A bifurcated catheter for stabilizing the catheters is also disclosed. The bifurcated catheter has a main catheter that divides into two separate catheters forming a “Y” shape. One leg of the catheter has a smaller diameter with a smaller working lumen (inner diameter) to carry the stabilizing wire and the other leg of the catheter has a larger working lumen for arterial stenting operations.

Abstract: A stent for bifurcation, including two cylindrical parts: a distal part (1.1) of smaller diameter and a proximal part (1.2) of greater diameter, connected by two arranged as opposite longitudinal connectors (1.3) having length (L1) of 0.5 to 8 mm and forming a cell of the stent having an enlarged surface area (1.4), the connectors having a curvilinear shape, in particular a sinusoidal shape. A method of introducing the stent and a system for intravascular implantation are disclosed.

Abstract: An implant delivery catheter enables permanent modification of the implant length in the vicinity of the treatment site prior to radial expansion thereof. The implant is releasable carried between inner and outer tubular members of the delivery catheter which, upon repositioning relative to one another using an actuator mechanism, impart any of tensile, compressile or torquing forces to the implant causing permanent modification of the implant length. In one embodiment, the circumference of the implant is substantially similar both before and after modification of the implant length. In another embodiment, the implant includes a plurality of strut sections interconnected by bridges which are capable of the deformation along the longitudinal axis of the implant.

Abstract: A combination double-barreled and debranching stent graft and methods for its use, where the stent graft comprises, a main body stent graft defining a single lumen with distal and proximal ends, a first bifurcation in the main body defining first and second lumens, the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body stent graft must exit by entering one of the first or second lumens, (c) a second bifurcation within the first lumen defining a first leg and a second leg, (d) a third bifurcation within the first leg defining a third leg and a fourth leg, and (e) a fourth bifurcation within the second leg between about 10 mm and about 20 mm distal from the second bifurcation defining a fifth leg and a sixth leg.

Abstract: The present embodiments provide an endoluminal prosthesis, comprising a prosthetic trunk and a prosthetic branch, each comprising proximal and distal ends and a lumen extending therebetween. The proximal end of the prosthetic branch is secured around an aperture formed in a side surface of the prosthetic trunk. A support structure is coupled to the prosthetic branch. In certain embodiments, a proximal end of the support structure comprises a first width, and a distal end of the support structure comprises a second width, wherein the first width is less than the second width.

Abstract: A stent graft (40) for treating Type-A dissections in the ascending aorta (22) is provided with a plurality of diameter reducing suture loops (56-60) operable to constrain the stent graft during deployment thereof in a patient's aorta. The diameter reducing loops (56-60) allow the stent graft (40) to be partially deployed, in such a manner that its location can be precisely adjusted in the patient's lumen. In this manner, the stent graft can be placed just by the coronary arteries (26, 28) with confidence that these will not be blocked. The stent graft (40) is also provided with proximal and distal bare stents (44,52) for anchoring purposes.

Abstract: A scaffold strut is shaped to improve hemocompatibility. After laser cutting, the scaffold is placed on a work piece and its struts are shaped by flame polishing or brushing. The abluminal surfaces and luminal surfaces can have corners rounded. The strut can have a sloped surface on its luminal side without reducing strut thickness needed for strength.

Abstract: Disclosed herein is a high strength, bioresorbable wall thickness suitable for use in an endoprosthesis such as a stent that is produced by first forming a wall thickness by melt processing or solution processing one or more bioresorbable materials into a tubular shape; drawing the shape from shorter length to an optimum longer length and reducing the diameter from a larger diameter to a smaller diameter to orient the molecular chains of the material; fabricating a stent from the tube formed of the oriented material by cutting a strut pattern in its wall thickness; covering the stent's struts with at least one coating to delay degradation of the bioresorbable material; covering the stent's struts with one or more controlled release active ingredients to minimize the risk of restenosis or other side effects; crimping the stent onto a balloon catheter assembly; delivering the stent into an anatomical lumen via percutaneous methods to a treatment location; radially expanding the stent from a smaller size to a la

Abstract: A system for delivering a surgical staple can include various components. The system may include an elongate body with a proximal end, a distal end, and a plurality of delivery platforms disposed adjacent the distal end. A sheath can move relative to the elongate body from a first position in which the distal end of the sheath is disposed distally of a distal-most distal delivery platform to a second position in which the distal end of the sheath is disposed proximally of at least one delivery platform. A plurality of intravascular tacks can be within the system with each disposed about a corresponding delivery platform.

Abstract: Provided is a drug-eluting coronary stent. In the drug-eluting coronary stent according to the present invention, electrospinning is used, thereby making it possible to precisely control a total content of an everolimus-based drug bound thereto and form a uniform layer in spite of not using a polymer causing late thrombosis, or the like.

Abstract: An introduction arrangement for a fenestrated or branched stent graft (13) intended for deployment into the lumen of a vessel having a blind vessel extending from it. The introducer (1) has a distal end intended to remain outside a patient in use and a proximal end with a nose cone dilator (11) and an arrangement to retain the branched stent graft distally of the nose cone dilator. A sheath (15) on the introducer extends over the branched stent graft to the nose cone dilator. An indwelling catheter (21) extends from the distal end of the introducer and enters the fenestration or side arm and through to the nose cone dilator, the indwelling catheter has a guide wire (29) extending through it. The guide wire can be extended beyond the nose cone dilator in use before the sheath is withdrawn from the branched stent graft so that it can be snared from the contra-lateral artery.

Abstract: An anchoring device for use within a cardiovascular structure includes an expandable ring having a central axis extending in a longitudinal direction. At least one leg extends from the ring in the longitudinal direction. The leg includes a first end connected to the ring and a free end, with at least one anchor connected to the leg. The anchoring device may be used to anchor a transcatheter heart valve within the cardiovascular structure.

Abstract: A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the proximal anchors can extend a significant distance away from the exterior of the frame, such as a length equal to or greater than about one half the diameter of the frame. As another example, the anchors can have looped ends.

Abstract: A stent including a plurality of curved sections and a connector. The curved sections surround a longitudinal axis to define a tube portion and are distributed along the longitudinal axis to form a helix. The connector includes a bioresorbable material and is positioned between two adjacent curved sections. The stent has a spring constant that changes to a different spring constant after exposure to biological material.

Abstract: A modular stent graft system and methods of assembly are disclosed. The stent graft assembly comprises a first stent graft having an interface region at its distal end and a first locking stent secured to an internal surface of the interface region. A second stent graft having an interface region at its proximal end is configured to at least partially overlap with the interface region at the distal end of the first stent graft. The second stent graft comprises a second locking stent secured to an external surface of the interface region. The first and second locking stents are configured to be engaged such that the second locking stent is nested between the first locking stent and an internal surface of the interface region of the first stent graft thereby interlocking the first and second stent grafts to each other.

Abstract: A stent delivery system, a core assembly, and methods of operating the same are provided. The delivery system can comprise a catheter and the core assembly. The core assembly can comprise a constraining member, protruding member, a core member, and a stent extending along the core member. The tubular constraining member can be spaced apart from the core member and define a capture area. The protruding member can be disposed along the core member at least partially distal of the capture area. The stent can have a first portion disposed within the capture area and a second portion, distal to the first portion, extending across or over an outer surface of the protruding member so that the protruding member and the constraining member cooperate to inhibit expansion of the first portion of the stent.

Abstract: A stent has a first end region, a middle region, and a second end region, each region including a plurality of strut columns. The stent includes at least one barb. Each barb in an expanded state is at an angle relative to the outer surface of the stent.

Abstract: A tubular conduit comprising: a tubular portion made from a flexible material. There is an external helical formation extending around the exterior of, and parallel to the axis of, the tubular portion and defining a first region of the tubular portion. The external helical formation is for supporting the tubular portion. There is also an internal helical formation, protruding inwardly of the interior of the tubular portion and extending parallel to the axis of the tubular portion and defining a second region of the tubular portion. The internal helical formation is for imparting helical flow on fluid passing through the tubular portion. The first region does not extend throughout the second region.

Abstract: A stent graft for placement in the thoracic arch of a patient has a tubular body defining a main lumen therethrough, a plurality of zig zag stents along the tubular body, each of the stents comprising a plurality of struts and bends, the bends being between adjacent struts. At least a first stent and an adjacent second stent having at least a pair of adjacent bends on the first stent aligned with an adjacent pair of bends on the second stent, whereby a first pair of adjacent struts of the first stent and a second pair of adjacent struts of the second adjacent stent together define a diamond shape region. A recess is within the diamond shaped region with the recess extending into the lumen of the tubular body. A fenestration extending into the tubular body within the recess in the diamond shaped region and a graft tube leading from the fenestration into the main lumen.

Abstract: A self-expanding wire frame for a pre-configured compressible transcatheter prosthetic cardiovascular valve, a combined inner frame/outer frame support structure for a prosthetic valve, and methods for deploying such a valve for treatment of a patient in need thereof, are disclosed.

Abstract: A device isolates a substance from blood. The substance includes particles with an effective diameter that is within a range defined by effective diameters of constituents of blood. The device comprises a first sheet of graphene including a first plurality of apertures. The first plurality of apertures are configured to pass objects with an effective diameter less than or equal to the effective diameter of the particles of the substance. The device comprises a second sheet of graphene including a second plurality of apertures. The second plurality of apertures are configured to pass objects with an effective diameter less than the effective diameter of the particles of the substance. The device may be configured to include a conduit system. The device may be configured to operate according to a reversible cycle.

Abstract: A method of laser machining a polymer construct to form a stent that includes a bioresorbable polymer and an absorber that increases absorption of laser energy during laser machining. The laser cuts the tubing at least in part by a multiphoton absorption mechanism and the polymer and absorber have a very low absorbance or are transparent to light at the laser wavelength.

Abstract: A method for automatic endovascular alignment of a prosthesis includes loading the prosthesis in a distal delivery assembly, positioning a guidewire into a curved implantation site, and threading a guidewire lumen over the guidewire with the delivery assembly and into an implantation site to at least approximately align the curved distal portion to a curve of a curved implantation site and, thereby aligning the prosthesis.

Abstract: A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage.

Abstract: A stent to be implanted in a living body is formed substantially as a tube having a form in which plural wavy annular members are arranged adjacent to each other in the axial direction of the stent, with the axially adjacent wavy annular members connected to each other. The stent possesses an outer diameter whose dimension is so set that the stent is insertable into a lumen inside a living body, and is expandable when a force spreading radially from the inside of the tube is applied. The wavy annular member has parallel straight-line portions extending parallel to the axis of the stent before and after the stent expands. The stent has connection portions each connecting ends of the parallel straight-line portions of the adjacent wavy annular members to each other.

Abstract: An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

Abstract: A stent graft having a tubular body with a ostium in the side wall of the tubular body and a side arm extending from the ostium. The side arm comprising a tube of graft material extending at least partially helically around and longitudinally along the tubular body of the stent graft at least one-fourth the circumference of the tubular body to an open end and has a resilient reinforcing ring attached about and encircling its open end. The resilient reinforcing ring is permanently attached to the tubular body with a tie down arrangement that passes through the graft material of the tubular body and through the side arm and engages the resilient reinforcing ring to permanently hold the open end of the side arm against the tubular body surface. A line of radiopaque markers extends along the length of the side arm from the ostium to the open end.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen that has a first end and a second end, (b) a diaphragm coupled to the main body stent graft, where the diaphragm defines at least three openings and (c) at least three stent graft extensions each defining a lumen, where a first end of each of the three stent graft extensions is coupled to one of the three openings.

Abstract: The bending flexibility profile of a stent closely matches the flexibilities of the stent delivery system on either side of the stent. In one embodiment, a stent has a longitudinal axis and at least one link attaching each ring to an adjacent ring. The links closest to the stent end rings have the greatest bending flexibility and the links closest to the center of the stent have the least bending flexibility.

Abstract: Bioabsorbable polymer scaffolds with coatings are disclosed that include immobilized antithrombotic agents on the scaffolds or in or on the coatings. The agents act synergistically with antiproliferative agents released from coatings by providing hemocompatibility during and without interfering with antiproliferative agent release. Methods of modifying scaffolds and coatings with the antithrombotic agents are disclosed.

Abstract: An implantable prosthesis includes a scaffold with a plurality of expandable segments axially spaced apart along a substrate, adjacent segments connected by one or more support members when the prosthesis is in a collapsed configuration and disconnected when the prosthesis is in an expanded configuration.

Abstract: A method of forming a stent includes forming a wave form from a formable material. The wave form includes a plurality of substantially straight portions and a plurality of curved portions, each curved portion connecting adjacent substantially straight portions. The method includes wrapping the wave form around a mandrel at an angle to form a helical coil comprising a plurality of turns, connecting a first curved portion of a first turn to an adjacent second curved portion of a second turn at a position along the wave form to define an end of the stent, and removing excess material from an end of the wave form extending past the first curved portion while smoothing the end of the stent.

Abstract: An expandable, bistable open cell design incorporates the following features: a first relatively stiff portion (152) having first and second ends and a first relatively flexible portion (154) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a first open area (156) of the stent structure; a second relatively stiff portion (158) having first and second ends and a second relatively flexible portion (160) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a second open area (162) of the stent structure; and an opening (110) formed through the first relatively stiff portion and the second relatively flexible portion such that the opening connects the first and second open areas, thereby creating first and second intermediate ends (152a, 152b) of the first r

Abstract: Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.

Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

Abstract: The disclosure relates to a tapered stent and flexible prosthesis. The stent has a first longitudinal region and a second longitudinal region. The second region is substantially parallel to and spaced axially apart from the first region. A plurality of struts is disposed intermediate the first region and the second region and circumferentially connects the first region and the second region. The first region has a longitudinal length that is greater than the second region longitudinal length. The struts have varying longitudinal lengths that gradually decrease from the first region to the second region. The flexible prosthesis comprises at least two alternating tapered stents.

Abstract: A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent has a proximal end, a distal end and a plurality of cells, each cell being formed by a plurality of struts. A valve assembly is secured to the stent and includes a cuff and a plurality of leaflets. The plurality of leaflets are attached to the cuff adjacent an underwire that extends about the perimeter of the cuff.

Abstract: A stent including a stent body and a plurality of cells is disclosed. The stent body defines a length. Each cell includes two structural members extending in an undulating pattern. Each structural member includes a plurality of cell segments defining a plurality of nodes therebetween. At least one node includes a non-constant radius of curvature.

Abstract: A stent delivery device comprises a guide member having a proximal end and a distal end, and a stent mounted to the guide member. A restraining member positioned about the stent comprises two or more portions that are held together by one or more actuating members. The one or more actuating members can be positioned by a user in a proximal direction, since the one or more actuating members extend to the proximal end, or handle, of the guide member. When a user moves the one or more actuating members in a proximal direction, the one or more actuating members slide away from the two or more portions, allowing the stent to expand. The stent delivery device can further be configured to include an embolic protection component.