Pore Gradient Patents (Class 623/1.4)
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Patent number: 11439731Abstract: The invention relates to the technical filed of tissue engineering and 3D printing, particularly relates to an artificial tissue progenitor and a method for preparing the same.Type: GrantFiled: August 27, 2018Date of Patent: September 13, 2022Assignee: REVOTEK CO., LTD.Inventors: Yujian James Kang, Xiao Zuo, Mingchun Du
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Patent number: 11399841Abstract: Thin-film mesh for medical devices, including stent and scaffold devices, and related methods are provided. Micropatterned thin-film mesh, such as thin-film Nitinol (TFN) mesh, may be fabricated via sputter deposition on a micropatterned wafer. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh used as a cover for a stent device. The stent device may include two stent modules that may be implanted at a bifurcated aneurysm such that one module passes through a medial surface of the other module. The thin-film mesh may include pores with complex, fractal, or fractal-like shapes. The thin-film mesh may be used as a scaffold for a scaffold device. The thin-film scaffold may be placed in a solution including structural protein such as fibrin, seeded with cells, and placed in the body to replace or repair tissue.Type: GrantFiled: June 6, 2017Date of Patent: August 2, 2022Assignee: MONARCH BIOSCIENCES, INC.Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta
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Patent number: 11284987Abstract: Aspects of the invention relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component is a perfusion pathway. In some embodiments, materials (e.g., synthetic materials) for the scaffold are printed, molded, cast, polymerized, or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.Type: GrantFiled: January 9, 2014Date of Patent: March 29, 2022Assignee: Biostage, Inc.Inventor: Ron Sostek
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Patent number: 10653518Abstract: Methods are presented that provide a thin, biocompatible, high-strength, composite material that is suitable for use in prosthetic valves. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to prosthetic valve leaflets. The composite material includes more than one porous expanded fluoropolymer layer and an elastomer present in the pores of the porous expanded fluoropolymer.Type: GrantFiled: January 16, 2015Date of Patent: May 19, 2020Assignee: W. L. Gore & Associates, Inc.Inventors: William C. Bruchman, Paul D. Gassler, Cody L. Hartman, Peter J. Walsh
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Patent number: 10154918Abstract: An expandable endoluminal prosthesis may include a graft body and a support structure attached to the graft body. The graft body may include a tubular body of nonwoven electrospun fibers disposed about a longitudinal axis. A first fiber matrix segment may be attached to and extend in a transverse direction along the tubular body. A second fiber matrix segment may be attached to and extend in a longitudinal direction along the tubular body.Type: GrantFiled: December 20, 2013Date of Patent: December 18, 2018Assignee: Cook Medical Technologies LLCInventors: Kenneth A. Haselby, William J. Havel, Rick Hadley, Keith R. Milner, Blayne A. Roeder, Sara M. Sherman
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Patent number: 9821093Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.Type: GrantFiled: April 23, 2013Date of Patent: November 21, 2017Assignee: OrbusNeich Medical, Inc.Inventors: Robert John Cottone, Jr., Stephen M. Rowland, Sherry Parker
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Patent number: 9199008Abstract: This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.Type: GrantFiled: March 11, 2014Date of Patent: December 1, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Bin Huang, David C. Gale, Daniel A. Castro, Vincent J. Gueriguian
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Publication number: 20130304178Abstract: The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. For controlling the degradation of the implant the method includes the following steps: (a) providing a first part of the implant body; and (b) performing heat treatment which alters the carbon content and/or the boron content and/or the nitrogen content in the structure of a near-surface boundary layer in the first part of the implant body in such a way that strain on the lattice or a lattice transformation, optionally following a subsequent mechanical load, is achieved in the near-surface boundary layer. Such an implant is also described.Type: ApplicationFiled: July 8, 2013Publication date: November 14, 2013Inventors: Ullrich Bayer, Bodo Gerold
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Publication number: 20130245745Abstract: In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.Type: ApplicationFiled: March 15, 2013Publication date: September 19, 2013Applicant: MICROVENTION, INC.Inventors: Shirley Vong, Priscilla Tsai, Cang Lam, Ross Soltanian, Greg Bak-Boychuk, Tai D. Tieu, Ponaka Pung, Arnold Tuason, Heather Griffith
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Publication number: 20130172975Abstract: Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.Type: ApplicationFiled: July 20, 2012Publication date: July 4, 2013Applicant: TYCO HEALTHCARE GROUP LPInventors: Aaron Lee Berez, Quang Quoc Tran
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Publication number: 20120310319Abstract: In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.Type: ApplicationFiled: December 21, 2010Publication date: December 6, 2012Inventors: Tai D. Tieu, Ponaka Pung, Heather Griffith, Shirley Vong
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Patent number: 8277926Abstract: A method for fabricating a coating for an implantable medical device is provided comprising applying a first polymer on at least a portion of the device to form a first layer of the coating and applying a second polymer on at least a portion of the first layer to form a second layer of the coating. The second polymer has a lower degree of hydration than the first polymer.Type: GrantFiled: January 18, 2008Date of Patent: October 2, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen D. Pacetti, Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Thierry Glauser
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Patent number: 8263171Abstract: The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.Type: GrantFiled: July 10, 2008Date of Patent: September 11, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: John T. Clarke, Timothy O'Connor
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Patent number: 8192484Abstract: Luminal endoprosthesis formed of a multi-layer braided framework. The framework is devoid of any cover layer, and formed of a plurality of stabilized layers of biocompatible metal wires which are interlaced, forming a lattice, a plurality of wires of a given layer being integrated in the lattice of the adjacent layers. The mechanical characteristics of an outermost layer is so that when in place, the layer applies against a vessel wall, the other layers extending substantially along cylindrical surfaces distinct from the outermost layer so as to form a multi-layer mat which affects the haemodynamic of a flow of blood passing along or through this mat and preventing a growing of plaque.Type: GrantFiled: February 20, 2007Date of Patent: June 5, 2012Assignee: Cardiatis S.A.Inventor: Noureddine Frid
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Patent number: 8052744Abstract: Medical devices, such as endoprostheses, and related methods are disclosed.Type: GrantFiled: September 13, 2007Date of Patent: November 8, 2011Assignee: Boston Scientific SciMed, Inc.Inventor: Timothy S. Girton
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Patent number: 8016879Abstract: Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.Type: GrantFiled: June 27, 2007Date of Patent: September 13, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: David C. Gale, Bin Huang
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Patent number: 8007529Abstract: A porous prosthesis for delivering a medication to the site of implantation. The prosthesis, such as a stent, includes a first porous region and a second porous region and is at least partially formed from a molybdenum-rhenium alloy. The porous regions can have different porosity. A stent includes first, second and third porous region, the first porous region being between the second and third porous regions, and a therapeutic agent is disposed in the first porous region. A stent can also include a solid core and inner and outer porous layers surrounding the core.Type: GrantFiled: August 1, 2008Date of Patent: August 30, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventor: John Y. Yan
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Patent number: 7976915Abstract: An endoprosthesis, such as a stent, includes a ceramic, such as IROX, having a select morphology and composition.Type: GrantFiled: May 23, 2007Date of Patent: July 12, 2011Assignee: Boston Scientific SciMed, Inc.Inventors: Torsten Scheuermann, Michael Kuehling, Umang Anand, Jaydeep Y. Kokate, Samuel Robaina
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Patent number: 7963990Abstract: Expandable intraluminal stents are provided as well their method of manufacture. These stents are made of metal, the metal characterized by a desired porosity, with a drug compressed into the pores of the stent. The stents are formed by subjecting one or more powdered metals in a die cavity to a pressure treatment followed by a heat treatment. The metal may be cast directly in a stent-like form or cast into sheets or tubes from which the inventive stents are produced. The so-formed porous metal stent is then loaded with one or more drugs.Type: GrantFiled: July 11, 2008Date of Patent: June 21, 2011Assignee: Boston Scientific Scimed, Inc.Inventor: Michael W Johnson
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Patent number: 7931931Abstract: A porous prosthesis for delivering a medication to the site of implantation, and a method of making the same, is disclosed.Type: GrantFiled: August 16, 2007Date of Patent: April 26, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventor: John Y. Yan
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Patent number: 7857843Abstract: A differentially expanded vascular graft for implantation within a body includes a PTFE tube formed of a homogeneous material. The PTFE tube has a longitudinal first portion which has been longitudinally expanded, and a longitudinal second portion which has been longitudinally expanded. The first and second portions have respective microstructures which are different from one another. A method and apparatus for making the differentially expanded vascular graft of the present invention facilitates the formation of the various expanded portions of the PTFE tube.Type: GrantFiled: December 31, 2004Date of Patent: December 28, 2010Assignee: Boston Scientific Scimed, Inc.Inventor: Jamie Henderson
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Publication number: 20090118809Abstract: An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g.Type: ApplicationFiled: November 2, 2007Publication date: May 7, 2009Inventors: Torsten Scheuermann, Jan Weber
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Publication number: 20080288058Abstract: A porous prosthesis for delivering a medication to the site of implantation, and a method of making the same, is disclosed.Type: ApplicationFiled: August 1, 2008Publication date: November 20, 2008Applicant: ADVANCED CARDOVASCULAR SYSTEMSInventor: John Y. Yan
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Publication number: 20080249600Abstract: A method of making drug eluting stents comprises forming ceramic surface coatings of two or more levels of porosity on a stent body. The less porous coating is more conducive to endothelial cell growth, while the more porous coating is better suited for storing and releasing drugs. The surface coatings of different porosities can be produced by coating stent body surface of differing roughness with coatings made by sol-gel method. Differing roughness of the stent body surface can be produced by selective etching of the stent body surface.Type: ApplicationFiled: April 6, 2007Publication date: October 9, 2008Applicant: Boston Scientific Scimed, Inc.Inventors: Liliana Atanasoska, Jan Weber, Robert W. Warner
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Publication number: 20080249599Abstract: A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of therapeutic agent-carrying regions and non therapeutic agent-carrying regions. The therapeutic agent-carrying regions are located within low strain regions of the stent and the non therapeutic agent-carrying regions are located within high strain regions of the stent. Another embodiment of the invention includes a method of manufacturing a therapeutic agent-carrying stent comprising forming a stent framework and applying a formulation containing one or more therapeutic agents to the stent framework while preventing the therapeutic agents from contacting the high strain regions of the stent framework.Type: ApplicationFiled: April 5, 2007Publication date: October 9, 2008Applicant: Medtronic Vascular, Inc.Inventors: Jeffrey Allen, Scott Doig, Matthew J. Birdsall, Darrel Untereker
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Publication number: 20080147171Abstract: There is described a synthetic aortic conduit formed from two tubular porous layers having a non-bioresorbable sealant, such as SEPs, interposed therebetween. The synthetic aortic conduit can be attached to an aortic valve, such as a xenograft valve, to form an aortic root replacement prosthesis. The synthetic aortic conduit has the advantage that it can be stored in the preservative solutions required for tissue valves without degradation.Type: ApplicationFiled: October 7, 2005Publication date: June 19, 2008Applicant: VASCUTEK LIMITEDInventors: Timothy Rawden Ashton, Roshan Maini, Paul Burns
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Patent number: 7306624Abstract: A method for reducing blood flow to an aneurysm proximate to a bifurcation having a source blood vessel a first branch vessel and a second branch vessel, the method comprising: providing a first mesh-like tube of bio-compatible material, the first mesh-like tube exhibiting a porosity index pre-selected to skew blood flow about the bifurcation away from the aneurysm; inserting the first mesh-like tube into the source blood vessel and the first branch vessel; and securing the first mesh-like tube to at least one of the source blood vessel and the first branch vessel, whereby blood flowing from the source blood vessel flows without undue impedance to the first branch vessel and the second branch vessel while being skewed away from the aneurysm.Type: GrantFiled: August 4, 2004Date of Patent: December 11, 2007Assignee: Surpass Medical Ltd.Inventors: Ofer Yodfat, Baruch Lieber, Ygael Grad, Boaz Nishri
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Patent number: 7297158Abstract: A multilayer composite vascular access graft and a method of constructing such a graft are disclosed. The mcVAG has improved performance characteristics, which include desirable handling characteristics such as ease of suturing, kink resistance and the ability to serve as a cannulation route soon after the implant procedure.Type: GrantFiled: June 14, 2004Date of Patent: November 20, 2007Assignee: Thoratec CorporationInventor: Bjorn Jensen
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Patent number: 6827737Abstract: An implantable composite device for regulated delivery of bioactive agents to the site of implantation includes at least two zones of distinct porosities through its cross-section. One zone is of a sufficient porosity to permit regulated transport of bioactive agents associated with the device to an area of the body in need of treatment. The bioactive agent associated with the device can be either a therapeutic or diagnostic agent. In a particular embodiment of the invention, the device includes a tubular body consisting of a first luminal layer of ePTFE having a porosity sufficient to promote cell endothelization along the luminal surface; and a second polymeric layer disposed on the first layer of a porosity permitting regulated transport of the bioactive agents.Type: GrantFiled: September 25, 2001Date of Patent: December 7, 2004Assignee: SciMed Life Systems, Inc.Inventors: Jason Peter Hill, David John Sogard, David Tseng
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Publication number: 20040236407Abstract: Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.Type: ApplicationFiled: June 3, 2004Publication date: November 25, 2004Applicant: Abbott Laboratories Vascular Enterprises LimitedInventors: Joost J. Fierens, Silvio R. Schaffner, Marc Gianotti, Gerd Seibold, Randolf von Oepen
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Publication number: 20040193242Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.Type: ApplicationFiled: April 9, 2004Publication date: September 30, 2004Applicant: Scimed Life Systems, Inc.Inventors: David Lentz, Jamie Henderson, Edward Dormier, Richard Zdrahala, Gary Loomis, Ronald Rakos, Krzysztof Sowinski
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Patent number: 6723120Abstract: A porous prosthesis for delivering a medication to the site of implantation is disclosed.Type: GrantFiled: September 3, 2002Date of Patent: April 20, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventor: John Y. Yan
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Patent number: 6719783Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.Type: GrantFiled: August 5, 2002Date of Patent: April 13, 2004Assignee: SciMed Life Systems, Inc.Inventors: David Lentz, Jamie Henderson, Edward Dormier, Richard Zdrahala, Gary Loomis, Ronald Rakos, Krzysztof Sowinski
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Patent number: 6673108Abstract: A multilayer ingrowth matrix is constructed within well-defined porosity of a prosthetic material. The matrix consists of either proteinaceous or synthetic layers or gradients, or a combination of proteinaceous and synthetic layers or gradients. Each layer within the matrix is designed to achieve a specific function, such as facilitation of ingrowth of a particular cell type or release of a particular growth factor. The well-defined porosity is in the form of either helically oriented, interconnected transmural ingrowth channels, or a porous wall structure containing uniformly shaped pores (i.e. voids) in a very narrow size range, or a combination of channels and pores. This invention allows for uninterrupted ingrowth of connective tissue into walls of a synthetic graft prosthesis made from the prosthetic material. Furthermore, this invention can produce small diameter prostheses having an internal diameter of 6 mm or less.Type: GrantFiled: May 10, 2002Date of Patent: January 6, 2004Assignee: Medtronic, IncInventors: Peter Paul Zilla, Deon Bezuidenhout, Theresa Yvonne Dower
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Patent number: 6579313Abstract: A method for implanting cells onto a prosthesis includes the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have diameters of more than about 40 &mgr;m, at least 25% of the pores on the outer surface of the tube have diameters of less than about 30 &mgr;m, and the tube includes a substantially continuous layer of a biocompatible material; (b) contacting the prosthesis with a suspension of cells; and (c) providing a pressure differential between the inner surface and the outer surface, whereby the cells are retained in the pores of the inner surface. A method for obtaining an endothelial cell culture from a blood sample involved:(a) obtaining a sample for mononuclear cells from a blood sample; and (b) culturing the sample of mononuclear cells, without further cell separation, on a cell adhesive polymer-coated solid support in the presence of endothelial growth factors.Type: GrantFiled: January 18, 2002Date of Patent: June 17, 2003Assignee: The Bringham and Women's HospitalInventors: Victor J. Dzau, Richard E. Pratt, Michael J. Mann, Afshin Ehsan, Daniel P. Griese
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Publication number: 20030004559Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.Type: ApplicationFiled: August 5, 2002Publication date: January 2, 2003Applicant: Scimed Life Systems, Inc.Inventors: David Lentz, Jamie Henderson, Edward Dormier, Richard Zdrahala, Gary Loomis, Ronald Rakos, Krzysztof Sowinski
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Patent number: 6440166Abstract: A multi-zone, multifinctional graft with two or more zones that have different chemical and biological characteristics is provided. The vascular conduit that has of an inner zone that is permanently non-thrombogenic and anti-proliferative, and one or more outer zones that allow for beneficial tissue in-growth and sealing of the graft to prevent leakage. The small diameter vascular conduits of the present invention containing these different zones may be fabricated from woven or knitted Dacron, extruded porous PTFE, from polyurethane polymer, or other similar materials, and the structure of these conduits so modified as to provide these different zones. One embodiment contains an inner non-thrombogenic layer and an outer thrombogenic layer, optionally containing a growth agent. A second embodiment contains a third intermediate layer having a growth agent impregnated therein.Type: GrantFiled: February 16, 2000Date of Patent: August 27, 2002Inventor: Omprakash S. Kolluri
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Patent number: 6428571Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.Type: GrantFiled: March 14, 2000Date of Patent: August 6, 2002Assignee: Scimed Life Systems, Inc.Inventors: David Lentz, Jamie Henderson, Edward Dormier, Richard Zdrahala, Gary Loomis, Ronald Rakos, Krzysztof Sowinski
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Patent number: 6406488Abstract: A transmyocardial implant establishes a blood flow path through a myocardium between a heart chamber and a lumen of a coronary vessel residing on an exterior of the heart. The implant includes a coronary portion sized to be received within the vessel. A myocardial portion is sized to pass through the myocardium into the heart chamber. A transition portion connects the coronary and myocardial portions for directing blood flow from the myocardial portion to the coronary portion. The coronary portion and the myocardial portion have an open construction for permitting tissue growth across a wall thickness of the coronary portion and the myocardial portion. The myocardial portion includes an agent for controlling a coagulation cascade and platelet formation.Type: GrantFiled: August 27, 1998Date of Patent: June 18, 2002Assignee: HeartStent CorporationInventors: Katherine S. Tweden, Guy P. Vanney
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Publication number: 20020058983Abstract: Disclosed herein is a method for implanting cells onto a prosthesis, including the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have diameters of more than about 40 &mgr;m, at least 25% of the pores on the outer surface of the tube have diameters of less than about 30 &mgr;m, and the tube includes a substantially continuous layer of a biocompatible material; (b) contacting the prosthesis with a suspension of cells; and (c) providing a pressure differential between the inner surface and the outer surface, whereby the cells are retained in the pores of the inner surface. Also disclosed herein are methods for culturing cells for implantation.Type: ApplicationFiled: January 18, 2002Publication date: May 16, 2002Inventors: Victor J. Dzau, Richard E. Pratt, Michael J. Mann, Afshin Ehsan, Daniel P. Griese
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Patent number: 6371982Abstract: A distensible artificial tubular graft structure is provided that has a compliance gradient. The graft may be used to repair a patient's body organ tubing. For example, the graft may be used to replace or supplement portions of a patient's vascular system. The ends of the graft structure may have compliances that are matched to the compliances of the body organ tubing to which they are attached. Distensible compliance-matched connector structures may be used to attach the graft to the body organ tubing.Type: GrantFiled: October 9, 1997Date of Patent: April 16, 2002Assignee: St. Jude Medical Cardiovascular Group, Inc.Inventors: Todd Allen Berg, David S. Goldsteen
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Patent number: 6352555Abstract: Disclosed herein is a method for implanting cells onto a prosthesis, including the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have diameters of more than about 40 &mgr;m, at least 25% of the pores on the outer surface of the tube have diameters of less than about 30 &mgr;m, and the tube includes a substantially continuous layer of a biocompatible material; (b) contacting the prosthesis with a suspension of cells; and (c) providing a pressure differential between the inner surface and the outer surface, whereby the cells are retained in the pores of the inner surface. Also disclosed herein are methods for culturing cells for implantation.Type: GrantFiled: July 8, 1999Date of Patent: March 5, 2002Assignee: The Brigham and Womens Hospital, Inc.Inventors: Victor J. Dzau, Richard E. Pratt, Michael J. Mann, Afshin Ehsan, Daniel P. Griese
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Publication number: 20020002395Abstract: A distensible artificial tubular graft structure is provided that has a compliance gradient. The graft may be used to repair a patient's body organ tubing. For example, the graft may be used to replace or supplement portions of a patient's vascular system. The ends of the graft structure may have compliances that are matched to the compliances of the body organ tubing to which they are attached. Distensible compliance-matched connector structures may be used to attach the graft to the body organ tubing.Type: ApplicationFiled: October 9, 1997Publication date: January 3, 2002Inventors: TODD ALLEN BERG, DAVID S. GOLDSTEEN
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Patent number: 6287337Abstract: A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.Type: GrantFiled: February 8, 1999Date of Patent: September 11, 2001Assignee: Atrium Medical CorporationInventors: Paul Martakos, Peter Gingras, Theodore Karwoski, Steve A. Herweck
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Patent number: 6261320Abstract: Disclosed is a radioactive tubular prosthesis formed by rolling a flexible sheet around a longitudinal axis. Preferably, the prosthesis is self expandable under the radially outwardly directed spring bias of the rolled sheet. At least a portion of the sheet is provided with a coating comprising at least one radioisotope.Type: GrantFiled: February 19, 1999Date of Patent: July 17, 2001Assignee: Radiance Medical Systems, Inc.Inventors: Lisa A. Tam, Brett A. Trauthen