Protein Patents (Class 623/1.48)
  • Polyurethane-sealed biocompatible device and method for its preparation
    Publication number: 20010053933
    Abstract: Provided is a biocompatible device which has been coated or sealed with a polyether or polyether/carbonate based urethane polymer that contains functional groups (e.g. carboxylic acid groups) which are capable of serving as anchor sites for protein binding.
    Type: Application
    Filed: February 28, 2001
    Publication date: December 20, 2001
    Inventors: Matthew D. Phaneuf, Donald J. Dempsey, William C. Quist, Frank W. Logerfo
  • Calcification-resistant biomaterials
    Patent number: 6193749
    Abstract: In general, the invention features a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structure having a quantity of calcification inhibitors releasably bound thereto. The storage structure can be a protein or a synthetic polymer. The calcification inhibitors include metal ions and phosphatase inhibitors generally. Bifunctional metal chelators can be bound to endogenous proteins to deliver metal ions.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: February 27, 2001
    Assignee: St. Jude Medical, Inc.
    Inventors: Richard F. Schroeder, Matthew F. Ogle