Abstract: Embodiments described herein are related to pellets that are placed within an extraction site that is in need of bone augmentation and preservation. The pellets are typically cylindrical in shape and comprise a material and a polymer coating. The goal of the pellets are to encourage sufficient new bone growth that jaw bone deterioration is prevented. The pellets create, arrange, and assemble an ideal growth environment for new bone growth to rapidly grow and preserve the original contours of an individual's jaw bone.

Abstract: An intramedullary nail system including an elongated nail member comprising a cavity and electrically conductive at least in part, a coil assembly, a first electrode connected to a first pole of the coil assembly and a second electrode connected to a second pole of the coil assembly. To improve such an intramedullary nail system the coil assembly is provided in an end cap assembly that is proximally releasably connected to the nail member and with at least one electrically conductive outer contact surface. At least one section of the electrically conductive outer contact surface forms the first electrode and at least one section of the nail member forms the second electrode.

Abstract: The present invention proposes an implant, in particular an intraluminal endoprosthesis, having a body, comprising at least one at least largely biodegradable metallic material, in particular magnesium or a magnesium alloy. To improve the degradation behavior, the implant has a first layer on at least a portion of its body surface, said layer containing a hydrogen-binding material, preferably palladium. Furthermore, methods for producing such an implant are given.

Abstract: Provided are apparatuses, systems, and methods for treating tissue at a tissue site in a mammal that includes a scaffold adapted to be disposed adjacent to the tissue site and to be fluidly coupled to a blood vessel of the mammal for receiving blood therefrom. Additionally, a scaffold is provided that includes a charged surface comprising a streaming potential.

Abstract: The invention relates to a replacement metallic prosthesis to be implanted which contains means monitor its condition during use in order to allow an early detection of failure or insufficient functionality, wherein said means comprise implanted sensors and electronics (3) and a remote device (9), to measure the implant's function and degradation during its life span, wherein said sensors are electro chemical sensors with electrodes (1). The prosthesis according to the invention may also be used to promote bone growth. The invention also relates to a method using the device of the invention.

Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.

Abstract: Provided are apparatuses, systems, and methods for treating tissue at a tissue site in a mammal that includes a scaffold adapted to be disposed adjacent to the tissue site and to be fluidly coupled to a blood vessel of the mammal for receiving blood therefrom. Additionally, a scaffold is provided that includes a charged surface comprising a streaming potential.

Abstract: An implant device having a non-conductive base structure with at least two exposed or exterior surfaces wherein at least one of the exposed or exterior surfaces has attained electrical conductivity on at least portions of the surface by an energy exposure wherein portions of the exposed or exterior surfaces are transformed by the energy exposure to attain the electrical conductivity.

Abstract: Provided are apparatuses, systems, and methods for treating tissue at a tissue site in a mammal that includes a scaffold adapted to be disposed adjacent to the tissue site and to be fluidly coupled to a blood vessel of the mammal for receiving blood therefrom. Additionally, a scaffold is provided that includes a charged surface comprising a streaming potential.

Abstract: The present invention relates to an osseous implant for osteogenesis promotion and maintenance, the implant having an exposed surface, and the improvement comprising an electrical circuit attached to the osseous implant. At least a portion of the electrical circuit comprises a trace of conductive particles deposited on the exposed surface of the osseous implant. The present invention also relates to a method of promoting and maintaining osteogenesis by implanting the osseous implant into a subject. Current is passed through the electrical circuit under conditions effective to promote and maintain osteogenesis in the subject. Also disclosed is a method of making an osseous implant for osteogenesis promotion and maintenance.

Abstract: Provided are apparatuses, systems, and methods for treating tissue at a tissue site in a mammal that includes a scaffold adapted to be disposed adjacent to the tissue site and to be fluidly coupled to a blood vessel of the mammal for receiving blood therefrom. Additionally, a scaffold is provided that includes a charged surface comprising a streaming potential.

Abstract: Provided are apparatuses, systems, and methods for treating tissue at a tissue site in a mammal that includes a scaffold adapted to be disposed adjacent to the tissue site and to be fluidly coupled to a blood vessel of the mammal for receiving blood therefrom. Additionally, a scaffold is provided that includes a charged surface comprising a streaming potential.

Abstract: A transcutaneous port includes a subcutaneous port section and a bone fixation section. The subcutaneous port section has upper portion which has an axial channel and a first micro-textured external surface, and a lower portion which has therein a transverse channel connecting to the axial channel. The bone fixation section has a transosseous collar portion which has a second micro-textured external surface, and a threaded shaft portion. The first and second micro-textured external surfaces include a multiplicity of alternating microgrooves and ridges for tissue and bone integration. The transcutaneous port is surgically implanted into a site of a patient and a conductive wire is introduced from the axial channel to the transverse channel, and placed in the subcutaneous soft tissue and in contact with a neural signal source for transmitting neural signals to a prosthetic motor device.

Abstract: Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The devices may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, and tissue regeneration promoting. The medical devices may be used as bone implants.

Abstract: Provided are apparatuses, systems, and methods for treating tissue at a tissue site in a mammal that includes a scaffold adapted to be disposed adjacent to the tissue site and to be fluidly coupled to a blood vessel of the mammal for receiving blood therefrom. Additionally, a scaffold is provided that includes a charged surface comprising a streaming potential.

Abstract: An implantable intervertebral fusion cage including a removable means for retaining material inside of the cage during implantation. Embodiments of the present invention are directed toward an implantable intervertebral fusion cage that includes at least one removable shield or veneer that is capable of retaining a surgically useful material, such as a spinal fusion-inducing material, inside of the fusion cage during implantation and/or until the shield or veneer is removed.

Abstract: An implant with a surface modified for improved bio-compatiability consisting of a metal or an alloy thereof, said implant surface comprising a modified outer layer is disclosed, wherein said metal preferably is titanium, zirconium, hafnium or tantalum, and most preferably titanium, and said modified outer layer preferably comprises a hydride of said metal. Also a method for the production of such an implant is disclosed.

Abstract: Disclosed and claimed is bone or bone tissue supplemented with a therapeutically effective compound and methods for supplementing bone or bone tissue with the therapeutically effective compound.

Abstract: A device for implantation into a mammalian spine which comprises: a body having a first end and a second end. The first end constructed and arranged to engage a lower surface of a spinal body when the body is implanted into an intervertebral space within the mammalian spine. The second end constructed and arranged to engage an upper surface of a spinal body when the body is implanted into an intervertebral space of the mammalian spine. The body defines an interior space. The body further includes a first edge and a second edge which define a longitudinal discontinuity extending from the first end of the body to the second end of the body, wherein the longitudinal discontinuity may be a space, slot or groove.

Abstract: A prosthetic implant system connected to the tissue of a living organism. The system contains a first device for measuring the mechanical strain in the implant in an area thereof which is not exposed to tissue regrowth, a second device for measuring the mechanical strain in the implant in an area thereof which is exposed to tissue regrowth, a device for continuously determining the stress/strain relationship of said implant, and a device for treating said tissue.

Abstract: A prosthetic lamina that replaces a portion of the lamina bone structure is described. The prosthetic lamina may be configured with means for delivering a variety of medical treatments, such as electrodes for electrical stimulation, fluid channels, catheters for dispensing drugs and means for healing bone tissue.

Abstract: The present invention relates to apparatus and methods for stabilizing and or maintaining adjacent bone portions in predetermined desired relationships and for constraining one, two or three-dimensional motion and/or rotation of the adjacent bone portions. More particularly, the present invention relates to a magnetic apparatus with at least two magnetic arrays, each of which may include any number of magnets arranged in a predetermined manner and each magnetic array generating a magnetic field therearound. Once implanted and secured to the adjacent bone portions, the apparatus provides interacting magnetic fields in the area of the bone portions and transduces magnetic energy into mechanical energy and mechanical energy into potential magnetic energy, thereby reproducing functionally anatomic and/or anatomically advantageous arrangement of the bone portions.

Abstract: A prosthetic lamina that replaces a portion of the lamina bone structure is described. The prosthetic lamina may be configured with means for delivering a variety of medical treatments, such as electrodes for electrical stimulation, fluid channels, catheters for dispensing drugs and means for healing bone tissue.