Having Bio-absorbable Component Patents (Class 623/23.75)
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Patent number: 8585774Abstract: The present invention describes an implantable tissue lifting and fixation device. More particularly, the present invention describes a temporal brow lifting device comprised of a bio-absorbable supportive backing. The device has a shape of a curvilinear end and a tail end region. The curvilinear end region comprises a plurality of attachment points protruding from the supportive backing, and the tail region comprises of a plurality of cavities in order to secure the device at the desired elevated position in the deep temporal fascia. The plurality of attachment points distributes tension in a multi-vector direction over the contact area between the device and the tissue. The attachment points can be manufactured separately and attached, however, preferably, the attachment points are made integral with the temporal brow lifting device.Type: GrantFiled: October 31, 2011Date of Patent: November 19, 2013Inventor: Jenifer Lee Henderson
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Publication number: 20130304174Abstract: The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (RPNI), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings. Such a nerve interface device includes a housing that may be formed of a scaffold, such as a biotic material or hydrogel, an autograft, and optionally an electrode and/or conducting polymer. The autograft may be free muscle or free skin tissue, which is attached to the nerve ending to permit reinnervation. The present disclosure also provides methods for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve, especially a peripheral nerve.Type: ApplicationFiled: July 17, 2013Publication date: November 14, 2013Inventors: Nicholas B. Langhals, Paul S. Cederna, Melanie G. Urbanchek
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Patent number: 8574311Abstract: The present invention provides a dual crosslinked biodegradable polymer and methods of making and using the polymer. The dual crosslinked biodegradable polymer composition includes a multifunctional monomer; a diol; and an unsaturated di-acid at least partially polymerized to form a network and photocrosslinked into a dual crosslinked polymer network.Type: GrantFiled: May 7, 2009Date of Patent: November 5, 2013Assignee: Board of Regents, The University of Texas SystemInventors: Jian Yang, Dipendra R. Gyawali, Minh-Tuan R. Tran
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Publication number: 20130253663Abstract: A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.Type: ApplicationFiled: August 17, 2011Publication date: September 26, 2013Inventors: Nicholas J. Amoroso, Stephen F. Badylak, Yi Hong, Alexander Huber, Keisuke Takanari, William R. Wagner
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Patent number: 8541764Abstract: A method of partial breast radiation therapy includes placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible material, said substantially radio-opaque implant supporting the tissue surrounding the breast cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast.Type: GrantFiled: August 6, 2012Date of Patent: September 24, 2013Assignee: Senorx, Inc.Inventors: John Corbitt, Lori Anthony
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Patent number: 8535388Abstract: The present invention relates to a novel bone graft and methods for producing said graft. Said bone graft can be used for surgical, plastic and/or cosmetic bone replacement for a patient in need thereof. The bone graft is made of a scaffold or matrix of sheet material having a 3-dimensional pattern of a continuous network of voids and/or indentations for enhancing new bone growth.Type: GrantFiled: November 23, 2011Date of Patent: September 17, 2013Inventor: Timothy Ganey
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Patent number: 8529625Abstract: Tissue fixation devices are provided. The devices include a first component and a second component, the components having different rates of in vivo degradation. The first component and second component are arranged so that, upon degradation of one of the components, the other component provides a scaffold into which bone can grow.Type: GrantFiled: August 22, 2003Date of Patent: September 10, 2013Assignee: Smith & Nephew, Inc.Inventors: David Farrar, Malcolm Brown, Michael Hall, John Eric Brunelle, Nicholas John Cotton, Rod Berube, John Lipchitz
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Patent number: 8518123Abstract: A system and method for the repair of damaged tissue and bones, congenitally missing tissue/cosmetic reconstruction of tissue is described. The system has a layered porous structure with a sufficiently large area of exposed pores to promote neo-vascularization as well as bone and tissue formation. The disclosed porous implant system can contain bioactive agents necessary for rapid tissue formation and keep ingrowth of unwanted tissue out of the implant surgical site. The implant can be reinforced with an additional, stronger polymer layer and/or may include an endoskeleton or exoskeleton for dimensional stability.Type: GrantFiled: September 11, 2006Date of Patent: August 27, 2013Assignee: Board of Trustees of the University of ArkansasInventors: Peder Jensen, Alexandru S. Biris
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Patent number: 8496970Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: GrantFiled: February 27, 2012Date of Patent: July 30, 2013Assignee: DePuy Mitek, LLCInventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Patent number: 8496714Abstract: The present invention aims to provide a material for revascularization which enables the regeneration of a blood vessel at an extremely high efficiency by being transplanted into a defect of the blood vessel. The present invention provides a tubular material for revascularization comprising a foamed body comprising a bioabsorbable material, a reinforcing member comprising a bioabsorbable material for reinforcing the foamed body, and a reinforcing yarn comprising a bioabsorbable material for reinforcing the foamed body, wherein the reinforcing yarn and the reinforcing member are located at the center or outer face of the foamed body, the inner face thereof is the foamed body, the reinforcing yarn is wound around in a spiral-shaped, ring-shaped or X-shaped manner, and the reinforcing yarn comprises a glycolide-?-caprolactone copolymer.Type: GrantFiled: July 28, 2009Date of Patent: July 30, 2013Assignee: Gunze LimitedInventors: Goki Matsumura, Yoshito Ikada, Yuki Sakamoto, Shojiro Matsuda
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Patent number: 8479742Abstract: Medical devices and related methods are disclosed for delivering an implant into the body of a patient. The devices include a damping assembly having an internal chamber with a varying inner diameter, and a piston slideably disposed therein. The piston is operably connected with a catheter portion such that movement of the piston is associated with concurrent movement of the catheter for implant delivery. The varying inner diameter of the damping assembly results in a decrease in damping force during implant delivery, thus providing a substantially constant velocity of implant delivery.Type: GrantFiled: February 28, 2011Date of Patent: July 9, 2013Assignee: Hologic, Inc.Inventor: Matthew LaPlaca
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Patent number: 8414657Abstract: The invention concerns an injection implant for filling up wrinkles, thin lines, skin cracks and scars, for reparative or plastic surgery, aesthetic dermatology, and for filling up gums in dental treatment. The invention concerns the use of biologically absorbable polymer microspheres or microparticles suspended in a gel. The suspension is produced either ready-for-use or freeze-dried. The biological absorbability of the microspheres is controlled and enables the production of implants having well defined persistence and deliberately limited to 3 years.Type: GrantFiled: May 21, 2012Date of Patent: April 9, 2013Assignee: Valeant International BermudaInventors: Jerome Asius, Hatem Fessi, Franck Gouchet, Benedicte Laglenne, Elisabeth Laugher-Laglenne
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Publication number: 20130084315Abstract: The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.Type: ApplicationFiled: November 26, 2012Publication date: April 4, 2013Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Boston Scientific Scimed, Inc.
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Publication number: 20130073055Abstract: Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation. Thus, the scaffold can be effectively used as a matrix for the regeneration of ligaments and tendons and the repair of injured muscles.Type: ApplicationFiled: March 16, 2011Publication date: March 21, 2013Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Jung-Keug Park, Young Kwon Seo, Mi Jung Han, Hwa Sung Lee, Su Rak Eo, Hee Hoon Yoon, Soon Yong Kwon, Hee Jung Park
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Publication number: 20130060348Abstract: A surgical implant is provided which includes a body and a coating in contact with at least a portion of the body, the body including metallic magnesium, the coating including a hydrogel having an adhesion peptide contained therein. The adhesion peptide may be derived from an extracellular matrix protein and may be covalently bonded to the hydrogel. A method of making a surgical implant includes providing a magnesium based degradable implant body; applying and adhering a functionalized reactive silane based adhesion promoting layer to the implant body; providing a hydrogel monomeric solution having extracellular matrix adhesion peptides incorporated therein; and contacting the hydrogel monomeric solution with the adhesion promoting layer such that the hydrogel polymerizes and bonds to the adhesion promoting layer and encapsulates at least a portion of the implant.Type: ApplicationFiled: August 27, 2012Publication date: March 7, 2013Applicant: Tyco Healthcare Group LPInventors: Gerald Hodgkinson, Ahmad Robert Hadba
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Patent number: 8361164Abstract: The construct described herein allows opposing tissues to form adhesions with either side of the construct, as part of the natural healing process. The construct however is multi-layered, wherein the space between the layers provides the protection from unwanted adhesions forming between and bonding separate tissues. In one embodiment, this space between layers of the construct may be developed spontaneously, that is the multiple layers are released by design after a finite time and the opposing tissues are free to move independent of each other, free of adhesions.Type: GrantFiled: July 19, 2010Date of Patent: January 29, 2013Assignee: Kensey Nash CorporationInventor: David M. Hoganson
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Publication number: 20130004549Abstract: An object of the present invention is to provide a three-dimensional cell support that is capable of uniformly distributing cells and retaining the cells in a state without nonuniformity and is made of a biodegradable material. The present invention provides a cell support consisting of a porous body made of a biodegradable material, the porous body having the following properties: (a) a porosity from 81% to 99.99%, (b) an average pore size of 10 to 400 ?m, (c) having a hole interconnecting pores, and (d) a water absorption rate from 1000% to 9900%.Type: ApplicationFiled: March 1, 2011Publication date: January 3, 2013Applicant: FUJIFILM CORPORATIONInventors: Kentaro Nakamura, Masaki Nakamura
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Patent number: 8288745Abstract: A novel method of partial breast radiation utilizing a breast implant which can provide a stable and improved target for stereotactic radiation treatment.Type: GrantFiled: April 28, 2008Date of Patent: October 16, 2012Assignee: Senorx, Inc.Inventors: John Corbitt, Lorl Anthony
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Patent number: 8226729Abstract: Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an intervertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50% of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenetic proteins and LIM mineralization proteins.Type: GrantFiled: October 24, 2001Date of Patent: July 24, 2012Assignee: Warsaw Orthopedic, Inc.Inventor: William F. McKay
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Patent number: 8226713Abstract: A coating for an orbital implant where the coating has an anterior portion having a different, longer term bioabsorbability than a posterior portion. This allows the implant to have a smooth surface for insertion and to provide reduced irritation to neighboring tissues, to help prevent exposure of the porous core of the implant, and to provide a stable anchorment for extraocular muscles, but which also encourages rapid fibrovascular ingrowth. The coating is marked with a visual indicator to facilitate proper orientation. Shell materials are further selected to allow for sterile packaging, the securing of therapeutic agents thereon, and to provide adequately strong securing of the coating to the core. Apertures are formed through the coating to enhance fluid flow to and from the core, and to provide exposure of the surface of the core to extraocular muscles, and for sutures. The apertures are sized and shaped to reduce irritating surface contact with orbital tissues.Type: GrantFiled: July 9, 2008Date of Patent: July 24, 2012Inventor: Arthur C. Perry
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Patent number: 8222349Abstract: A bioabsorbable material which is flexible and degradable at a controlled rate, and an in-vivo indwelling device made thereof. The bioabsorbable material is a copolymer composed of an aromatic compound having an ?,?-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, and a polycarbonate or a monomer constituting polycarbonate. Alternatively, it is a copolymer composed of, as the first component, an aromatic compound having an ?,?-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, as the second component, an aromatic compound having an ?,?-unsaturated carboxylic group and at least two hydroxyl groups as substituents on the aromatic ring, and, as the third component, a polycarbonate or a monomer constituting polycarbonate.Type: GrantFiled: September 21, 2010Date of Patent: July 17, 2012Assignee: Terumo Kabushiki KaishaInventors: Mitsuru Akashi, Michiya Matsusaki, Yotaro Fujita, Makoto Onishi
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Patent number: 8216299Abstract: The present invention provides remodelable materials for retracting the interior walls of a body vessel via remodeling processes. Also provided are methods, kits and devices for the same.Type: GrantFiled: March 31, 2005Date of Patent: July 10, 2012Assignee: Cook Medical Technologies LLCInventors: Ram H. Paul, Jr., Brian C. Case
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Patent number: 8211085Abstract: Therapeutic device intended for the selective cytoreductive treatment of an obstruction in a natural lumen or passage of the human or animal body, said lumen being obstructed by the effect of a local cell proliferation, said device comprising a tubular element, in particular of cylindrical shape, intended to be placed in said natural lumen and sufficiently flexible to conform to said natural lumen, but sufficiently rigid to maintain an artificial channel in said lumen. The tubular element supports lengthwise a medicinal sleeve which is intended to come into line with, and into contact with, the obstruction once the natural lumen has been intubated, and is designed to deliver locally, at least in its outer surface portion, at least one therapeutic agent which is cytoreductive, in particular cytotoxic, through contact with the cells under whose effect said lumen is obstructed.Type: GrantFiled: December 22, 2004Date of Patent: July 3, 2012Inventor: Marian Devonec
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Patent number: 8211168Abstract: This invention is directed to graft materials for implanting, transplanting, replacing, or repairing a part of a patient and to methods of making the graft materials. The present invention is also directed to stent grafts and endoluminal prostheses formed of the graft materials. More specifically, the present invention is a graft material which includes porous polymeric sheet, extracellular matrix material (ECM) disposed on at least a portion of the porous polymeric sheet and at least one polymer layer disposed on at least a portion of the ECM. The ECM may be in a gel form. The polymeric sheet and the polymer layer may be made from foam material and may comprise a polyurethane urea and a surface modifying agent such as siloxane.Type: GrantFiled: February 20, 2007Date of Patent: July 3, 2012Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLCInventors: James D. Purdy, David D. Grewe, Kurt Dierking, Lal Ninan, Jichao Sun
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Patent number: 8197553Abstract: A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 ?m.Type: GrantFiled: September 29, 2008Date of Patent: June 12, 2012Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Dan Gazit, Abraham J. Domb, Gadi Turgeman, Gadi Pelled, Tony Azzam
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Patent number: 8177854Abstract: “Implants, such as interbody spacers, fusion devices and bone grafts, are provided having improved mechanical properties and/or degradation profiles. Such implants include a three-dimensional scaffold formed from particles, such as microspheres, which may in some embodiments be resorbable or biodegradable and which may have at least two different degradation rates. In some embodiments, the scaffold may be elastomeric. The three-dimensional scaffold may be for example, porous or semi-porous. Also provided are kits including such implants, and methods of producing and using the same.Type: GrantFiled: July 31, 2009Date of Patent: May 15, 2012Assignee: Globus Medical, Inc.Inventor: Mark Borden
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Patent number: 8172908Abstract: The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site.Type: GrantFiled: December 23, 2008Date of Patent: May 8, 2012Assignee: The University of Hong KongInventors: Wing Yuk Ip, Chi Keung Yuen
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Patent number: 8142502Abstract: An apparatus and method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.Type: GrantFiled: July 19, 2010Date of Patent: March 27, 2012Assignee: Biomet Sports Medicine, LLCInventors: Kevin T. Stone, Karen S. Troxel
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Patent number: 8137702Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: GrantFiled: December 29, 2010Date of Patent: March 20, 2012Assignee: DePuy Mitek, Inc.Inventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Patent number: 8128707Abstract: The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material.Type: GrantFiled: May 20, 2009Date of Patent: March 6, 2012Assignee: Children's Medical Center CorporationInventor: Anthony Atala
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Patent number: 8127770Abstract: A method of treating a ligament or tendon according to the present invention can include inserting a tissue-generating implant into the ligament or tendon to thereby treat the defect. The tissue-generating implant has a plurality of microparticles. The microparticles subsequently form a biological scaffold which operates at least as partial connective tissue in the ligament or tendon giving structural support during regrowth.Type: GrantFiled: August 30, 2005Date of Patent: March 6, 2012Assignee: SpineOvations, Inc.Inventors: Neville Alleyne, Stuart Young
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Patent number: 8118867Abstract: A coating for an orbital implant where the coating has an anterior portion having a different, longer term bioabsorbability than a posterior portion. This allows the implant to have a smooth surface for insertion and to provide reduced irritation to neighboring tissues, to help prevent exposure of the porous core of the implant, and to provide a stable anchorment for extraocular muscles, but which also encourages rapid fibrovascular ingrowth. The coating is marked with a visual indicator to facilitate proper orientation. Shell materials are further selected to allow for sterile packaging, the securing of therapeutic agents thereon, and to provide adequately strong securing of the coating to the core. Apertures are formed through the coating to enhance fluid flow to and from the core, and to provide exposure of the surface of the core to extraocular muscles, and for sutures. The apertures are sized and shaped to reduce irritating surface contact with orbital tissues.Type: GrantFiled: March 21, 2007Date of Patent: February 21, 2012Inventors: Arthur C. Perry, Roger J. Greenwald
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Patent number: 8105391Abstract: Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.Type: GrantFiled: April 1, 2010Date of Patent: January 31, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Connie S. Kwok
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Patent number: 8088060Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.Type: GrantFiled: November 15, 2006Date of Patent: January 3, 2012Assignee: OrbusNeich Medical, Inc.Inventors: Robert John Cottone, Jr., Margaret Yoklavich, Sherry Parker
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Patent number: 8083726Abstract: A method including combining a cellular component with a viability enhancer material wherein the combination will inhibit an interaction between the cellular component and a delivery device; and delivering the cellular component through the delivery device. An apparatus including a delivery cannula having dimensions suitable for percutaneous delivery and a lumen therethrough, wherein a portion of a luminal surface of the cannula includes a coating that is amenable to a cellular component delivered through the delivery cannula. A method including percutaneously introducing a delivery cannula into a blood vessel; advancing a distal portion of the delivery cannula to a treatment site; and delivering a cellular component through a lumen of the delivery cannula, wherein a portion of a luminal surface of the cannula includes a coating that is amenable to a cellular component delivered through the delivery cannula.Type: GrantFiled: September 30, 2005Date of Patent: December 27, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Edwin Wang
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Patent number: 8067071Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.Type: GrantFiled: September 18, 2008Date of Patent: November 29, 2011Assignee: Gore Enterprise Holdings, Inc.Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
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Patent number: 8048503Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.Type: GrantFiled: July 29, 2005Date of Patent: November 1, 2011Assignee: Gore Enterprise Holdings, Inc.Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
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Patent number: 8048500Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.Type: GrantFiled: February 19, 2009Date of Patent: November 1, 2011Assignee: Gore Enterprise Holdings, Inc.Inventors: Paul D. Drumheller, Ted R. Farnsworth, Charles Flynn, Byron K. Hayes, Charles F. White
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Publication number: 20110264237Abstract: The present invention relates to an implant intended to replace or reinforce defective orthopaedic tissue, such as a tendon or ligament, comprising: a bioresorbable porous matrix based on a collagen sponge; a porous three-dimensional knit having a longitudinal direction, characterized in that: said porous matrix fills said three-dimensional knit said three-dimensional knit having two opposite faces, a front face and a rear face, connected to one another by a spacer, at least one of said front and rear faces has at least one weave of pillar stitch type in the longitudinal direction of said knit.Type: ApplicationFiled: October 21, 2009Publication date: October 27, 2011Applicant: SOFRADIM PRODUCTIONInventors: Yves Bayon, Philippe Gravagna, Alfredo Meneghin
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Patent number: 8029575Abstract: Implants, such as interbody spacers, fusion devices and bone grafts, are provided having improved mechanical properties and/or degradation profiles. Such implants include a three-dimensional scaffold formed from particles, such as microspheres, which may in some embodiments be resorbable or biodegradable and which may have at least two different degradation rates. In some embodiments, the scaffold may be elastomeric. The three-dimensional scaffold may be for example, porous or semi-porous. Also provided are kits including such implants, and methods of producing and using the same.Type: GrantFiled: October 24, 2006Date of Patent: October 4, 2011Assignee: Globus Medical, Inc.Inventor: Mark Borden
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Patent number: 8025676Abstract: Provided is a method of producing a bioabsorbable, implantable substrate having a graded molecular weight distribution, comprising exposing at least a portion of the implantable substrate to electron beam irradiation. There is also provided a bioabsorbable, implantable substrate comprising a bioabsorbable polymer having a graded molecular weight distribution through at least a portion of its thickness.Type: GrantFiled: February 10, 2005Date of Patent: September 27, 2011Assignee: The Queen's University of BelfastInventor: Fraser James Buchanan
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Patent number: 8016865Abstract: A method of replacing an ACL with a graft. The method provides for the drilling bone tunnels in a femur and a tibia. A replacement graft is provided having first and second ends. A biodegradable composite screw is provided. The screw is made from a biodegradable polymer and a bioceramic or a bioglass. At least one end of the graft is secured in a bone tunnel using the biodegradable composite screw.Type: GrantFiled: September 29, 2003Date of Patent: September 13, 2011Assignee: DePuy Mitek, Inc.Inventors: Lisa Donnelly, Yufu Li, Joan M. Sullivan, Gregory Whittaker, J. Jenny Yuan
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Patent number: 8007542Abstract: The invention involves a submucosa tissue that has the capability of being shape formed or shape configured. The submucosa involves a purified form of submucosa tissue. Optionally, the submucosa can be packaged in such a manner to permit sterility or maintain sterility of the submucosa.Type: GrantFiled: October 31, 2007Date of Patent: August 30, 2011Assignee: Cook Biotech IncorporatedInventors: Michael C. Hiles, Umesh H. Patel
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Patent number: 8002843Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: February 4, 2004Date of Patent: August 23, 2011Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, John Winterbottom, David Kaes, Todd Boyce, Lawrence A. Shimp
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Patent number: 7947073Abstract: Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.Type: GrantFiled: October 23, 2009Date of Patent: May 24, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Barry N. Gellman, Jianmin Li
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Patent number: 7931030Abstract: The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods of the invention may be further characterized in that they contain less than 20 mg/ml HA, at least 5% (w/w) of which is in a gel form, such as, e.g., hylan B. In an illustrative embodiment, hylan G-F 20 (Synvisc®) is administered in a single intra-articular knee injection of 6±2 ml.Type: GrantFiled: December 20, 2005Date of Patent: April 26, 2011Assignee: Genzyme CorporationInventor: François Bailleul
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Patent number: 7923022Abstract: An implantable medical device is disclosed comprising: a structural element, wherein the structural element includes: a continuous phase comprising a first polymer of LPLG; a discrete phase within the continuous phase, wherein the discrete phase comprises a second polymer including rapidly eroding elastic discrete phase segments. The second polymer further includes anchor segments that have the same or substantially the same chemical make up as the first polymer of the continuous phase, and at least some of the anchor segments have partially or completely phase-separated from the discrete phase into the continuous phase.Type: GrantFiled: September 13, 2006Date of Patent: April 12, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Yunbing Wang, David C. Gale
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Patent number: 7897167Abstract: An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.Type: GrantFiled: June 21, 2006Date of Patent: March 1, 2011Assignees: Cook Incorporated, Cook Biotech IncorporatedInventors: David N. Armstrong, Brian L. Bates, Mark W. Bleyer, F. Joseph Obermiller, Umesh H. Patel
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Publication number: 20110034996Abstract: One embodiment of the invention concerns a medical implant with the basic body having an antioxidative substance.Type: ApplicationFiled: July 20, 2010Publication date: February 10, 2011Inventor: Alexander Borck
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Patent number: RE43714Abstract: Repairs of cartilage defects or of cartilage/bone defects in human or animal joints with the help of devices including a bone part (1), a cartilage layer (2) and a subchondral bone plate (4) or an imitation of such a plate in the transition region between the cartilage layer (2) and the bone part (1). After implantation, the bone part (4) is resorbed and is replaced by reparative tissue only after being essentially totally resorbed. In a critical phase of the healing process, a mechanically inferior cyst is located in the place of the implanted bone part (1). In order to prevent the cartilage layer (2) from sinking into the cyst space during this critical phase of the healing process the device has a top part (11).Type: GrantFiled: December 12, 2000Date of Patent: October 2, 2012Assignee: Zimmer Orthobiologics, Inc.Inventors: Daniel Nadler, Pedro Bittmann, Margarete K. Akens, Brigitte Von Rechenberg, Jorg Auer