Abstract: Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The completed fitted assembly supports and allows for transporting a graft or implant with an assembly that comprises; a vial that is either cylindrical or rectangular cuboid and lid that includes a poly-cone insert, a support base so that the vial is able to stand upright and remain motionless, support columns integrated seamlessly within the vial with apertures that provide for full fluid communication and notches for positioning and support of an assembled corneal tissue carrier that is suited to accommodate compressive force generated between said lid and said notches, in addition to being able to accommodate a tissue carrier assembly via compression forces between said lid and a bottom surface of said vial, and a rectangular cuboid shape that also includes a flat transparent surface that provides inspection of corneal tissue visually or via instrumentation.

Abstract: An ophthalmic implant including an intraocular lens (IOL) and at least one drug delivery device. The IOL including an anterior side, a posterior side, a lens, and at least one haptic extending outwardly from the lens and including a first haptic extending from the lens at a first optic-haptic junction. The at least one drug delivery device including a first drug delivery device including a pad and a fixation portion extending from the pad. The pad including at least one therapeutic agent contained therein, an anterior surface, a posterior surface, and a sidewall extending around the pad and between the anterior surface and the posterior surface. The drug delivery device configured for attachment to the IOL via the fixation portion. In an assembled state of the implant, the first drug delivery device is attached to the IOL and the pad overlays the first optic-haptic junction.

Abstract: Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The assembly includes a corneal tissue carrier within a vial, the transport vial removably coupled to a stabilization base, wherein the ease of access to the graft carrier allows administering the corneal tissue sample to a patient in rapid succession so that more surgeries can be performed by a single surgeon in a single day.

Abstract: Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The assembly includes a corneal tissue carrier, optimized for DSAEK and UT-DSAEK corneal grafts, within a transport vial, the transport vial removably coupled to a stabilization base, wherein the ease of access to the graft carrier allows administering the corneal tissue sample to a patient in rapid succession so that more surgeries can be performed by a single surgeon in a single day.

Abstract: The invention is directed to an intraocular lens having an optical body, two haptic elements and first and second sets of a plurality of ropes corresponding to respective ones of the first and second haptic elements. The ropes are secured to the optical body and to the haptic element and have a severing sequence. The haptic elements each have a compressed state, a partly compressed state and an uncompressed state. In the compressed state, the first rope of the severing sequence is configured to deform the haptic element in a direction toward the optical body as a result of which the first rope is under a tensile stress and the rest of the ropes are stress-free and, by the ropes being severed successively in the severing sequence, the haptic element can be brought firstly to the partly compressed state. All the ropes are severed in the uncompressed state.

Abstract: A method and device for reducing intraocular pressure in a patient. The method may comprise deploying administering a viscoelastic material into Schlemm's canal to open aqueous humor outflow pathways. The device is adapted to perform the method. The viscoelastic material may be configured to lower the intraocular pressure within the eye.

Abstract: The invention relates to an apparatus and method that provides hydraulically assisted delivery of intraocular lenses (IOL) from a insertion tool. The IOL insertion system having an insertion rod with a tube having a first end and a second end, a piston head affixed to the insertion rod and positioned between the first and second end, a hydraulic chamber, an aspiration line communicatively connected to the hydraulic chamber, and at least one valve in fluid communication with the aspiration line, wherein the insertion rod moves in response to the displacement of hydraulic fluid within the hydraulic chamber.

Abstract: Intraocular lens delivery devices and methods of use.

Abstract: The present disclosure relates generally to the fields of medical devices, ophthalmology, and cataract surgery, and more particularly to, for example, a capsular tension ring. The capsular tension ring can include an inner ring section, and an outer ring section at least partially enveloping the inner ring section. The outer ring section can have an outer ring surface, an inner ring surface, and a plurality of raised polygon features on the inner ring surface, wherein each of the raised polygon features is radially symmetric.

Abstract: An intraocular lens (IOL) insertion apparatus includes a handpiece body having a distal tip and a proximal section. The IOL insertion apparatus also includes a folding chamber located within the handpiece body, the folding chamber shaped to fold an IOL advancing through the folding chamber. The IOL insertion apparatus also includes an advancement system. The advancement system includes an advancement carriage movable between a first position and a second position within the handpiece body. The advancement carriage includes a spring system biasing the advancement carriage in a distal direction toward the second position and a dampening system to dampen motion of the advancement carriage. The advancement system further includes an elongated advancement plunger that includes a distal end to advance the IOL through the folding chamber and a proximal end connected to the advancement carriage.

Abstract: An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. The implant includes a spine extending along a longitudinal axis of the implant, a plurality of curved supports extending from the spine, each support comprising a first end extending from a first location on a first side of the spine and a second end extending from a second location on a second side of the spine, the second location being proximal to the first location, so that each support forms a portion of a helix, the spine and supports defining a volume having a maximum width perpendicular to the longitudinal axis between 0.005 inches and 0.04 inches, the ocular implant being configured to bend preferentially in a preferential bending plane.

Abstract: An intra-ocular device includes an electronic lens that can be controlled to control the overall optical power of the device. The device can be installed within a flexible polymeric material shaped to conform to the inside surface of a lens capsule of an eye. Accommodation forces applied to the device and/or polymeric material via the lens capsule can cause a change in the optical power of the device and/or polymeric material. Further, such accommodation forces can be detected by an accommodation sensor of the device and the optical power of the electronic lens can be controlled based on the detected accommodation forces. Operated in this way, the device and polymeric material can restore a degree of accommodation to the eye that is related to existing mechanisms for controlling such accommodation, i.e., forces exerted by the eye via the lens capsule.

Abstract: An apparatus includes an intraocular pseudophakic contact lens. The intraocular pseudophakic contact lens includes an optical lens configured to at least partially correct a residual refractive error in an eye. The residual refractive error includes a refractive error that exists in the eye after implantation of an artificial intraocular lens in the eye. The intraocular pseudophakic contact lens also includes one or more haptics configured to be inserted under an anterior leaflet of a capsular wall in the eye in order to capture and confine the one or more haptics under the anterior leaflet and secure the intraocular pseudophakic contact lens against the artificial intraocular lens.

Abstract: Medical kits and methods for performing small incision DLEK include a corneal transplantation donor tissue graft formed into an implantable and compact rolled configuration using the flexible substrate.

Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.

Abstract: Intraocular lens inserters and methods of use are disclosed. An example intraocular lens inserter may include an interior assembly having a movable member disposed therein. The movable member is movable in response to a pressure of a compressed gas. In response to the pressure of the compressed gas, the moveable member pressurizes a substantially incompressible fluid. The pressurized substantially incompressible fluid is used to advance a plunger. The plunger advances an intraocular lens through a lumen for insertion into an eye.

Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

Abstract: A method of inserting an intraocular lens into an eye comprises: determining preoperative values of an eye; selecting an intraocular lens based on the preoperative values; inserting the intraocular lens into the eye; determining intraoperative values of the eye; providing an eye model, wherein the eye model includes plural parameters; determining the second value representing a postoperative visual defect of the eye using the eye model, wherein the preoperative values of the eye are assigned to a first subset of the plural parameters of the eye model and wherein the intraoperative values of the eye are assigned to a second subset of the plural parameters of the eye model; and correcting the position and/or the orientation of the inserted intraocular lens or inserting a different intraocular lens based on the value representing the postoperative visual defect of the eye.

Abstract: A prosthetic capsular device configured to be inserted in an eye includes a housing structure and a ring structure. The housing structure includes a first side, a second side opposite the first side, a third side, a fourth side opposite the third side, a posterior side including a refractive surface, an anterior side opposite the posterior side, and a longitudinal axis. The first side, the second side, the third side, the fourth side, the posterior side, and the anterior side at least partially define a cavity configured to contain an intraocular device (e.g., an IOL). The anterior side includes an opening. The ring structure includes a ring structure portion extending radially outward from proximate one of an end of the first side and an end of the second side.

Abstract: An intraocular lens injection instrument including: an injection part formed with an inner wall for folding the soft IOL and a front end for injecting the IOL folded along the inner wall into an eye; a cylinder body part provided with the injection part at its end portion; a push member for pushing the IOL toward the front end of the injection part, a restriction member attached to the cylinder body part to restrict movement of the IOL which is placed outside the axis; and a release member for releasing the restriction member and pushing the IOL onto the axis, wherein the release member includes a contact portion to be brought into contact with the IOL when the restriction by the restriction member is released, the contact portion having a setting surface to be brought into contact with the IOL placed on the axis.

Abstract: An intraocular lens inserting instrument (1) capable of folding a lens (2) and pressing it by a plunger (4) to discharge it into an eye and capable of taking out the folded lens (2) by tweezers (15). The intraocular lens inserting instrument (1) for inserting a foldable intraocular lens (2) into an eye has a tubular body (3) for allowing the intraocular lens (2) to pass through it and introducing it into the eye, and a plunger (4) for pressing the intraocular lens (2) to discharge it into the eye, wherein the intraocular lens (2) is folded by a folding member (8) provided at a lens placing section (5). The lens placing section (5) has an open/close lid (12) so that the folded intraocular lens (2) can be held by the tweezers (15).

Abstract: An apparatus comprising a deformable lens element can be provided wherein a deformable lens element can be deformed to change an optical property thereof by the impartation of a force to the deformable lens element.

Abstract: A single-optic accommodative lens system includes two intraocular elements designed to be located within the capsular bag to extend depth of focus and/or restore accommodation following cataract extraction of a natural lens. A first intraocular element comprises a circumferential capsular ring having interlock features to couple to and control the dynamic vault response of a second intraocular element. This second intraocular element comprises an intraocular lens (IOL) having an optic and a plurality of haptics and is designed to move axially in response to changes in the geometry of the eye capsule and thus provide a range of accommodative power. The IOL further comprises interlock features complementary to the interlock features of the first intraocular element for coupling the IOL to the capsular ring in a manner that provides for controlled movement of the IOL in response to capsular forces.

Abstract: Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A cap is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.

Abstract: A system for easily transferring an intraocular lens (IOL) from a lens case to an inserter, and then into a patient's eye. The lens case has a transfer mechanism therein which retains the IOL until engagement with the inserter. The transfer mechanism may include jaws having a closed configuration for retaining the IOL and an open configuration for releasing the IOL. Engagement of the inserter with the lens case automatically opens the jaws and transfers the IOL to the inserter. The IOL is transferred into a load chamber of a nosepiece rotatably coupled to a handpiece. After transfer of the IOL, the nosepiece is rotated from a load position to a delivery position. The IOL may have an optic and a haptic coupled to the optic, and the lens case may be capable of configuring the haptic as desired to facilitate its transfer into an inserter and/or into the eye. For instance, the lens case may fold one or both of the haptics over the optic.

Abstract: A method for inserting a lens into a corneal pocket or flap includes providing a lens inserter device, opening a first leaf and a second leaf of the device, positioning a slot of each one of a first and a second lens shaped portion over a post on a packaging of the lens, positioning the lens between the first leaf and the second leaf, inserting the lens into the corneal pocket, and releasing the lens from the lens inserter device.

Abstract: An apparatus for safely retaining an eye implant lens for transport and access for inspection and use in which a holding apparatus has a chamber for holding a lens. In one embodiment the chamber has a pin on which a lens can be placed and a ramp leading to the pin so that a gripping member can slide up the ramp into proper placement to grip the lens and remove it. The gripper can be configured so that after removing the lens from the holding apparatus, it can be used to implant the lens. Also, a system including the apparatus and a bottle assembly that will hold the apparatus in the bottle. A method for holding an eye implant lens in which a lens is placed in the apparatus which can then be placed in a bottle assembly.

Abstract: A system designed to store an implant together with the tools necessary to implant the stored implant, and a method of using such system. Such system includes an implant storage tool adapted to retain the implant within a storage container. The implant storage tool is operable to provide an implant applicator.

Abstract: An intraocular lens inserter can include an energy storage portion, an actuator portion, and a lens support portion. The energy storage portion can include a compressible energy storage device, such as a compressible fluid, springs, and other devices. The inserter can include an actuator portion operating with a substantially incompressible fluid, such as liquids or other noncompressible fluids. The actuator can be configured to provide an operator with control over the release of energy from the energy storage portion so as to move a plunger for the discharge of a lens from an intraocular lens cartridge.

Abstract: The invention relates to an implant device comprising a sensor module which comprises one or more first fastening means, an implant module which comprises one or more second fastening means, and a connecting module, by means of which the sensor module is connected to the implant module via the one or the first fastening means and via the one or the second fastening means, and comprising a fold axis, along which the implant device can be folded up.

Abstract: Intraocular lens delivery devices and methods of use.

Abstract: An intraocular lens insertion instrument capable of smoothly pushing out a preset lens is provided. An intraocular lens insertion instrument (1) comprises: a main body (3) including a lens setting section (8) on which a lens (2) is set, a transition section (22) that deforms the lens (2), and a nozzle piece (21) that releases the lens (2); and a lens push-out mechanism (4) that pushes out the lens (2) set on the lens setting section (8). The instrument (1) further includes a releasing means (11) for releasing the lens (2) pushed by the lens push-out mechanism (4) from the lens setting section (8). The releasing means (11) has a posture holding mount (12) that holds the lens (2) with a forward tilt relative to an axial line (A) of lens movement. The posture holding mount (12) has a passage (15) through which the lens push-out mechanism (4) passes.

Abstract: A system for easily transferring an intraocular lens (IOL) from an inserter into a patient's eye. The system includes an inserter handpiece with a holding station for receiving or storing an IOL. The IOL may be pre-loaded within the holding station during manufacture, and the inserter handpiece coupled to a delivery tube so that the entire system is ready for use by a surgeon to implant an IOL. The IOL may have an optic and leading and trailing haptics coupled to the optic, and the holding station may be capable of manipulating the haptics as desired to facilitate transfer of the IOL through the delivery tube into the eye. For instance, the holding station may fold one or both of the haptics over the optic. Preferably, the holding station maintains the haptics in their folded positions during transfer of the IOL into the delivery tube. The holding station desirably maintains the IOL in a relaxed configuration during storage.

Abstract: Various systems, apparatuses, and processes may be used for intraocular lens surgery. In particular implementations, a system for intraocular lens surgery may include an intraocular lens insertion cartridge and an intraocular lens interface adapted to engage intraocular lens for advancement through the intraocular lens insertion cartridge. The system may also include a bracket that is detachably attached to the intraocular lens insertion cartridge and that facilitates securing the intraocular lens interface relative to the intraocular lens insertion cartridge.

Abstract: An intraocular lens (IOL) transfer case for transferring an IOL to an injection cartridge includes a lens holder for holding the IOL. The lens holder includes a bore. Folding members within the lens holder are configured to fold the IOL into a partially folded position when the IOL is slid through the bore across the folding members. The IOL transfer case also includes an interface configured to removably connect to an injection cartridge. The interface is positioned to deliver the IOL in the partially folded position within the injection cartridge when the interface is connected to the injection cartridge. The IOL transfer case also includes a plunger connected to the lens holder and configured to push the IOL in the partially folded position through the bore to deliver the IOL into the injection cartridge.

Abstract: An injector for inserting an intraocular lens (IOL) into an eye, comprising: a first side wall and a second side wall which are movable relative to one another, each side wall including a void, the voids positioned opposite one another in a direction perpendicular to a longitudinal axis of the injector. The injector may be in a combination with the IOL, the IOL disposed on a portion of the injector. The IOL may be in an unstressed state. A first portion of a haptic of the IOL may extend into the void in the first side wall.

Abstract: Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.

Abstract: Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.

Abstract: A sealing device for use inside a capsular bag after the natural lens has been removed has a plug part adapted to seal a rhexis in a capsular bag, thus preventing displacement through the rhexis of a lens-forming liquid material injected through the rhexis and adapted to replace the natural lens and form an intraocular lens implant. The plug part has a slightly larger area than the capsulorhexis and is made of a deformable polymer. The sealing device further has a removable adjuster connected to the plug part, the adjuster protruding anteriorly from an outer surface of the plug part and being capable of positioning the plug part to a desired location.

Abstract: An assembly for implanting ocular implants into a mammalian eye is provided. The assembly generally includes a cannula having a curved distal end, an injector mechanism coupled to the cannula for linearly moving one or more implant segments in the cannula toward the curved distal end, and a rotator mechanism for rotating the cannula about a longitudinal axis thereof.

Abstract: An intraocular lens (IOL) injector for delivering an IOL into an eye of a patient includes an IOL load chamber and connected delivery tube, and a push rod for urging the IOL through the delivery tube and out of a distal tip thereof. The push rod is guided and biased against one side of the injector load chamber. The injector may include an inflatable pusher for urging the IOL through the delivery tube and out of a distal tip thereof. The inflatable pusher has a proximal end that may be open to an internal cavity of the injector, wherein a plunger movable in the injector cavity forces fluid such as air or saline into the pusher. A distal end of the pusher may be forked to capture a trailing end of the IOL, or may have a bulbous configuration to ensure the pusher does not pass the IOL.

Abstract: A method of delivering an intraocular lens into an eye is disclosed. The intraocular lens is heated. The intraocular lens is maintained within a desired temperature range. The intraocular lens is injected into the eye when the intraocular lens is within the desired temperature range.

Abstract: A method of folding a multiple element IOL comprising folding the first lens element and second lens element such that the second lens element at least partially surrounds the first lens element and such that, after folding, both the first lens element and the second lens element are substantially aligned along the optical axis. A hinged apparatus such as a cartridge may be used to cause the second lens element to be folded. A method of loading a multielement IOL comprising folding the haptics such that a portion of the haptics contacts an exterior side of one of the first lens element and the second lens element.

Abstract: An injector (1) for folding and injecting into the eye of a patient a flexible intraocular lens, the injector comprising an assembly of an injection nozzle (202), a lens compartment that holds an unfolded flexible intraocular lens (400) and is in communication with the injection nozzle, an injector body (3) communicating with the lens compartment and a plunger (2) that is inserted in the free end of the injector body, wherein lens compartment and injector body comprise a mechanism whereby the lens is first folded by forces compressing the lens in a non-axial direction in response to an axial movement of the plunger over a first distance and is subsequently expelled from the injector through the injection nozzle in response to an axial movement of the plunger over a second distance.

Abstract: A intravitreous stent includes a multi-loop single wire having a proximal end; a distal end; at least a first loop defined by the proximal end and a first portion of the single wire; at least a second loop defined by the distal end and a second portion of the single wire; wherein the first portion is joined to the second portion via a reversing loop portion.

Abstract: System and methods for a corrective eye procedure include at least one application device configured to be positioned at a selected area of an eye (e.g., equatorial sclera, posterior sclera, cornea, etc.). The at least one device includes at least one channel and at least one illumination guide. A cross-linking agent source is coupled to the at least one channel. An illumination source is coupled to the at least one illumination guide. The at least one device delivers the cross-linking agent to the selected area of the eye. The at least one device delivers photo-activating light from the illumination source to the selected area of the eye after the cross-linking agent has been delivered. The photo-activating light includes one or more doses necessary for activating the cross-linking agent and for activating TGF-? isoforms to improve health of extracellular matrices in the selected area of the eye.

Abstract: An intraocular lens (IOL) delivery device is disclosed. The device includes an intraocular lens cartridge having an internal coating wherein the coating includes a polymeric material that is compatible with a polymeric material of a material that forms the cartridge. Preferably, the polymeric material of the coating, the cartridge or both is a polyurethane material.

Abstract: An intraocular lens injection device comprises a tubular housing with a plunger longitudinally disposed within the tubular housing. An electric drive system longitudinally translates the plunger so that its tip engages an insertion cartridge to fold and displace an intraocular lens disposed within and to inject the folded lens into the lens capsule of an eye. A control circuit is configured to start translation of the plunger, responsive to user input, to detect at least one fault condition based on a counter-electromotive force produced by the electric motor, and to stop translation of the plunger assembly responsive to the detected fault condition, which may comprise excessive resistance to forward or rearward translation of the plunger or insufficient resistance to forward translation of the plunger.

Abstract: A method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.