Abstract: An intraocular lens comprising an optic and four haptics extending from the optic, each haptic having a proximal end meeting with the optic at differing points about a periphery of the optic. The four haptics are arranged into a first pair comprising two arcuate haptics with curvature orientated toward each other such that a distal end of each of the two haptics of the first pair are in nearer relation than their proximal ends; and, a second pair comprising two arcuate haptics with curvature orientated toward each other such that a distal end of each of the two haptics of the second pair are in nearer relation than their proximal end.

Abstract: The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.

Abstract: Generally, an intraocular implant and methods for treating an ocular condition. As to certain embodiments, an intraocular biocompatible biodegradable implant (11) which can provide a biocompatible biodegradable material in the form of a flexible membrane (12) containing an active agent (24) which implanted between an intraocular lens (8) and the surface of the posterior capsule (5) of the eye (1)(4) inhibits migration of residual lens epithelial cells after cataract surgery by providing structural or pharmaceutical barriers to reduce posterior capsule (5) opacification of the eye (1)(4).

Abstract: Multifocal intraocular lens with extended depth of field that comprises, in at least one of the surfaces (2), a small zone with a multifocal profile with a defined optical axis (3) and, in the peripheral region and coaxial to the multifocal zone, a ring-shaped opaque mask (1) that partially or totally block light to produce a small aperture effect and, therefore, the multifocal profile has a radius equal or larger than the internal radius of the mask (1), and there is at least one transition between focal zones or one diffractive step inside the internal radius of the mask (1).

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: An intraocular lens (IOL) has an optic, a peripheral rim, and a reduced thickness region connecting the optic to the peripheral rim. The peripheral rim has a continuously curving outer edge that it does not include any tangents parallel to the optical axis either along its length or at the intersection of the outer edge with the anterior or posterior surfaces of the IOL.

Abstract: A thin IOL capable of insertion through a small incision into the capsular bag of an eye includes haptics having free ends configured to absorb compressive forces resulting from shrinkage of the capsular bag in the weeks following surgery.

Abstract: Generally, an intraocular implant and methods for treating an ocular condition. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: An intraocular lens to be implanted into the capsular bag after ablation of the crystalline lens includes a central optical portion and a haptic portion including haptic members arranged on the periphery of the optical part and for positioning the intraocular lens in the capsular bag. On the one hand, the posterior surface of the optical portion includes a sharp ridge at the peripheral edge and, on the other hand, the posterior surface of the haptic members includes a proximal area in the vicinity of the peripheral edge of the optical portion, each proximal area including at least one tooth extending substantially along the entire width of each haptic member, the tooth or teeth having a sharp edge that becomes serrated in the posterior capsule in order to limit the migration of the epithelial cells of the haptic members towards the optical portion.

Abstract: Generally, an intraocular implant and methods for treating an ocular condition. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: An intraocular lens comprises an optic and one or more haptics, wherein the or each haptic can be compressed in the plane of the lens, and which additionally comprises, around the optic, an annular rim that, in use, is in contact with the posterior capsular sac.

Abstract: Intraocular lenses with high contrast haptics, materials and methods for making optical blanks and lenses, and methods of use are disclosed and claimed. Such lenses may provide easily recognizable visual cues that may be used to detect and correct misorientation of lenses prior to and during use.

Abstract: An intraocularlens of novel structure by which the outer circumferential part of an optical portion can be pressed stably against a posterior capsule under worn state and crisis of secondary cataract can be suppressed more advantageously. A pair of coupling portions (14, 14) are formed to hold an optical portion (12) between them in one direction perpendicular to the optical axis, wherein the outer fringe parts of the coupling portions (14, 14) are made thicker than the outer fringe part of the optical portion (12), a pair of supporting portions (16, 16) are formed to project from the outer fringe parts of the coupling portions (14, 14) and a edge contour part (32) is formed continuously on the outer fringe parts of the optical portion (12) and respective posterior surfaces (20, 24) of the coupling portions (14, 14) so as to extend smoothly along the entire circumference thereof.

Abstract: Generally, an intraocular implant and methods for treating an ocular condition. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: Provided are a process for producing an intraocular lens capable of inhibiting secondary cataract that may occur after the insertion of an intraocular lens and a secondary-cataract-inhibiting intraocular lens obtained by the above process, and the process is for producing a surface-treated intraocular lens, which comprises irradiating the surface of an intraocular lens with active light that works to decompose oxygen molecules to generate ozone and that also works to decompose the ozone to generate active oxygen, in the presence of oxygen, and the lens is a secondary-cataract-inhibiting intraocular lens obtained by the above process.

Abstract: Various polymers are provided that can be polymerized in the lens capsule with the ability to covalently bond an intraocular lens implant to the posterior capsule of the eye such that there is no space available between the intraocular lens implant and the lens capsule for lens epithelial cells to proliferate and thereby significantly reducing posterior capsule opacification.

Abstract: An accommodating intraocular lens comprising an optic made from solid silicone and liquid silicone. The optic has a central anterior area or membrane that can vary in radius and thus change power.

Abstract: The present invention is in the field of ophthalmic surgery and relates to a method for the prevention of capsular opacification, especially after extraction of the natural lens from the lens capsule of the eye. Particular methods disclosed include replacing the natural lens with a capsule filling implant comprising an injectable material and injecting an agent capable of inhibiting the proliferation of lens epithelial cells, migration of lens epithelial cells, and/or production of extra-cellular matrix by lens epithelial cells into a space between the inserted capsule filling implant and the lens capsule using an instrument having a hydrophobic outer surface such that the composition reaches a germinative zone of the capsular bag.

Abstract: An intraocular lens with an ordered polymer system contained within a lens capsule or a membrane in the lens capsule. The ordered polymer system includes at least one negatively charged copolymer comprising hydrophilic groups, anionic groups and hydrophobic groups, and at least one positively charged copolymer comprising hydrophilic groups, cationic groups and hydrophobic groups. The at least one negatively charged copolymer and the at least one positively charged copolymer are associatively arranged through non-covalent interactions in the lens capsule or the membrane.

Abstract: An intraocular lens for inhibiting posterior capsular opacification, or secondary cataract, includes an optic having a periphery provided with at least two sharp edges which lie radially spaced from each other with respect to the optical axis of the lens optic.

Abstract: An intraocular lens to be implanted into the capsular bag after ablation of the crystalline lens includes a central optical portion and a haptic portion including haptic members arranged on the periphery of the optical part and for positioning the intraocular lens in the capsular bag. On the one hand, the posterior surface of the optical portion includes a sharp ridge at the peripheral edge and, on the other hand, the posterior surface of the haptic members includes a proximal area in the vicinity of the peripheral edge of the optical portion, each proximal area including at least one tooth extending substantially along the entire width of each haptic member, the tooth or teeth having a sharp edge that becomes serrated in the posterior capsule in order to limit the migration of the epithelial cells of the haptic members towards the optical portion.

Abstract: A thin intraocular lens for inhibiting posterior capsular opacification (PCO) includes an optic having a sharp edge which extends posteriorly and between a posterior concave region and an outer-most peripheral edge surface that extends parallel to the optical axis.

Abstract: An accommodating intraocular lens having an optic and portions extending from the optic radially outwards preferably with fixation devices at their distal ends, the optic designed such that it has a sharp posterior edge for 360 degrees of its perimeter and the lens designed such that the optic can move forward and backwards with constriction and relaxation of the ciliary muscle.

Abstract: An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.

Abstract: Coated medical implants have an implant body configured for securing in or adjacent to body tissue of a patient. The implant body has an implant surface and a coating is formed on at least a portion of the implant surface. The coating includes a coating outer surface of a first chemical component that is chemically bonded to a carboxylate functionality of a second chemical component. The second chemical component is immobilized by amide linkage to an underlying third chemical component that is plasma coated directly onto implant body surfaces. The coating either inhibits or prevents the adhesion of protein and/or cellular proliferation or may be a non-fouling coating.

Abstract: An intraocular lens for providing vision to a subject contains an optic, a support structure coupled to the optic. The intraocular lens also includes a textured surface and/or subsurface layer. The optic is disposed about an optical axis and comprises an anterior surface and an opposing posterior surface, the surfaces being configured to focus light when implanted within an eye having a capsular bag. The textured surface is disposed over a surface portion of the intraocular lens and includes a plurality of periodically-spaced protrusions, each protrusion having a smooth distal face and a sharp corner edge configured to engage a wall of the capsular bag and/or at least one cell disposed along the wall.

Abstract: An intraocular lens for providing vision to a subject contains an optic, a support structure coupled to the optic. The intraocular lens also includes a textured surface and/or subsurface layer. The optic is disposed about an optical axis and comprises an anterior surface and an opposing posterior surface, the surfaces being configured to focus light when implanted within an eye having a capsular bag. The textured surface is disposed over a surface portion of the intraocular lens and includes a plurality of periodically-spaced protrusions, each protrusion having a smooth distal face and a sharp corner edge configured to engage a wall of the capsular bag and/or at least one cell disposed along the wall.

Abstract: An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge between the faces. The peripheral edge has one or more curved or angled surfaces that reduce glare within the IOL. For instance, a rounded transition surface on the anterior side of the peripheral edge diffuses the intensity of reflected light, or a particular arrangement of straight edge surfaces refracts the light so as not to reflect, or does not reflect at all. The intersection of the peripheral edge and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge and the intersecting face or faces.

Abstract: An intraocular lens for implantation in a capsule of an eye comprises an optic which has a substantially circular rim, an optical axis, and a lens plane that extends vertically of the optical axis; at least two haptics for support of the optic on the capsule, the haptics being fixed to the optic and forming one piece with the optic and consisting of reversibly deformable material, each haptic having a first Z-shaped haptic clamp articulated to the rim, a second Z-shaped haptic clamp articulated to the rim, and a connecting clamp which is concave in relation to the optical axis, uniting the first haptic clamp and the second haptic clamp.

Abstract: The invention relates to an intraocular implant comprising an optical portion presenting an anterior optical surface (24) and a posterior optical surface (26), and at least one haptic element (12, 14), each haptic element presenting a connection zone at the periphery of the optical portion. Outside the connection zones, the optical portion further comprises a cylindrical side face of diameter D1 connected to the posterior optical surface of the optical portion. The posterior optical surface (26) is bounded by a circle of diameter D1. In each connection zone, the implant comprises a radial extension (30) presenting an anterior face (30a), a posterior face (30b), and a side face (30c) substantially disposed on a ruled surface of diameter D2 where D2>D1, and presenting a length h? in the direction of the axis, said length h? being substantially equal to h. The posterior face (30b) of each extension is disposed on the spherical cap containing the posterior optical surface.

Abstract: An ophthalmologic implant for the prophylaxis or treatment of capsule opacification after implantation and completion of wound healing of a synthetic lens is described. This treatment can be repeated if necessary.

Abstract: An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge between the faces. The peripheral edge has one or more curved or angled surfaces that reduce glare within the IOL. For instance, a rounded transition surface on the anterior side of the peripheral edge diffuses the intensity of reflected light, or a particular arrangement of straight edge surfaces refracts the light so as not to reflect, or does not reflect at all. The intersection of the peripheral edge and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge and the intersecting face or faces.

Abstract: The invention relates to optical elements whose optical properties can be repeatedly adjusted over time. Through the use of modifying compositions capable of stimulus induced polymerization coupled with a blend of stimulus absorbers and initiators, it is possible to repeatedly adjust the optical properties of the element by exposing the lens to a stimulus which exceeds the absorption capacity of the stimulus absorber.

Abstract: A method for prevention of capsular opacification is provided.

Abstract: An intraocular lens for inhibiting PCO and glare includes an optic having a periphery provided with a sharp edge which presses against the posterior capsule wall thereby creating a barrier to LEC migration. While the sharp edge forms a 90° angle, the anterior peripheral surface portion extends along an arc which directs incident light striking the edge of the lens away from the retina.

Abstract: Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.

Abstract: An intraocular lens for inhibiting posterior capsular opacification, or secondary cataract, includes an optic having a periphery provided with a sharp, flexible flange which presses against the posterior capsule wall thereby creating a barrier to LEC migration.

Abstract: An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.

Abstract: A method for prevention of migration of epithelial cells in a capsular bag of an eye of a mammal is provided. The method comprises removing the natural lens of the eye from the capsular bag; introducing an object with at least one sharp edge into the capsular bag, in such a way that said sharp edge contacts the inside of the capsular bag to form a barrier preventing migration of epithelial cells across said barrier; and injecting a lens-forming composition into the capsular bag.

Abstract: Apparatus and methods for protecting the edge geometry of an intraocular lens during polishing are disclosed. The apparatus comprises a protective device having a cavity configured to receive the lens and an annular peripheral portion for surrounding and protecting at least one edge corner of the lens. In one embodiment, the peripheral portion has a constant inner diameter and receives the lens in an interference fit. In another embodiment, the lens is trapped between flanges which extend radially inwardly from the peripheral portion. A lens that is encased in the protective device will have a polished central portion and an unpolished peripheral portion after the polishing process has been completed and the protective device has been removed.

Abstract: An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.

Abstract: An intraocular lens for inhibiting posterior capsular opacification, or secondary cataract, includes an optic having a periphery provided with at least two sharp edges which lie radially spaced from each other with respect to the optical axis of the lens optic.

Abstract: An ophthalmological implant including a layer of pharmaceutical agent and an overlying layer of a bioerodible material, a biodegradable material a bioavailable material or a mixture thereof.

Abstract: An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge between the faces. The peripheral edge has one or more curved or angled surfaces that reduce glare within the IOL. For instance, a rounded transition surface on the anterior side of the peripheral edge diffuses the intensity of reflected light, or a particular arrangement of straight edge surfaces refracts the light so as not to reflect, or does not reflect at all. The intersection of the peripheral edge and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge and the intersecting face or faces.

Abstract: An intraocular lens (IOL) includes an optic for focusing light, an outer ring for supporting the optic in a capsular bag of an eye and a plurality of radially spaced apart, elongated intermediate members connecting the optic to the outer ring. The intermediate members are configured to convert radial forces exerted by the capsular bag on the support ring into axial movement of the optic, allowing a presbyopic patient to more effectively focus on near objects. The outer ring is preferably contoured to conform to the portion of the capsular bag between the anterior and posterior zonules, and has sufficient axial thickness to contact both sets of zonules. In addition, the edge of the ring includes at least one sharp edge corner to prevent epithelial cell growth toward the optic. In addition, the outer ring may include weakened areas configured to allow consistent and repeatable deformation in response to compressive forces.

Abstract: An intraocular lens for inhibiting posterior capsular opacification, or secondary cataract, includes an optic having a peripheral wall provided with a sharp posterior edge wherein a majority of the optic mass is located posteriorly of the optic-haptic junction.

Abstract: An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge between the faces. The peripheral edge has one or more curved or angled surfaces that reduce glare within the IOL. For instance, a rounded transition surface on the anterior side of the peripheral edge diffuses the intensity of reflected light, or a particular arrangement of straight edge surfaces refracts the light so as not to reflect, or does not reflect at all. The intersection of the peripheral edge and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge and the intersecting face or faces.

Abstract: An intraocular lens for inhibiting posterior capsular opacification, or secondary cataract, includes an optic having a periphery provided with at least two sharp edges which lie radially spaced from each other with respect to the optical axis of the lens optic.

Abstract: An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge between the faces. The peripheral edge has one or more curved or angled surfaces that reduce glare within the IOL. For instance, a rounded transition surface on the anterior side of the peripheral edge diffuses the intensity of reflected light, or a particular arrangement of straight edge surfaces refracts the light so as not to reflect, or does not reflect at all. The intersection of the peripheral edge and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge and the intersecting face or faces.

Abstract: An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a peripheral edge between the faces. The peripheral edge has one or more curved or angled surfaces that reduce glare within the IOL. For instance, a rounded transition surface on the anterior side of the peripheral edge diffuses the intensity of reflected light, or a particular arrangement of straight edge surfaces refracts the light so as not to reflect, or does not reflect at all. The intersection of the peripheral edge and at least one of the anterior face and the posterior face, preferably both of such faces, forms a peripheral corner located at a discontinuity between the peripheral edge and the intersecting face or faces.