Abstract: The invention pertains to a polymer composition possessing improved resistance towards degradation and discolouring phenomena induced by UV radiation, said composition comprising at least one aromatic sulfone polymer; at least one organic UV absorber and at least one basic compound selected from the group consisting of (i) basic oxides and hydroxides of divalent metals and (ii) salts of a weak acid, and to methods for its manufacture and to shaped articles obtained therefrom.

Abstract: A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 mm Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.

Abstract: Opthalmic devices, particularity intraocular lenses (IOL), with improved contrast sensitivity and methods of making same. In one aspect, blue light blocking chromophores (BLBC) are diffused into, e.g. an IOL lens body to create a BLBC gradient in the lens. Orange dyes are preferred BLBCs.

Abstract: A method for determining the propensity of an intraocular lens material to prevent posterior capsule opacification is disclosed. The method involves contacting a sample of an IOL material having the shape of an IOL optic with collagen to form a contact area, incubating the sample in a liquid composition comprising lens epithelial cells, determining whether lens epithelial cells grow on the collagen in the contact area.

Abstract: A surface treated intraocular lens implant for use in the replacement of a cataractous natural lens to prevent posteriror capsular opacification. The surface treated intraocular lens includes one or more proteins, polypeptides, polyamino acids or polyamines bound to the surface of the intraocular lens implant covalently, non-covalently or a combination thereof. The one or more proteins, polypeptides, polyamino acids or polyamines present on the surface of the intraocular lens implant serves to reduce or eliminate residual lens epithelial cell migration within the lens capsule. By preventing residual lens epithelial cell migration, posterior capsular opacification of the intraocular lens implant is thus reduced or eliminated.

Abstract: A method for determining the propensity of an intraocular lens material to prevent posterior capsule opacification is disclosed. The method involves incubating replicate samples of an IOL material with collagen IV, washing off any loosely bound collagen IV. Following the washing step, one sample is counted to determine the amount of collagen IV that remains adhered to the IOL material. A second sample is further processed prior to counting by subjecting it to a desorption step and a further washing step.

Abstract: A method of selecting an intraocular lens material for toric lenses is disclosed. The method comprises determining the tack of the material.

Abstract: A method of selecting an intraocular lens material for toric lenses is disclosed. The method comprises determining the material's Collagen IV Index.

Abstract: This invention comprises purified native state Type VI collagen/&bgr;ig, Type VI-&bgr;ig collagen gel, including the crosslinked gel, and the use of the gel in fibrosis limited wound healing, and methods of preparation of the collagens.