Abstract: Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.

Abstract: A positive power anterior chamber ocular implant for placement in a phakic eye is disclosed to correct refractive errors caused by hyperopia which includes at least one convex surface and haptics for positioning the lens in the anterior chamber of the eye. Contact between the lens and other anatomic bodies, such as the anatomical lens, the corneal endothelium and iris is avoided, and the haptics avoid contact with the iris.

Abstract: Intraocular lenses and methods producing the same are provided. The intraocular lens includes an optic and a haptic that are integrally formed together. The haptic has a polyimide coating. The polyimide coating promotes fibrosis in the surrounding eye tissue to enhance the anchoring of the IOL after it is implanted in an eye.

Abstract: The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.

Abstract: The invention relates to optical elements whose optical properties can be repeatedly adjusted over time. Through the use of modifying compositions capable of stimulus induced polymerization coupled with a blend of stimulus absorbers and initiators, it is possible to repeatedly adjust the optical properties of the element by exposing the lens to a stimulus which exceeds the absorption capacity of the stimulus absorber.

Abstract: The subject invention provides an intraocular lens comprising an optic lens body and a layer of a photocatalytic material coated on at least a portion of a surface of the optic lens body. The intraocular lens of the subject invention can eliminate endophthalmitis and inhibit after-cataracts following cataract surgery.

Abstract: A method of preparing phakic intraocular lenses from hydrophobic materials is described. In this process, the lens is tested to determine whether it can float submerged in an aqueous medium. If it cannot (e.g., if it remains on top of the aqueous medium), the lens is surface treated (for example, by vacuum UV or corona discharge processes) to increase its wetting ability (e.g., to reduce its hydrophobicity). The lenses prepared by this process are also described.

Abstract: The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.

Abstract: An implantable device and method for making the device. The device includes a metabolically-active coating on at least a portion of a surface of the device. Preferably, the coating has a thickness of less than about 500 angstroms. The coating improves the bio-compatibility of the device with the human body. The method is particularly applicable to implantable devices for implantation within the human eye, including intraocular lenses.

Abstract: The invention relates to novel composite materials comprising

Abstract: The invention relates to an ophthalmic molding such as a contact lens or any kind of ocular prostheses comprising an organic bulk material having covalently bonded to its surface an acceptor saccharide to which is enzymatically attached one or more further carbohydrates. The ophthalmic moldings of the invention have desirable characteristics regarding, for example, adherence to the substrate, durability, hydrophilicity, wettability or biocompatibility.

Abstract: A surface treated intraocular lens implant for use in the replacement of a cataractous natural lens to prevent posteriror capsular opacification. The surface treated intraocular lens includes one or more proteins, polypeptides, polyamino acids or polyamines bound to the surface of the intraocular lens implant covalently, non-covalently or a combination thereof. The one or more proteins, polypeptides, polyamino acids or polyamines present on the surface of the intraocular lens implant serves to reduce or eliminate residual lens epithelial cell migration within the lens capsule. By preventing residual lens epithelial cell migration, posterior capsular opacification of the intraocular lens implant is thus reduced or eliminated.

Abstract: A surgically implantable synthetic intraocular lens having a wavelength blocker for blocking transmission of 100% or at least a portion of blue light of wavelengths between about 400 and 510 nanometers, as well as for blocking ultraviolet A and B wavelengths and optionally infrared wavelength transmissions. A preferred wavelength transmission blocker is a tint composition either disposed exteriorly upon the lens or blended interiorly within the lens. Lens utility is found in replacement of the natural crystalline lens to achieve visual correction of aphakia, as well as in correcting refractive errors of the eye through implantation without removal of the natural crystalline lens to thereby provide filtering properties that yield maximum visual acuity along with blockage of untoward wavelength transmissions. The lens implants thereby support vision health by protecting eyes from damage caused through the transmission of untoward wavelengths to the interior of the eye.

Abstract: A corneal onlay or corneal implant is disclosed which is to be placed within or onto the surface of the cornea, being a biocompatible, optically transparent, synthetic and biostable polymeric material, said material comprising a surface that supports the attachment and growth of tissue cells, and where the exterior surface of the implant onto which epithelial tissue is to be attracted and to become attached, or in the case of a corneal onlay the anterior surface of the onlay, has a topography comprising a plurality of surface indentations.

Abstract: IOL bodies comprising materials having a Fibronectin/Vitronectin Compatibility Index>1 and a Lens Epithelial Cell Growth Biocompatibility Index≧1 on their posterior surface have a low incidence of posterior capsule opacification.

Abstract: A biocompatible lens used for a contact lens directly contacted to the eyeball via tears or for an artificial crystalline lens, in which alkoxyalkyl (meth)acrylate (co)polymer layer is formed on the surface of the lens. This biocompatible lens is almost free from adhesion of lipid and protens in tears and even if they adhere on its surface, it is possible to wash out them easily.

Abstract: Intraocular lens coating compositions for reducing the risk of posterior capsule opacification are disclosed. The coating materials, which differ from the substrate material, consist essentially of at least two aryl acrylic hydrophobic monomers of the formula wherein: X is H or CH3; m is 0-10; Y is nothing, O, S, or NR wherein R is H, CH3, CnH2n+1 (n=1−10) iso OC3H7, C6H5, or CH2C6H5; Ar is any aromatic ring which can be unsubstituted or substituted with CH3, C2H5, n-C3H7, iso-C3H7, OCH3, C6H11, Cl, Br, C6H5, or CH2C6H5.