Abstract: A method and system for creating a custom-fit orthopedic cast comprises obtaining at least one measurements taken from at least one image of a body part, selecting a template cast, modifying the template cast according to the measurements taken from the at least one image to generate a custom cast model and rendering a custom cast based on the custom cast model.

Abstract: Methods and systems described herein are directed to viewpoint coordination of multiple users on artificial reality collaboration models. Multiple users can collaborate on 3D models in an artificial reality environment. Attention indicators can indicate to the other users where a user is looking or where the user is pointing. In some implementations, there is a central model that each user sees from her own perspective (e.g., in the center of a virtual table all users are seated around) and/or instances of the model that only an individual user sees or can manipulate. The user's attention indicators can be based on where the user is looking or pointing on the model instances. Additionally, attention indicators can be translated from a controlling user's perspective to a coordinate system defined by the model, which allows the indicators to be then presented in that model coordinate system for all users.

Abstract: A method for operating an apparatus for predicting confirmed cases of an infectious disease is provided. The method comprises predicting infectious disease information per country, including an infection risk per country, expected number of entrants per country, and number of imported cases per country, based on collected epidemic statistics data per country and inflow data between a corresponding country and a destination country, grouping two or more countries based on geographic or economic relevance, and correcting the infectious disease information per country of countries within a grouped group according to a contagion risk impact set depending on a correlation between the countries within the group, and predicting total number of imported cases flowing into the destination country by re-correcting the infectious disease information per country through applying a correlation for the confirmed cases of the infectious disease between groups to the infectious disease information per country.

Abstract: Infusion systems, infusion devices, and related patient monitoring systems and methods are provided. A method of monitoring a physiological condition of a patient involves providing, on a display device, a graphical user interface display depicting forecast values with respect to different time periods in the future and including graphical user interface elements to allow a user to adjust a characteristic of an event likely influence the physiological condition of the patient at a respective time period. In response to an adjustment to a graphical user interface element, the method continues by dynamically updating the forecast values on the graphical user interface display using a forecasting model associated with the patient.

Abstract: A system and method for converting medical images of a particular patient into high resolution, 3D dynamic and interactive images interacting with medical tools including medical devices by coupling a model of tissue dynamics and tool characteristics to the patient specific imagery for simulating a medical procedure in an accurate and dynamic manner. The method includes a tool to add and/or to adjust the dynamic image of tissues and ability to draw and add geometric shapes on the dynamic image of tissues. The system imports the 3D surgery plan (craniotomy, head position, approach etc.). The surgeon establishes multiple views, rotates and interacts with the navigation image to see behind pathology and vital structures. The surgeon can make structures such as tumors, vessels and tissue transparent to improve visualization and to be able to see behind the pathology. The System can warn on proximity of tools to specific anatomical structure.

Abstract: In a general aspect, input data for a computer process are preprocessed by a preprocessor unit that includes a quantum processor. In some aspects, a preprocessor unit obtains input data for a computer process that is configured to run on a computer processing unit. Randomized parameter values are computed for variable parameters of a quantum logic circuit based on the input data. A classical processor in the preprocessor unit computes the randomized parameter values from the input data and a set of random numbers. A quantum processor in the preprocessor unit produces quantum processor output data by executing the quantum logic circuit having the randomized parameter values assigned to the variable parameters. Preprocessed data generated based on the quantum processor output data are then provided as the input for the computer process configured to run on the computer processing unit.

Abstract: A system and method for patient health data prediction and analysis which utilizes an automated text mining tool to automatically format ingested electronic health record data to be added to a knowledge graph, which enriches the edges between nodes of the knowledge graph with fully interactive edge data, which can extract a subgraph of interest from the knowledge graph, and which analyzes the subgraph of interest to generate a set of variables that define the subgraph of interest. The system utilizes a knowledge graph and data analysis engine capabilities of the data platform to extract deeper insights based upon the enriched edge data.

Abstract: A method for evaluating an ophthalmic lens for a given wearer according to a visual performance parameter includes providing wearer's data for the given wearer. The method further includes providing a visual performance parameter tolerance range for the wearer. The method further includes providing an ophthalmic lens to be evaluated, the ophthalmic lens being characterized by opto-geometrical features. The method further includes computing a value of the visual performance parameter for the lens to be evaluated on the basis of a model. The method further includes evaluating the ophthalmic lens by comparing the computed value of the visual performance parameter with the visual performance parameter tolerance range.

Abstract: A computer-implemented method according to one embodiment includes identifying a textual document, determining a chemical reaction within the textual document, extracting a plurality of chemical terms from the chemical reaction, creating an annotation for the chemical reaction, utilizing the plurality of chemical terms, and storing a representation of the annotation for the chemical reaction.

Abstract: A method of training for welding through virtual reality (VR) provides a VR headset, a processing device, and a welding training tool. The processing device is communicably coupled with the VR headset and the hand-held welding training tool designed to simulate a real-world welding experience in VR. A virtual welding environment is displayed through the VR headset, and motion tracking input is received through the welding training tool. The user input is analyzed using an AI algorithm to evaluate user welding performance. User feedback devices such as sound and scent generation may be implemented in order to simulate a welding procedure. AI user feedback is implemented based on the welding performance to guide learning. Welding scenarios may be completed to train for welding in the virtual welding environment, and virtual currency may be awarded for gamification purposes. Multi-participant welding scenarios and immersive, objective-based, simulated real-world environments are further implemented.

Abstract: A computer-implemented method for clinical decision support is provided according to an embodiment of the present disclosure. In the method, patient information can be obtained that comprises at least one clinical condition. A graph can be searched for at least one rule matching the at least one clinical condition. The graph represents a plurality of rule sets. The rule set comprises one or more rule. The rule can be indicated with a path comprising at least one first node and a second node. The first node can indicate a clinical condition, and the second node can indicate a clinical conclusion. Then, a clinical conclusion can be determined based on the at least one path in response that the at least one path matching the at least one clinical condition is searched out.

Abstract: A tactile display device including a nodule having variable stiffness under a surface to provide a near-real feeling of palpation for a physician. The device utilizes granular jamming technology using pneumatic actuation to control a nodule that maintains its shape while allowing the modulation in stiffness. The nodule includes two hemispheres, a contact portion and an actuation portion, forming a sphere. The contact portion and the actuation portion include different thicknesses and/or materials, while the dimensions of the dimensions of the nodule are maintained. As such, a physician can utilize the device to identify the difference between a normal lump and an affected lump even if the shape of each lump appears to be the same. With the tactile display device, due to the different levels of stiffness, a physician can detect the severity of the lump.

Abstract: Hybrid terrain-adaptive lower-extremity apparatus and methods that perform in a variety of different situations by detecting the terrain that is being traversed, and adapting to the detected terrain. In some embodiments, the ability to control the apparatus for each of these situations builds upon five basic capabilities: (1) determining the activity being performed; (2) dynamically controlling the characteristics of the apparatus based on the activity that is being performed; (3) dynamically driving the apparatus based on the activity that is being performed; (4) determining terrain texture irregularities (e.g., how sticky is the terrain, how slippery is the terrain, is the terrain coarse or smooth, does the terrain have any obstructions, such as rocks) and (5) a mechanical design of the apparatus that can respond to the dynamic control and dynamic drive.

Abstract: A facility for processing a medical imaging image is described. The facility applies each of a number of constituent models making up an ensemble machine learning models to the image to produce a constituent model result that predicts a value for each pixel of the image. The facility aggregates the results produced by the constituent models of the plurality to determine a result of the ensemble machine learning model. For each of the pixels of the accessed image, the facility determines a measure of variation among the values predicted for the pixel among the constituent models. Facility determines a confidence measure for the ensemble machine learning model result based at least in part on for how many of the pixels of the accessed image a variation measure is determined that exceeds a variation threshold.

Abstract: Provided are methods for estimating a Reserve Strength Ratio in a segment of a blood vessel or a lymphatic vessel.

Abstract: Techniques for evaluating dynamically modified plans are provided. A selection of a treatment plan template is received, where the treatment plan template specifies a plurality of treatment stages, where each treatment stage defines a plurality of treatment options. A plurality of modifications to the treatment plan template is generated. It is determined, for each respective modification of the plurality of modifications, whether the respective modification is permissible, based on one or more predefined institutional criteria. Upon determining that a first modification of the plurality of modifications is permissible, a first treatment plan is generated based on the first modification to the treatment plan template. Further, a first predicted efficacy measure is generated for the first treatment plan based on analyzing a knowledge graph. Finally, the first treatment plan is provided, along with at least an indication of the first predicted efficacy measure.

Abstract: Provided herein are methods for predicting chemotherapy benefit. The invention predicts chemotherapy benefit based on the expression analysis of biomarkers, e.g., RNA biomarker transcription analysis, taken from a tumor sample. The biomarker expression data can be combined with clinical variables, e.g., tumor size and nodal status, to generate a profile that predicts the benefit of including chemotherapy as a treatment decision.

Abstract: Methods, systems, and computer-readable media are provided for aggregating, partitioning, and storing healthcare data. Healthcare data is collected from various disparate healthcare data sources. The data is aggregated into batches of the same type of data. From here, the data is partitioned according to the data's originating healthcare data source. The aggregated and partitioned healthcare data is then stored in a long term storage data store. This system of storing healthcare data allows for efficient retrieval and processing by computing solutions that need access to batches of healthcare data. The system also reduces costs associated with storing data as duplicate storage is eliminated.

Abstract: The present invention provides a human-computer interactive rehabilitation system, which can automatically calculate rehabilitation strength suitable for the patient, so that it is not necessary to manually evaluate and adjust the parameter settings in human-computer interactive rehabilitation system when different patients use it. At the same time, the human-machine interactive rehabilitation system and the hospital end can track the rehabilitation status and intervene through the data platform at any time. The platform establishes a cloud community feedback and encouragement mechanism, and immediately transmits the rehabilitation results to the designated barriers of the patients, provides patient encouragement feedback, and strengthens the community interaction and linkage in the medical relationship.

Abstract: A method for calculating binding free energy, where the method includes a plurality of steps each including adding a distance restraint potential between a binding calculation target molecule and a target molecule, wherein the method is a method for calculating binding free energy between the binding calculation target molecule and the target molecule using a computer, and wherein anchor points of the binding calculation target molecule in the plurality of the steps are identical anchor points, and anchor points of the target molecule in the plurality of the steps are different anchor points.

Abstract: During operation, the system obtains the time-series sensor signals, which were gathered from sensors in a monitored system. Next, the system classifies the time-series sensor signals into stair-stepped signals and un-stair-stepped signals. The system then replaces stair-stepped values in the stair-stepped signals with interpolated values determined from un-stair-stepped values in the stair-stepped signals. Next, the system divides the time-series sensor data into a training set and an estimation set. The system then trains an inferential model on the training set, and uses the trained inferential model to replace interpolated values in the estimation set with inferential estimates. Next, the system switches roles of the training and estimation sets to produce a new training set and a new estimation set. The system then trains the inferential model on the new training set, and uses the trained inferential model to replace interpolated values in the new estimation set with inferential estimates.

Abstract: A method for intraoperatively planning and facilitating a revision arthroplasty procedure. The method includes capturing positions of a tracked probe as the tracked probe contacts an interface area between a bone and a primary implant component implanted on the bone, intraoperatively generating a virtual boundary corresponding to a portion of the interface area to be removed to detach the primary implant component from the bone using the positions of the tracked probe and without use of pre-operative medical imaging, facilitating removal of the primary implant component from the bone by providing a constraint on operation of a cutting tool while the cutting tool removes the portion of the interface area, the constraint based on a relationship between the cutting tool and the virtual boundary.

Abstract: Certain aspects relate to systems and techniques for surgical robotic arm setup. In one aspect, there is provided a system including a first robotic arm configured to manipulate a medical instrument, a processor, and a memory. The processor may be configured to: determine a minimum stroke length of the first robotic arm that allows advancing of the medical instrument by the first robotic arm to reach a target region from an access point via a path, determine a boundary for an initial pose of the first robotic arm based on the minimum stroke length and a mapping stored in the memory, and during an arm setup phase prior to performing a procedure, provide an indication of the boundary during movement of the first robotic arm.

Abstract: Various technologies relating to constructing an answer to a query are described herein, wherein the answer is in list form. The answer includes a header and a list element. A deep model receives content of a webpage that is deemed relevant to the query by a search engine and constructs the answer to the webpage upon receipt of the query.

Abstract: A system for providing images of a human scalp and associated information for assisting in hair transplant planning, the system includes a support and at least one camera selectively connectable to the support, the camera and/or the support being configured for acquiring at least one, preferably a plurality of scale calibrated overview images of the human scalp of a patient's head, preferably from different predefined angles, optical acquisition means, preferably a video-dermatoscope, being configured for acquiring a plurality of microscopic images within different regions of the scalp, a processing unit configured to process and/or analyse image data provided by the camera means and the optical acquisition means, in particular for measuring areas of the human scalp, identify and measure hair in microscopic images and/or quantitatively plan a hair transplant operation, wherein the processing unit comprises a user interface configured for interacting with a user.

Abstract: A method for the deconvolution of nucleic acid-containing substance mixtures using synthetically generated target nucleotide sequences. Starting from a plurality of nucleotides,, a plurality of different target nucleotide sequences (TNS) is generated according to a predetermined algorithm. At least one of the TNS generated is associated with at least one substance or substance combination and chemically coupled thereto. At least one substance mixture to be analysed and having at least two different TNS is provided and is sequenced according to a sequencing method., at the same time all TNS contained in the substance mixture are detected in a common sequence spectrum. To facilitate the deconvolution, the sequence spectra of a substance mixture should be deducted/subtracted from each other prior to and after a selection experiment.

Abstract: The disclosure relates to digital twin of cardiovascular system called as cardiovascular model to generate synthetic Photoplethysmogram (PPG) signal pertaining to disease conditions. The conventional methods are stochastic model capable of generating statistically equivalent PPG signals by utilizing shape parameterization and a nonstationary model of PPG signal time evolution. But these technique generates only patient specific PPG signatures and do not correlate with pathophysiological changes. Further, these techniques like most synthetic data generation techniques lack interpretability. The cardiovascular model of the present disclosure is configured to generate the plurality of synthetic PPG signals corresponding to the plurality of disease conditions. The plurality of synthetic PPG signals can be used to tune Machine Learning algorithms. Further, the plurality of synthetic PPG signals can be utilized to understand, analyze and classify cardiovascular disease progression.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: Described herein is a discovery Platform Technology for analyzing a biological system or process (e.g., a disease condition, such as cancer) via model building.

Abstract: Methods, systems, and apparatuses, including computer programs encoded on a computer storage medium, can be implemented to perform certain actions. The actions can include maintaining biological data related to multiple biological systems in a first format in a data repository, receiving a first selection of a biological system of the multiple biological systems for constructing a model that simulates a behavior of the biological system, retrieving a subset of data of the biological data that is associated with the first selection of the biological system, receiving a second selection of a modeling technique of the multiple modeling techniques for constructing the model, compiling the subset of biological data into configuration data of a second format that is specific to the modeling technique and that is different from the first format, and generating the model using the modeling technique and the configuration data.

Abstract: A computer-aided pre-operative planning tool with interactive surgeon interface for total knee replacement implements a method that allows implant size selection, implant positioning, and surgical cut planes estimation (with construction of corresponding surgical jig), based upon a series of coronal, axial and sagittal image slices of a patient's leg. Limb alignment and corresponding surgical cut planes are defined based upon joint anatomical-matching analysis to minimize joint wear and restore a pre-arthritic alignment (rather than an always fully neutral alignment). Using the interface, a surgeon has the option to adjust the varus/valgus alignment within recommended bounds between the pre-arthritic and fully neutral alignments. Implant size may be selected based on a best fit to the patient's leg obtained from analysis of the images.

Abstract: A method of utilizing a computing device to correct source data used in machine learning includes receiving, by the computing device, first data. The computing device corrects the source data via an application of a covariate shift to the source data based upon the first data where the covariate shift re-weighs the source data.

Abstract: A device that includes a model training engine implemented by a processor. The model training engine is configured to obtain a set of data values associated with a feature vector. The model training engine is further configured to generate a set of gradients by dividing separation distances by an average separation distance and to compare each gradient to a gradient threshold value. The model training engine is further configured to identify a boundary in response to determining a gradient exceeds the gradient threshold value, to determine a number of identified boundaries, and to determine a number of clusters based on the number of identified boundaries. The model training engine is further configured to train the machine learning model to associate the determined number of clusters with the feature vector.

Abstract: Embodiments related to a method is described. The method comprises receiving an image file of a region of interest of an anatomy of a living organism, analyzing the image file and extracting image coordinates and density information of a plurality of points in the image file, training a neural network using collective information available in a database, registering the region of interest of the anatomy as a virtual version using an input from the neural network, and subsequently training the neural network using a user input from a user and the collective information available in the database. The collective information is recorded in the database with respect to a plurality of clusters of different physiological states of the living organism. The method further comprises performing a treatment on the region of interest. In an embodiment, the treatment is performed using the input from the neural network.

Abstract: Conduction velocity information for a cardiac region can be used to map the cardiac muscle fiber orientation of that region. In particular, for a plurality of locations within the cardiac region, a relationship between a local conduction velocity, a maximum local conduction velocity within the region, and a minimum local conduction velocity within the region is used to determine the cardiac muscle fiber orientation at the respective location. Even more particularly, when the local conduction velocity at the respective location equals the maximum local conduction velocity, the cardiac muscle fiber orientation is parallel to a direction of a conduction velocity vector at the respective location, and when the local conduction velocity at the respective location equals the minimum local conduction velocity, the cardiac muscle fiber orientation is perpendicular to a direction of a conduction velocity vector at the respective location.

Abstract: Systems and methods are disclosed for determining anatomy directly from raw medical acquisitions using a machine learning system. One method includes obtaining raw medical acquisition data from transmission and collection of energy and particles traveling through and originating from bodies of one or more individuals; obtaining a parameterized model associated with anatomy of each of the one or more individuals; determining one or more parameters for the parameterized model, wherein the parameters are associated with the raw medical acquisition data; training a machine learning system to predict one or more values for each of the determined parameters of the parameterized model, based on the raw medical acquisition data; acquiring a medical acquisition for a selected patient; and using the trained machine learning system to determine a parameter value for a patient-specific parameterized model of the patient.

Abstract: A bipartite graph structure is utilized to better store data. The bipartite graph structure may be used in a biochemical database to efficiently store a variety of molecules and processes that might occur between the molecules. Molecules are represented as molecule nodes, which may have metadata fields including a molecule name, a molecule type, a molecular formula, a sequence, a molecular charge, a set of molecular properties, and a set of component molecules. Processes operating on the molecules are represented by process nodes, which may have metadata fields including a process name, a set of process roles, a set of process properties, and a set of sub-processes. Edges, called roles, each associate a molecule node with a process node and represent the role the associated molecule plays in the associated process. The roles may contain metadata identifying the role type and the stoichiometry coefficient of the molecule in the process.

Abstract: An emotion estimation device includes: an emotion estimation unit estimating a user emotion as an emotion associated with an index value of a facial expression of a user between (i.e., involving/during a period having) a plurality of consecutive events, based on a correspondence between (A) the index value which is at least one of (i) a facial expression score of (i.e., representing) the facial expression of the user and (ii) a feature amount about a change of such facial expression score and (B) the facial expression of the user correlated with the plurality of consecutive events.

Abstract: A system may include a plurality of continuous conveyors configured for moving objects throughout a facility, and a plurality of sensors positioned at different locations within the facility for collecting telemetry data associated with the travel of the objects along the conveyors. The system may also include a computing device configured to store the telemetry data from the sensors in a database, generate an animation of the conveyors and the objects traveling along the conveyors within the facility based upon the telemetry data stored in the database, and play the animation on a display via a graphical user interface (GUI).

Abstract: Generating a three-dimensional radiation dose matrix for a patient for controlling the delivery of radiation dose to patients. The three-dimensional radiation dose matrix for the patient based on an intensity of radiation fields delivered by a radiation therapy delivery system that intersect with volume elements of a patient and determined by a predictive model. The intensity of the radiation fields at volume elements of the patient determined from spatial position data of the volume elements in a patient and radiation therapy delivery system data.

Abstract: Compositions and methods are provided for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery is selectively activated by the presence of a cytoplasmic protein of interest. In one embodiment of the invention, the cytotoxic molecule is a Granzyme B (GrB) polypeptide. In the compositions of the invention, GrB is modified to render its cytotoxic enzymatic functions inactive, until the presence of an intracellular antigen unlocks the GrB molecule to enable enzymatic activities.

Abstract: Systems, methods, and devices, including computer-readable media, for managing operation of devices in complex systems and changing environments. In some implementations, a server system stores data indicating management plans for each of a plurality of different devices, each management plan indicating a device-specific set of program states for programs in a predetermined set of programs. The server system alters the management plans and enforces interdependence of the programs, and the server system generates a customized instruction that alters operation of the device according to the device-specific set of program states assigned in the altered management plan for the device. The server system causes each device to perform one or more operations of the device determined according to the device-specific set of program states assigned in the altered management plan for the device.

Abstract: One embodiment includes a cardiac ablation system, including an ablation probe including at least one ablation application element to ablate tissue in a chamber of a heart of a living subject, a tracking module to track a position of the at least one ablation application element within the heart, a memory to store a map of the chamber of the heart and store a different, respective default ablation-parameter set for each different region of the chamber, and processing circuitry to segment the map of the chamber into the different regions, receive a user input indicative of commencement of an ablation procedure, identify, responsively to the tracked position, a region of the chamber with which the at least one ablation application element is in contact, retrieve the respective default ablation-parameter set assigned to the identified region, and apply the retrieved default ablation-parameter set in controlling the ablation procedure.

Abstract: Biometric authentication of a subject utilizing bone and/or blood vessel (vein or artery) structures is provided. A vertice profile is generated from a non-invasive, multi-dimensional image scan of a subject or a portion thereof. The vertice profile is generated by identifying relative locations of divots and peaks on a surface of a bone structure or by identifying branch intersections and traversals of blood vessels. Additional variation techniques can be used for proof of life (verification of human subject). If authenticated, access to physical or digital/virtual assets is allowed.

Abstract: A method and system for modeling trends in crop yields is provided. In an embodiment, the method comprises receiving, over a computer network, electronic digital data comprising yield data representing crop yields harvested from a plurality of agricultural fields and at a plurality of time points; in response to receiving input specifying a request to generate one or more particular yield data; determining one or more factors that impact yields of crops that were harvested from the plurality of agricultural fields; decomposing the yield data into decomposed yield data that identifies one or more data dependencies according to the one or more factors; generating, based on the decomposed yield data, the one or more particular yield data; generating forecasted yield data or reconstructing the yield data by incorporating the one or more particular yield data into the yield data.

Abstract: The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.

Abstract: A surgical imaging system comprising circuitry configured to accentuate an image characteristic of an area in captured images; identify the change of the image characteristic in the area; and identify the position of a physiological feature relative to the surgical device on the basis of the change in the image characteristic.

Abstract: A vegetation index calculation apparatus (10) is provided with a specification unit (11) that collates height distribution data indicating a distribution of the height of plants that exist in a target region with predicted height data of a crop targeted for calculation of a vegetation index, and specifies a region where the crop exists within the target region, and a vegetation index calculation unit (12) that calculates the vegetation index of the crop that exists in the region specified by the specification unit (11).

Abstract: Systems are provided for generating data representing electromagnetic states of a heart for medical, scientific, research, and/or engineering purposes. The systems generate the data based on source configurations such as dimensions of, and scar or fibrosis or pro-arrhythmic substrate location within, a heart and a computational model of the electromagnetic output of the heart. The systems may dynamically generate the source configurations to provide representative source configurations that may be found in a population. For each source configuration of the electromagnetic source, the systems run a simulation of the functioning of the heart to generate modeled electromagnetic output (e.g., an electromagnetic mesh for each simulation step with a voltage at each point of the electromagnetic mesh) for that source configuration.

Abstract: Disclosed are methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties. Some embodiments use genetic algorithms and structural data to filter out uninformative data. Some embodiments use a support vector machine to train the sequence activity model. The filtering and training methods can generate a sequence activity model having higher predictive power than conventional modeling methods. Systems and computer program products implementing the methods are also provided.