Abstract: In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.

Abstract: Described are techniques for use with an injection port. The injection port includes a needle support structure configured to accommodate a needle containing a sample aspirated therein. The injection port includes a needle seal having a first surface thereof in contact with a second surface of a tip of the needle. A seal is formed when the first surface contacts the second surface and a sufficient force is applied to the needle.

Abstract: A sample injection port 10 for injecting a sample into a chromatograph or other devices is composed of a body 13 made of an inelastic material, a first seal member 14 made of an elastic material and attached to one end of the body part 13, and a second seal member 15 made of an elastic material and attached to the other end of the body part 13. A first through hole formed in the first seal member 14 , a second through hole formed in the second seal member 15 and a third through hole formed in the body part 13 are coaxially connected to form an introduction hole for sample injection. With this construction, a sample injection port which has a small inner diameter, is easy to manufacture, and yet capable of achieving a high pressure resistance can be provided.

Abstract: The invention relates to an injection port for analysis appliances, said injection port (10), when fitted correctly on an analysis appliance, forming an access line which leads to an analysis chamber of the analysis appliance and through which it is possible to guide the cannula of a sample injector containing a sample to be analysed, characterized in that the injection port comprises at least one elastic valve element (24) which can be opened and closed in a controlled manner and by means of which the access line to the analysis chamber can be sealed off both in the absence of a cannula and also when a cannula is guided through the injection port. The invention further relates to an analysis appliance provided with a corresponding injection port, and to a device for actuating the injection port.

Abstract: A sample feeding apparatus includes a first cylinder, a second cylinder, and a sealing section. The first cylinder is configured to be mounted with a sample tube. The second cylinder is configured to move the first cylinder between a first position and a second position, the first position being for mounting of the sample tube, the second position being for feeding of a sample in the sample tube. The sealing section is configured to cover the sample tube, the sample tube being mounted to the first cylinder being at the second position, the first cylinder applying pressure to an inner space of the sealing section at the second position.

Abstract: Described are techniques for use with an injection port. The injection port includes a needle support structure configured to accommodate a needle containing a sample aspirated therein. The injection port includes a needle seal having a first surface thereof in contact with a second surface of a tip of the needle. A seal is formed when the first surface contacts the second surface and a sufficient force is applied to the needle.

Abstract: A method for validating or calibrating a chemical detector at a point of use. The method includes presenting a device to the chemical detector, the device comprising a frangible container defining a predetermined volume and a chemical material sealed within the frangible container in a predetermined amount, and breaking the frangible container to release the chemical material for detection by the chemical detector. A device and method of making the device for validating or calibrating a chemical at a point of use are also provided.

Abstract: Preparation methods for introducing liquid samples to gas analysis instruments include 1) complete evaporation of a liquid sample in a sample chamber, and 2) allowing the sample vapor in the sample chamber to equilibrate for a predetermined time. An inert carrier gas (e.g., dry nitrogen or zero air) is also admitted to the sample chamber. After equilibration, the sample vapor is admitted as a conditioned sample to an analysis instrument. Preferably, the predetermined equilibration time is sufficiently long that the sample vapor in the sample chamber becomes substantially homogeneous with respect to both concentration and isotopic ratio. Vapor derived from a liquid calibration standard in this manner can be employed as an accurate gas-phase calibration reference.

Abstract: A test adapter for the saturated vapor calibration of gas-measuring devices. The test adapter (2) has, in an adapter housing (15), a peripheral edge (7) for receiving a gas-measuring device and has a depression (10) for receiving the sample liquid in the area of the gas-sensitive surface of the gas-measuring device.

Abstract: A docking mechanism provided for analytical apparatus, such as an acoustic bio-sensor apparatus. The mechanism is operable releasably to receive a cartridge (58) for use in analysing a sample comprising a fluid and having a flow cell (104, 106; 304, 306) for the sample and an electrically operated sensor (92) for performing the analysis. The docking mechanism has a clamping mechanism (12, 8, 10) for urging a fluid connector such as ferules (50, 52) against the cartridge to provide a fluid connection between the flow cell inlet and a sample delivery device.

Abstract: A pullout mechanism for a biosensor, wherein the pullout mechanism includes a permanent seat, a sliding seat, a resetter and a push type brake seat. The sliding seat is set into the sliding seat space of the permanent seat in a sliding state. A resetter is arranged between the permanent seat and the sliding seat, enabling resetting of the sliding seat. A push type brake seat is arranged laterally onto the casing. The push type brake seat includes a pushing portion and a driving end. The driving end can penetrate the threading portion of the permanent seat. When the pushing portion is pressed, said driving end can push the driven end of the sliding seat to control the state of the sliding seat, allowing for automatic pullout of the specimen in the specimen inserting portion, and improving the ease of operation with stronger applicability.

Abstract: The present invention is directed to an enhanced sampling device, herein referred to as an ESD, for enhancing the collection efficiency of the SPME method by enhancing the flow of the analytes onto the sampling fiber. The ESD includes a tubular main body, used for a sampling shroud, which directs a flow of analytes to contact the fiber during collection. One end of the main body is open and faces the sample, allowing analytes to flow into the ESD and contact the fiber. A second piece of tubing branches from the other end of the main body and becomes an outlet port, possibly leading to a pump. The ESD permits more rapid transport and absorption of the analytes to the fiber for collection.

Abstract: An apparatus for the transfer of samples from an analytical instrument has a sealable transfer capsule and a means for connecting the transfer capsule to a vacuum instrument, such as a FIB, through an interface connected to the instrument. The capsule has a door that can be opened to insert a sample holder, such as a TEM sample holder, into the instrument, and then closed when the sample holder holding an excised sample is retracted back into the transfer capsule. The instrument interface contains means for sealing the instrument before the transfer capsule holding a sample is disconnected, and for purging the transfer capsule with an inert gas. The sample may thus be transported in the sealed transfer capsule without exposure to the ambient atmosphere. The sample may be transported to and connected to a glove box also purged with an inert gas for examination or further operations.

Abstract: The disclosure relates to instrument assemblies that can include a sample introduction port coupled to a chamber configured to receive the sample from the sample introduction port and provide analysis of the sample with a valve between the sample introduction port and the chamber. The instrument assemblies can include a septum housing assembly coupled to an analysis chamber interface with the interface including a valve and a cam rotatably mounted to the septum housing assembly and/or coupled to the valve. Analysis methods are also provided that can include introducing a sample to an instrument through both a sample introduction port and a valve coupled to the sample introduction port, and, after introducing the sample, closing the valve to seal the sample introduction port from a remainder of the instrument, with the remainder of the instrument being configured to analyze the sample after the introducing through the sample introduction port.

Abstract: A method and apparatus are provided for obtaining a reproducible sample of solid particles. The reproducible sample is obtained by receiving solid particles into a collection system that includes a sheltered volume. Solid particles that settle outside of the sheltered volume are purged from the collection system. The remaining solid particles inside the sheltered volume correspond to the reproducible sample.

Abstract: The invention relates to a sample entry device for delivering medical samples, preferably blood samples, from diverse sample containers to an analyzer, wherein sample transfer between sample intake and measuring cells of the analyzer taking place via gas-tight sample lines. According to the invention a fixed intake needle is provided at the entry side of the analyzer, which includes an elastic intake element that is axially slideable on the intake needle and has a conical intake opening. In addition, a holding element is provided, which is axially slideable parallel to the intake needle and can be shifted relative to the intake element. In a first position the holding element exposes the intake element and in a second position places a conical opening above the intake element to accommodate a syringe.

Abstract: A method for sampling reaction products includes delivering a reactant through a sampling probe to contact a substance deposited on a substrate and reacting the reactant to form a reaction product. At least a portion of the reaction product is withdrawn through the sampling probe and analyzed. The sampling probe is contacted with the substrate during at least a portion of the delivering, reacting and withdrawing steps.

Abstract: A sampling probe for delivering a reactant to a substance deposited on a substrate to form a reaction product and for transporting the reaction product to a product analyzer for analysis. The probe includes a tip positionable over the substance on the substrate. The probe has a recess in the tip sized and shaped for receiving at least a portion of the reaction product. The probe has a product sampling passage extending from the recess adapted for connection to the product analyzer for transporting the portion of the reaction product to the product analyzer. Further, a reactant delivery passage extends to an outlet at the recess for delivering reactant to the substance on the substrate to form the reaction product.

Abstract: The invention relates to a temperature-controlled injector for a chemical analysis unit, in particular a gas chromatograph, comprising an injector tube, which can be received by a receiving tube, having a cooling system, which surrounds the receiving tube, through which coolant can flow, which has coolant connections and which is designed as a metallic tube coil, and a resistance heating system for the injector tube, in which injector the receiving tube consists of a material of good thermal conductivity, is electrically insulating towards the outside, and the tube coil rests on the receiving tube, has an electrical resistance which is sufficient to rapidly heat the injector tube and can be acted on by current via electrical connection pieces.

Abstract: An improved nozzle system for a flow cytometer and accompanying methods have been invented for a high efficiency orientation and sorting process of a flat sample and dedicates items such as equine or bovine sperm cells. This improved nozzle system comprises a nozzle with a novel interior surface geometry that can both gently accelerate the cells and can include an elliptical-like, single torsional interior surface element within the nozzle, i.e., a single torsional orientation nozzle. The elliptical-like, single torsional interior surface element may have a laminar flow surface and may produce the simplest flow path for applying minimal forces which act in either an accelerative nature or orienting hydrodynamic forces, namely, the single torsional orientation forces, to orient a flat sample such as animal sperm cells into a proper direction for an analyzing and efficiently sorting process in clinical use, for research and for the animal insemination industry.

Abstract: An instrument provides a quantitative measurement of an analyte in a gas. It includes a detection cell that provides an indication of an amount of analyte present in the gas, and a valve having a closed position, a sample gas position, and a calibration gas position. There is a calibration gas inlet orifice in communication with a gas outlet through a first flow path including the valve and the detection cell, and a sample gas inlet orifice in communication with the gas outlet through a second flow path including a scrubber, the valve, and the detection cell. Two orifices of different sizes, a sample gas orifice along the second flow path, and a bypass orifice positioned between the sample gas orifice and the gas outlet, prevent a build up of excessive pressure in the instrument when the valve is in the closed position or the calibration gas position.

Abstract: A fluid sampling device or system for providing a fluid to a fluid processing apparatus. The system includes a plurality of sampling lines, each having an inlet line and an outlet line connected by a valve. The valve has a closed position preventing a fluid flow between the two lines and an opened position allowing such a fluid flow. A first and a second purge line are provided, respectively connected to the inlet and outlet lines for purging fluid therefrom. Rotometers or other similar devices are provided for controlling each of the purge lines. A connecting line is provided for connecting each of the outlet lines to each other and to the outlet. In operation, one of the valves is opened and the others are closed. Fluid flows from the selected valve to the apparatus and backwards through the outlet lines of the unselected sampling channels, providing a backpurge of these outlet lines through the second purge lines.

Abstract: The storage medium stores multiple samples of liquid and is movable for providing those samples from a loading position to a position where the samples can be provided to an analysis system.

Abstract: A fluid sampling device or system for providing a fluid to a fluid processing apparatus. The system includes a plurality of sampling lines, each having an inlet line and an outlet line connected by a valve. The valve has a closed position preventing a fluid flow between the two lines and an opened position allowing such a fluid flow. A first and a second purge line are provided, respectively connected to the inlet and outlet lines for purging fluid therefrom. Rotometers or other similar devices are provided for controlling each of the purge lines. A connecting line is provided for connecting each of the outlet lines to each other and to the outlet. In operation, one of the valves is opened and the others are closed. Fluid flows from the selected valve to the apparatus and backwards through the outlet lines of the unselected sampling channels, providing a backpurge of these outlet lines through the second purge lines.

Abstract: A gas sampling system includes a sample trapping module having a gas pump and a power supply, and a removable magazine that fits within a port of the trapping module. The magazine contains a non-volatile electronic memory, which controls operation of the trapping module, and has a rotating carousel for holding sample tubes. Individual sample tubes are sealed at each end by a cap that has a needle-pierceable septum, and contain a solid collector material to trap chemical and biological contaminants in a gas sample drawn through the sample tube. Individual sample tubes are moved into and out of a sampling location by incremental rotation of the carousel and, while at the sampling location, a pair of hollow bore needles are inserted through the sample tube end caps to allow the drawing of a gas sample through the tube.

Abstract: A device for transferring a liquid sample drawn by suction, through a wall having an orifice, the device including a conduit, a plunger sealingly sliding in the conduit, and a rod controlling the plunger. The device includes a joining piece extending the conduit, with an outer cross-section adapted to fit in the aperture, for example sealing it, with close working clearance required for inserting the joining piece in the orifice, the joining piece being arranged to be separated from the conduit once it is engaged in the orifice, and to seal the orifice, when or once the joining piece engaged in the orifice is separated from the conduit.

Abstract: A collector and method for collecting samples of liquid from at least one source of liquid for automated analysis of the samples. The collector has at least one receptacle for receiving liquid from the source of liquid and holding a quantity of the liquid for obtaining a sample. Each receptacle has an inlet for delivery of liquid from the respective source of liquid and an open top sized to admit the sample collection device into the receptacle. The collector also has a spillway in fluid communication with the open top of the receptacle for receiving excess liquid spilling over the open top of the receptacle. The collector is constructed so that liquid continuously flows through the collector. A drain of the collector receives liquid from the spillway for draining the liquid from the collector.