Peptides Containing The Sequence (a-arg-pro-pro-gly-phe-ser-pro-phe-arg Oh), A Being H Or Lys, E.g., Kallidin, Bradykinin, Etc. Or Related Peptides (c07k-99/18) Patents (Class 930/DIG600)
Abstract: Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose desired destination is the interstitial fluid compartment of the brain. Alternatively, the permeabilizer A-7 or conformational analogues can be administered sequentially with the molecule(s) of interest and these molecules can also be administered by routes other than intravascular. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive in the interstitial fluid.
Type:
Grant
Filed:
November 12, 1993
Date of Patent:
November 11, 1997
Assignee:
Alkermes, Inc.
Inventors:
John W. Kozarich, Gary F. Musso, Bernard Malfroy-Camine
Abstract: A bradykinin analog which contains nine or ten amino acid residues and at least one [CH.sub.2 NH] pseudopeptide bond, the analog being useful as an antagonist or agonist of the naturally occuring bradykinin.
Type:
Grant
Filed:
December 9, 1988
Date of Patent:
November 10, 1992
Assignee:
The Administrators of the Tulane Educational Fund
Inventors:
David H. Coy, Jacques-Pierre Moreau, John E. Taylor, Sun H. Kim