Search Patents
  • Rna purification methods
    Publication number: 20040181049
    Abstract: Methods for the preparation and isolation of high quality RNA are described. The methods do not require lysis of red blood cells and may be used to isolate high quality RNA from cells such as epithelial cells, fibroblasts, bone marrow progenitors, brain tissue or brain cells. The present invention is also directed to kits for practicing the disclosed high quality RNA isolation methods.
    Type: Application
    Filed: May 7, 2004
    Publication date: September 16, 2004
    Inventors: Michael S. Orr, Daniel Bednarik, Daniel J Wilson
  • 70 human secreted proteins
    Publication number: 20050215775
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: November 2, 2004
    Publication date: September 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Carrie Fischer, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Yanggu Shi
  • 70 Human Secreted Proteins
    Publication number: 20070238664
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: May 22, 2007
    Publication date: October 11, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Carrie Fischer, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Yanggu Shi
  • 186 human secreted proteins
    Publication number: 20060084082
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 6, 2005
    Publication date: April 20, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Carrie Fischer, Reinhard Ebner, Laurie Brewer, Paul Moore, Yanggu Shi, David LaFleur, Yi Li, ZhiZhen Zeng, Hla Kyaw
  • Secreted protein HRGDF73
    Publication number: 20020164669
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 19, 2001
    Publication date: November 7, 2002
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi
  • PRODUCTION OF INFECTIOUS RNA VIRUSES IN YEAST
    Publication number: 20140242669
    Abstract: The method described herein provides a novel platform utilizing yeast as a biological non-host system to express and assemble whole viruses for use as attenuated or killed vaccines.
    Type: Application
    Filed: August 20, 2012
    Publication date: August 28, 2014
    Inventors: Arun K. Dhar, Daniel Bednarik
  • Secreted Protein HODAZ50
    Publication number: 20030027132
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 4, 1998
    Publication date: February 6, 2003
    Inventors: STEVEN M. RUBEN, CRAIG A. ROSEN, CARRIE L. FISCHER, DANIEL R. SOPPET, KENNETH C. CARTER, DANIEL R. BEDNARIK, GREGORY A. ENDRESS, GUO-LIANG YU, JIAN NI, PING FENG, PAUL E. YOUNG, JOHN M. GREENE, ANN M. FERRIE, ROXANNE DUAN, JING-SHAN HU, KIMBERLY A. FLORENCE, HENRIK S. OLSEN, REINHARD EBNER, LAURIE A. BREWER, YANGGU SHI
  • Secreted protein HODAZ50
    Patent number: 6590075
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: July 8, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi
  • Secreted protein HRGDF73
    Patent number: 7053190
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: May 30, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi
  • 186 human secreted proteins
    Publication number: 20030225248
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: June 10, 2002
    Publication date: December 4, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 186 human secreted proteins
    Publication number: 20030049618
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: March 16, 2001
    Publication date: March 13, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 186 human secreted proteins
    Publication number: 20030175858
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 18, 2001
    Publication date: September 18, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, ZhiZhen Zeng, Hla Kyaw
  • 186 human secreted proteins
    Patent number: 6420526
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: July 16, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel P. Soppet, Kenneth C. Carter, Daniel R. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 186 Human Secreted Proteins
    Publication number: 20090011983
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: May 8, 2007
    Publication date: January 8, 2009
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 186 Human Secreted Proteins
    Publication number: 20120122762
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: January 26, 2012
    Publication date: May 17, 2012
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • Soluble interleukin-1 receptor accessory molecule
    Publication number: 20050171337
    Abstract: The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are futher provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
    Type: Application
    Filed: February 25, 2005
    Publication date: August 4, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Daniel Bednarik, Henrik Olsen, Craig Rosen
  • LIGAND INDUCIBLE POLYPEPTIDE COUPLER SYSTEM
    Publication number: 20180348231
    Abstract: The invention relates to a novel ligand inducible polypeptide coupling system and methods of modulating cell signal transduction pathways and other intracellular and extracellular protein-protein interactions.
    Type: Application
    Filed: March 29, 2016
    Publication date: December 6, 2018
    Applicant: Intrexon Corporation
    Inventors: Daniel Paul BEDNARIK, Charles REED, Vinodh KURELLA
  • Heart failure gene determination and therapeutic screening
    Publication number: 20060275770
    Abstract: Genes implicated in the progression of heart failure and in the endogenous myocardial recovery and repair mechanism provide the basis for screening potential therapeutic compounds for use as pharmaceutical preparations for the treatment of congestive heart failure. Target genes or target gene products whose expression level or biological activity are altered by a potential therapeutic compound can be validated functionally, by determining the physiological effect(s) precipitated by compound-induced changes in gene expression or biological activity of gene products. In particular, changes in the expression of the target gene(s) or in the biological activity of target gene product(s) can be correlated with indices of cardiac function, and a potential therapeutic compound that causes a therapeutically significant change such expression or activity warrants further clinical investigation as a drug candidate.
    Type: Application
    Filed: November 26, 2003
    Publication date: December 7, 2006
    Inventor: Daniel Bednarik
  • HUMAN HYPOXANTHINE- (GUANINE) PHOSPHORIBOSY1 TRANSFERASE-2
    Publication number: 20020065393
    Abstract: A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
    Type: Application
    Filed: November 12, 1998
    Publication date: May 30, 2002
    Inventors: DANIEL P. BEDNARIK, CRAIG A. ROSEN, MARK D. ADAMS
  • Soluble Interleukin-1 Receptor Accessory Molecule
    Publication number: 20080261252
    Abstract: The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
    Type: Application
    Filed: June 11, 2008
    Publication date: October 23, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Henrik S. Olsen, Craig A. Rosen
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