Search Patents
  • Anti-Coronavirus Antibodies and Methods of Use
    Publication number: 20240150438
    Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.
    Type: Application
    Filed: March 31, 2023
    Publication date: May 9, 2024
    Applicants: AbCellera Biologics Inc., The United States of America, as represented by the Secretary, Department of Health and Human Svcs.
    Inventors: Kathryn WESTENDORF, Stefanie ZENTELIS, Krithika MUTHURAMAN, Kevin JEPSON, Ester FALCONER, John MASCOLA, Barney GRAHAM, Kizzmekia CORBETT, Julie LEDGERWOOD, Lingshu WANG, Olubukola ABIONA, Wei SHI, Wing-pui KONG, Yi ZHANG, Bryan Edward JONES, Denisa FOSTER, Julian DAVIES, Qing CHAI, Christopher Carl FRYE, Ganapathy GOPALRATHNAM, Jörg HENDLE, John Michael SAUDER, Jeffrey Streetman BOYLES, Anna PUSTILNIK
  • Label-free, real-time, whole-cell response monitoring with liquid Raman spectroscopy
    Publication number: 20230324381
    Abstract: Improved surface enhanced Raman spectroscopy (SERS) of biological targets in liquids is provided. Nanoparticles are treated with a surfactant to provide an electrostatic attraction between the nanoparticles and the biological targets. The resulting clustering of the nanoparticles at the biological targets improves the SERS signal, Such SERS spectroscopy enables real time monitoring of the biological targets, thereby enabling a wide variety of assays etc.
    Type: Application
    Filed: September 1, 2021
    Publication date: October 12, 2023
    Inventors: Loza Fekadu Tadesse, Jack HU, Amr Ahmed Essawi Saleh, Stefanie S. Jeffrey, Jennifer A Dionne
  • Resonant nanophotonic biosensors
    Publication number: 20230341384
    Abstract: Optical sensing of biological targets is provided using a metasurface having guided mode resonances with electric field profiles that extend out from the metasurface. Surface functionalization of such metasurfaces can be used to provide sensing for biological targets, such as nucleic acids, proteins, small molecules, extracellular vesicles, and whole cells. Binding of the target to the surface functionalization can affect the resonance wavelength of the guided mode resonances, thereby providing a sensitive assay for the biological targets.
    Type: Application
    Filed: October 8, 2021
    Publication date: October 26, 2023
    Inventors: Jennifer A. Dionne, John Abendroth, Mark Lawrence, Jack Hu, Fareeha Safir, Jefferson Dixon, Stefanie S. Jeffrey
  • Electropermanent magnet activated microfluidic droplet size modulation
    Publication number: 20180093265
    Abstract: An active microfluidic droplet generation device includes a droplet generation junction joining at least one continuous phase channel for carrying a ferrofluid, and a dispersed phase channel for carrying a dispersed phase (e.g., aqueous) flow. A miniature electropermanent magnet (EPM) upstream from the junction generates a magnetic field to modulate a flow rate of a ferrofluid in the continuous phase channel so that dispersed phase droplets are generated with volumes actively controlled on-demand and under continuous flow.
    Type: Application
    Filed: September 30, 2016
    Publication date: April 5, 2018
    Inventors: Jose I. Padovani Blanco, Ali Mohamed Ibrahim, Yasser Hussein Anis, Stefanie S. Jeffrey, Roger T. Howe
  • Electropermanent magnet activated microfluidic droplet size modulation
    Patent number: 10385893
    Abstract: An active microfluidic droplet generation device includes a droplet generation junction joining at least one continuous phase channel for carrying a ferrofluid, and a dispersed phase channel for carrying a dispersed phase (e.g., aqueous) flow. A miniature electropermanent magnet (EPM) upstream from the junction generates a magnetic field to modulate a flow rate of a ferrofluid in the continuous phase channel so that dispersed phase droplets are generated with volumes actively controlled on-demand and under continuous flow.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: August 20, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jose I. Padovani Blanco, Ali Mohamed Ibrahim, Yasser Hussein Anis, Stefanie S. Jeffrey, Roger T. Howe
  • Apparatus for magnetic separation of cells
    Patent number: 9267943
    Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: February 23, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz
  • Apparatus for Magnetic Separation of Cells
    Publication number: 20120045828
    Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
    Type: Application
    Filed: October 28, 2011
    Publication date: February 23, 2012
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz
  • Methods and Apparatus for Magnetic Separation of Cells
    Publication number: 20090220979
    Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
    Type: Application
    Filed: December 11, 2008
    Publication date: September 3, 2009
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz
  • Methods and apparatus for magnetic separation of cells
    Patent number: 8071395
    Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: December 6, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz
  • Production of lithium diphenylphosphide
    Patent number: 9464101
    Abstract: Lithium diphenylphosphide solutions in a solvent, e.g., diethoxymethane (DEM), that are more stable than when tetrahydrofuran (THF) is used as a solvent. Methods of producing them are also disclosed.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: October 11, 2016
    Assignee: ROCKWOOD LITHIUM INC.
    Inventors: Jeffrey Alan McCall, Mark J. Hintze
  • Production of lithium diphenylphosphide
    Patent number: 9175020
    Abstract: Lithium diphenylphosphide solutions in a solvent, e.g., diethoxymethane (DEM), that are more stable than when tetrahydrofuran (THF) is used as a solvent. Methods of producing them are also disclosed.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: November 3, 2015
    Assignee: Rockwood Lithium Inc.
    Inventors: Jeffrey Allen McCall, Mark J. Hintze
  • Methods of treating the skin
    Publication number: 20060008538
    Abstract: The invention features a method of (i) reducing the appearance of pores or oil on the skin and (ii) evening skin tone or smoothing skin by applying to an area of skin in need of such treatment a composition including an anti-acne agent, an antimicrobial agent, and a lactate.
    Type: Application
    Filed: June 20, 2005
    Publication date: January 12, 2006
    Inventors: Jeffrey Wu, Jue-Chen Liu, Jeannette Chantalat, Ying Sun, Stefanie Johnsen, Hanuman Jampani
  • DOMINANT NEGATIVE SARM1 MOLECULES AS A THERAPEUTIC STRATEGY FOR NEURODEGENERATIVE DISEASES OR DISORDERS
    Publication number: 20210187069
    Abstract: The present invention provides compositions useful as inhibitors of SARM1 activity, pharmaceutical compositions thereof, and methods of using the same. The present invention provides dominant negative SARM1 molecules useful for treating a neurodegenerative or neurological disease or disorder, pharmaceutical compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 18, 2018
    Publication date: June 24, 2021
    Applicant: Washington University
    Inventors: Aaron DiAntonio, Jeffrey D. Milbrandt, Daniel Summers, Stefanie Geisler, Xianrong Mao
  • ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
    Publication number: 20190345458
    Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: July 30, 2019
    Publication date: November 14, 2019
    Inventors: Nicholas J. Agard, Oscar Alvizo, Melissa Ann Mayo, Stefanie Ng Minor, James Nicholas Riggins, Jeffrey C. Moore
  • ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
    Publication number: 20210301266
    Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 30, 2021
    Inventors: Nicholas J. Agard, Oscar Alvizo, Melissa Ann Mayo, Stefanie Ng Minor, James Nicholas Riggins, Jeffrey C. Moore
  • ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
    Publication number: 20180030419
    Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: October 13, 2017
    Publication date: February 1, 2018
    Inventors: Nicholas J. Agard, Oscar Alvizo, Melissa Ann Mayo, Stefanie Ng Minor, James Nicholas Riggins, Jeffrey C. Moore
  • Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
    Patent number: 9822346
    Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: November 21, 2017
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Oscar Alvizo, Melissa Ann Mayo, Stefanie Ng Minor, James Nicholas Riggins, Jeffrey C. Moore
  • Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
    Patent number: 11060072
    Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: July 13, 2021
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Oscar Alvizo, Melissa Ann Mayo, Stefanie Ng Minor, James Nicholas Riggins, Jeffrey C. Moore
  • METHODS OF TREATING THE SKIN
    Publication number: 20100166886
    Abstract: The invention features a method of (i) reducing the appearance of pores or oil on the skin and (ii) evening skin tone or smoothing skin by applying to an area of skin in need of such treatment a composition including an anti-acne agent, an antimicrobial agent, and a lactate.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 1, 2010
    Inventors: Jeffrey M. Wu, Jue-Chen Liu, Jeannette Chantalat, Ying Sun, Stefanie A. Johnsen, Hanuman B. Jampani
  • Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
    Patent number: 10407668
    Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: September 10, 2019
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Oscar Alvizo, Melissa Ann Mayo, Stefanie Ng Minor, James Nicholas Riggins, Jeffrey C. Moore
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