Patents Represented by Attorney 17th Street Legal, PLLC.

Find this attorney in the Justia Lawyer Directory

  • Activation of peptide prodrugs by hK2
    Patent number: 7906477
    Abstract: The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodrug by hK2, the therapeutic drugs are activated and exert their toxicity. Methods for treating cell proliferative disorders are also featured in the invention.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: March 15, 2011
    Assignee: Genspera, Inc.
    Inventors: Samuel R. Denmeade, John T. Isaacs, Hans Lilja