Abstract: The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
Abstract: The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.
Abstract: The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula
wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating arthritis, inflammation, cancer and other disorders.
Type:
Grant
Filed:
August 5, 2003
Date of Patent:
December 7, 2004
Assignee:
Warner-Lambert Company
Inventors:
Joseph Armand Picard, Michael William Wilson
Abstract: A compound of the formula
wherein R1-R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidemrolysis bullosa, scleritis and other disease characterized by matrix metalloproteinase activity, as well as AIDS, sepsis, septic shock and other diseases involving the production of TNF.
Abstract: The present invention is a composition comprising (a) thiocyanogen or a thiocyanogen halide and (b) an .alpha.,.beta.-unsaturated ketone, e.g. chloranil, in solution in (c) an inert organic solvent. The composition is useful for the introduction of thiocyanate functionality into organic compounds in the same manner as thiocyanogen or thiocyanogen chloride, but is stable over longer periods of time, i.e. one year or more.
Abstract: It has now been found that certain phosphonate derivatives of bis(aminoalkyl) piperazines are good threshold agents to prevent metal ion precipitation in aqueous solutions. They also function as sequestering and/or chelating agents as do those which do not contain the phosphonate group.
Type:
Grant
Filed:
February 24, 1984
Date of Patent:
July 14, 1987
Assignee:
The Dow Chemical Company
Inventors:
Druce K. Crump, Jaime Simon, David A. Wilson
Abstract: For measurement of chlorine concentration in a process stream, an improved device is set forth measuring light transmission in a selected frequency range. The preferred embodiment uses a light source, a light filter and an optical fiber extending to a pipe or other vessel with flowing chlorine. The light is transmitted from a lens system to another lens system and into a second optical fiber. The second fiber extends to a measuring device.
Type:
Grant
Filed:
June 17, 1985
Date of Patent:
March 3, 1987
Assignee:
The Dow Chemical Company
Inventors:
Thomas E. Morris, Tarver G. Snedecor, Jr.
Abstract: An aqueous composition containing hydrogen peroxide, or a precursor which will form said peroxide in aqueous solution, is inhibited from decomposition in the presence of small amounts of copper, iron, manganese or other transition metal ions and in the presence of significant amounts of alkaline earth metal ions, e.g. Ca or Mg, by the presence of a combination of inhibitors one being from the group consisting of alkyleneaminephosphonic acids and the other being from the group consisting of polyalkylenepolycarboxylic acids and their analogous amides and sulfonic acid derivatives.
Abstract: New stable complexing agents for radionuclides which are phosphonate derivatives of certain polyamidoamines have been found which are useful in imaging the skeletal system in animals. Even though the complexing agents have high molecular weights the complexes clear rapidly and very efficiently through the kidneys, with large amounts being taken up in the bone. The ratio of uptake in bone to that in surrounding soft tissue is high even at relatively short times after injection.
Type:
Grant
Filed:
July 2, 1984
Date of Patent:
August 19, 1986
Assignee:
The Dow Chemical Company
Inventors:
Jaime Simon, Wynn A. Volkert, David A. Wilson
Abstract: The process is an improvement over the chlorination of EDC in a boiling bed. The reactants, chlorine and dichloroethane (either 1,1- or 1,2-) are mixed in the vapor phase and passed over a molecular sieve which serves as a catalyst to produce 1,1,2-trichloroethane.
Type:
Grant
Filed:
October 29, 1982
Date of Patent:
August 12, 1986
Assignee:
The Dow Chemical Company
Inventors:
Roger L. Juhl, Mark S. Johnson, Thomas E. Morris
Abstract: A method of purifying 3-chloro-2-hydroxypropyl trialkylammonium chloride. An aqueous slurry is prepared containing about 70-98 wt. % total solids including the chloride and impurities associated with the preparation thereof. To this slurry is then added a miscible alcohol having about 3-4 carbon atoms. A solid filtrate is collected and optionally washed with additional alcohol and dried. The solid filtrate is substantially more pure in the chloride than the starting material.
Abstract: Stable methylchloroform solvent compositions in combination with from about 3 to about 5 volume percent of 2-butanol and from about 1 to about 3 volume percent of 3-methyl-1-butyn-3-ol have been shown to be superior solvents for removing flux from circuit boards. Such compositions have no flash point and maintain excellent distribution of the components in the vapor and liquid sections of the defluxing apparatus.
Type:
Grant
Filed:
February 15, 1985
Date of Patent:
July 1, 1986
Assignee:
The Dow Chemical Company
Inventors:
Susan M. Dallessandro, Wesley L. Archer, Stephen P. Krupp
Abstract: The imaging of cardiac infarcts with complexed radioactive metals is improved by employing as the complexing agent a compound of the formula ##STR1## wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms), methylenephosphonic, methylene-, ethylene-, and propylenesulfonic, carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts thereof and wherein at least one A, B, X and Y is methylenephosphonic acid or a salt thereof. In particular Tc-99m complexes have been found useful for imaging damaged cardiac tissue.
Type:
Grant
Filed:
September 19, 1983
Date of Patent:
April 15, 1986
Assignee:
The Dow Chemical Company
Inventors:
Jaime Simon, David A. Wilson, Wynn A. Volkert
Abstract: An alumina support which contains cesium is prepared by adding a fusible compound of cesium to alumina along with known binders and porosity control agents. The cesium compound should be fusible below the temperature at which the alumina fuses. Such a support is especially useful as a support for a silver catalyst employed in the oxidation of ethylene to ethylene oxide.
Type:
Grant
Filed:
February 8, 1984
Date of Patent:
March 11, 1986
Assignee:
The Dow Chemical Company
Inventors:
Harold W. Young, Jr., Oliver C. Ainsworth, Jr., William E. Fry, Lawrence E. Neil
Abstract: New compounds have been prepared from dicyclopentadiene bis(methylamine) which have the following formula ##STR1## wherein substituents A, B, X and Y each are independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) phosphonic, sulfonic, hydroxyethyl- and hydroxypropylsulfonic, methylenephosphonic methylene-, ethylene- and propylenesulfonic, alkylcarboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts of any of the phosphonic, sulfonic or carboxylic acid derivatives. At least one of the substituents must be other than a hydrogen. These compounds are useful chelating agents and those containing the methylenephosphonic substituents are good threshold agents.
Abstract: A process of preventing precipitation of scale producing metal ions, e.g. calcium, from their aqueous solutions by adding an effective amount of a methylenephosphonic acid derivative of bis(methylamine)-norbornane. These compounds are effective in threshold amounts.
Type:
Grant
Filed:
January 28, 1985
Date of Patent:
February 4, 1986
Assignee:
The Dow Chemical Company
Inventors:
Jaime Simon, Druce K. Crump, David A. Wilson
Abstract: Radionuclide complexes of phosphonate derivatives of bis(aminoalkyl)piperazine have been found which are useful for imaging and/or treating therapeutically the skeletal system to detect and treat bone tumors. These complexes clear readily through the kidneys and the ratio of uptake in bone to that in surrounding soft tissue is high.
Type:
Grant
Filed:
April 10, 1984
Date of Patent:
December 24, 1985
Assignee:
The Dow Chemical Company
Inventors:
Jaime Simon, David A. Wilson, Wynn A. Volkert, Druce K. Crump
Abstract: Distillation of the heavy waste stream from the manufacture of phenol via the cumene process provides an overhead stream containing phenol, acetophenone and 2-phenyl propionaldehyde. Extraction of the overhead stream with aqueous caustic removes the phenol and subsequent distillation of the remaining two components in the presence of a catalytic amount of caustic provides a substantially pure acetophenone distillate.
Type:
Grant
Filed:
July 11, 1983
Date of Patent:
December 17, 1985
Assignee:
The Dow Chemical Company
Inventors:
Loren L. Swearingen, Alfred W. Heinsohn, Craig W. Snook, Wallace E. Embrey, Garnet E. McConchie
Abstract: An improved process of making an oxidation catalyst containing vanadium, tin, potassium and a silicate binder which comprises employing a porosity control agent and calcination conditions to produce a catalyst having a mean pore diameter in the range of 5-15.mu. and at least 90% of the pores having diameters <10.mu..
Type:
Grant
Filed:
December 20, 1982
Date of Patent:
August 6, 1985
Assignee:
The Dow Chemical Company
Inventors:
Nobuyuki Ishibe, Renard L. Thomas, Emmett L. Tasset
Abstract: Superior solder flux, e.g., rosin flux, removal compositions are disclosed which have no flash point and are substantially non-corrosive toward aluminum. These compositions consist of about 0.5 to less than 2% methanol with about 3 to 10% of one or more alcohols containing 2-5 carbon atoms the balance being an inhibited 1,1,1-trichloroethane, wherein percentages are based on volume of the total composition.
Type:
Grant
Filed:
November 4, 1983
Date of Patent:
June 18, 1985
Assignee:
The Dow Chemical Company
Inventors:
Emmett L. Tasset, Susan M. Dallessandro, Warren F. Richey