Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces hygroscopicus ATCC 53626. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
Type:
Grant
Filed:
December 5, 1989
Date of Patent:
April 27, 1993
Assignee:
Pfizer Inc.
Inventors:
John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
Abstract: Process and intermediates for isopropyl 3S-amino-4-cyclohexyl-2R-hydroxybutyrate and 3S-amino-2R-hydroxy-5-methylhexanoate from R-malic acid. These products are of known utility in the synthesis of certain renin inhibitors.
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