Abstract: Decompression from dives using nitrogen or hydrogen as a dilutent gas are celerated by introducing into the large intestine an enzyme or, preferably non-toxic bacteria from the group that metabolizes hydrogen or from the group that metabolizes nitrogen. The bacteria are encouraged to multiply and feed on the hydrogen or nitrogen (dependent on the gas mixture used in the dive) by metabolizing the diluent gas released into the large intestine and the new product is vented from the large intestine. The metabolism of the hydrogen or nitrogen causes a reduction of the partial pressure of the metabolized gas in the large intestine thereby increasing the diffusion of the metabolized gas from the blood and surrounding tissues into the intestine. The delivery of the bacteria is accomplished by any one of several means with packaging of the enzyme or bacteria in enteric coatings for oral ingestion as a prefered means.

Abstract: A recombinant fusion protein (DEN-2 MBP) containing the B domain of the due (DEN 2 envelope protein is disclosed as a candidate subunit immunogen for vaccination against dengue virus infection. A gene fragment encoding amino acid 298 to amino acid 400 of the DEN-2 virus envelope was expressed as a fusion protein with the maltose binding protein (MBP) of Escherichia coli (E. coli). The recombinant fusion protein was purified and analyzed for its antigenicity imunogenicity and ability to protect mice against lethal challenge. This antigen is detected by monoclonal antibody (3H5) which is specific for a neutralizing epitope on the DEN-2 envelope and reacted with homologous polyclonal mouse immune ascitic fluid and DEN-2 immune human sera. A recombinant fusion plasmid bearing the DEN-2 MBP DNA sequence, expressing the fusion product in E. coli is disclosed.

Abstract: A monoclonal antibody is disclosed which is reactive to Bacteroides gingivalis and produced by the hybridoma deposited under ATCC HB 9968. The invention also discloses diagnostic reagents and methods for detecting Bacteroides gingivalis utilizing the hybridoma deposited under ATCC HB 9968.

Abstract: Decompression from dives using nitrogen or hydrogen as a dilutent gas are accelerated by introducing into the large intestine an enzyme or, preferably non-toxic bacteria from the group that metabolizes hydrogen or from the group that metabolizes nitrogen. The bacteria are encouraged to multiply and feed on the hydrogen or nitrogen (dependent on the gas mixture used in the dive) by metabolizing the diluent gas released into the large intestine and the new product is vented from the large intestine. The metabolism of the hydrogen or nitrogen causes a reduction of the partial pressure of the metabolized gas in the large intestine thereby increasing the diffusion of the metabolized gas from the blood and surrounding tissues into the intestine. The delivery of the bacteria is accomplished by any one of several means with packaging of the enzyme or bacteria in enteric coatings for oral ingestion as a prefered means.

Abstract: Antisense oligonucleotides complementary to human mRNAs or pre-mRNAs coding or VCAM-I are used in a therapeutic treatment of sepsis (sepsis, the sepsis syndrome, septic shock and all other manifestations of the sepsis disease, including but not inclusive of, adult respiratory distress syndrome, multi-organ failure, or cardiovascular dysfunction).

Abstract: The present invention provides a method for the treatment of septic shock d inflammatory complications of shock. A process for selectively inhibiting the expression of the human ELAM-I mRNA transcript using at least one oligonucleotide which is substantially complementary to at least a portion of the ELAM-I gene is disclosed, as are composition comprising the oligonucleotide.

Abstract: The present invention provides a method for the treatment of septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I mRNA transcript using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I mRNA is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I mRNA and compositions comprising the oligonucleotides.