Abstract: This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.
Abstract: A cigarette testing device (10) detects improperly filled or missing cigarettes in groups of cigarettes in a cigarette packing machine. Tappets (20) are positioned against the ends of cigarettes (11) and the position of tappets (20) is determined by optical sensors (28). Defective cigarettes (15) are removed from the group by nozzles (24). One to one correspondence between cigarettes, tappets, sensors, and nozzle ejectors allows single defective cigarettes to be rejected without rejecting the entire group of cigarettes.
Type:
Grant
Filed:
February 8, 1982
Date of Patent:
May 1, 1984
Assignee:
Philip Morris Incorporated
Inventors:
Raymond J. Knight, Robert T. Mitten, Robert L. Ripley
Abstract: This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.
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