Abstract: A transdermal patch for delivering nicotine for prolonged periods of 12-24 hours. The patch includes a rate-controlling membrane or monolith to keep the nicotine flux within useful and safe limits. The patch is typically replaced once a day, and can be used for smoking cessation therapy or in other situations where systemic nicotine delivery is indicated.

Abstract: A controlled release drug delivery system for placement in the periodontal pocket, gingival sulcus, tooth socket, wound or other cavity within the mouth. The system incorporates drug-containing microparticles in a fluid carrier medium, and is effective in the environment of use for up to 30 days.

Abstract: A portable infusion device assembly, having two side-by-side compartments, the first containing the drug or agent to be infused and an osmotic pump, and the second containing the driving liquid for the pump. The two chambers are separated during storage by a barrier. When the barrier is ruptured, the driving fluid is carried by means of a wick to the osmotic pump. The drug is then forced out of the device by the pressure developed by the osmotic pump. The assembly is characterized by a very flat profile, and is light, comfortable, and inconspicuous in use.