Abstract: A device and method for the localized treatment of vasculature with drugs and medicaments is described herein. Centrifugal force is used to drive a material from a reservoir to the outer surface of the application device and thereby deliver the treatment substance to the chosen area.

Abstract: Transdermal permeation of physostigmine free base and its chemical analogs are increased by the action of fatty acid esters of mono and difunctional alcohols.

Abstract: A method for fabrication of multilayer transdermal drug release devices that divides the assembly of the various drug delivery components of the device into their unit operations; treats the prefabricated units as modules that are later combined to obtain the finished transdermal drug delivery device. A variety of different configurations are available depending upon the drug or drugs to be administered.

Abstract: Disclosed herein is a bracket assembly for installing and removing an electrical device into and out of electrical equipment. The bracket assembly includes a slide and a mating carrier. The slide is semi-permanently mounted in electrical equipment, such as a computer work station or a shoe box or a personal computer. A compatible carrier includes the electrical device mounted thereon and engages and mates with the semi-permanently mounted slide. The slide is electrically connected to the electrical equipment and the carrier is electrically connected to the slide. In addition to being physically connected to the electrical device, the carrier is electrically connected to the electrical device by means of an electrical interconnect. Additionally, the carrier includes a configuration identification switch which allows the user to assign a device identification number while the electrical device is mounted on the carrier. The device identification number is visible to the user.

Abstract: A portable infusion device assembly where the drug is contained in a separate or separatable pouch in pressure transmitting relationship with a driving medium. The driving medium is pressurized by activation of osmotic pump, and the rate of delivery of the drug is regulated by a rate controlling means. Manufacture and sterilization of the infusate containing pouch separately from the other components of the systems to facilitates construction of sterile infusion pumps and provides an additional measure of safety.

Abstract: A method for smoking cessation therapy is described that utilizes transdermal nicotine delivery for obtaining base-line coupled with buccal administration of nicotine to satisfy transient craving.

Abstract: A means for elimination or compression of trapped air spaces in osmotically powered pumps is disclosed in which the housing of the pump is constructed of movable portions so that movement of the said housing portions will force air out of the device or compress it to such an extent that activation of the pump will result in the minimum lag time between activation of the pump and infusate flow.

Abstract: A transdermal patch for delivering nicotine for prolonged periods of 12-24 hours. The patch includes a rate-controlling membrane or monolith to keep the nicotine flux within useful and safe limits. The patch is typically replaced once a day, and can be used for smoking cessation therapy or in other situations where systemic nicotine delivery is indicated.

Abstract: A controlled release drug delivery system for placement in the periodontal pocket, gingival sulcus, tooth socket, wound or other cavity within the mouth. The system incorporates drug-containing microparticles in a fluid carrier medium, and is effective in the environment of use for up to 30 days.

Abstract: A portable infusion device assembly, having two side-by-side compartments, the first containing the drug or agent to be infused and an osmotic pump, and the second containing the driving liquid for the pump. The two chambers are separated during storage by a barrier. When the barrier is ruptured, the driving fluid is carried by means of a wick to the osmotic pump. The drug is then forced out of the device by the pressure developed by the osmotic pump. The assembly is characterized by a very flat profile, and is light, comfortable, and inconspicuous in use.