Abstract: Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, a, b, and X are as defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II.

Abstract: An ultrasonic welder for splicing a plurality of workpieces has four anvils, each formed with a meeting surface and displaceable to form a workpiece nest, which has a rectangular shape of a predetermined width. The width of the workpiece nest is sufficient to receive only at least one vertical column of workpieces to be welded, so as to produce a vertical splice. The ultrasonic welder further has a controller controlling a starting position of tooling, which forms the predetermined width of the workpiece nest, and displacing at least one of tools, which form side faces of the nest in reciprocal and time controlled manner. The displaceable tool is brought back to its starting position corresponding to the predetermined width of the workpiece nest before a new bundle of workpieces is loaded therein.

Abstract: A coupling serves for leakproof connection of two shaft-like medical instruments (10, 90) along their shaft axis (53, 97), in particular for connection of an arthroscope shaft to an optical system. A coupling element (80) is provided, arranged on a first instrument (10) and having a contact surface (66), against whose contact surface (66) a contact surface (106) of a coupling element (92) of the second instrument (90) can be applied. Also provided is an interlock system for releasable interlocking of the two coupling elements (80, 92), the contact surfaces (64, 106) resting against one another in leakproof fashion.

Abstract: The present invention relates to a process for manufacturing a pulverous preparation of a submicron-sized biologically active compound comprising the steps of dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; and rapidly expanding the compressed solution thereby precipitating the dissolved compound. An alternative process comprises dissolving the biologically active compound in compressed dimethylether, which may optionally contain a surface modifier; and spraying the compressed solution into an antisolvent phase, optionally containing a surface modifier, under vacuum, atmospheric pressure or elevated pressure. An optional third step involves converting the antisolvent phase into a pulverous preparation using conventional powder processing.

Abstract: An ankle-foot orthosis (A.F.O.) has an upper post for securing to a patient's leg, a shoe with an exterior surface on the heel, and a shoe-attachment device that attaches to the shoe and pivotably couples to the upper post member. A first shoe attachment device has a u-shaped member that is angled inward to be substantially co-planar with the exterior angled surface of the shoe to engage it and that has attachment posts that pivotably connect to the upper post. It also has an edge that engages the shoe. A second shoe attachment device is a u-shaped member having channel-and-hook connection on each end that is operable to receive and hold a fastener that extends through a channel in the heel of the shoe. It may also have a convex portion that mates with a trough on the shoe. Methods of manufacturing these types of systems are also presented.

Abstract: A handle for a medical instrument which has two jaw parts movable independently of one another has a handle body on which two handle elements, movable independently of one another, for selectable actuation of the jaw parts are arranged. Arranged at the proximal end of the handle body is a thumb handle element which has a thumb ring. The movable handle elements are arranged in a manner spaced distally away from the thumb handle element on the handle body, and protrude laterally therefrom. The thumb handle element is rotatable about a longitudinal handle axis relative to the movable handle elements, so that the one and the other movable handle element are movable alternately into a position forming in each case with the thumb handle element a handle arrangement operable in scissor fashion.

Abstract: An apparatus for puffing granular material, in particular cereals and legumes, has a heating apparatus for preheating the granular material and a puffing reactor for puffing the material. For effective, fast, and uniform heating of the material, it is proposed that: the heating apparatus have a free jet fluidized bed without a flow impact floor in which a batch of the material to be heated can be acted upon, in a preheating operation synchronized with the puffing process and proceeding batchwise, by a heat-carrying gaseous medium.

Abstract: The invention is characterised by the provision that in a slit lamp or a slit lamp projector an oblique thin glass flat with a partial reflection of the light is disposed at a defined angle relative to the optical path above the filter assembly between the latter and the “slit projector” lens (4), and in the configuration with an achromatic doublet lens between the lens assemblies in the parallel optical path, in such a way that as a result one part of the incident rays is incident as deflected light cone on a detector assembly which is arranged laterally in the housing at an angle dependent on the angle of the thin glass flat in the housing, which detector assembly measures the respectively existing luminous intensity, transmits the detected values to an evaluation and control means which compares the values so received against a predetermined maximum value, calculates the irradiation dose for the phakic or aphakic eye and, when the value is exceeded, signals this situation on an indicating alarm

Abstract: A dielectric protection layer is formed on the top and first and second side walls of a second pole tip portion of a second pole piece layer for preventing alteration of the track width of the second pole tip portion during subsequent fabrication of metallic components of the write head, such as a write coil, terminal leads to a read sensor and the write coil and studs to the terminal leads.

Abstract: Azole derivatives of the formula I wherein R14, R15 are each independently hydrogen or fluorine, T is a group of the formula: wherein R9 is pyrrolidinyl or a group A—NH—B—, A is hydrogen or straight-chain or branched C1-C5 alkyl; B is straight-chain or branched C1-C4 alkylene, —CH2—CONH—CH2 or —CH2CH2CH2—CH(NH2); and X− is a pharmaceutically acceptable anion; and pharmaceutically acceptable salts of said compounds, and hydrates and solvates of the compounds of formula I and the salts thereof can be used in the production of medicaments for treating fungal infections and mycoses.

Abstract: A combination rollover/vent valve, fuel pump and fuel level sender which is installed through a single access opening in the top of a fuel tank. The rollover/vent valve has a resilient mounting strip attached and the rollover/vent valve is attached to the fuel pump level sender module by a substantially rigid vent tube and the vent tube is ported exteriorly through the module. Upon insertion of the rollover/vent valve through the access opening, the mounting strip engages ratchet teeth formed in the top and bottom of the tank to secure the rollover/vent valve at a location of the highest level of the tank, remote from the module. The module thus locates the vent line, fuel feed line and electrical connections all at a single location on the tank top. The vent tube may be formed to a curved configuration to accommodate a dished or recessed tank top.

Abstract: An endoscope having a distally disposed lens and an optical transmission system which transmits the image of the lens to the proximal end of the endoscope is provided. The transmission system includes at least one reversing system, which includes two elements in mutual mirror-inverted arrangement. Each element includes a rod lens with planar faces and at least one optically thin lens having a planar surface. The rod lenses consist of an inhomogeneous material having a positive dispersion and an inhomogeneous refractive index in the radial direction, while the thin lenses are plano-convex lenses.

Abstract: A handle for a medical instrument comprises a first connecting means for connecting a shaft of said instrument of said handle, said shaft defining a longitudinal axis of said instrument. The handle further comprises a second connecting means for connecting a force transmission element of said instrument to said handle, said second connecting means being movable relative to said first connecting means for moving said force transmission element relative to said shaft for moving at least one tool disposed at the distal end of said shaft. The handle further comprises a first grip element and a second grip element, said first grip element and said second grip element being movable relative to each other, at least one of said first grip element and said second grip element being operatively connected with said second connecting means.

Abstract: A modular conveyor beam assembly is disclosed using readily removable stock components comprising a conveyor beam having an upper surface; a plurality of brackets mounted on the upper surface; a wearstrip mounted to the plurality of brackets; an endless chain having a conveying portion and a return portion, the conveying portion supported by the wearstrip; a plurality of support segments to receive the return portion of the endless chain; and an apex formed in the upper surface of the conveyor beam to drain the conveyor beam after washing. In a preferred embodiment, the modular conveyor beam assembly further comprises a first member contained in at least one bracket for mounting a guide rail section and a first mount element wherein a position of the guide rail section is adjustable, and wherein the support segments join substantially flat, planar side surfaces of the conveyor beam and are freely removable.

Abstract: The invention relates to a method and an apparatus for drying or heat-treating substances or products at a pressure other than atmospheric pressure. The invention relates furthermore to banana chips dried by means of this method and banana powder produced therefrom. For drying or heat-treating, the products to be treated are loaded in transport receptacles which are subsequently charged via charging lock chambers into a treatment chamber and discharged therefrom via discharging lock chambers. For drying or heat-treating, at least one microwave source is provided in the treatment chamber. Furthermore an infrared heating source may be provided. After heat-treating or drying a resting period may be scheduled. More particularly for this purpose a vertically oriented conveying system is provided in the treatment chamber when a longish resting period is involved. The transport receptacle is configured dished and may comprise nets on which the products are applied.

Abstract: Compounds of formula (I) as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance described in the specification, inhibit the binding of adhesive proteins to the surface of different types of cell and accordingly influence cell-cell and cell-matrix interactions. They can be used in the form of pharmaceutical preparations in the control or prevention of neoplasms, tumor metastasizing, tumor growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure as well as infections caused by viruses, bacteria or fungi.

Abstract: A suturing aid for closing minilaparotomies from minimal-invasive surgical operations comprises a shaft whose distal end is provided with at least one plane support that can be swung out laterally. An actuating element serves for swinging out the support, whereby the support can be moved between a first working position, in which it is folded up towards the proximal end, a second position, in which it is folded out laterally and a third working position, in which it is folded out towards the distal end of said shaft.

Abstract: The compounds of the related invention are related to 4-phenyl-pyridine derivatives connected by a bridge containing oxygen or nitrogen to a phenyl derivative.