Abstract: A method and apparatus for forming and controlling a microwave Bessel beam which may be utilized for examining microstructure including very early stage tumors.

Abstract: An exercise monitoring pedometer for pets is directed toward measuring a pet's exercise over some, period of time, such as a day or week or month. The pet pedometer includes a solid state three-axis accelerometer, a signal processing unit, a CPU, a memory chip and a display with settable controls, and may include a voice recorder/player; or these functions may reside mainly on an application specific integrated circuit. The settable controls are directed toward providing a setting for pet stride size for conversion for walking and running, and for manual resetting. The pet pedometer auto-selects automatically for a pet's stride both a walking stride and a running stride. The present invention may also contain a recorder, typically a solid state recorder, which provide for a recording of the pet “owner's” voice, or selected music, so that the owner may record encouragement, etc., to his/her pet.

Abstract: An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane.

Abstract: An electrochemical sensor includes electronic circuitry for automatically performing on a periodic basis, e.g., every 1 to 24 hours, specified integrity tests which verify proper operation of the sensor.

Abstract: Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used.

Abstract: The difficulties encountered with attaching tabs to very thin metal layer, e. g., a layer of gold from 0.3 .mu.m to 50 .mu.m thick are severe. Typically, in the uses envisioned for the thin metal layer, which is for a compact battery, a plastic sheet such as polyimide underlies the thin metal layer. Polyimide has a relatively low melting point. The thin polyimide substrate melts when resistance welding is used. Ultrasonic welding doesn't work because the sound wave energy is absorbed by the polyimide. This invention solves the attachment problem by using wire bonding to the thin metal sheet and to its tab. The tab attachment for a thin metal layer comprises a thin metal layer, a metal tab, and a wire and the wire is bonded to the thin metal layer and the wire is bonded to the metal tab. The thin metal layer may be gold; the thickness of the gold is between 0.3 .mu.m and 50.0 .mu.m.

Abstract: A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material includes a thin layer or layers of alumina, zirconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils while soaking in a saline solution at temperatures up to 80.degree. C. over a three month period.

Abstract: An implantable living tissue stimulator avoids the use of conventional coupling capacitors in its output stage, yet still prevents an average dc current flow from flowing through living tissue in electrical contact with the stimulator. The output stage generates and applies a biphasic stimulating current pulse to selected paired output terminals. The terminals, in turn, are electrically connected to respective electrodes which are positioned so as to contact the living tissue to be stimulated. In one embodiment, special circuitry is employed within the output stage to block dc current flow through the living tissue and to balance the electrical charge that is delivered to the living tissue. In another embodiment, the electrodes themselves are made from a material that allows them to function as a capacitor. In yet an additional embodiment, the coupling capacitors are integrated into the leads that connect the output terminals of the output stage with the electrodes.

Abstract: A low power switched rectifier circuit is realized using P-MOS and N-MOS FET switches that are turned ON/OFF at just the right time by a detector and inverter circuit (which form an integral part of the rectifier circuit) to rectify an incoming ac signal in a highly efficient manner. Parasitic diodes and transistors that form an integral part of the FET circuitry respond to and rectify the incoming signal during start up, i.e., when no supply voltage is yet present, thereby providing sufficient operating voltage for the FET switches to begin to perform their intended rectifying function. In the absence of an incoming ac signal, i.e., during the time between biphasic pulses, the rectifier circuit is biased with an extremely small static bias current; but in the presence of an incoming ac signal, at a time when the positive and negative phases of the incoming signal are to be connected to positive and negative supply lines, a much larger dynamic bias current is automatically triggered.

Abstract: An implantable sensor/stimulator is connectable to a controller using just two conductors, which two conductors carry both operating power and data (data commands and/or measured data) between the sensor/stimulator and control circuit. Each sensor/stimulator may be serially connected to another sensor/stimulator, again using only two conductors, thereby allowing a "daisy chain" of such sensors/stimulators to be formed. Each sensor/stimulator in the daisy chain is individually addressable by the control circuit. Input data is sent to the sensors over the two conductors using a phase-modulated biphasic modulation scheme, which scheme also provides operating power for each sensor/stimulator connected to the two conductors. Output data is sent from the sensors to the controller over the same two conductors using a pulse-position presence/absence modulation scheme. The data transmission schemes provide a very high signal-to-noise ratio.