Patents Represented by Attorney A. Sheffer
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Patent number: 5407808Abstract: Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting the cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating the cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in the cells thereby causing a buildup of protoporphyrin IX in the cells. Also disclosed is a method for the production of protoporphyrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphyrinogen oxidase inhibitor.Type: GrantFiled: December 20, 1993Date of Patent: April 18, 1995Assignee: FMC CorporationInventors: Blaik P. Halling, Debra A. Yuhas
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Patent number: 5298502Abstract: Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating said cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in said cells thereby causing a buildup of protoporphyrin IX in said cells. Also disclosed is a method for the production of protoporphyrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphyrinogen oxidase inhibitor.Type: GrantFiled: December 23, 1991Date of Patent: March 29, 1994Assignee: FMC CorporationInventors: Blaik P. Halling, Debra A. Witkowski
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Patent number: 5294595Abstract: Herbicidal compounds of the formula ##STR1## in which, for example, X is Br, Cl or F; Y is Cl or Br, R.sup.2 is CHF.sub.2, R.sup.3 is CH.sub.3, R is alkyl, dialkylamino, carboxymethyl, hydroxy, haloalkyl, or aryl, and R.sup.1 is H, Na, lower alkyl or --SO.sub.2 R.Type: GrantFiled: March 22, 1993Date of Patent: March 15, 1994Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 5041155Abstract: Herbicidal compounds of the formula ##STR1## in which, for example, X is Br, Cl or F; Y is Cl or Br, R.sup.2 is CHF.sub.2, R.sup.3 is CH.sub.3, R is alkyl, dialkylamino, carboxymethyl, hydroxy, haloalkyl, or aryl, and R.sup.1 is H, Na, lower alkyl or --SO.sub.2 R.Type: GrantFiled: December 28, 1989Date of Patent: August 20, 1991Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 5011933Abstract: Process for the nitration of a compound of formula I below with nitric acid in sulfuric acid, according to the following general equation: ##STR1## where X is a Cl or F and R is haloalkyl, for example CHF.sub.2 or CF.sub.2 CHF.sub.2, in which the improvement comprises carrying out said reaction in fuming sulfuric acid.Type: GrantFiled: February 26, 1990Date of Patent: April 30, 1991Assignee: FMC CorporationInventors: John H. Hoare, Marc Halfon
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Patent number: 4994104Abstract: Disposed are herbicidal compounds of the formula ##STR1## wherein Q is a heterocyclic ring having 5 to 7 ring atoms and having the formula ##STR2## wherein Z is an oxygen or sulfur atom or a vinylene group, R.sup.4 and R.sup.5 are independently alkylene groups having 1 to 4 carbon atoms, and m and n are each independently an integer of 0 or 1; and in which R.sup.1 is H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, alkoxyalkyl, alkoxyalkoxyalkyl, cycloalkyl, aralkyl, alkylthioalkyl, hydroxy, alkoxy, cyanoalkyl or alkylcarbonylalkyl; R.sup.2 and R.sup.3 are independently H or alkyl; and X is H, Cl or F. Also disclosed are herbicidal compositions and an herbicidal method of use for the herbicidal compounds.Type: GrantFiled: December 19, 1988Date of Patent: February 19, 1991Assignee: FMC CorporationInventor: Jun H. Chang
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Patent number: 4985065Abstract: Herbicidal compounds of the formula ##STR1## in which Q is ##STR2## M is CH or N; Z is O, S, NH or alkylamino;R.sup.3 is H, OH, alkoxy, alkenyloxy or alkynyloxy, alkoxyalkoxy, alkenyloxyalkoxy or alkynyloxyalkoxy, alkyl, substituted alkyl, OZ.sup.2 where Z.sup.2 is of a salt-forming group, amino, arylamino, alkylamino, alkenylamino, alkoxyamino, substituted alkoxyamino or --NHSO.sub.2 R.sup.5 where R.sup.5 is alkyl, haloalkyl or aryl;R.sup.1 is H, alkyl, halogen, haloalkyl, nitro, NH.sub.2, lower alkoxy, alkylthio or cyano;R.sup.2 is H, lower alkyl, lower alkenyl, lower alkynyl, halogen, CN, or COR.sup.3 ;R is H, lower alkyl, halogen, or lower alkoxy or R and R.sup.2 together constitute a double bond;R.sup.4 is H, halogen, lower alkyl, lower alkenyl, or lower alkynyl;R.sup.7 is H or lower alkyl; andR.sup.a, X and Y are so chosen that when Q is methoxy or propargyloxy, instead of Q having the formula given above, the compound is a herbicide.Type: GrantFiled: May 10, 1989Date of Patent: January 15, 1991Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4980480Abstract: Process for the production of an aryl triazolinone of the formula: ##STR1## in which R is halogen, alkyl, haloalkyl, cyanoalkyl, arylalkyl, alkoxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl or phenyl,each X is independently, H, halogen, lower alkyl, lower alkoxy, --NO.sub.2, --OH, --NHSO.sub.2 R', --N(SO.sub.2 R').sub.2 or --N(R')SO.sub.2 R' where R' is lower alkyl, and n is a number from 1 to 3,by treating an aryl triazolidinone of the formula: ##STR2## with a halogen of the group consisting of chlorine, bromine and iodine, or a hypohalous acid of said halogen or a salt of said acid.Type: GrantFiled: September 8, 1989Date of Patent: December 25, 1990Assignee: FMC CorporationInventors: George Theodoridis, John W. Lyga
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Patent number: 4956004Abstract: Herbicidal compounds of the formula ##STR1## in which Q is ##STR2## M is CH or N; Z is O, S, NH or alkylamino;R.sup.3 is H, OH, alkoxy, alkenyloxy or alkynyloxy, alkoxyalkoxy, alkenyloxylakoxy or alkynyloxyalkoxy, alkyl, substituted alkyl, OZ.sup.2 where Z.sup.2 is of a salt-forming group, amino, arylamino, alkylamino, alkenylamino, alkoxyamino, substituted alkoxyamino or --NHSO.sub.2 R.sup.5 where R.sup.5 is alkyl, haloalkyl or aryl;R.sup.1 is H, alkyl, halogen, haloalkyl, nitro, NH.sub.2, lower alkoxy, alkylthio or cyano;R.sup.2 is H, lower alkyl, lower alkenyl, lower alkynyl, halogen, CN, or COR.sup.3 ;R is H, lower alkyl, halogen, or lower alkoxy, R and R.sup.2 together constitute a double bond;R.sup.4 is H, halogen, lower alkyl, lower alkenyl, or lower alkynyl;R.sup.7 is H or lower alkyl;R.sup.b and R.sup.c are each H or together constitute a double bond; andR.sup.a, X and Y are so chosen that when Q is methoxy or propargyloxy, instead of Q having the formula given above, the compound is a herbicide.Type: GrantFiled: May 10, 1989Date of Patent: September 11, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4954159Abstract: The present application discloses herbicidal phosphorylaminophenyltetrahydrophthalimides, compositions of them, methods of preparing them, and methods for controlling undesired plant growth by preemergence or postemergence application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds are compounds of the formula ##STR1## in which X and Y are independently F, Cl, or Br; R.sup.1 is selected from lower alkyl, lower haloalkyl, cycloalkyl of 3 to 7 ring carbon atoms, lower alkenyl, lower haloalkenyl, lower alkynyl, lower haloalkynyl, and benzyl which is unsubstituted or substituted on the phenyl ring with one or more substituents selected from halogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl, cyano, and nitro; and R.sup.2 is independently selected from among --OR.sup.1 or is hydroxy, amino, lower alkylamino, or lower dialkylamino; R.sup.3 is H, lower alkyl, or lower alkenyl; or a base addition salt of the compound as defined above in which R.sup.2 is hydroxy.Type: GrantFiled: March 17, 1989Date of Patent: September 4, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4932996Abstract: The present application discloses herbicidal phosphorylaminophenyltetrazolinones, compositions of them, methods of preparing them, and methods for controlling undesired plant growth by preemergence or postemergence application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds are compounds of the formula ##STR1## in which X and Y are independently F, Cl, or Br; R is lower alkyl or lower haloalky; R.sup.1 is selected from lower alkyl, lower haloalkyl, cycloalkyl of 3 to 7 ring carbon atoms, lower alkenyl, lower haloalkenyl, lower alkynyl, lower haloalkynyl, and benzyl which is unsubstituted or substituted on the phenyl ring with one or more substituents selected from halogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl, cyano, and nitro; R.sup.2 is independently selected from among --OR.sup.1 or is hydroxy, amino, lower alkylamino, or lower dialkylamino; R.sup.Type: GrantFiled: March 7, 1989Date of Patent: June 12, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4919708Abstract: Herbicidal 1-aryl-1,2,4-triazolin-5(1H)-ones having a haloalkyl group (e.g. CHF.sub.2, CF.sub.3 or CClF.sub.2) attached to the carbon atom at the 3-position of the triazolinone ring.Type: GrantFiled: June 26, 1989Date of Patent: April 24, 1990Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 4909829Abstract: Quinolinone compounds of the formula ##STR1## in which R.sup.2 is H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, alkoxyalkyl, alkoxyalkoxyalkyl, cycloalkyl, alkylthioalkyl, aralkyl, cyanoalkyl, alkoxycarbonylalkyl, hydroxy, or alkoxy; X is H, halogen, alkyl, or haloalkyl; Y is H, halogen, alkyl, haloalkyl, alkoxycarbonyl, cyano, or nitro; Z is H, halogen, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, haloalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, cyano, or nitro; and R.sup.1 is alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, or haloalkoxyalkyl; and the corresponding 3,4-dihydroquinolinone compounds as herbicides.Type: GrantFiled: December 29, 1987Date of Patent: March 20, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4906284Abstract: Herbicidal compound of the formula ##STR1## whose Difluoromethyl Analog or Methyl Analog is a herbicide (the Difluoromethyl Analog being identical except that it has a --CHF.sub.2 group instead of the --CH.sub.2 CH.sub.2 CH.sub.2 F group of said compound and the Methyl Analog being identical except that it has a --CH.sub.3 group instead of the --CH.sub.2 CH.sub.2 CH.sub.2 F group of said compound), Ar being an aryl radical.Type: GrantFiled: August 23, 1988Date of Patent: March 6, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4906281Abstract: Disclosed are herbicidal compounds of the formula ##STR1## wherein W is sulfur or oxygen;X is Br, Cl, F, alkyl, or haloalkyl; Y is Br, Cl, F, methyl, haloalkyl, haloalkoxy, nitro, or a radical of the formula --CH.sub.2 QR.sup.8 in which Q is O, S, S(O), or S(O).sub.2 and R.sup.8 is alkyl, alkenyl, alkynyl, optionally substituted phenyl; R is alkyl, haloalkyl, dialkylamino, carboxymethyl, hydroxy, or optionally substituted phenyl; R.sup.1 is hydrogen, alkyl, benzyl, haloalkyl, alkoxy, alkynyl, alkenyl, alkoxymethyl, cyanomethyl, hydroxycarbonylmethyl, alkoxycarbonylmethyl, or a group of the formula --SO.sub.2 R or --alkylene--SO.sub.2 R in which R is as defined above; or R and R.sup.1 together are a divalent alkylene radical; or a base addition salt of a compound as defined above in which R or R.sup.1 is or contains an acidic proton.Type: GrantFiled: July 1, 1988Date of Patent: March 6, 1990Assignee: FMC CorporationInventor: Jun H. Chang
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Patent number: 4902338Abstract: The present invention application discloses herbicidal phosphorylaminophenylhydantoins, compositions of them, methods of preparing them, and methods for controlling undesired plant growth by preemergence or postemergence application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds are compounds of the formula ##STR1## in which X and Y are independently, F, Cl, or Br; R is lower alkyl or lower haloalkyl; R.sup.1 is selected from lower alkyl, lower haloalkyl, cycloalkyl of 3 to 7 ring carbon atoms, lower alkenyl, lower haloalkenyl, lower alkynyl, lower haloalkynyl, and benzyl which is unsubstituted or substituted on the phenyl ring with one or more substituents selected from halogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl, cyano, and nitro; R.sup.2 is independently selected from among --OR.sup.1 or is hydroxy, amino, lower alkylamino, or lower dialkylamino; or a base addition salt of the compound as defined above in which R.sup.2 is hydroxy.Type: GrantFiled: March 17, 1989Date of Patent: February 20, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4898606Abstract: The present application discloses herbicidal phosphorylaminophenyltriazolinones, compositions of them, methods of preparing them, and methods for controlling undesired plant growth by preemergence or postemergence application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds are compounds of the formula ##STR1## in which X and Y are independently F, Cl, or Br; R is lower alkyl or lower haloalkyl; R.sup.1 is selected from lower alkyl, lower haloalkyl, cycloalkyl or 3 to 7 ring carbon atoms, lower alkenyl, lower haloalkenyl, lower alkynyl, lower haloalkynyl, and benzyl which is unsubstituted or substituted on the phenyl ring with one or more substituents selected from halogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl, cyano, and nitro; R.sup.2 is independently selected from among --OR.sup.1 or is hydroxy, amino, lower alkylamino, or lower dialkylamino; R.sup.Type: GrantFiled: March 7, 1989Date of Patent: February 6, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4894084Abstract: Quinolinone compounds of the formula ##STR1## in which R.sup.3 is H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, alkoxyalkyl, alkoxyalkoxyalkyl, cycloalkyl, alkylthioalkyl, aralkyl, cyanoalkyl, alkoxycarbonylalkyl, hydroxy, or alkoxy; X is H, halogen, alkyl, or haloalkyl; Y is H, halogen, alkyl, haloalkyl, alkoxycarbonyl, cyano, or nitro; Z is H, halogen, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, haloalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, cyano, or nitro; R.sup.1 is alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, or haloalkoxyalkyl; and R.sup.2 is alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, or halogen; and the corresponding 3,4-dihydroquinolinone compounds as herbicides.Type: GrantFiled: December 29, 1987Date of Patent: January 16, 1990Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4885025Abstract: Disclosed are herbicidal aryltetrazolinones in which the aryl moiety is a substituted-phenyl radical having at the 5-position of the phenyl ring a group of the formula ##STR1## wherein Z is O, S, NH, or alkylamino; R.sup.1 is H, alkyl, halogen, haloalkyl, NO.sub.2, NH.sub.2, CN, lower alkoxy or lower alkylthio; and Q.sup.3 is a group of the formula --[O--CH(R.sup.4a)CO].sub.m --OCH(R.sup.4)Q.sup.2 in which Q.sup.2 is --(C(O)R.sup.3 or --CN; R.sup.4 and R.sup.4a are each independently H, CH.sub.3 or C.sub.2 H.sub.5 ; R.sup.3 is OH, alkoxy, alkylthio, lower alkenyloxy or alkynyloxy, amino, arylamino, alkylamino, alkenylamino, alkynylamino, alkoxyamino or alkyl-, haloalkyl- or arylsulfonylamino of the formula -NHSO.sub.2 R.sup.5 or --N(SO.sub.2 R.sup.5)SO.sub.2 R.sup.6, or an --O--N.dbd.R.sup.8 radical where R.sup.8 is alkylidene; R.sup.5 and R.sup.6 are each independently alkyl, haloalkyl or aryl; and "m" is zero or one.Type: GrantFiled: December 23, 1986Date of Patent: December 5, 1989Assignee: FMC CorporationInventor: George Theodoridis
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Patent number: 4878941Abstract: Quinolinone compounds of the formula ##STR1## in which R.sup.3 is H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, alkoxyalkyl, alkoxyalkoxyalkyl, cycloalkyl, alkylthioalkyl, aralkyl, cyanoalkyl, alkoxycarbonylalkyl, hydroxy, or alkoxy; X is H, halogen, alkyl or haloalkyl; Y is H, halogen, alkyl, haloalkyl, alkoxycarbonyl, cyano, or nitro; Z is H, halogen, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, haloalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, cyano, or nitro; R.sup.1 alkyl, alkenyl, alkynyl, haloalkyl alkoxyalkyl, or haloalkoxyalkyl; and R.sup.2 is H, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylsulfinyl, alkyl, alkoxy, halolkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, or halogen; and the corresponding 3,4-dihydroquinolinone compounds as herbicides.Type: GrantFiled: December 29, 1987Date of Patent: November 7, 1989Assignee: FMC CorporationInventor: George Theodoridis