Patents Represented by Attorney Adam Cochran

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  • Liposomal targeting of ischemic tissue
    Patent number: 5593688
    Abstract: Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 14, 1997
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventor: John D. Baldeschwieler
  • Liposome dispersion
    Patent number: 5589189
    Abstract: A process for the production of a non-aggregating, filterable dispersion of liposomal encapsulated hemoglobin includes the addition of a plasma protein such as human serum albumin to a liposome dispersion and the application of liposome-forming energy to the dispersion sufficient to form unilamellar vesicles having a diameter smaller than 0.2 .mu.m.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: December 31, 1996
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventor: Karen L. Moynihan
  • Liposomal targeting of ischemic tissue
    Patent number: 5527538
    Abstract: Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas in the absence of antibodies bound to the liposomes to effect the delivery.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: June 18, 1996
    Assignee: Vestar, Inc.
    Inventor: John D. Baldeschwieler
  • Phospholipid analogue vesicle
    Patent number: 5419914
    Abstract: Delivery vehicle formulations comprising active agents encapsulated within microparticles which include a succinimidyl moiety extending externally from a lipid molecule therein are capable of the cytoplasmic or nuclear cell delivery of intact encapsulated active agents.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: May 30, 1995
    Assignee: Vestar, Inc.
    Inventor: Sean M. Sullivan
  • Prevention of synovial adhesions
    Patent number: 5411743
    Abstract: Adhesions in synovial capsules are prevented through the administration of liposome intercalated nonsteroidal anti-inflammatory agents.
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: May 2, 1995
    Assignee: Vestar, Inc.
    Inventors: Larry J. Moore, Jill Adler-Moore
  • Liposome targeting using receptor specific ligands
    Patent number: 5258499
    Abstract: Delivery vehicle formulations comprise active agents encapsulated within liposomal vesicles to which are attached protein hormones (ligands) such as interleukin-2. The ligands are capable of showing affinity for specific cell receptors resulting in delivery of the encapsulated active agent to target cells, enabling delivery of active agents to particular cell populations in the treatment of conditions such as immune system disorders.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: November 2, 1993
    Assignee: Vestar, Inc.
    Inventors: Paula J. Konigsberg, Leroy L. Richer, Paul G. Schmidt, Joseph A. Uliana
  • Encapsulation process
    Patent number: 5227170
    Abstract: A process for the encapsulation of oligonucleotides in liposomes includes the suspending of liposomes containing a divalent cation in a solution containing an oligonucleotide and having an osmolarity of a less than that of the internal aqueous phase.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: July 13, 1993
    Assignee: Vestar, Inc.
    Inventor: Sean M. Sullivan
  • Systemic plant interface
    Patent number: 5225342
    Abstract: A systemic plant interface replaces the roots of a growing plant by providing a perforate surface which mates to growing xylem tissue of a vascular plant and provides fluid communication and support necessary to sustain the aerial portions of a viable plant.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: July 6, 1993
    Inventor: Michael E. Farrell
  • Method and device to sustain a cut flower and its blossoms
    Patent number: 5167672
    Abstract: A plant stem is provided with liquid only after the liquid has passed through a membrane having a porosity which is insufficient to permit the passage of microorganisms with the liquid to the stem.
    Type: Grant
    Filed: October 21, 1988
    Date of Patent: December 1, 1992
    Inventor: Michael E. Farrell
  • Method and device to sustain a cut flower and its blossoms
    Patent number: 5103586
    Abstract: A plant stem is sealed aseptically by an initially imperforate, stem-penetrable elastomer which is sufficiently flowable and has sufficient self-affinity to form a seal against the stem which is sufficient to resist the flow of liquid around the stem at a pressure of about 0.9 to about 1.2 psi, and an elastomer is provided containing dispersed, suspended particles of a water-insoluble, hydroscopic polymer.
    Type: Grant
    Filed: May 9, 1990
    Date of Patent: April 14, 1992
    Inventor: Michael E. Farrell
  • Film-forming evaporation apparatus
    Patent number: 5028297
    Abstract: A thin-film evaporator for preparing liposomes in commercial quantities provides a film-forming zone of uniform thickness which enables the uniform evaporation of an organic solvent to form a film of uniform thickness, followed by in situ hydration of the film in an aqueous phase by agitation with a rotor.
    Type: Grant
    Filed: June 6, 1990
    Date of Patent: July 2, 1991
    Assignee: Vestar, Inc.
    Inventor: Kevin R. Bracken
  • Method for vesicle formation
    Patent number: 4935171
    Abstract: A single-vessel method is provided for preparing liposomes in commercial quantities by forming a homogeneous and uniform lipid film in a thin-film evaporator by evaporation of the organic solvent, followed by in situ hydration of the film in an aqueous phase by agitation with the rotor.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: June 19, 1990
    Assignee: Vestar, Inc.
    Inventor: Kevin R. Bracken