Abstract: A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells.
Type:
Grant
Filed:
October 26, 1999
Date of Patent:
April 9, 2002
Assignee:
Osiris Therapeutics, Inc.
Inventors:
Kevin R. McIntosh, Joseph D. Mosca, Elena N. Klyushnenkova
Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are human Hox C10 polypeptides. The invention also relates to identifying mesenchymal stem cells (MSCs) or other cells comprising such polypeptides or polynucleotides that encode the polypeptides.
Abstract: Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods and preparations for treating and regenerating connective tissue and enhancing bone marrow engraftment in an individual; and for using genetically engineered allogeneic human mesenchymal stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins in gene therapy for correction of genetic disorders or “rebuilding” proteins important in tissue repair.
Type:
Grant
Filed:
March 12, 1999
Date of Patent:
March 12, 2002
Assignee:
Osiris Therapeutics, Inc.
Inventors:
Scott P. Bruder, Kevin R. McIntosh, Daniel R. Marshak, Joseph D. Mosca
Abstract: The present invention relates to an apparatus to perform reagent-free assays, which apparatus utilizes an all solid probe having an enzyme label that acts on a substrate by obtaining electrons directly from the electrode by bioelectrocatalysis.
Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are human slit polypeptides. The invention also relates to identifying mesenchymal stem cells (MSCs) or other cells comprising such polypeptides or polynucleotides that encode the polypeptides.
Abstract: This invention relates to newly identified auxotrophs, polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production and isolation of such polynucleotides and polypeptides. More particularly, the polynucleotides and polypeptides of the present invention have been putatively identified as being very important to the growth and/or reproduction of Aspergillus fumigatus.
Abstract: Disclosed is a method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells.
Type:
Grant
Filed:
March 12, 1999
Date of Patent:
December 11, 2001
Assignee:
Osiris Therapeutics, Inc.
Inventors:
Kevin R. McIntosh, Joseph D. Mosca, Elena N. Klyushnenkova
Abstract: Processes for the amplification of target DNA sequences in the form of single or double stranded circular DNA molecules, especially those present in colony and plaque extracts, using multiple specific and/or random sequence oligonucleotide primers are disclosed along with methods for detecting such amplified target sequences. A kit containing components for use in the invention is also described.
Type:
Grant
Filed:
June 28, 2000
Date of Patent:
November 27, 2001
Assignee:
Molecular Staging, Inc.
Inventors:
Roger S. Lasken, Frank B. Dean, John Nelson
Abstract: Methods for the amplification of selected nucleic acids at high rate but with high specificity and control are disclosed using a secondary, tertiary, quaternary or higher order platform especially designed to amplify selected sequences within the primary product of linear or exponential rolling circle amplification and amplifying said sequences along with specialized detector or reporter molecules that serve to enhance the ability to detect the amplification products.
Type:
Grant
Filed:
May 24, 2000
Date of Patent:
September 18, 2001
Assignee:
Molecular Staging, Inc.
Inventors:
Stephen Kingsmore, R. Steven Wiltshire, Jeremy P. Lambert
Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are PERV-D env polypeptides. The invention also relates to detecting the presence of a porcine retrovirus in tissue comprising such polypeptides or polynucleotides that encode the polypeptides.
Type:
Grant
Filed:
August 18, 1999
Date of Patent:
July 17, 2001
Assignee:
BioTransplant, Inc.
Inventors:
Papia T. Banerjee, Clive Patience, Goran K. Andersson
Abstract: This invention relates to newly identified auxotrophs, polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production and isolation of such polynucleotides and polypeptides. More particularly, the polynucleotides and polypeptides of the present invention have been putatively identified as being very important to the growth and/or reproduction of Aspergillus fumigatus.
Abstract: A multiple vitamin supplement composition comprising folic acid and vitamin B.sub.12 disclosed that is essentially free of antioxidants is disclosed. The multiple vitamin supplement composition may contain vitamin B.sub.6. The multiple vitamin supplement composition is useful for lowering serum homocysteine levels to protect against related blood vessel disorders. Further disclosed is a method of preparing such a multiple vitamin supplement and a method of administration.