Patents Represented by Attorney, Agent or Law Firm Alan Scrivner
  • Pyrrolo[1,2-b][1,2,4]oxadiazine diones useful as nitric oxide synthase inhibitors
    Patent number: 6774126
    Abstract: Pyrrolo[1,2-b][1,2,4]oxadiazine-2,3(6H)-diones having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: August 10, 2004
    Assignee: Pharmacia Corporation
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Alok K. Awasthi, Suzanne Metz, Jeffrey A. Scholten, Jeffery S. Snyder, Mihaly V. Toth, Ronald Keith Webber
  • Lactone integrin antagonists
    Patent number: 6720327
    Abstract: The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: April 13, 2004
    Assignee: Pharmacia Corporation
    Inventors: Peter Ruminski, Thomas D. Penning, Lan Jiang, Balekudru Devadas, Thomas Rogers, Jennifer VanCamp, Chester Yuan
  • Site specific ligation of proteins to synthetic particles
    Patent number: 6682727
    Abstract: The present invention relates to site-specific conjugation of synthetic particles to proteins.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: January 27, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Stephen C. Lee, Ranjani V. Parthasarathy
  • &agr;&ngr;&bgr;3 integrin antagonists in combination with chemotherapeutic agents
    Patent number: 6372719
    Abstract: The present invention is directed to compounds of the formula and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: April 16, 2002
    Inventors: Jay Cunningham, Gary B. Gordon, G. Allen Nickols, William F. Westlin, Thomas Edward Rogers, Peter Gerrard Ruminski
  • Process for the enzymatic resolution of lactams
    Patent number: 6277626
    Abstract: A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid. The hydrolysis product is then separated from the unreacted lactam esters. The enzyme is then recycled for reuse in the next enzymatic resolution. The undesired isomer is also racemized and reused in the next enzymatic resolution.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: August 21, 2001
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mahima Trivedi, Rolando E. Gapud, John S. Ng, Alok K. Awasthi, Ping T. Wang