Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
Type:
Grant
Filed:
June 17, 2003
Date of Patent:
January 30, 2007
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
Abstract: A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.
Type:
Grant
Filed:
May 15, 1995
Date of Patent:
March 28, 2000
Assignee:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Danny W. Chladek, David E. Gorcyca, Louis L. Harris
Abstract: The present invention relates to indolinones of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
Type:
Grant
Filed:
March 26, 1999
Date of Patent:
March 28, 2000
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Wolfgang Grell, Helmut Wittneben, Jacobus Constantinus Antonius van Meel, Norbert Redemann, Rainer Walter, Armin Heckel, Frank Himmelsbach, Robert Haigh
Abstract: An improved process for making chiral, .alpha.-methylated, .alpha.-substituted amino acids of the formula I ##STR1## wherein Y is a hydrogen atom and R.sub.2 is the residue of a natural or unnatural amino acid, in which process an oxazolidinone of the formula II ##STR2## is formed by reacting a protected amino acid of the formula IA ##STR3## wherein Y is a protecting group, with an aldehyde of the formula RCHO, or an equivalent thereof, in the presence of a chlorinating agent and a Lewis acid.The group R.sub.2 is introduced into the oxazolidinone intermediate of formula II in a conventional manner, and subsequent hydrolysis and deprotection, both carried out in a conventional manner, yield the chiral, .alpha.-methylated, .alpha.-substituted amino acid.
Type:
Grant
Filed:
June 29, 1999
Date of Patent:
March 28, 2000
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Inventors:
Denice M. Spero, Suresh Kapadia, Elio Napolitano
Abstract: The invention relates to cyclic imino derivatives of general formulaB--X.sub.5 --X.sub.4 --X.sub.3 --X.sub.2 --X.sub.1 --A--Y--E(I)whereinA, B, E, X.sub.2 to X.sub.5 and Y are defined as in claim 1, the stereoisomers, tautomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions which contain these compounds and processes for preparing them.
Type:
Grant
Filed:
December 23, 1993
Date of Patent:
October 3, 1995
Assignee:
Karl Thomae
Inventors:
Volkhard Austel, Wolfgang Eisert, Frank Himmelsbach, Guenter Linz, Thomas Mueller, Helmut Pieper, Johannes Weisenberger
Abstract: Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.
Type:
Grant
Filed:
December 20, 1988
Date of Patent:
January 1, 1991
Assignee:
Boehringer Ingelheim KG
Inventors:
Claus Schneider, Herbert Merz, Rainer Sobotta, Rudolf Bauer, Joachim Mierau, Gunter Schingnitz
Abstract: Novel discrete coaxial cable and coaxial cable assembly constructions are disclosed. One preferred embodiment of the invention is a flat coaxial cable assembly. The invention also provides a novel method for manufacturing the coaxial elements which are the primary structural components of the coaxial cables and assemblies. In this method a signal wire and at least one drain wire are embedded in a minor matrix of dielectric material. A portion of the minor matrix material is peeled or skived away to expose the drain wire or wires. The resulting product is then wrapped in metal foil so that the foil makes electrical contact with the exposed drain wires. This step yields a completed coaxial element. A single element may be embedded in a major matrix of dielectric to yield a coaxial cable or several elements may be so embedded to yield a coaxial cable assembly.
Type:
Grant
Filed:
July 6, 1982
Date of Patent:
December 11, 1984
Assignee:
Brand-Rex Company
Inventors:
John M. Gentry, Virgil T. Bolick, Jr., Kenneth W. Brownell, Jr.
Abstract: A low density matting structure of improved transverse strength obtained by vertically laying continuous melt-spun thermoplastic macrofilaments (diameter=0.1-1.5 mm) onto a horizontally moving profiled support in overlapping rows of irregularly looped filaments to form a peak and valley three-dimensional structure undulating in its longitudinal and/or transverse direction. The matting articles consist essentially of the melt-spun filaments which are self-bonded or fused at random points of intersection without using any bonding agent or reinforcing inserts, and the resulting matting is especially distinguished by a high transverse strength per unit of surface weight of at least 2 Nm/g and preferably 4 Nm/g.
Type:
Grant
Filed:
February 4, 1980
Date of Patent:
August 3, 1982
Assignee:
Akzona Incorporated
Inventors:
Alfred Rasen, Rolf Vollbrecht, Klemens Schenesse, Joachim Behnke
Abstract: A solution containing cellulose dissolved in a mixture of a tertiary amine N-oxide solvent for cellulose and a compound which increases the rate of dissolution of cellulose in the solvent such as a tertiary amine or other compound which increases the pH of the solvent, a process for making such a solution and a process for making shaped articles therefrom are provided. The solvent dissolves cellulose at a faster rate and at a lower temperature than a solvent consisting of the same tertiary amine N-oxide.