Patents Represented by Attorney Albert E. Frost
  • Patent number: 4892590
    Abstract: A two component binder system comprising a highly dispersible, high specific surface area precipitated calcium carbonate (colloidal PCC) and a cationic starch, especially a cationic potato starch, for improving filler retention, opacity and strength during papermaking.
    Type: Grant
    Filed: June 3, 1988
    Date of Patent: January 9, 1990
    Assignee: Pfizer Inc.
    Inventors: Robert A. Gill, Nigel D. Sanders
  • Patent number: 4861891
    Abstract: Certain N-substituted nicotinamide compounds having formula (I) below ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is 1-piperidyl, 1-(3-indolyl)ethyl, C.sub.1-4 alkyl, phenyl, 1-(1-phenylethyl), benzyl or mono-substituted benzyl wherein the substituent is methyl, methoxy, chloro or fluoro; and R.sup.2 is bicyclo[2.2.1]hept-2-yl or ##STR2## wherein Y is hydrogen, fluoro or chloro; and X is hydrogen, fluoro, chloro, methoxy, trifluoromethyl, cyano, carboxy, carbo (C.sub.1-4 alkoxy), methylcarbamoyl or dimethylcarbamoyl function as selective inhibitors of calcium-independent phosphodiesterase and are useful as antidepressants.
    Type: Grant
    Filed: August 31, 1988
    Date of Patent: August 29, 1989
    Assignee: Pfizer Inc.
    Inventors: Nicholas A. Saccomano, Fredric J. Vinick
  • Patent number: 4861596
    Abstract: A method for enhancing the unrolling of a rolled active agent-containing laminate device in an aqueous use environment which comprises coating one side of the device with an elastomer prior to constraining it in a rolled configuration; and the devices so treated.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: August 29, 1989
    Assignee: Pfizer Inc.
    Inventors: Alan C. Curtiss, Jeelin Lo
  • Patent number: 4851548
    Abstract: Boric acid or aluminum salts, especially aluminum chloride, aluminum sulfate and aluminum nitrate and hydrates of said salts, are superior catalysts for preparation of 3-amino-2,2,4,4-tetramethylthietane via the Leuckart reaction.
    Type: Grant
    Filed: April 12, 1988
    Date of Patent: July 25, 1989
    Assignee: Pfizer Inc.
    Inventor: Bruce A. Hay
  • Patent number: 4851388
    Abstract: Peptides useful as antiinfective agents, immunomodulators for stimulation of host defenses in patients with an increased risk of bacterial infections, intermediates and process therefor.
    Type: Grant
    Filed: August 17, 1987
    Date of Patent: July 25, 1989
    Assignee: Pfizer Inc.
    Inventor: Gene M. Bright
  • Patent number: 4835192
    Abstract: Compounds having the formula ##STR1## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.
    Type: Grant
    Filed: February 4, 1988
    Date of Patent: May 30, 1989
    Assignee: Pfizer Inc.
    Inventors: Michael R. Johnson, Lawrence Melvin, Jr.
  • Patent number: 4831059
    Abstract: Compounds having the formula ##STR1## R.sub.1 is hydrogen, benzyl or an ester moiety; Y is --CH(R.sub.2 ")CH(R.sub.2)-- or --CH(R.sub.3)CH hd 2--;R.sub.2 " is hydrogen or methyl;R.sub.2 is OH or X-substituted (C.sub.1-6)alkyl;R.sub.3 is OH, cyano or X-substituted (C.sub.1-3)alkyl;X is --OR.sub.6, --SR.sub.6, --S(O)R.sub.6, --S(O).sub.2 R.sub.6, --NR.sub.6 R.sub.7, --COOR.sub.7, --CONR.sub.7 R.sub.8 or oxo;with the proviso that when X is --NR.sub.6 R.sub.7, --COOR.sub.7 or --CONR.sub.7 R.sub.8, said group is located on the terminal carbon atom of R.sub.2 or R.sub.3 ;R.sub.6 is hydrogen, (C.sub.1-6)alkyl or acetyl;each of R.sub.7 and R.sub.8 is hydrogen or (C.sub.1-6)alkyl;s is an integer of 1 or 2;with the proviso that when R.sub.6 is acetyl, R.sub.7 is hydrogen and X is other than S(O)R.sub.6 or S(O).sub.2 R.sub.6 ;Z-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain, and their use as CNS agents, antidiarrheals and anti-emetics.
    Type: Grant
    Filed: February 23, 1988
    Date of Patent: May 16, 1989
    Assignee: Pfizer Inc.
    Inventors: Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4830860
    Abstract: A matrix device for controlled release of at least one active agent to an ambient environment, said matrix comprising an active agent--or agents--containing polymer which has been subjected to tensile stress. Included is a laminate device comprising at least one matrix as core sheet, said core sheet or sheets comprising the active agent or agents in a polymer matrix which has been subjected to stress and, in a further embodiment, a porosity enhancing agent in admixture with said agent; the core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agent or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. Also included are methods for making such a device.
    Type: Grant
    Filed: October 30, 1986
    Date of Patent: May 16, 1989
    Assignee: Pfizer Inc.
    Inventor: Gautam R. Ranade
  • Patent number: 4797401
    Abstract: Antiarrhythmic agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R and R.sup.1, which are the same or different, are C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl, --CH.sub.2 CH.sub.3, --CH.sub.2 Cl, --CF.sub.3 or --NH.sub.2 ;R.sup.2 and R.sup.3, which are the same or different, are H, halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; andX is --CH.sub.2 --, ##STR2## or --CH(OH)--.
    Type: Grant
    Filed: July 15, 1987
    Date of Patent: January 10, 1989
    Assignee: Pfizer Inc.
    Inventors: John E. G. Kemp, Peter E. Cross
  • Patent number: 4772597
    Abstract: Certain 2-azacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R is ##STR2## A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen, S(O).sub.m, or N--R.sub.3 ;B is carbonyl, thiocarbonyl, methylene or imine;R.sub.1 is hydrogen or forms an ester group which is hydroyzed in vivo;R.sub.2 is hydrogen, formyl, alkylcarbonyl, N-alkylaminocarbonyl, N-alkylaminosulfonyl, aminosulfonyl, aminocarbonyl, alkoxycarbonyl having 2-5 carbon atoms, alkylsulfonyl, alkyl, or alkyl substituted by aminocarbonyl, alkyl--S(O).sub.m --, hydroxyl, amino, alkylcarbonylamino, formamido or alkylsulfonylamino, wherein each alkyl has 1-4 carbon atoms;R.sub.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: September 20, 1988
    Assignee: Pfizer Inc.
    Inventor: Ernest S. Hamanaka
  • Patent number: 4769232
    Abstract: Solutions of indolmycin in a pharmaceutically-acceptable solvent are of special value in the treatment of susceptible bacterial infections in mammals, particularly swine.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: September 6, 1988
    Assignee: Pfizer Inc.
    Inventors: Larry R. Chappel, Jay J. Rash
  • Patent number: 4767743
    Abstract: Peptide components of formula 1, pharmaceutically acceptable base salts thereof, pharmaceutical compositions and their use as antiinfective agents ##STR1## where R.sub.1 is alkyl, cycloalkyl or cycloalkylmethyl; R.sub.2 is hydrogen or alkyl and R.sub.3 is hydroxy or an amino acid residu of the formula ##STR2## where X is hydrogen, alkyl or hydroxymethyl and n is an integer of 0 to 4 and R.sub.4 and R.sub.5 are alkyl, hydrogen, benzyl or cyclohexylmethyl.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: August 30, 1988
    Assignee: Pfizer Inc.
    Inventor: James P. Rizzi
  • Patent number: 4767777
    Abstract: A triazole of the formula ##STR1## wherein R is phenyl substituted by difluoro, fluoro, dichloro or chloro and R' is phenyl substituted by chloro or fluoro are useful antifungal agents.
    Type: Grant
    Filed: November 14, 1985
    Date of Patent: August 30, 1988
    Assignee: Pfizer Inc.
    Inventors: Robert J. Bass, Kelvin Cooper, Kenneth Richardson
  • Patent number: 4766117
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.
    Type: Grant
    Filed: December 12, 1986
    Date of Patent: August 23, 1988
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Patent number: 4762838
    Abstract: Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazolin-4-(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates therefor.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: August 9, 1988
    Assignee: Pfizer Inc.
    Inventor: Edward A. Glazer
  • Patent number: 4762921
    Abstract: 6-(1-Acyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.
    Type: Grant
    Filed: March 11, 1987
    Date of Patent: August 9, 1988
    Assignee: Pfizer Inc.
    Inventor: Lawrence A. Reed, III, deceased
  • Patent number: 4761485
    Abstract: A two-step process for the synthesis of certain indol-2(3H)-ones from indoles, and the 3,3-dibromoindol-2(3H)-ones which are intermediates in that process.
    Type: Grant
    Filed: March 11, 1987
    Date of Patent: August 2, 1988
    Assignee: Pfizer Inc.
    Inventor: Anthony Marfat
  • Patent number: 4757833
    Abstract: A method for improving the mobility and pipeline transport of a viscous crude oil by forming an oil-in-water emulsion with said oil and from 10 to 80% by weight of water in the presence of 100 to 1500 parts by weight of a surfactant blend per million parts by weight of said emulsion, said blend comprising from 15 to 85 parts by weight of an anionic or amphoteric surfactant (A) selected from those of the formulae Ar(OCH.sub.2 CH.sub.2).sub.n OSO.sub.3 H, ##STR1## a sodium and ammonium salt thereof, and from 85 to 15 parts by weight of a nonionic surfactant selected from (B) of the formula Ar(OCH.sub.2 CH.sub.2).sub.p OH or (C) of the formula ##STR2## the latter having an HLB value of from 10 to 20; where Ar is octylphenyl or nonylphenyl,n is 2 to 10,p is 10 to 100,a is 10 to 40, b is 15 to 55, c is 10 to 40,R.sup.1 is C.sub.8 to C.sub.18 alkyl andR.sup.2 is C.sub.12 to C.sub.18 alkyl;and said emulsion.
    Type: Grant
    Filed: May 8, 1987
    Date of Patent: July 19, 1988
    Assignee: Pfizer Inc.
    Inventor: Dennis E. Danley
  • Patent number: 4758569
    Abstract: This invention relates to the use of doxazosin or a pharmaceutically acceptable acid addition salt thereof as an agent for retarding the development of atherosclerosis in a mammal, especially for reducing atherosclerotic plaque involvement and for retarding and reducing both the fibrosis and lipid deposition of developing atherosclerotic plaques associated with atherosclerosis.
    Type: Grant
    Filed: August 26, 1987
    Date of Patent: July 19, 1988
    Assignee: Pfizer Inc.
    Inventor: Archie C. Swindell
  • Patent number: 4753956
    Abstract: Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.
    Type: Grant
    Filed: May 28, 1987
    Date of Patent: June 28, 1988
    Assignee: Pfizer Inc.
    Inventor: Rodney C. Schnur