Abstract: The invention relates to substituted 10-oxo-10H-pyridazino(6,1-b)quinazoline-2-carboxylic acids having the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen; R.sub.2 is hydrogen, lower alkyl containing one to three carbon atoms, or wherein R.sub.1 and R.sub.2 taken together with the carbon atoms to which they are attached in a benzo ring, and the pharmaceutically acceptable salts thereof. These compounds are useful as anti-allergic agents.