Abstract: Animal cells are grown in a vertically disposed cylindrical vessel containing a stack of parallel spaced-apart discs inclined at least 5.degree. from the horizontal and mounted to a rotatable axial shaft. The vessel is closed by a top plate having a plurality of inlets and a bottom plate with an outlet, and contains an external pumping loop for circulating contents of the vessel from the bottom to the top of the vessel. Growing of the cells is carried out by substantially filling the vessel with a mixture of animal cells and growth medium, allowing the cells to settle on the disc surfaces and then rotating the axial shaft at a speed of at least 5 rpm while continuously circulating the vessel contents from the bottom to the top of the vessel. This process and apparatus provides efficient mixing and ensures a homogeneous system within the vessel.

Abstract: 1-Cycloalkyl phosphonium salts represented by the formula ##STR1## wherein: R is selected from the group consisting of lower alkyl, hydroxy lower alkyl, halo lower alkyl, amino lower alkyl, cyano lower alkyl, lower alkenyl with the limitation that the double bond is not on the carbon atom attached to the oxygen atom, benzyl, substituted benzyl and ##STR2## wherein q is 0 or 1 and R.sub.4 is selected from the group consisting of hydroxy, loweralkoxy, phenyl, substituted phenyl, and ##STR3## wherein R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen and loweralkyl or taken together form a 5 or 6 membered ring; m is 1, 2 or 3; n is 0 or 1; o is 0 or 1; p is 0 or 1; R.sub.1, R.sub.2 and R.sub.3 are the same or different members of the group consisting of hydrogen, lower alkyl, lower alkoxy and halo; and X is a pharmaceutically acceptable anion. The compounds are useful as analgesic agents.

Abstract: A compound of the formula ##STR1## wherein R is hydrogen or lower alkyl having 1-7 carbon atoms; R', R", and R'" are each individually hydrogen or methyl; n is 0-3; and Ar is phenyl, halosubstituted phenyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1-4 carbon atoms, lower alkoxy substituted phenyl wherein the lower alkoxy contains 1-4 carbon atoms, p-biphenyl, or trifluoromethyl substituted phenyl. Compounds of the present invention are useful as antifertility agents.

Abstract: The present invention relates to novel compounds and a method for the prophylaxis and treatment of Inflammatory Bowel Disease (IBD) via the administration of an effective amount in a suitable pharmaceutical dosage form of an azobenzene compound of formula I or a pharmacologically acceptable salt, which is reductively cleaved to 5-aminosalicylic acid (5-ASA) by bacteria in the large intestine.

Abstract: Complexes of radiolabelled metals with N-(tri-substituted alkyl)-iminodiacetic acids or salts thereof having utility as radiopharmaceutical agents for monitoring the activity of an organ, their preparation and a method employing such complexes for externally monitoring the activity of an organ are disclosed.

Abstract: A stable solid dosage form of the compound .+-.methyl(7-[3(.alpha.)-hydroxy-2-.beta.-(4(RS)-4-hydroxy-4-methyl-trans- 1-octen-1-yl)-oxycyclopent-1.alpha.-yl]heptanoate, said solid dosage form comprising from about 50 to about 500 parts of a polymer selected from the group consisting of hydroxypropylmethyl cellulose and polyvinylpyrolidone per part of said compound.

Abstract: Phosphonium salts represented by the formula ##STR1## wherein: R is selected from the group consisting of lower alkyl, phenyl, substituted phenyl, benzyl and substituted benzyl; R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or loweralkyl; or R.sub.1 and R.sub.2 taken together form a 5 or 6 membered saturated or unsaturated carbocyclic ring with the limitation that R.sub.1 is on the carbon atom adjacent the carbon atom bearing R.sub.2, m is 1,2 or 3; n is 0 or 1; o is 0 or 1; p is 0 or 1; R.sub.3, R.sub.4 and R.sub.5 are the same or different members of the group consisting of hydrogen, lower alkyl, lower alkoxy and halo; R.sub.6 is hydrogen or C.sub.1 --C.sub.3 straight or branched chain alkyl; and X is a pharmaceutically acceptable anion. Compounds wherein R is phenyl, substituted phenyl, benzyl or substituted benzyl are narcotic antagonists. Compounds wherein R.sub.1 and R.sub.2 are hydrogen or lower alkyl when R is lower alkyl are mixed agonist/antagonist analgesic agents and compounds where R.

Abstract: An adhesive surgical dressing which comprises a backing material provided on one side with a composition comprising per 100 parts, by weight, of a non-biodegradable, tacky, polymeric binding agent, from 12 to 25 parts, by weight, of an inert reinforcing filler and a coating on at least the intended skin contacting face of the dressing of a non-biodegradable, water-activated adhesive/thickner, the composition having an aqueous swell value of from 5 to 40% and a cold flow value of from 50 to 90%, is disclosed.An adhesive surgical dressing composition which comprises per 100 parts, by weight, of a non-biodegradable, tacky, polymeric binding agent, from 5 to 150 parts, by weight, of a non-biodegradable, water-activated adhesive/thickner and from 12 to 25 parts, by weight, of an inert reinforcing filler, is also disclosed.

Abstract: Derivatives of .alpha.,.beta.-unsaturated ketones having anticonvulsant activity and methods of their preparation from heterocyclic phosphonium salts and acyclic phosphoranes are disclosed.

Abstract: 4,5-Unsaturated 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g. gastric antisecretory, are described herein.

Abstract: N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines and salts thereof which are pharmacologically active as inhibitors of gastric secretion and their preparation from isothioureas are disclosed.

Abstract: A carrier gas for chromatographic analysis of gaseous samples containing sulfur bearing molecules utilizes a sulfur-containing nucleophile mixed with the inert component of the carrier gas to deactivate sulfur reactive and adsorbtive sites in the analysis system and facilitates accurate analysis of the sample composition.

Abstract: The present invention encompasses a method for reducing offensive odors in poultry houses comprising adding at least 10 pounds of composted cow manure per ton of poultry manure. The method of the present invention substantially reduces offensive odor in poultry houses especially ammonia odor and thereby provides a healthier environment for poultry and poultry workers. Since the ammonia loss to the environment is reduced, the nitrogen is retained in the poultry manure providing a product with higher nitrogen content.

Abstract: Novel .alpha.-aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkyl amine and subsequently hydrolyzing the resulting nitrile with concentrated sulfuric acid.

Abstract: 25-Alkylcholest-5-ene-3.beta.,22-diols and esters thereof adapted to inhibit the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase are disclosed.

Abstract: The present invention provides Diaryl-(1-azabicyclo [2.2.2]octan-2-yl)alkanols of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R is a cycloalkanol having 4-8 carbon atoms, an alkanol having 1-2 carbon atoms, or a radical of the formula ##STR2## wherein R.sub.1 and R.sub.2 are each H or a C.sub.1 -C.sub.5 alkyl, and R.sub.3 is H or an acyl of the formula ##STR3## wherein R.sub.4 is H or a C.sub.1 -C.sub.4 alkyl. These alkanols are useful as antidiarrheal agents.

Abstract: The present invention provides 2-substituted quinuclidines of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R is phenyl, halogen-substituted phenyl, lower alkyl-substituted phenyl, pyridyl or 5-methyl-1,3,4-oxadiazol-2-yl.These quinuclidine compounds are useful as anti-diarrheal agents.

Abstract: Borohydride hydrogenations using agents of the formula M[RR'R"BH] wherein M is a metal and R, R', and R" are each organic groups, at least one of them being a secondary or tertiary alkyl group, are described herein. These compounds are active hydrogenating agents which are particularly useful because they permit steric control of the hydrogenation of carbonyl groups, they permit selective hydrogenation of functional groups or, where one of the R groups is optically active, they permit stereoselective hydrogenation.

Abstract: A synchronized drive and cable handling system is disclosed for a rotational element, such as a rotational gantry of a tomographic scanning machine, upon which element are carried load devices to which a medium, such as oil or electricity, is required to be supplied through the cables. A pair of spaced-apart sets of idler pulleys are disposed to either side of the rotational element with a cable being wound about the respective pulley sets to form an elongated loop, one end of each respective cable being attached to a load device which is disposed on the rotational element. One pulley set of each pair of sets is disposed about a translatable axis, the position of which is controlled by a lead screw drive to vary the distance between the pair of pulley sets and to thus vary the amount of cable which is played-out and taken-in therefrom.

Abstract: In an improved system for medical imaging employing a transducer for transmitting and detecting ultrasonic vibrations, a digital scan converter accepts echo signals detected by the transducer and transducer position signals identifying the point of origin of the signals in a scanning plane transversely oriented relative to the body of the patient under study. The amplitudes of the echoes detected are stored at memory locations associated with the points of origin of the echoes. Peak detection analysis is performed on large echoes emanating from higher impedance tissue interfaces within the scanning plane, while cumulation and normalization analysis is performed on small echoes emanating from low impedance tissue interfaces within the scanning plane.