Patents Represented by Attorney Alice P. Bradney
  • Patent number: 8137681
    Abstract: The present invention relates to the field of vaccines, and in particular vaccines comprising antigens of low isoelectric point at pH 7.0, in particular the capsular polysaccharide or oligosaccharide of H. influenzae B (PRP). Immunogenic compositions and methods of making such compositions are presented in which the PRP is surprisingly protected from immune interference by adding a polyanionic polymer (such as PLG—poly-L-glutamic acid) to the composition.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: March 20, 2012
    Assignee: Glaxosmithkline Biologicals, S.A.
    Inventors: Nathalie Marie-Josephe Garcon, Dominique Lemoine, Florence Emilie Jeanne Francoise Wauters
  • Patent number: 8007818
    Abstract: The present invention relates to the field of vaccines, and in particular vaccines comprising antigens of low isoelectric point at pH 7.0, in particular the capsular polysaccharide or oligosaccharide of H. influenzae B (PRP). Immunogenic compositions and methods of making such compositions are presented in which the PRP is surprisingly protected from immune interference by adding a polyanionic polymer (such as PLG-poly-L-glutamic acid) to the composition.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: August 30, 2011
    Assignee: GlaxoSmithKline Biologicals, S.R.
    Inventors: Nathalie Marie-Josephe Garcon, Dominique Lemoine, Florence Emilie Jeanne Francoise Wauters
  • Patent number: 7655693
    Abstract: The invention provides a compound of formula (I), pharmaceutical compositions thereof, and methods of treatment using the same.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: February 2, 2010
    Assignee: Glaxo Group Limited
    Inventors: Giuseppe Alvaro, Markus Bergauer, Roberto Profeta, Riccardo Giovannini
  • Patent number: 7628995
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: December 8, 2009
    Assignees: GlaxoSmithKline Biologicals S.A., University of Utrecht
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefsen, Johannes Petrus Maria Tommassen
  • Patent number: 7324864
    Abstract: An axial force measurement apparatus (40) comprises a head member (42) adapted for receiving force imparted by an external force-applying source, and a transducer (44) such as a load cell for measuring the amount of force applied to the head member (42). Electronic circuitry (61) for receiving, processing, storing and/or sending electrical information generated by the transducer is provided either externally to the measurement apparatus (40), or is integrated with the apparatus (40). The apparatus (40) can be used to calibrate the valve crimping station (75) and/or the test firing station (125) of a metered dose delivery canister production line. The apparatus (40) is designed to emulate an actual canister (12).
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: January 29, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Lee A. Barger, David Brian Moody, Donald Devereaux Munn
  • Patent number: 7321059
    Abstract: Compounds of formula (I): or salts or solvate thereof, wherein: n and N independently represent an integer 2 to 12; m1 and m2 independently represent an integer 1 to 15; and R1 and R2 independently represent —(CO)xC1-9 alkyl or —(CO)xC1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1, as well as pharmaceutical formulations containing such compounds and processes for the manufacture of such compounds are disclosed. Intermediates of such compounds and processes for the manufacture of such intermediates are also disclosed.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: January 22, 2008
    Assignee: Glaxo Group Limited
    Inventors: Brian Edgar Looker, Christopher James Lunniss, Alison Judith Redgrave
  • Patent number: 7319109
    Abstract: The invention relates to a compound of formula (I): wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: January 15, 2008
    Assignee: Smith Kline Beecham Corporation
    Inventors: Sharon D Boggs, Jon L Collins, Stephen M Hyatt, Patrick R Maloney
  • Patent number: 7302948
    Abstract: A fluid dispensing device comprising a body defining a cavity and a dispensing nozzle. A fluid discharging device is housed in the cavity. The fluid discharging device has a hollow casing defining a reservoir for containing a volume of fluid and a plunger slidingly engaged within the hollow casing. The plunger has a tubular portion which is arranged to extend from a first end of the hollow casing for co-operation with the dispensing nozzle. A biasing means is interposed between a second end of the hollow casing and an end wall of the cavity to bias the hollow casing towards the dispensing nozzle. A locking means holds the biasing means in a compressed state. Upon release of the locking means, the force stored in the biasing means is applied to the hollow casing thereby causing fluid to be ejected from the reservoir into the dispensing nozzle.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: December 4, 2007
    Assignee: Glaxo Group Limited
    Inventor: Gregor John McLennan Anderson
  • Patent number: 7277168
    Abstract: A system for real-time fluorescent determination of trace elements comprising transport means for moving a plurality of samples, means for generating a plurality of incident radiation pulses of different wavelength, means for illuminating at least a respective one of the samples with at least a respective one of the radiation pulses during the movement of the samples, means for detecting the resultant fluorescence emitted from each of the samples and control means for controlling the movement of the samples and the incident radiation.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: October 2, 2007
    Assignee: SmithKline Beecham Corporation
    Inventor: Dwight Sherod Walker
  • Patent number: 7258119
    Abstract: A dispensing apparatus for dispensing a unit dose of a pharmaceutical substance, in particular for intranasal administration, is described. The apparatus includes a nozzle unit having a safety cap thereon and an actuating device. The safety cap has legs, which can locate within the actuating device. Upon mounting the nozzle unit on the actuating device, the legs on the safety cap push down a ram in the device against the action of a spring, until the head of the ram engages over a shoulder. The ram is released by depression of a button on the device and by relative movement of two parts of the device.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: August 21, 2007
    Assignee: Glaxo Group Limited
    Inventor: Paolo Mazzoni
  • Patent number: 7217833
    Abstract: Compounds of formula (I) or a salt or solvate thereof, wherein: x represents 0 or 1; y represents 0 or 1; R1 and R2 independently represent —C1-9 alkyleneC1-6 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms and wherein the R1 and/or R2 moiety is optionally interrupted by an ether link, processes for their preparation, use of the compounds in the preparation of pharmaceutical formulations and the formulations are described.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: May 15, 2007
    Assignee: Glaxco Group Limited
    Inventors: Brian Edgar Looker, Christopher James Lunniss, Alison Judith Redgrave
  • Patent number: 7217409
    Abstract: A method for treating respiratory disorders comprises administering to a patient a pharmaceutical aerosol formulation comprising: (i) a compound of formula (I) or a salt or solvate thereof, wherein: n represents an integer 1 to 6; N represents an integer 1 to 15; R1 represents —(CO)xC1-9 alkyl or —(CO)xC1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1; and R2 and R3 independently represent C1-3alkyl or hydrogen, (ii) at least one medicament, and (iii) at least one propellant.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: May 15, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Brian Edgar Looker, Christopher James Lunniss, Alison Judith Redgrave, Derek Peter Reynolds
  • Patent number: 7195752
    Abstract: A pharmaceutical aerosol formulation that includes a particulate medicament, one or more fluorocarbon or hydrogen-containing fluorocarbon propellants and a compound of the general formula (I) or a salt or solvate thereof is disclosed, wherein A represents a straight chain C1-16 alkylene substituted by n groups of formula B; n represents an integer 1 to 3; and B independently represents C1-4 fluoroalkylC0-6 alkylene-, C1-4 fluoroalkylC0-6 alkylene-O—, or C1-4 alkylC0-6 alkylene-O— wherein at least one substituent of formula B contains at least one fluorine atom and each C1-4 fluoroalkyl- moiety contains one or more fluorine atoms but not more than 3 consecutive perfluorinated carbon atoms. Compounds of formula (I) and uses of such compounds are also disclosed.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: March 27, 2007
    Assignee: Glaxo Group Limited
    Inventors: Istvan Kaldor, Brian Edgar Looker, Christopher James Lunniss, Alison Judith Redgrave
  • Patent number: 7157457
    Abstract: There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: January 2, 2007
    Assignee: Glaxo Group Limited
    Inventors: Rachael Anne Ancliff, Caroline Mary Cook, Colin David Eldred, Paul Martin Gore, Lee Andrew Harrison, Simon Teanby Hodgson, Duncan Bruce Judd, Suzanne Elaine Keeling, Xiao Qing Lewell, Graeme Michael Robertson, Stephen Swanson