Abstract: Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single protein family may be immobilized on the protein-coated substrate or array. The protein-coated substrates and protein arrays are particularly useful in high-throughput drug screening and clinical diagnostics.
Type:
Grant
Filed:
May 12, 2000
Date of Patent:
November 5, 2002
Assignee:
Zyomyx, Incorporated
Inventors:
Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin
Abstract: Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thinfilms on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.
Type:
Grant
Filed:
July 14, 1999
Date of Patent:
November 5, 2002
Assignee:
Zyomyx, Incorporated
Inventors:
Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin
Abstract: Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single protein family may be immobilized on the protein-coated substrate or array. The protein-coated substrates and protein arrays are particularly useful in high-throughput drug screening and clinical diagnostics.
Type:
Grant
Filed:
July 14, 1998
Date of Patent:
June 18, 2002
Assignee:
Zyomyx, Incorporated
Inventors:
Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin
Abstract: Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.
Type:
Grant
Filed:
May 18, 2000
Date of Patent:
April 2, 2002
Assignee:
Zyomyx, Incorporated
Inventors:
Peter Wagner, Steffen Nock, Dana Ault-Riche, Christian Itin
Abstract: Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.
Type:
Grant
Filed:
July 14, 1999
Date of Patent:
December 11, 2001
Assignee:
Zyomyx, Incorporated
Inventors:
Peter Wagner, Steffen Nock, Dana Ault-Riche, Christian Itin