Patents Represented by Attorney, Agent or Law Firm Alissa M. Eagle
  • Patent number: 7732678
    Abstract: Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in cotton fiber, particularly in very early fiber development. The DNA constructs comprise a cotton fiber transcriptional initiation regulatory region associated with a gene which is expressed in cotton fiber.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: June 8, 2010
    Assignee: Calgene LLC
    Inventors: Kevin McBride, David M. Stalker, Julie R. Pear, Luis Perez-Grau
  • Patent number: 6576818
    Abstract: Provided are two plant cDNA clones that are homologs of the bacterial CelA genes that encode the catalytic subunit of cellulose synthase, derived from cotton (Gossypium hirsutum). Also provided are genomic promoter regions to these encoding regions to cellulose synthase. Methods for using cellulose synthase in cotton fiber and wood quality modification are also provided.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: June 10, 2003
    Assignee: Calgene LLC
    Inventors: David M. Stalker, Julie R. Pear, Deborah Delmer
  • Patent number: 6492509
    Abstract: By this invention, nucleic acid sequences encoding for fatty acyl-CoA: fatty alcohol acyltransferase (wax synthase) are provided, wherein wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest is are nucleic acid sequences obtainable from a jojoba embryo wax synthase having an apparent molecular mass of approximately 33 kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: December 10, 2002
    Assignee: Calgene LLC
    Inventors: Kathryn Dennis Lardizabal, James George Metz, Michael W. Lassner
  • Patent number: 6483008
    Abstract: By this invention, methods to produce oleic fatty acids in plant seed oils are provided. The methods of the present invention generally involve the suppression of a host plant cells endogenous &bgr;-ketoacyl-ACP synthase I protein. Also described in the instant invention are the plants, cells and oils obtained therefrom.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: November 19, 2002
    Assignee: Calgene LLC
    Inventors: Katayoon Dehesh, Vic C. Knauf, Gregory A. Thompson
  • Patent number: 5928904
    Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 27, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham P.L.C.
    Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester
  • Patent number: 5919636
    Abstract: Attachment enhanced human embryonic kidney cells, 293, are provided. These cells have been modified to contain a selected mammalian scavenger gene, which has been found to improve the ability of these cells to attach in culture. The improved cells of the invention are useful in assays in which the unmodified 293 cells could be used.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: July 6, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul George Lysko, Nabil Abd Elsalam Elshourbagy, Mary Ellen Brawner
  • Patent number: 5914110
    Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 22, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester
  • Patent number: 5889168
    Abstract: A nucleic acid comprising a sequence encoding a fusion protein comprising a portion of the glycoprotein B of HCMV fused to a portion of the glycoprotein D of HSV-2.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: March 30, 1999
    Assignee: SmithKline Beecham s.a.
    Inventor: Dirk Richard Gheysen
  • Patent number: 5880105
    Abstract: This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.
    Type: Grant
    Filed: December 24, 1997
    Date of Patent: March 9, 1999
    Assignees: SmithKline Beecham Corporation, The Trustees of the University of Pennsylvania
    Inventors: Derk Jon Bergsma, Dwight Edward Stambolian, Steven M. Ruben, Craig A. Rosen
  • Patent number: 5863798
    Abstract: Attachment enhanced human embryonic kidney cells, 293, are provided. These cells have been modified to contain a selected mammalian scavenger gene, which has been found to improve the ability of these cells to attach in culture. The improved cells of the invention are useful in assays in which the unmodified 293 cells could be used.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: January 26, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul G. Lysko, Nabil A. Elshourbagy, Mary E. Brawner
  • Patent number: 5858759
    Abstract: Processes are provided for the production of a carbamoylase enzyme which has the capability of converting a D-N-carbamoyl (optionally substituted phenyl) glycine by expressing recombinant DNA encoding a carbamoylase in a homologous host. Also provided are specific recombinant DNA vectors producing high levels of expression of the carbamoylase enzyme and/or hydantoinase enzyme in homologous and heterologous hosts and their use in the production of D-.alpha. amino acids.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: January 12, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Robert John Neal, Alison Michelle Griffin, Hazel Claire Gorham
  • Patent number: 5851525
    Abstract: Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: December 22, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert S. Ames, Jr., Edward Robert Appelbaum, Irwin M. Chaiken, Richard M. Cook, Mitchell Stuart Gross, Stephen Dudley Holmes, Lynette Jane McMillan, Timothy Wayne Theisen
  • Patent number: 5830649
    Abstract: This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: November 3, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Jon Bergsma, Dwight Edward Stambolian
  • Patent number: 5789223
    Abstract: This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: August 4, 1998
    Assignees: SmithKline Beecham Corporation, The Trustees of the University of Pennsylvania
    Inventors: Derk Jon Bergsma, Dwight Edward Stambolian, Steven M. Ruben, Craig A. Rosen
  • Patent number: 5786189
    Abstract: The Bordetella pertussis toxin is genetically modified to express a toxin protein which is deficient in target-cell receptor binding and is used in a vaccine for protection against whooping cough.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: July 28, 1998
    Assignee: SmithKline Beecham Biologicals (S.A.)
    Inventors: Camille Locht, Yves Lobet
  • Patent number: 5783184
    Abstract: The present invention relates to treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs and other altered antibodies such as Fabs, chimeric, human and humanized antibodies that do not block binding of human IL-5 to the .alpha.-chain of the human IL-5 receptor.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: July 21, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Edward Robert Appelbaum, Richard Murray Cook
  • Patent number: 5783181
    Abstract: A soluble protein having IL4 and/or IL13 antagonist or partial antagonist activity comprises an IL4 mutant or variant fused to least one human immunoglobulin constant domain or fragment thereof.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 21, 1998
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Michael Joseph Browne, Peter Ronald Young, Allan Richard Shatzman, Kay Elizabeth Murphy, Conrad Gerald Chapman, Helen Elizabeth Clinkenbeard
  • Patent number: 5739292
    Abstract: A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: April 14, 1998
    Assignee: SmithKline Beecham Biologicals (s.a.)
    Inventor: Dirk Richard Gheysen
  • Patent number: 5723631
    Abstract: The present invention relates to a process for the preparation of a compound of the following structure: ##STR1## wherein, substituents are as defined in the specification.
    Type: Grant
    Filed: June 22, 1995
    Date of Patent: March 3, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Ashok Dharmaji Patil, Robert Philip Hertzberg, Geoffrey B. Dreyer, Alan James Freyer, John W. Westley, Balan Chenera, Michael Leo West
  • Patent number: 5705359
    Abstract: The present invention provides a method for the expression of heterologous genes, under the control of a Drosophila metollothionein promoter, inserted at high copy number into Drosophila melanogaster cells.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: January 6, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Hanne Ranch Johansen, Ariane Adrienne Van Der Straten-Ponthoz, Martin Rosenberg