Patents Represented by Attorney, Agent or Law Firm Alissa M. Eagle
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Patent number: 7732678Abstract: Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in cotton fiber, particularly in very early fiber development. The DNA constructs comprise a cotton fiber transcriptional initiation regulatory region associated with a gene which is expressed in cotton fiber.Type: GrantFiled: December 3, 1997Date of Patent: June 8, 2010Assignee: Calgene LLCInventors: Kevin McBride, David M. Stalker, Julie R. Pear, Luis Perez-Grau
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Patent number: 6576818Abstract: Provided are two plant cDNA clones that are homologs of the bacterial CelA genes that encode the catalytic subunit of cellulose synthase, derived from cotton (Gossypium hirsutum). Also provided are genomic promoter regions to these encoding regions to cellulose synthase. Methods for using cellulose synthase in cotton fiber and wood quality modification are also provided.Type: GrantFiled: April 18, 2001Date of Patent: June 10, 2003Assignee: Calgene LLCInventors: David M. Stalker, Julie R. Pear, Deborah Delmer
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Patent number: 6492509Abstract: By this invention, nucleic acid sequences encoding for fatty acyl-CoA: fatty alcohol acyltransferase (wax synthase) are provided, wherein wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest is are nucleic acid sequences obtainable from a jojoba embryo wax synthase having an apparent molecular mass of approximately 33 kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.Type: GrantFiled: December 4, 1998Date of Patent: December 10, 2002Assignee: Calgene LLCInventors: Kathryn Dennis Lardizabal, James George Metz, Michael W. Lassner
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Patent number: 6483008Abstract: By this invention, methods to produce oleic fatty acids in plant seed oils are provided. The methods of the present invention generally involve the suppression of a host plant cells endogenous &bgr;-ketoacyl-ACP synthase I protein. Also described in the instant invention are the plants, cells and oils obtained therefrom.Type: GrantFiled: May 3, 1999Date of Patent: November 19, 2002Assignee: Calgene LLCInventors: Katayoon Dehesh, Vic C. Knauf, Gregory A. Thompson
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Patent number: 5928904Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.Type: GrantFiled: June 7, 1995Date of Patent: July 27, 1999Assignees: SmithKline Beecham Corporation, SmithKline Beecham P.L.C.Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester
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Patent number: 5919636Abstract: Attachment enhanced human embryonic kidney cells, 293, are provided. These cells have been modified to contain a selected mammalian scavenger gene, which has been found to improve the ability of these cells to attach in culture. The improved cells of the invention are useful in assays in which the unmodified 293 cells could be used.Type: GrantFiled: November 26, 1997Date of Patent: July 6, 1999Assignee: SmithKline Beecham CorporationInventors: Paul George Lysko, Nabil Abd Elsalam Elshourbagy, Mary Ellen Brawner
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Patent number: 5914110Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.Type: GrantFiled: June 7, 1995Date of Patent: June 22, 1999Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester
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Patent number: 5889168Abstract: A nucleic acid comprising a sequence encoding a fusion protein comprising a portion of the glycoprotein B of HCMV fused to a portion of the glycoprotein D of HSV-2.Type: GrantFiled: November 18, 1996Date of Patent: March 30, 1999Assignee: SmithKline Beecham s.a.Inventor: Dirk Richard Gheysen
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Patent number: 5880105Abstract: This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.Type: GrantFiled: December 24, 1997Date of Patent: March 9, 1999Assignees: SmithKline Beecham Corporation, The Trustees of the University of PennsylvaniaInventors: Derk Jon Bergsma, Dwight Edward Stambolian, Steven M. Ruben, Craig A. Rosen
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Patent number: 5863798Abstract: Attachment enhanced human embryonic kidney cells, 293, are provided. These cells have been modified to contain a selected mammalian scavenger gene, which has been found to improve the ability of these cells to attach in culture. The improved cells of the invention are useful in assays in which the unmodified 293 cells could be used.Type: GrantFiled: October 9, 1997Date of Patent: January 26, 1999Assignee: SmithKline Beecham CorporationInventors: Paul G. Lysko, Nabil A. Elshourbagy, Mary E. Brawner
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Patent number: 5858759Abstract: Processes are provided for the production of a carbamoylase enzyme which has the capability of converting a D-N-carbamoyl (optionally substituted phenyl) glycine by expressing recombinant DNA encoding a carbamoylase in a homologous host. Also provided are specific recombinant DNA vectors producing high levels of expression of the carbamoylase enzyme and/or hydantoinase enzyme in homologous and heterologous hosts and their use in the production of D-.alpha. amino acids.Type: GrantFiled: March 11, 1997Date of Patent: January 12, 1999Assignee: SmithKline Beecham p.l.c.Inventors: Robert John Neal, Alison Michelle Griffin, Hazel Claire Gorham
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Patent number: 5851525Abstract: Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.Type: GrantFiled: September 30, 1997Date of Patent: December 22, 1998Assignee: SmithKline Beecham CorporationInventors: Robert S. Ames, Jr., Edward Robert Appelbaum, Irwin M. Chaiken, Richard M. Cook, Mitchell Stuart Gross, Stephen Dudley Holmes, Lynette Jane McMillan, Timothy Wayne Theisen
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Patent number: 5830649Abstract: This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.Type: GrantFiled: May 26, 1995Date of Patent: November 3, 1998Assignee: SmithKline Beecham CorporationInventors: Derk Jon Bergsma, Dwight Edward Stambolian
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Patent number: 5789223Abstract: This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.Type: GrantFiled: May 26, 1995Date of Patent: August 4, 1998Assignees: SmithKline Beecham Corporation, The Trustees of the University of PennsylvaniaInventors: Derk Jon Bergsma, Dwight Edward Stambolian, Steven M. Ruben, Craig A. Rosen
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Patent number: 5786189Abstract: The Bordetella pertussis toxin is genetically modified to express a toxin protein which is deficient in target-cell receptor binding and is used in a vaccine for protection against whooping cough.Type: GrantFiled: December 11, 1996Date of Patent: July 28, 1998Assignee: SmithKline Beecham Biologicals (S.A.)Inventors: Camille Locht, Yves Lobet
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Patent number: 5783184Abstract: The present invention relates to treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs and other altered antibodies such as Fabs, chimeric, human and humanized antibodies that do not block binding of human IL-5 to the .alpha.-chain of the human IL-5 receptor.Type: GrantFiled: June 21, 1996Date of Patent: July 21, 1998Assignee: SmithKline Beecham CorporationInventors: Edward Robert Appelbaum, Richard Murray Cook
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Patent number: 5783181Abstract: A soluble protein having IL4 and/or IL13 antagonist or partial antagonist activity comprises an IL4 mutant or variant fused to least one human immunoglobulin constant domain or fragment thereof.Type: GrantFiled: June 6, 1995Date of Patent: July 21, 1998Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.Inventors: Michael Joseph Browne, Peter Ronald Young, Allan Richard Shatzman, Kay Elizabeth Murphy, Conrad Gerald Chapman, Helen Elizabeth Clinkenbeard
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Patent number: 5739292Abstract: A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.Type: GrantFiled: May 18, 1995Date of Patent: April 14, 1998Assignee: SmithKline Beecham Biologicals (s.a.)Inventor: Dirk Richard Gheysen
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Patent number: 5723631Abstract: The present invention relates to a process for the preparation of a compound of the following structure: ##STR1## wherein, substituents are as defined in the specification.Type: GrantFiled: June 22, 1995Date of Patent: March 3, 1998Assignee: SmithKline Beecham CorporationInventors: Ashok Dharmaji Patil, Robert Philip Hertzberg, Geoffrey B. Dreyer, Alan James Freyer, John W. Westley, Balan Chenera, Michael Leo West
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Patent number: 5705359Abstract: The present invention provides a method for the expression of heterologous genes, under the control of a Drosophila metollothionein promoter, inserted at high copy number into Drosophila melanogaster cells.Type: GrantFiled: May 3, 1995Date of Patent: January 6, 1998Assignee: SmithKline Beecham CorporationInventors: Hanne Ranch Johansen, Ariane Adrienne Van Der Straten-Ponthoz, Martin Rosenberg