Abstract: Compounds of formula I: wherein a, R1, R2, R3, R4, R5 and R6 are defined herein, are useful as inhibitors of HIV replication.
Type:
Grant
Filed:
May 11, 2010
Date of Patent:
December 25, 2012
Assignee:
Gilead Sciences, Inc.
Inventors:
Christiane Yoakim, Murray Bailey, Francois Bilodeau, Rebekah Carson, Lee Fader, Stephen Kawai, Sebastien Morin, Carl Thibeault, Bruno Simoneau, Simon Surprenant, Youla Tsantrizos, Steven Laplante
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Type:
Grant
Filed:
July 27, 2005
Date of Patent:
December 11, 2012
Assignee:
Gilead Sciences, Inc.
Inventors:
Constantine G. Boojamra, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Oleg V. Petrakovsky, Adrian S. Ray, Lijun Zhang
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Type:
Grant
Filed:
July 26, 2005
Date of Patent:
November 27, 2012
Assignee:
Gilead Sciences, Inc.
Inventors:
Constantine G. Boojamra, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Oleg V. Petrakovsky, Adrian S. Ray, Lijun Zhang
Abstract: The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
Type:
Grant
Filed:
February 22, 2008
Date of Patent:
April 3, 2012
Assignee:
Gilead Sciences, Inc.
Inventors:
Manoj C. Desai, Hongtao Liu, Lianhong Xu
Abstract: The present application provides for a compound of Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
Type:
Grant
Filed:
July 3, 2008
Date of Patent:
January 3, 2012
Assignee:
Gilead Sciences, Inc.
Inventors:
Manoj C. Desai, Hon C. Hui, Hongtao Liu, Jianyu Sun, Lianhong Xu
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Type:
Grant
Filed:
July 26, 2005
Date of Patent:
January 18, 2011
Assignee:
Gilead Sciences, Inc.
Inventors:
Constantine G. Boojamra, Kuei-Ying Lin, Richard Mackman, David Y. Markevitch, Oleg V. Petrakovsky, Adrian S. Ray, Lijun Zhang
Abstract: The present invention provides an underwater breathing device that does not require the use of a pump, engine or pressurized air supply. The invention includes two overlapping hollow cylindrical tubes. The outer tube has holes at its base to let the flow of air move inside the device, up the inside of the outer tube and into the inner tube so that the swimmer can breath in air without any water. The device is constructed to operate whether it is right side up or upside down and can be utilized by more than one swimmer at the same time.