Patents Represented by Attorney, Agent or Law Firm Allan N. Kutzenco
  • Modulators of pharmacokinetic properties of therapeutics
    Patent number: 8067449
    Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: November 29, 2011
    Assignee: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Allen Y. Hong, Hongtao Liu, Randall W. Vivian, Lianhong Xu
  • Modulators of pharmacokinetic properties of therapeutics
    Patent number: 7939553
    Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: May 10, 2011
    Assignee: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Allen Yu Hong, Hongtao Liu, Randall W. Vivian, Lianhong Xu
  • Prodrugs of phosphonate nucoleotide analogues
    Patent number: 7803788
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: September 28, 2010
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • 4-Cyclohexyl-1,3,2-oxazaborolidine chiral accessories
    Patent number: 6509472
    Abstract: Prochiral ketones are enantioselectively reduced to chiral secondary alcohols with a compound having the formula I: where, the two R2 groups are identical and are each a substituted or unsubstituted, aryl, alkyl, cycloalkyl or aralkyl group; and R3 is a hydrogen atom or a substituted or unsubstituted, alkyl, aryl, aralkyl or alkoxy group; wherein the substituents on the R2 and R3 groups are substantially non-reactive.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: January 21, 2003
    Assignee: Schering Corporation
    Inventor: Richard W. Draper
  • Methods for treating proliferative diseases
    Patent number: 6333333
    Abstract: Methods are provided for treating proliferative diseases, especially cancers, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an antineoplastic agent and/or radiation therapy.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: December 25, 2001
    Assignee: Schering Corporation
    Inventors: Walter R. Bishop, Joseph J. Catino, Ronald J. Doll, Ashit Ganguly, Viyyoor M. Girijavallabhan, Paul Kirschimeier, Ming Liu, Loretta L. Nielsen, David L. Cutler
  • Methods of inducing cancer cell death and tumor regression
    Patent number: 6316462
    Abstract: Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: November 13, 2001
    Assignee: Schering Corporation
    Inventors: Walter R. Bishop, Diana L. Brassard, Tattanahalli L. Nagabhushan
  • Methods of using temozolomide in the treatment of cancers
    Patent number: 6251886
    Abstract: Methods are disclosed for treating cancer in a patient in need of such treating comprising administering temozolomide in an amount effective to achieve a clinical response wherein the temozolomide is administered in a microcrystalline suspension.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: June 26, 2001
    Assignee: Schering Corporation
    Inventor: Henry S. Friedman
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6225322
    Abstract: Novel compounds of formula are disclosed. Also disclosed is a method of inhibiting farnesyl protein transferase function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Also disclosed is a method of effecting an anti-allergic response by administering the compounds.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: May 1, 2001
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Jagdish A. Desai, Anil K. Saksena, Viyyoor M. Girijavallabhan, James J-S Wang