Abstract: This invention encompasses compounds of the formulas: ##STR1## where R.sub.1, R.sub.3, R.sub.4, R.sub.6, X, Y, and Z are T are variables; andM is ##STR2## where R.sub.2 is a variable; or R.sub.1 and R.sub.2 together may represent --(CH.sub.2).sub.n.sbsb.1 where n.sub.1 is 1, 2, or 3.These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.

Abstract: This invention involves methods and compositions for preparation of unstable carbonated calcium phosphate solutions, which are supersaturated with respect to calcium phosphate solids and carbon dioxide and the use of such solutions for the treatment of dental tissue and hyposalivation. Specifically the methods include mixing a stable alkaline carbonated solution containing carbonate with a stable acidic calcium solution, either or both solutions also containing phosphate to create an unstable carbonated solution with respect to calcium phosphate and carbon dioxide. Also, the methods include adding aqueous solution to the solids containing calcium salts, phosphate salts and carbonate salts to create an unstable carbonated solution supersaturated with respect to calcium phosphate solids and carbon dioxide. The methods further include using alkaline solutions to remove the acidic residue from dental tissue and maintain cariostatic conditions.

Abstract: The invention comprises a disposable handle cover and entertainment center which may be detachably secured to a shopping cart handle. The invention provides the child with a more sanitary environment and also amuses and arouses the attention of the child carried in the shopping cart. The handle cover and entertainment center is of a rigid material e.g., cardboard or the like, and is therefore relatively inexpensive. Furthermore, the handle cover and entertainment center provides at least one amusement item and is also equipped with a drawing surface where the child can either draw or color with a drawing instrument included with the handle cover and entertainment center. The entertainment center can also contain advertisements or other commercial messages, or it can be in the form of a bingo card.

Abstract: This invention encompasses compounds of the formula: ##STR1## and pharmaceutically acceptable non-toxic salts thereof wherein: n is 0, 1, or 2, X is ##STR2## and R.sub.1, R.sub.2, R.sub.3, W and Y are variables These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.

Abstract: A process for the treatment of liquids containing sulfides comprising moving at least one injection wand into a tank containing the liquid to be treated, wherein the angle between the injection wand and the tank bottom or the angle between the injection wand and the wall of the tank can be altered, and injecting a treating solution through the injection wand to increase the reaction mixing between the injected treating solution and the liquid being treated.

Abstract: Coupling for connecting an implantable port catheter to flexible catheter tubes of varying size and diameter. A rigid tapered tube extends from a port opening in the catheter system housing and the catheter tube slides onto the end of the rigid tube. A clamping sleeve having a bore larger than the outer diameter of the tube has a circular gripping shoulder which bites into the flexible tube as the tube and sleeve are pushed onto the tapered surface of the rigid tube extending from the port opening to clamp the flexible catheter tube firmly between the shoulder and the tapered surface. The distance between the gripping shoulder and the tapered tube is variable to accommodate the size of the flexible catheter tube.

Abstract: This invention encompasses pharmaceutical compositions containing exendin-3 or exendin-4, fragments thereof, or any combination thereof, and methods for the treatment of diabetes mellitus and the prevention of hyperglycemia.

Abstract: Apparatus and methods for stabilizing a line of sight of an optical system without the use of gimbals. The apparatus includes a fixed plano-concave lens element mounted in a frame and a moveable plano-convex lens element mounted in a carriage. The frame mounts onto a preexisting optical system such that the lens elements are nominally aligned with the line of sight of the preexisting optical system. A motor driving unit is provided in the frame which moves the plano-convex lens element back and forth relative to the fixed plano-concave lens element about two orthogonal movement axes in response to small amplitude disturbances imparted to the optical system. The line of sight stabilization apparatus is suitable for retrofit installation onto preexisting optical systems, and in particular, to missile tracking guidance and sighting systems which were originally manufactured or installed without line of sight stabilization capability.

Abstract: An automatic loss compensation for use in a two to four wire hybrid converter in a telephone system. Many hybrid converters provide a substantially fixed gain for receive signals that are provided to the customer loop telephone line and for transmit signals that are provided to the digital carrier transmission line. The compensation circuit includes a measurement circuit, controller, and receive and transmit amplifier. The measurement circuit determines the length of the customer loop telephone line and provides a length signal. The controller receives the length signal and categorizes the length as being within one of a plurality of segments. The controller appropriately varies the amplification and phase of the receive signal, which is then combined with an inverted transmit signal, in order to substantially reduce reflected signals from the transmission line and transmission line termination.

Abstract: This invention permits one to trace more than one electrical conductor, each of the electrical conductors being associated with both a circuit breaker and an electrical outlet. The invention consists of a receiver and multiple transmitters. Further, in a single transmitter form of the invention, the invention permits the transmitter to continually transmit its signature signal without power dissipation concerns, just like the ability to continually transmit in the multiple transmitter form of the invention. Lastly, the device is able to trace conductors regardless of the load electrically connected to the conductor.

Abstract: A partial frame detector provides detection of a frame synchronization pattern in an environment of burst noise that prohibits detection by correlation. A frame synchronization pattern capable of sustaining a minimum of 17 bits clustered in error plus random errors while still providing frame detection is achieved by utilizing a 64 bit Barker derived frame synchronization pattern and an additional process included in a correlation algorithm.

Abstract: A softgel having a texture on at least a portion of its surface and a process and apparatus for the manufacture thereof.

Abstract: A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin from about 6 hours to about 19 hours prior to when the normal sleep phase should begin, depending on whether a phase advance shift in circadian rhythms or a phase delay shift is desired. This is typically from about 4 hours to about 17 hours prior to the time of endogenous melatonin onset.

Abstract: The invention provides a methods for making water-blown closed cell rigid foams comprising using as a polymer base a polyol selected from the group consisting of:(a) a polyester polyol with an average functionality of at least 1.6 and an OH value of at least 200; and(b) a polyether polyol with an average functionality of at least 2 and an OH value of at least 200.The invention also provides water-blown closed cell rigid foams comprising a polymer base selected from the group consisting of:(a) a polyester polyol with an average functionality of at least 1.6 and an OH value of at least 200; and(b) a polyether polyol with an average functionality of at least 2 and an OH value of at least 200.

Abstract: Apparatus and methods for detecting the location of transverse holes of an intramedullary nail which has been inserted into a long bone and for aligning a surgical drill to the transverse holes. An insert having a light source at its distal end emitting non-ionizing electromagnetic radiation in the visible spectrum or infrared is inserted into the intramedullary nail, such that the light source is placed adjacent to the transverse holes. The light source may be a directional radiation output emitting the radiation in a direction perpendicular to the axis of the intramedullary nail. The light source may alternatively be an isotropic radiation output emitting radiation in all directions. The surgeon detects the transmitted radiation on the surface of the body of the patient and aligns the drill with the emitted radiation.

Abstract: This invention relates to an animal model for human ocular disease, particularly glaucoma. The invention provides methods for determining the causes of human ocular diseases, and specifically provides methods for the anatomical, histochemical and molecular biological evaluation of the effects of elevated intraocular pressure on various tissues in mammalian eyes in vivo. The invention also provides methods for non-invasively measuring intraocular pressure and for evaluating the efficacy of treatment stategies for glaucoma involving glaucoma-relieving drugs.

Abstract: This invention is a reusable single piece securing device including a head having a first side and a second side, a first channel passing through the head having a first aperture associated with the first end of the head and a second aperture associated with the second end of the head, a lace lock flexibly associated with the head, and an elongated flexible lace having a first end integral to the head, and a second end, the first and second ends divided by an intermediate section including a plurality of lace teeth.

Abstract: An improved backplane apparatus for transmitting signals to and from a modem system. The modem system includes more than one modem for transmitting data via at least one telephone line and via at least one network. The modem system has a first bus for management signal communication with the modems at a predetermined first data rate, and a second bus for transmitting data between the telephone line and the modems at a predetermined second data rate greater than the first data rate. The modem system also has a third bus for transmitting data between the modems and the network at a predetermined third data rate greater than the second data rate, and a fourth bus for distributing DC power and ground potential. The modem system defines a first impedance for terminating the first bus, a second impedance for terminating the second bus, and a third impedance for terminating the third bus.

Abstract: A hinged connector for joining a first structural member to a second structural member in a support structure, comprising first and second metal connector members each having a base portion for attachment to a respective structural member and a tab integral with the base portion. Each base portion includes an integral upset gusset welded to the tab of the respective connector member to add support to the tab and add stiffness to the connector member.