Patents Represented by Attorney, Agent or Law Firm Allen W. Wark, Esq.
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Patent number: 7141042Abstract: A method for lubricating a sealing member in a drug delivery device includes the steps of washing and rinsing the sealing members in hot deionized water following by drying the sealing members. The dried sealing members are tumbled with polymeric silicone and then irradiated at a target dose between 2.5 and 4.0 Mrads. The irradiated sealing members are then utilized in a variety of drug delivery devices including syringes, pre-filed syringes, drug cartridges, and needleless injector ampules.Type: GrantFiled: December 14, 2000Date of Patent: November 28, 2006Assignee: Becton Dickinson and CompanyInventor: Thea E. Lubrecht
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Patent number: 6382204Abstract: A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like is provided. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is securely retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system.Type: GrantFiled: October 14, 1999Date of Patent: May 7, 2002Assignee: Becton Dickinson and CompanyInventors: Hubert Jansen, Lionel Vedrine
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Patent number: 6378714Abstract: An improved transferset assembly for transferring fluids between a first container, such as a medicament vial and a second container, such as a syringe, which includes an integral polymeric transfer assembly having a tubular collar portion, a radial portion overlying the rim of the first container, an outer tubular portion and an inner tubular portion which is integrally joined to the outer tubular portion by a radial intermediate web portion, a piercing member telescopically received in the inner tubular portion having a piercing end to pierce the closure sealing the open end of the first container and a removable closure which seals the open ends of the outer and inner tubular portions of the transfer assembly.Type: GrantFiled: October 20, 1999Date of Patent: April 30, 2002Assignee: Becton Dickinson and CompanyInventors: Hubert Jansen, Jean-Claude Thibault
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Patent number: 6378576Abstract: This invention relates to an improved vial transfer assembly or vial transferset which may be attached to a vial under sterile conditions and used to transfer fluid to or from a conventional vial. The transferset includes a tubular transfer member which is sealingly supported on the rim portion of a vial stopper, a piercing member having a piercing end reciprocally supported by an internal surface of the transfer member, a cap enclosing the tubular transfer member and a collar preferably formed of a malleable material which secures the assembly on the stopper, which is crimped beneath the vial rim. The piercing member has a generally longitudinal external channel which, upon piercing the planar portion of the stopper, establishes fluid communication with the vial through the tubular transfer member. The distal end of the tubular transfer member includes a Luer lock for establishing fluid communication to a syringe, IV set or the like.Type: GrantFiled: June 7, 2001Date of Patent: April 30, 2002Assignee: Becton Dickinson and CompanyInventors: Jean Claude Thibault, Hubert Jansen
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Patent number: 6331266Abstract: A device, preferably a micro-device, is molded from a plastic material by injection molding, compression molding or embossing. A microabrader can be molded having microneedles for abrading the stratum corneum of the skin to form an abraded site in the tissue for enhancing drug delivery. The micro-device is molded using a mold assembly having a silicon molding surface. The silicon molding surface can include a recess corresponding to the desired shape and length of the microneedles. The silicon molding surface enables micron and submicron size features to be molded from polymeric materials without the polymeric material adhering to the mold surface. Micro-devices having molded features having micron and submicron dimensions can be rapidly produced without the use of a release agent.Type: GrantFiled: September 29, 1999Date of Patent: December 18, 2001Assignee: Becton Dickinson and CompanyInventors: Kenneth G. Powell, Larry A. Monahan, Burton H. Sage, Jr.
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Patent number: 6014904Abstract: A method for automatically classifying multi-parameter data into cluster groups for the purpose of defining different populations of particles in a sample by automatically defining a position of at least one variable position, geometric boundary surface on a two-dimensional scatter plot so as to enclose a group of the displayed particles in a data cluster; with the boundary surface having a polygonal shape defined by a plurality of vertices about at least one cell cluster created by building at least one histogram from cross sections of the two-dimensional scatter plot. Preferably, each cross section of the geometric boundary includes a rectangular, two dimensional gate. The method is particularly useful in the field of cellular analysis using, for example, flow cytometers wherein multi-parameter data is recorded for each cell that passes through an illumination and sensing region.Type: GrantFiled: October 27, 1997Date of Patent: January 18, 2000Assignee: Becton, Dickinson and CompanyInventor: Michael D. Lock
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Patent number: 5682726Abstract: A method for forming and packaging an iontophoretic patch in an inert atmosphere to provide increased shelf-life. The method includes a number of sub-assemblies for forming a well in a laminate material, forming the reservoir and dosing the reservoir, sealing the laminate material and another laminate material together to form a continuous web from which the individual patches are cut. In addition, the patch can be subsequently enclosed in an individual package. In this way, the patch and/or package provides a commercially suitable shelf-life to the drug-filled patch stored therein.Type: GrantFiled: October 16, 1996Date of Patent: November 4, 1997Assignee: Becton Dickinson and CompanyInventors: Philip G. Green, Ronald J. Clark, Bernt Fredrik Julius Broberg
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Patent number: 5682038Abstract: A flow cytometry system includes a flow tube through which particles marked with different fluorochromes pass from a first location, illuminated by a red laser, to a second location, illuminated by a blue laser. A "red" photodetector is optically coupled to detect red fluorescence from both locations. "Yellow" and "green" photodetectors respectively detect yellow and green fluorescence from the second location, while a "scattered light" detector detects scattered light from the second location. During a sample run, the red photodetector can output pulses that correspond primarily to APC fluorochrome at the first location and to PerCP at the second location respectively. A delay device delays the APC pulse relative to the PerCP pulse so that the peaks can be scaled and subtracted in the analog electrical domain to remove APC/PerCP crosstalk. The delay is calibrated using a set of APC tagged cells.Type: GrantFiled: April 6, 1995Date of Patent: October 28, 1997Assignee: Becton Dickinson and CompanyInventor: Michael A. Hoffman
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Patent number: 5645526Abstract: An iontophoretic drug delivery device including a reusable controller and patch are disclosed. The controller and patch include electronics which ensure compatibility of the reusable iontophoretic controller with the specific patch to which it is connected. If the controller determines that the patch is incompatible with the controller, the controller does not apply current to the patch.Type: GrantFiled: September 30, 1994Date of Patent: July 8, 1997Assignee: Becton Dickinson and CompanyInventor: Ronald J. Flower
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Patent number: 5627442Abstract: The apparatus includes a combination of a microscope and an interative image analysis system comprising a camera and a computer work station. The purpose of the apparatus is to facilitate the interactive control of coordinate displacements of the stage of the microscope. For each coordinate x and y an electromechanical control channel is established. At the input of the control channel two cascaded wheels in a coaxial arrangement and two angle encoders are used as a detached, independent tool which is not kinematically linked to the stage. In the middle of the control channel, the pulses of the angle encoders undergo a non-linear transformation. A processor performs a calculation which discriminates between slow displacements and fast displacements. At the end of the control channel, a flat, easily accessible platform of the microscope stage has two working areas, one for manual previewing and one for interactive scanning of a specimen.Type: GrantFiled: October 3, 1995Date of Patent: May 6, 1997Assignee: Becton Dickinson and CompanyInventors: Peter D. Engelse, Alexander Flipse, Walter Janus
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Patent number: D454394Type: GrantFiled: March 19, 2001Date of Patent: March 12, 2002Assignee: Becton Dickinson and CompanyInventor: Hubert Jansen
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Patent number: D463546Type: GrantFiled: April 5, 2000Date of Patent: September 24, 2002Assignee: Becton Dickinson and CompanyInventors: Hubert Jansen, Lionel Vedrine, Eric Denis, Samuel Bernier, Emmanuel Delarue