Patents Represented by Attorney, Agent or Law Firm Anderson & Citkowski, P.C.
  • Patent number: 8318428
    Abstract: Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS:1-89, and 96-104. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS:1-89, and 96-104. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV. Mutations in both the reverse transcriptase and the protease of HIV can be detected using the methods described herein.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: November 27, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventors: Jeffrey A. Johnson, Walid Heneine
  • Patent number: 8318717
    Abstract: The present invention relates to compounds capable of inhibiting binding of the Smac protein to Inhibitors of apoptosis (IAPs). Such compounds are preferably capable of inhibiting IAP and thus may promote apoptosis or sensitize cells for apoptosis. The compounds may be used in the treatment of proliferative diseases, such as cancer.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: November 27, 2012
    Assignee: 2cureX
    Inventors: Ole Thastrup, Jens Chr. Norrild
  • Patent number: 8312927
    Abstract: Apparatus and methods are described for recovering hydrocarbonaceous and additional products from nonrubilized oil shale and oil/tar sands. One or more initial condensation steps are performed to recover crude-oil products from the effluent gas, followed by one or more subsequent condensation steps to recover additional, non-crude-oil products. The effluent gas is maintained under a negative pressure from the hole and through the initial and subsequent condensation steps. This provides numerous advantages, including the adjustment of various physical parameters during the extraction process. Such adjustment allows the ratio of oils types to be varied, the ratio of hydrocarbonaceous products to non-crude products to be varied, contamination control, and other disclosed advantages.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: November 20, 2012
    Assignee: General Synfuels International, Inc.
    Inventors: Michael D. Lockhart, Ron McQueen
  • Patent number: 8312928
    Abstract: Apparatus and methods for recovering hydrocarbonaceous and additional products from nonrubilized oil shale and oil/tar sands. One or more initial condensation steps are performed to recover crude-oil products from the effluent gas, followed by one or more subsequent condensation steps to recover additional, non-crude-oil products. At least a portion of the exhaust gas from a combustor may be routed through a heat exchanger to produce the processing gas, the composition of which may be adjusted so that it contains approximately 1% oxygen or less. The subsequent condensation steps may be carried out in at least one cooled chamber having a sequence of critical orifices maintained at a negative pressure. Carbon sequestration steps may be performed wherein recovered carbon dioxide is delivered down the hole following the recovery of the hydrocarbonaceous products. Various physical parameters may be adjusted to vary the recovery of crude oil or other products or contaminants from the effluent gas.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: November 20, 2012
    Assignee: General Synfuels International, Inc.
    Inventors: Michael D. Lockhart, Ron McQueen
  • Patent number: 8313798
    Abstract: A process for fabricating a structural color having ultraviolet reflectance is provided. The process includes providing an atomizing nozzle, a first nanoparticle solution and a second nanoparticle solution. The atomizing nozzle is used to spray a plurality of first nanoparticle solution layers, the plurality of first nanoparticle layers forming a low index of refraction stack. In some instances, a polymer solution can be sprayed before and/or after the spraying of each first nanoparticle solution layer. The atomizing nozzle is also used to spray a plurality of second nanoparticle solution layers, the plurality of second nanoparticle layers form a high index of refraction stack. Similar to the first nanoparticle solution layers, a polymer solution can be sprayed before and/or after the spraying of each second nanoparticle solution layer.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: November 20, 2012
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Massachusetts Institute of Technology
    Inventors: Grinia Michelle Nogueira, Debasish Banerjee, Michael F. Rubner, Robert E. Cohen
  • Patent number: 8313708
    Abstract: An apparatus for treating objects with a treatment gas comprises a treatment chamber, a chamber input through which objects enter the treatment chamber, and a chamber output (which may be the same as the chamber input) through which the objects leave the treatment chamber. The treatment chamber encloses the treatment gas, which can be steam. The chamber output and/or the chamber input include an intermediate medium, such as a liquid, through which the objects pass. The intermediate medium prevents escape of the treatment gas from the treatment chamber and the ingress of external gases into the treatment chamber, while facilitating input of the objects to the chamber, and output of the objects from the chamber.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: November 20, 2012
    Assignee: The Penn State Research Foundation
    Inventor: Paul N. Walker
  • Patent number: 8307598
    Abstract: The present invention concerns an insulating wall system for a building structure, wherein the wall system comprises a first wall having an exterior surface with insulation material attached to the exterior surface of the first wall by elongated fastening members extending through at least one wall member of a second wall and the insulation material and being fixed to the first wall, wherein the elongated fastening members are mounted substantially perpendicular to the exterior surface of the first wall and that the elongated fastening members are mounted pre-stressed with a predetermined amount of tension so that frictional forces between the insulation material and the exterior surface of the first wall and the inner surface of the second wall, respectively, are established. A wall system according to the invention includes fewer components and may provide an improved insulation as the components constituting thermal bridging may be reduced.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: November 13, 2012
    Assignee: Rockwool International A/S
    Inventors: David Overton Charbre Holm, Preben Riis
  • Patent number: 8308226
    Abstract: A storage panel assembly for a vehicle includes a panel having a louvered exterior and internal surfaces. A vent structure is formed on a portion of the panel. At least one jack wrench clip assembly is formed on the portion of the panel including the vent structure. The exterior louvered surface of the panel remains unblemished.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: November 13, 2012
    Assignee: Toyota Motor Engineering & Manufacturing North America, Inc.
    Inventors: Matthew Frank Parkinson, Robert Charles Steinbrecher
  • Patent number: 8308601
    Abstract: A differential gear device includes a case in which a housing portion is formed, and which rotates around a rotation center line; a first protruding portion that is located at a position away from the rotation center line, and protrudes from an inner surface of the case toward the rotation center line, wherein the first protruding portion tapers in a direction from the inner surface of the case toward the rotation center line; a first gear that is provided around the first protruding portion, and that is rotatable; a second gear that engages with the first gear, and that is connected with a first output shaft; and a third gear that engages with the first gear, and that is connected with a second output shaft.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: November 13, 2012
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Shinichiro Ishikawa, Masato Kurosaki
  • Patent number: 8307912
    Abstract: Disclosed is a tool (5) comprising a cam track (A) and cam follower (B), wherein the cam track (A) comprises a first cam track wall (15) and the cam follower (B) comprises a first cam follower wall (15), and the first cam track wall (10) and first cam follower wall (15) face one another. The cam track (A) further comprises a second cam track wall (30) and the cam follower (B) comprise a second cam follower wall (35), and the second cam track wall (30) and second cam follower wall (35) face one another. The first and second cam track wall (10, 30) are disposed so as to face one another. The first and second cam follower wall are disposed so as to oppose one another, e.g. back to back. The first/second cam track wall (10, 30) comprise a first/second cam track wave (20, 40). The second cam follower wall (15, 35) comprise a first/second cam follower wave (25, 45).
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: November 13, 2012
    Inventor: Hugh Edward Fisher
  • Patent number: 8309541
    Abstract: Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: R2-R-R1, where R is phenyl, where R1 is (CH2)nSe—C(?NH)—NH2, where R2 is (CH2)nSe—C(?NH)—NH2 or R2 is H, and where each n is independently 2, 3, 4, 5, 6, 7, or 8. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including one or more compounds having the structural formula I to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: November 13, 2012
    Assignee: The Penn State Research Foundation
    Inventors: Gavin P. Robertson, SubbRao V. Madhunapantula, Shantu Amin, Dhimant Desai
  • Patent number: 8306708
    Abstract: A control device for a vehicular automatic transmission which can realize a shifting with quickened response with suppressing a turbine blow-up during the shifting is provided. When a response in hydraulic pressure control by a hydraulic pressure control circuit 42 fails to satisfy a preset predetermined determining criterion, a shifting response is prevented from improving, in comparison to a case where the determining criterion is satisfied. Under a relatively low response of the hydraulic pressure control by the hydraulic pressure control circuit 42 due to air mixture to working oil, a control to inhibit a high-response shifting or the like is performed, so that a turbine blow-up caused by a delayed response of hydraulic pressure can be prevented. Thus, the control device for the vehicular automatic transmission can be provided, which can realize the shifting with quickened response, with suppressing the turbine blow-up during the shifting.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: November 6, 2012
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Keisuke Ota, Hitoshi Matsunaga, Koji Oshima
  • Patent number: 8305048
    Abstract: A vehicle power generating device includes an alternator which has a voltage regulator that keeps the voltage of generated power constant, and an electronic control unit that controls the voltage regulator. In this vehicle power generating device, the alternator has an abnormally high temperature determining portion that determines whether the temperature of the alternator is abnormally high, and an abnormal signal outputting portion which, when it has been determined by the abnormally high temperature determining portion that the temperature of the alternator is abnormally high, outputs a signal indicative of the determination that the temperature is abnormally high to the electronic control unit. Also, when the electronic control unit receives the signal indicative of the determination that the temperature is abnormally high, the electronic control unit controls the voltage regulator such that the voltage generated by the alternator is suppressed.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: November 6, 2012
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventor: Hidehiko Matsui
  • Patent number: 8303941
    Abstract: A composition comprising mineral water and a chelating agent present in an amount sufficient to maintain all of the minerals in the water in solution. The mineral water is preferably obtained from Mount Clemens, Mich., US, and is preferably chelated with an ammonium and/or a sodium salt of an acid selected from the group consisting of ethylenediaminetetraacetic acid, nitrilotetraacetic acid, ?-alaninediacetic acid, ethylenediaminosuccinic acid, aminotrimethylenephosphoric acid, serinediaacetic acid, asparaginediacetic acid, methylgylcinediacetic acid and mixtures thereof. The resultant chelated mineral water may be combined with a cosmetically acceptable skin-conditioning agent and a cosmetically acceptable topical carrier, thereby resulting in a cosmetic composition that will confer beneficial effects on the skin, e.g., softening, hydrating and healing effects.
    Type: Grant
    Filed: April 19, 2008
    Date of Patent: November 6, 2012
    Assignee: Geologix, Inc.
    Inventor: Stephen Musumeci
  • Patent number: 8302810
    Abstract: A tissue dispenser for use with a cup holder having a body including a lower portion dimensioned for being received within an inner wall associated with the cup holder. An opening is provided in the body for withdrawing successive tissues. A waste storage compartment is configured within the body separate from the opening for storing used tissues.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: November 6, 2012
    Inventors: Elie Mulhem, Miguel A. Linares
  • Patent number: 8305444
    Abstract: A motor vehicle with an integrated visual display system for displaying proximity location information on an external object while the motor vehicle is parked or moving is provided. The integrated visual display system is operable to display information from a plurality of proximity sensors on a single display screen. The plurality of proximity sensors can be part of an autonomous and/or cooperative collision warning system.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: November 6, 2012
    Assignee: Toyota Motor Engineering & Manufacturing North America, Inc.
    Inventor: Hideki Hada
  • Patent number: 8306720
    Abstract: In a power output apparatus, when the fuel vapor concentration is high and the target purge rate is high, an operating point on a purge priority operating line is selected as a target operating point of an engine. As a result, the intake manifold negative pressure greater than that when an operating point on an optimum fuel efficiency operating line is selected, so that the flow rate of purge gas released from a canister is increased. When the fuel vapor concentration does not fall within a high-concentration range, the necessity to immediately purge fuel vapor trapped in the canister into the intake pipe is low, and thus an operating point on the optimum fuel efficiency operating line is selected to keep the engine operating at high fuel efficiency.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: November 6, 2012
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Makoto Yamazaki, Shunsuke Fushiki
  • Patent number: 8305572
    Abstract: A material which is generally transparent in the visible region of the spectrum but reflective at laser wavelengths reduces undesirable, substrate-induced Raman and fluorescence scattering. A substrate provides a surface for supporting the sample, with the material being disposed between the surface of the substrate and the sample. The material is substantially transparent in the visible region of the spectrum but reflective at the laser wavelength, thereby minimizing unwanted Raman or fluorescence scattering that would be produced by the substrate if the material were not present. The substrate will typically be a glass microscope slide or multi-cell well plate. The optical filter material is preferably a multilayer dielectric filter acting as a “hot mirror” that reflects near-infrared energy. An advantage of visible transmission is that it allows back illumination from behind/underneath the slide or well plate, thereby being visible to a microscope's eyepiece or video camera.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: November 6, 2012
    Assignee: Kaiser Optical Systems
    Inventor: Ronald C. Fairchild
  • Patent number: D670187
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: November 6, 2012
    Inventors: David L. Hall, Andrew D. Frost, Andrew Stouffer
  • Patent number: D670893
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: November 20, 2012
    Inventor: Craig Feller