Patents Represented by Attorney, Agent or Law Firm Andrea G. Reister
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Patent number: 6830737Abstract: Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the separated second phase, which is then returned (solvent poor) to the emulsion. This process of separation of a solvent rich phase, extraction of solvent, and return of a solvent poor phase, is carried out until a selected level of solvent in the emulsion is achieved. Alternatively, the separated solvent rich phase is not returned to the emulsion, but replaced with another solution, such as an aqueous solution, that is free from solvent. The solvent is preferably extracted into an extraction liquid that functions as a “solvent sink” for the solvent.Type: GrantFiled: September 6, 2002Date of Patent: December 14, 2004Assignee: Alkermes Controlled Therapeutics Inc. IIInventor: J. Michael Ramstack
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Patent number: 6827943Abstract: Described are dermatological compositions for treating, protecting and re-epitheliazing cutaneous wounds and damaged skin, such compositions including about 21 to about 40% urea and trace amounts of zinc, copper and manganese in the form of their respective pharmaceutically acceptable salts.Type: GrantFiled: December 23, 2002Date of Patent: December 7, 2004Assignee: Bradley Pharmaceuticals, Inc.Inventors: Bradley P. Glassman, Dileep Bhagwat, Daniel Glassman
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Patent number: 6824822Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.Type: GrantFiled: August 31, 2001Date of Patent: November 30, 2004Assignee: Alkermes Controlled Therapeutics Inc. IIInventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
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Patent number: 6803055Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.Type: GrantFiled: February 6, 2003Date of Patent: October 12, 2004Assignees: Alkermas Controlled Therapeutics Inc. II, Janssen PharmaceuticaInventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins
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Patent number: 6800663Abstract: The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with &agr;-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(&agr;-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(&agr;-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.Type: GrantFiled: October 18, 2002Date of Patent: October 5, 2004Assignee: Alkermes Controlled Therapeutics Inc. II,Inventors: Firouz Asgarzadeh, Henry R. Costantino
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Patent number: 6766799Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.Type: GrantFiled: April 16, 2001Date of Patent: July 27, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: David Edwards, Mark Delong, Craig Dunbar, Ernest E. Penachio, Kevin Stapleton, Mark Wolff
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Patent number: 6743417Abstract: A method of treating onychomycosis is described which includes administration of a topical formulation containing an effective amount of urea and an antioxidant to an infected area around a nail of a patient.Type: GrantFiled: April 22, 2002Date of Patent: June 1, 2004Assignee: Bradley Pharmaceuticals, Inc.Inventors: Bradley P. Glassman, Dileep Bhagwat, Daniel Glassman
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Patent number: 6732732Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.Type: GrantFiled: October 10, 2002Date of Patent: May 11, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: David Edwards, Colleen Conlon, Sarah Dreesen, Mark DeLong
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Patent number: 6730772Abstract: A polymer of a ring-opened functionalized epoxide is formed by the polymerization of a functionalized epoxide monomer having the structure E-CHR-G wherein E represents an epoxide group, R is hydrogen or an alkyl group, and G is a derivatizable group such as an unsaturated functionality or ester substituent.Type: GrantFiled: June 22, 2001Date of Patent: May 4, 2004Inventor: Venkatram P. Shastri
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Patent number: 6727347Abstract: Polycation bioconjugates and a method for producing them. The polycations are capable of transporting active substances of different types. The polycations function as carrier molecules that transport enhancer molecules, thereby enhancing the biological effectiveness of the transported molecules. The polycation bioconjugates of the present invention may inhibit malignant cell proliferation, possess antimicrobial effect, or be configured for gene transport.Type: GrantFiled: May 7, 2002Date of Patent: April 27, 2004Inventor: Peter Szego
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Patent number: 6715259Abstract: Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a container receptacle, and a cap carrier defining a cap receptacle. The system also includes a dosing portion having a dosing plate defining a dosing hole. The dosing plate is movable between two positions so that when the dosing plate is in the first position the dosing hole is positioned to receive a dose of powder. When the dosing plate is in the second position, the dosing hole is positioned to dispense the dose of powder into the container receptacle.Type: GrantFiled: January 23, 2002Date of Patent: April 6, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: Lloyd P. Johnston, Kevin Stapleton, Ernest Penachio, Mark Wolff
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Patent number: 6713090Abstract: Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.Type: GrantFiled: January 31, 2003Date of Patent: March 30, 2004Assignee: Alkermas Controlled Therapeutics Inc. IIInventors: Shawn L. Lyons, Steven G. Wright
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Patent number: 6705757Abstract: Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.Type: GrantFiled: December 16, 2002Date of Patent: March 16, 2004Assignee: Alkermes Controlled Therapeutics, Inc. IIInventors: Shawn L. Lyons, Steven G. Wright
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Patent number: 6703477Abstract: Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.Type: GrantFiled: February 1, 2002Date of Patent: March 9, 2004Assignee: Alkermes Controlled Therapeutics, Inc. IIInventor: Chiem V. Pham
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Patent number: 6673842Abstract: A method of treating onychomycosis is described which includes administration of an effective amount of urea in a topical formulation to an infected area around a nail of a patient.Type: GrantFiled: March 20, 2002Date of Patent: January 6, 2004Assignee: Bradley Pharmaceuticals, Inc.Inventors: Dileep Bhagwat, Bradley P. Glassman, Daniel Glassman
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Patent number: 6667061Abstract: Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.Type: GrantFiled: September 30, 2002Date of Patent: December 23, 2003Assignee: Alkermes Controlled Therapeutics, Inc.Inventors: J. Michael Ramstack, M. Gary I. Riley, Stephen E. Zale, Joyce M. Hotz, Olufunmi L. Johnson
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Patent number: 6595951Abstract: The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member having first and second ends. The closure system includes a deformable closure means adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.Type: GrantFiled: May 19, 2000Date of Patent: July 22, 2003Assignee: Alza CorporationInventors: Patrick S. -L. Wong, James Horvath, Radomir N. M. Vukadin, Joyce C. Anthony, Vincent J. Ferrari, Jeffrey W. Etter, Christopher M. G. Ohms
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Patent number: 6596316Abstract: An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.Type: GrantFiled: January 31, 2002Date of Patent: July 22, 2003Assignee: Alkermes Controlled Therapeutics, Inc. IIInventors: Shawn L. Lyons, J. Michael Ramstack, Steven G. Wright
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Patent number: 6572582Abstract: The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.Type: GrantFiled: November 23, 1999Date of Patent: June 3, 2003Assignee: Alza CorporationInventors: Patrick S. L. Wong, Stephen S. Hwang, Vincent J. Ferrari
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Patent number: 6544559Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.Type: GrantFiled: January 29, 2002Date of Patent: April 8, 2003Assignees: Alkermes Controlled Therapeutics Inc. II, Janssen ParmaceuticaInventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins