Abstract: Porous filter media and methods for characterizing, selecting and using such media based on their dynamic wettability are disclosed. The dynamic wettability of a medium is a measure of how quickly a given liquid is absorbed by the medium.

Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Abstract: Apparatus (10), systems and methods are disclosed for treating a biological fluid with light. A container (206) of biological fluid is introduced into a fluid treatment chamber (40) where it is contacted with light provided by one or more light sources (60, 70) in proximity to the fluid treatment chamber (40). A light sensing system (650) senses the intensity of illumination of the light. A radiometer (460) may be inserted into fluid treatment chamber (40) to calibrate the light sensing system (650). An electronic control system (600) utilizes an interface circuit board (606) to interface a computer circuit board (602) to a display panel (37), a user interface panel (39, 39a), a relay circuit board (640), light sensors 404 and various other sensors (649). A detector (385) senses agitating movement of a tray (90) that contains biological fluids.

Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Abstract: Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Abstract: Methods and systems for preparing blood products that are ready for treatment in established pathogen inactivation procedures are disclosed. The methods include providing a source of a blood component and combining the blood component with a synthetic medium in a selected ratio of the blood component to the synthetic media, whereby the resulting blood product is treatment-ready.

Abstract: Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit selected from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller including programs for use with the fluid circuits.

Abstract: Automated systems and methods for withdrawing and replacing fluids in a patient are disclosed. The system withdraws blood from a donor or patient, separates the blood into two or more components and collects the separated component. A replacement fluid capable of at least partially providing the biological function of the separated component is infused into the patient.

Abstract: Automated systems and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.

Abstract: Apparatus for withdrawing whole blood from a donor, separating the whole blood to obtain a target cell population and returning a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in association with a rotatable separation device of the apparatus may also be provided. The disposable inset may include a chamber for receiving a cell suspension that includes the target cell, a receptacle for containing particles having a binding site for selectively binding to the target cell and a means for introducing the particles into the chamber.

Abstract: Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further processes or treats the separated component.

Abstract: Methods are disclosed for the collection of red blood cells whereby whole blood is combined with an anticoagulant, red cells are separated from the whole blood and the separated red cells are combined with a storage solution. The red cells may be stored for an extended period of time.

Abstract: An apparatus is disclosed for separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force or faster rate than the second type of particle. A housing is provided having a generally cylindrical inner surface in which is mounted a rotor having a generally cylindrical outer surface. The outer surface of the rotor is spaced from the inner surface of the housing to define a suspension processing gap. A filter membrane is provided on the surface of the rotor or the housing that has pores with substantially precisely dimensioned shapes and sizes to correspond substantially to the shape of the first type of particle, thus allowing passage of the first type of particle and blocking passage of the second type of particle. A suspension is directed into the processing gap for either a selected residence time in contact with the filter membrane and/or at a selected force.

Abstract: Plastic compositions, medical containers and methods for providing such compositions and containers are disclosed. The plastic compositions and the medical containers made thereof include a plastic resin, Vitamin E and a plasticizer. The plastic resin may be polymeric material such as polyvinyl chloride or polyolefin.

Abstract: A blood sampling system for obtaining blood samples from a fluid flow path is disclosed. The sampling system includes a container that can be isolated from the remainder of a blood processing set and allows for collection of a sample either before or after the blood donation.

Abstract: Containers and methods for making containers are disclosed. The containers include a chamber and a pouch fixed within the chamber. During manufacture, the open edges of the pouch are sealed between the walls of the container by a seal defining, in part, the peripheral edge of the chamber.

Abstract: Platelet suspensions and methods for resuspending platelet concentrates are disclosed. The platelet concentrates are resuspended by combining a platelet concentrate with a substance capable of resuspending platelets, such as a salt solution. The resuspended platelets may be stored and/or administered to a patient.

Abstract: A container for irradiation comprises a flexible, flat collapsible wall defining a sealed chamber, the plastic material of said wall being substantially transparent to the irradiation, which is typically ultraviolet radiation. An access port or ports are provided for communicating through the wall to the chamber. A flap is provided, integral with the wall and spaced from the chamber. The flap carries identifying indicia including a typically bar code indicia, so that the wall which defines the chamber may be at least substantially free of opaque indicia. Also, means may be provided for detecting an indicating exposure of the container to such irradiation, such as ultraviolet sensitive tape adhering to the flap. Alignment holes may be provided, typically in the flap, to facilitate the orientation of the container with apparatus for irradiation and apparatus for bar code reading, making use of alignment pins carried by such apparatus.

Abstract: Apparatus for separating a biological component from a biological fluid are disclosed. The apparatus includes a chamber for receiving a biological fluid including a biological component, and a rotor for creating a centrifugal field within the chamber. A source of particles may be included wherein the particles have a binding site for selectively binding to the biological component. The particles may be aseptically introduced into the chamber. The apparatus may withdraw whole blood from a donor, separate the whole blood to obtain a target cell population and return a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in conjunction with a rotatable separation device such as the apparatus described above may also be provided.

Abstract: Apparatus and methods for treating a biological fluid with light and for inactivating contaminants in biological fluid. The biological fluid is contacted with a light source providing a high intensity light to the biological fluid. The biological fluid may include a quantity of a photochemical agent that when activated by light is operable to cause inactivation of at least some of the contaminants.