Abstract: The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant<1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system; a pharmaceutical composition comprising said binding molecule; and a method of treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system.
Type:
Grant
Filed:
October 27, 2008
Date of Patent:
April 24, 2012
Assignee:
Novartis AG
Inventors:
Carmen Barske, Stefan Frentzel, Anis Khusro Mir, Martin E. Schwab, Alessandra Vitaliti Garami
Abstract: Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-?) and methods useful in their preparation are provided. The compositions comprise the IFN-? solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 3.0 to about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-? in pharmaceutical compositions, are provided.
Type:
Grant
Filed:
April 9, 2008
Date of Patent:
February 22, 2011
Assignee:
Novartis Vaccines and Diagnostics
Inventors:
Bret A Shirley, Susan Babuka, Bao-Lu Chen, Maninder Hora, Minna Choe, Melanie Tellers
Abstract: The present invention relates to novel uses of a construct consisting of virus-like particle (VLP) structure chemically coupled to a fragment of the A?-1-42 peptide and its pharmaceutically acceptable salts (hereinafter CONSTRUCT), in particular to dosage regimens, modes of and dosage forms for the administration of a CONSTRUCT for the treatment of patients suffering from dementia, in particular dementia of the Alzheimer's type.
Type:
Grant
Filed:
November 3, 2005
Date of Patent:
January 11, 2011
Assignee:
Novartis AG
Inventors:
Ana Graf, Matthias Staufenbiel, Thomas Blättler, Paolo Paganetti
Abstract: Methods and compositions for the prevention, treatment and diagnosis of Lyme disease. Novel B. burgdorferi polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof. Fusion proteins and multimeric proteins comprising same. Multicomponent vaccines comprising novel B. burgdorferi polypeptides in addition to other immunogenic B. burgdorferi polypeptides. DNA sequences, recombinant DNA molecules and transformed host cells useful in the compositions and methods. Antibodies directed against the novel B. burgdorferi polypeptides, and diagnostic kits comprising the polypeptides or antibodies.
Type:
Grant
Filed:
September 14, 1998
Date of Patent:
April 6, 2004
Assignee:
Yale University
Inventors:
Richard A. Flavell, Erol Fikrig, Tuan T. Lam, Fred S. Kantor, Stephen W. Barthold