Abstract: The present invention is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such labels; and to processes for performing bioanalytical assays for target analytes which use such labels. Assays for folate, theophylline, and tobramycin (using such labels with hydrophilic modifiers such as nonionic polyethylene glycol and polyionic spermine disulfonate and polyionic spermine dicarboxylate) are described in detail.

Abstract: An apparatus and a method for analyzing a plurality of samples according to an analysis protocol is described, wherein each of the samples is contained within a liquid test package comprising a plurality of liquid and air segments including a reagent segment and wherein during at least a portion of the protocol the reagent segment emits photons. At least one of the liquid test pack includes a buffer segment separated from the reagent segment by a vanish bubble. The apparatus comprises a fluid conduit through which the liquid test packages are flowed, a first luminometer positioned along the fluid conduit for detecting photons emitted by the reagent segment of the at least one of the liquid test packages, a second luminometer positioned along the fluid conduit for detecting photons emitted by the reagent segments of the liquid test packages other than the at least one of the liquid test packages, and a vanish zone contained within the fluid conduit between the first and second luminometers.

Abstract: An adapter for holding a sample container includes a main body portion and a tapered body portion that forms a continuation of the main body portion. The tapered body portion includes a mouth opening that is of lesser diameter than the diameter of the main body portion. The mouth opening of the adapter is sized to provide direct support of a sample container which holds a liquid sample. During liquid level sensing ultrasonic waves from an ultrasound detector are reflected back to the sound detector as echoes from the lip flange of the sample container and from the liquid level within the sample container. The tapered surface of the adapter deflects sound echoes away from the sound detector. The adapter is thus invisible to the ultrasound detector. The echo from the liquid level is a variable duration echo and the echo from the lip flange of the sample container is a fixed duration echo that is always of lesser duration than the variable duration echo.

Abstract: The invention relates to crosslinked bead polymers doped with superparamagnetic iron oxide, to a process for the preparation of the bead polymers, and to the use thereof in nucleic acid diagnosis.

Abstract: The reagent package includes a container housing section and a container lid that arc sealed together to define one or more inside chambers. An opening in the container lid provides access to a corresponding chamber. The chamber opening is controlled by a valve that is pivotable from an open position to a closed position and vice versa. When the valve is in an open position the container chamber can be accessed through the valve with an aspiration probe and a dispensation probe. The reagent package accommodates a filter screen member and a glass ampoule in the container chamber. The glass ampoule contains one reagent ingredient, which can be a dry powder and the space within the chamber outside the glass ampoule can contain a reconstituting liquid. When the reagent package is ready for use a pressure force is imposed on the outside wall of the chamber adjacent the glass ampoule to crush the ampoule and permit the liquid within the chamber to mix with the dry powder released from the glass ampoule.

Abstract: A method for feeding containers into an analytical instrument whereby a sample handler moves and positions racks, containing sample tubes, into, within and out of the analytical instrument. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. The racks are seated within the in-feed and are transported onto a cross-feed. The cross-feed moves the racks to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.

Abstract: A method and apparatus for controlling a stream of liquid and air segments wherein the liquid and air segments are selectively aspirated into a first fluid conduit in a plurality of cycles, each cycle beginning with the aspiration of a first air segment and ending with the aspiration of a final air segment. The liquid and air segments are then transferred from the first fluid conduit to a second fluid conduit. The volume of the final air segment of each cycle is then adjusted after the final air segment has moved into the second fluid conduit. Next, the liquid segments and the air segments of each cycle are transferred from the second fluid conduit to a third fluid conduit. The volume of the first air segment of each cycle is then adjusted after the first air segment has moved into the third fluid conduit.

Abstract: The present invention relates to methods for the production of a stable troponin preparation and its use as a calibrator and/or control in immunoassays. The formulation is prepared from mammalian, preferably bovine, heart tissue which provides a calibrator/control composition which remains stable over a long period of time.

Abstract: Racks having sample containers mounted therein are transported within an analytical system so that a robotic arm can remove the sample containers and deliver them to a desired location within the system. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. Sample tube racks are seated within the in-feed and are transported onto a cross-feed. The cross-feed comprises a movable track having a platform mounted thereto. The cross-feed moves the sample tube racks from a position behind the in-feed to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.

Abstract: A sample handler moves and positions sample tube racks in an analytical instrument. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. Sample tube racks are seated within the in-feed and are transported onto a cross-feed. The cross-feed comprises a movable track having a platform mounted thereto. The platform includes spring loaded gripper fingers that engages and secures the sample tube rack to the platform. The cross-feed moves the sample tube racks to a point where they are accessed by the analytical instrument. Thereafter, the cross-feed moves the sample tube racks to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.

Abstract: The reagent package includes a container housing section and a container lid that are sealed together to define one or more inside chambers. The reagent package accommodates a filter screen member and a glass ampoule in the container chamber. The glass ampoule contains one reagent ingredient, usually in a dry powder form and the space within the chamber outside the glass ampoule usually contains a reconstituting liquid ingredient. When the reagent package is ready for use a pressure force is imposed on the outside wall of the chamber adjacent the glass ampoule to crush the ampoule and permit the liquid ingredient within the chamber to mix with the powder ingredient released from the glass ampoule.

Abstract: A method whereby a sample handler moves and positions racks, containing sample tubes, in an analytical instrument. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. The racks are seated within the in-feed and are transported onto a cross-feed. The racks and tubes contained thereon are moved past detection devices that identify the samples and measure various properties thereof. Thereafter, the cross-feed moves the racks to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.

Abstract: The sample dilution module includes an oil filled aspiration probe and mixing chamber that communicate with each other while the mixing chamber is maintained at an angle of approximately 5 to 45 degrees below a horizontal axis. The aspiration probe is maintained in a vertical orientation. A micro-bubble is aspirated between separate aspirations of test sample and diluent to prevent contact between the sample and diluent in the aspiration probe. The test sample and diluent are then drawn from the vertically oriented aspiration probe into the mixing chamber. After the sample and diluent are in the mixing chamber the micro-bubble of air can migrate away from the test sample and diluent to enable the test sample and diluent to contact each other. Mixing of the test sample and diluent is accomplished by moving the test sample and diluent back and forth in the mixing chamber without physical agitation of the mixing chamber and without any mixing element in the mixing chamber.

Abstract: Racks having sample containers mounted therein are transported within an analytical system so that a robotic arm can remove the sample containers and deliver them to a desired location within the system. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. Sample tube racks are seated within the in-feed and are transported onto a cross-feed. The cross-feed comprises a movable track having a platform mounted thereto. The cross-feed moves the sample tube racks from a position behind the in-feed to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.

Abstract: A sample handler moves and positions racks, containing sample tubes, in an analytical instrument. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. The racks are seated within the in-feed and are transported onto a cross-feed. The racks and tubes contained thereon are moved past detection devices that identify the samples and measure various properties thereof. Thereafter, the cross-feed moves the racks to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.

Abstract: A robotic arm has a pair of gripper fingers designed to grip a variety of containers, including capped and uncapped test tubes as well as containers having unique gripping means. The fingers each have upper and lower projections separated by a groove, the respective projections facing each other when mounted to grippers on the robotic arm. The projections and groove serve to firmly hold the containers as well as self-align the unique gripping means on initially unaligned containers within the fingers as the fingers close around the containers. The fingers have clearance to avoid contact with caps on capped test tubes. Stops are provided at the top of each finger to engage one another and prevent fully closed fingers from deforming. The robotic arm may be transported along a rail mounted above the instrument and a gripper assembly, having a gripper arm, mounted to the robotic arm may be rotated above the instrument to move the container to various locations within the instrument.

Abstract: The conveyor system for clinical test apparatus includes a main transport conveyor and a plurality of auxiliary conveyors located alongside the main transport conveyor. The auxiliary conveyors define straight line paths of travel parallel to the straight line paths of travel of the main conveyor. Each of the auxiliary conveyors is operated by drive means separate from the main transport conveyor. Two crossover points are provided between the main transport conveyor and the auxiliary conveyor. One crossover point is an entrance from the main transport conveyor to the auxiliary conveyor and the other crossover point is an exit from the auxiliary conveyor to the main transport conveyor. Each crossover point is controlled by a gate. One of the gates is a divert gate which can be actuated to block the main transport path thereby diverting puck traffic onto the auxiliary conveyor.

Abstract: The stat shuttle adapter and transport device includes a conveyor with a movable platform for securement of the stat shuttle adapter. The stat shuttle adapter is a universal holding device that includes a carrier housing having male and female surfaces that engage complementary shaped female or male surfaces of a rack that is held by the carrier housing. The conveyor has a forward load position wherein racks are loaded onto the carrier housing. The conveyor also has a rearward unload position wherein the loaded rack is locked onto the carrier housing to facilitate removal of the contents of the rack from the carrier housing without upsetting the rack. A latch device on the carrier housing is normally biased to a lock position but is maintained in an unlock position when the carrier housing is at the forward load position of the conveyor. A latch engagement device on the conveyor maintains the latch in the unlock position while the carrier housing is at the forward load position of the conveyor.

Abstract: A profile of a rack, that may have zero, one, or a plurality of containers may be obtained using an ultrasonic sensor. The sensor emits a plurality of ultrasonic bursts and the rack is transported under the sensor at a slew speed that allows the sensor to detect at least first and second echoes from each of the bursts. Data points, corresponding to each of the first and second echoes, are generated and the data points are captured in a memory device. The data points, generally reflecting the levels of the rack and any containers, are processed to dynamically and non-invasively (i.e., without physically contacting the liquid with a probe) determine information about the container types, whether any container is capped, and, if one or more containers are uncapped, the liquid level in the uncapped containers.